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The map label for this gene is argH

Identifier: 159900651

GI number: 159900651

Start: 5285338

End: 5286702

Strand: Reverse

Name: argH

Synonym: Haur_4138

Alternate gene names: 159900651

Gene position: 5286702-5285338 (Counterclockwise)

Preceding gene: 159900652

Following gene: 159900650

Centisome position: 83.3

GC content: 53.77

Gene sequence:

>1365_bases
ATGTGGGGTGGACGATTTAGTGGCTCGTTGGCTGAGCATATGCGCTTATTCAACGATTCGTTTCCAATCGATCGGCGCTT
ATGGGCCGAGGATATTCGCGGCTCAATTGCTTGGGCCAATGGCTTAGAACGCGCTGGCATTTTGCAAGCCGCCGAATGCC
AAGAACTGATCGCAGGCTTGCGCCAAGTCTATCAAGAGTTTGAAGAAGGCCTGTTTTTGCCATTAACCAGCGACGAAGAT
ATTCACACGGCGGTCGAACGCCGCTTGGGTGATTTTATCGGAGCCTTGGCGGGCAAATTGCATACTGGCCGCTCCCGCAA
CGATCAAGTGGCGACCGATACCCGTTTGTGGACATTGGGCGCACTCAAATTGGCCGATGATCTTATTCGTGATGTGCAAG
CGGCCTTGCTGGAACAAGCCAAAGCGGTTGGCGAAGCAATGTTACCTGGCTATACCCACCTGCAACGGGCGCAGCCAGTC
TTGTTATCGCACGCACTTTTAGCCCATTTTTGGCGTTTAGATCGCGATCGCCAACGCTTGCACGATGCAACCAAGCGCGT
CAGCGTACTGCCGTTAGGCTCAGGCGCACTGGCTGGTACAGCCTTCGCGGTTGATCGGGCGGCACTGGCAGCCGAATTAG
GCTTTACCAGCATCAGCCAAAATAGCCTCGATGCTACCAGTGATCGCGATTATATTGTCGAAATTTTGGCGGCAATCGCG
CTGTTGGGTGTCCACATTAGCCAGCTCGCCGAGGATTGGATCATCTGGAGCAGCTCGGAATGGGGTTTTGTCGCGCTAGA
CGATGCCTATTCAACTGGCTCAAGTTTAATGCCGCAGAAGAAAAACCCTGATTCGTTGGAGTTGGCTCGTGGCAAATCTG
GCCGTTTGATCGGCAATTTAATTACCGTTTTGACCTTGCTCAAAGGCCTGCCATCGGCCTACGACAAAGATTTACAAGAA
GATAAAGCGCCCTTATTCGATGCGATCGATACATTAAGCCTGACGTTACCAGTGGTTGCAGGTGCAATTCGTACCGCTCG
TTTCAACACCGAACGCATGGAATCGGCGCTTGATGATGCAATGCTGGCAACCGATGTAGCCGATGAATTGGTACGCCGGG
GAGTGCCATTCCGCGAGGCGCATCATATTGCTGGGCGTTTGGTGCGCGAAGCCGAACAACGTGGGGTTGGCATGCGCCAA
TTGCCTGCCGAAAGCTTCGTAGCCGCCCACCCAAGCCTGACCGATGTTGCTGGTTTATTCGATTTTGCTCGTTCCGTCGC
CATGCGCGACGTACCTGGTGGAACAGCGCCCAACGCCGTGCGCGACCAACTGATTGCTGCTCAACACGTTTTAGCAGAAG
GTTGA

Upstream 100 bases:

>100_bases
ATAGGCTAGTGGAATTTCGTTGGAAGATCAACAAAAGCCTATAGCCTTACCGATCCCCAATCCCCAGCTACCGACATCCA
AATAACGAGGTAACCAAACC

Downstream 100 bases:

>100_bases
GGTGGCTGCTAGCACCCTCGCCCTGCCGTTAATCAAACGGAGGCTTCCCAATGACACACCCACTTCTTGGTCGCGATTTA
CTGGCCTTGGCGGATTGGAA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MWGGRFSGSLAEHMRLFNDSFPIDRRLWAEDIRGSIAWANGLERAGILQAAECQELIAGLRQVYQEFEEGLFLPLTSDED
IHTAVERRLGDFIGALAGKLHTGRSRNDQVATDTRLWTLGALKLADDLIRDVQAALLEQAKAVGEAMLPGYTHLQRAQPV
LLSHALLAHFWRLDRDRQRLHDATKRVSVLPLGSGALAGTAFAVDRAALAAELGFTSISQNSLDATSDRDYIVEILAAIA
LLGVHISQLAEDWIIWSSSEWGFVALDDAYSTGSSLMPQKKNPDSLELARGKSGRLIGNLITVLTLLKGLPSAYDKDLQE
DKAPLFDAIDTLSLTLPVVAGAIRTARFNTERMESALDDAMLATDVADELVRRGVPFREAHHIAGRLVREAEQRGVGMRQ
LPAESFVAAHPSLTDVAGLFDFARSVAMRDVPGGTAPNAVRDQLIAAQHVLAEG

Sequences:

>Translated_454_residues
MWGGRFSGSLAEHMRLFNDSFPIDRRLWAEDIRGSIAWANGLERAGILQAAECQELIAGLRQVYQEFEEGLFLPLTSDED
IHTAVERRLGDFIGALAGKLHTGRSRNDQVATDTRLWTLGALKLADDLIRDVQAALLEQAKAVGEAMLPGYTHLQRAQPV
LLSHALLAHFWRLDRDRQRLHDATKRVSVLPLGSGALAGTAFAVDRAALAAELGFTSISQNSLDATSDRDYIVEILAAIA
LLGVHISQLAEDWIIWSSSEWGFVALDDAYSTGSSLMPQKKNPDSLELARGKSGRLIGNLITVLTLLKGLPSAYDKDLQE
DKAPLFDAIDTLSLTLPVVAGAIRTARFNTERMESALDDAMLATDVADELVRRGVPFREAHHIAGRLVREAEQRGVGMRQ
LPAESFVAAHPSLTDVAGLFDFARSVAMRDVPGGTAPNAVRDQLIAAQHVLAEG
>Mature_454_residues
MWGGRFSGSLAEHMRLFNDSFPIDRRLWAEDIRGSIAWANGLERAGILQAAECQELIAGLRQVYQEFEEGLFLPLTSDED
IHTAVERRLGDFIGALAGKLHTGRSRNDQVATDTRLWTLGALKLADDLIRDVQAALLEQAKAVGEAMLPGYTHLQRAQPV
LLSHALLAHFWRLDRDRQRLHDATKRVSVLPLGSGALAGTAFAVDRAALAAELGFTSISQNSLDATSDRDYIVEILAAIA
LLGVHISQLAEDWIIWSSSEWGFVALDDAYSTGSSLMPQKKNPDSLELARGKSGRLIGNLITVLTLLKGLPSAYDKDLQE
DKAPLFDAIDTLSLTLPVVAGAIRTARFNTERMESALDDAMLATDVADELVRRGVPFREAHHIAGRLVREAEQRGVGMRQ
LPAESFVAAHPSLTDVAGLFDFARSVAMRDVPGGTAPNAVRDQLIAAQHVLAEG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=445, Percent_Identity=49.2134831460674, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI68303542, Length=445, Percent_Identity=49.2134831460674, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI68303547, Length=445, Percent_Identity=46.5168539325843, Blast_Score=387, Evalue=1e-108,
Organism=Homo sapiens, GI68303549, Length=445, Percent_Identity=46.2921348314607, Blast_Score=384, Evalue=1e-107,
Organism=Escherichia coli, GI1790398, Length=451, Percent_Identity=45.8980044345898, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321806, Length=450, Percent_Identity=47.3333333333333, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI221473854, Length=445, Percent_Identity=44.9438202247191, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI78706858, Length=445, Percent_Identity=44.9438202247191, Blast_Score=387, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_HERA2 (A9AWL1)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001546898.1
- ProteinModelPortal:   A9AWL1
- SMR:   A9AWL1
- GeneID:   5735999
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_4138
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BioCyc:   HAUR316274:HAUR_4138-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 49449; Mature: 49449

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWGGRFSGSLAEHMRLFNDSFPIDRRLWAEDIRGSIAWANGLERAGILQAAECQELIAGL
CCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHH
RQVYQEFEEGLFLPLTSDEDIHTAVERRLGDFIGALAGKLHTGRSRNDQVATDTRLWTLG
HHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
ALKLADDLIRDVQAALLEQAKAVGEAMLPGYTHLQRAQPVLLSHALLAHFWRLDRDRQRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCHHHHHH
HDATKRVSVLPLGSGALAGTAFAVDRAALAAELGFTSISQNSLDATSDRDYIVEILAAIA
HHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHH
LLGVHISQLAEDWIIWSSSEWGFVALDDAYSTGSSLMPQKKNPDSLELARGKSGRLIGNL
HHHHHHHHHHHHHEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHH
ITVLTLLKGLPSAYDKDLQEDKAPLFDAIDTLSLTLPVVAGAIRTARFNTERMESALDDA
HHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MLATDVADELVRRGVPFREAHHIAGRLVREAEQRGVGMRQLPAESFVAAHPSLTDVAGLF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHCCCCHHHHHHHH
DFARSVAMRDVPGGTAPNAVRDQLIAAQHVLAEG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MWGGRFSGSLAEHMRLFNDSFPIDRRLWAEDIRGSIAWANGLERAGILQAAECQELIAGL
CCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHH
RQVYQEFEEGLFLPLTSDEDIHTAVERRLGDFIGALAGKLHTGRSRNDQVATDTRLWTLG
HHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
ALKLADDLIRDVQAALLEQAKAVGEAMLPGYTHLQRAQPVLLSHALLAHFWRLDRDRQRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHCHHHHHH
HDATKRVSVLPLGSGALAGTAFAVDRAALAAELGFTSISQNSLDATSDRDYIVEILAAIA
HHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHH
LLGVHISQLAEDWIIWSSSEWGFVALDDAYSTGSSLMPQKKNPDSLELARGKSGRLIGNL
HHHHHHHHHHHHHEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHH
ITVLTLLKGLPSAYDKDLQEDKAPLFDAIDTLSLTLPVVAGAIRTARFNTERMESALDDA
HHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
MLATDVADELVRRGVPFREAHHIAGRLVREAEQRGVGMRQLPAESFVAAHPSLTDVAGLF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHCCCCHHHHHHHH
DFARSVAMRDVPGGTAPNAVRDQLIAAQHVLAEG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA