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The map label for this gene is ndk

Identifier: 159900737

GI number: 159900737

Start: 5384359

End: 5384808

Strand: Direct

Name: ndk

Synonym: Haur_4224

Alternate gene names: 159900737

Gene position: 5384359-5384808 (Clockwise)

Preceding gene: 159900736

Following gene: 159900739

Centisome position: 84.84

GC content: 49.78

Gene sequence:

>450_bases
GTGGAAAAGTCATTGATCATCTTAAAGCCTGATGCAGTTCAACGTGGTTTAATTGGGCCAATTTTGACCCGCTTGGAAGC
TCGCGGCTTGAAATTTATCGGCATCAAATTGTCGCAAGTTAGCAGCGAGTTGGCCCACAAGCACTATGGCGTACACGAAG
GCAAGCCATTTTTCGCTGGCTTAGTTTCGTACATTACCTCAGGCCCAGTGCTGGTTGTTGCAGTTGAAGGCAAAGATGTG
ATCGAAATTGTGCGCTCAACCGTTGGCGCAACCAATCCCGTCAAGGCTGCCCCTGGCACAATCCGTGGCGATTTTGGTGT
GAACATCGGGCGCAACTTGATCCACGCCTCAGACTCACCTGAAAATGGCGATCATGAAGTGGCCTTGTTCTTCAGCAGCG
AAGAATTGATCCGCTCAGAACGCTCAGTCGATCAATGGATTACCGAGTAA

Upstream 100 bases:

>100_bases
TCGCTTTTTTTATGGCCGCTTGGCTAAATATGCTACAATGCCCACGGTCGTGTAAACGATTCTTTCTTTGATTAACGAAG
CATAATGGAGGCATTTCCCT

Downstream 100 bases:

>100_bases
TCTAGCTGGTTGATACGCCTTGGGATGTACATCCCAAGGCTTTTTATTTTAATTCGACCATAATTTAGATGTTTCGGGTG
AAGCAGTGATTAATCAGCAT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MEKSLIILKPDAVQRGLIGPILTRLEARGLKFIGIKLSQVSSELAHKHYGVHEGKPFFAGLVSYITSGPVLVVAVEGKDV
IEIVRSTVGATNPVKAAPGTIRGDFGVNIGRNLIHASDSPENGDHEVALFFSSEELIRSERSVDQWITE

Sequences:

>Translated_149_residues
MEKSLIILKPDAVQRGLIGPILTRLEARGLKFIGIKLSQVSSELAHKHYGVHEGKPFFAGLVSYITSGPVLVVAVEGKDV
IEIVRSTVGATNPVKAAPGTIRGDFGVNIGRNLIHASDSPENGDHEVALFFSSEELIRSERSVDQWITE
>Mature_149_residues
MEKSLIILKPDAVQRGLIGPILTRLEARGLKFIGIKLSQVSSELAHKHYGVHEGKPFFAGLVSYITSGPVLVVAVEGKDV
IEIVRSTVGATNPVKAAPGTIRGDFGVNIGRNLIHASDSPENGDHEVALFFSSEELIRSERSVDQWITE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI4557797, Length=149, Percent_Identity=45.6375838926174, Blast_Score=152, Evalue=7e-38,
Organism=Homo sapiens, GI38045913, Length=149, Percent_Identity=45.6375838926174, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI37693993, Length=148, Percent_Identity=45.945945945946, Blast_Score=152, Evalue=1e-37,
Organism=Homo sapiens, GI66392227, Length=149, Percent_Identity=42.2818791946309, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI66392205, Length=149, Percent_Identity=42.2818791946309, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI4505409, Length=149, Percent_Identity=42.2818791946309, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI66392192, Length=149, Percent_Identity=42.2818791946309, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI66392203, Length=149, Percent_Identity=42.2818791946309, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=44.8529411764706, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=33.0882352941176, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=31.1111111111111, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=31.1111111111111, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=41.1347517730496, Blast_Score=123, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17506807, Length=149, Percent_Identity=41.6107382550336, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322783, Length=148, Percent_Identity=48.6486486486487, Blast_Score=163, Evalue=1e-41,
Organism=Drosophila melanogaster, GI45549037, Length=148, Percent_Identity=45.945945945946, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=27.6119402985075, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_HERA2 (A9AXD6)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001546984.1
- ProteinModelPortal:   A9AXD6
- SMR:   A9AXD6
- GeneID:   5736078
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_4224
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   HAUR316274:HAUR_4224-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16114; Mature: 16114

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKSLIILKPDAVQRGLIGPILTRLEARGLKFIGIKLSQVSSELAHKHYGVHEGKPFFAG
CCCCEEEECCCHHHHCCHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHCCCCCCCHHHHH
LVSYITSGPVLVVAVEGKDVIEIVRSTVGATNPVKAAPGTIRGDFGVNIGRNLIHASDSP
HHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCEEECCCCC
ENGDHEVALFFSSEELIRSERSVDQWITE
CCCCCEEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKSLIILKPDAVQRGLIGPILTRLEARGLKFIGIKLSQVSSELAHKHYGVHEGKPFFAG
CCCCEEEECCCHHHHCCHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHCCCCCCCHHHHH
LVSYITSGPVLVVAVEGKDVIEIVRSTVGATNPVKAAPGTIRGDFGVNIGRNLIHASDSP
HHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCEEECCCCC
ENGDHEVALFFSSEELIRSERSVDQWITE
CCCCCEEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA