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The map label for this gene is pyrC [H]

Identifier: 159900613

GI number: 159900613

Start: 5232239

End: 5233660

Strand: Reverse

Name: pyrC [H]

Synonym: Haur_4100

Alternate gene names: 159900613

Gene position: 5233660-5232239 (Counterclockwise)

Preceding gene: 159900614

Following gene: 159900606

Centisome position: 82.46

GC content: 54.99

Gene sequence:

>1422_bases
ATGTCACGGATTGTGATCAAAAACGGCTGTATCATCGATCCAGCCCGCAAAACTGCGACCGTCGGGGATTTGGTGCTGGA
AAATAATCGGGTACGCGAGGTTATCGAGTTGGCCATGGCTCCCGATTCCTATGGCGATGATGTTGAGTTTATTGATGCTT
CGGGCTGTTTTGTGACCCCTGGCTTCATTGATATTCACACCCACTTGCGCGAACCAGGCTTTGAAGGCAAGGAAACGATT
GCCACCGGTATGGATGCAGCGGTGCGCGGTGGCTATACCACGATTTGCCCAATGCCCAACACCAATCCTTCGCTCGATTC
GGCTCCGCTGATTCGCCAACAATTTGATATTGCCGCCCGCCATGGGCCAATTCATGTGCTGCCAATCGGTGCAGTGACGC
TTGGGCGTGAAGGCAAGGTATTGGCTCCCTTGGTCGAGTTGGCCGAAGCTGGCGCACATGGGTTTAGTGATGATGGCTCG
CCCGTGTGGGATGCCCACATCATGCGTCAAGCCCTGTTGTATAGCAAAATGACTGGCCGCCCCGTGATGAATCACTGCGA
AGATTTGAGCATCGTGCGCGGCGCTCCAATGAACGAAGGTGCGGTTGCCACCCGTTTGGGTTTGAGCGGTTGGCCGGCTG
CTGGCGAAGAGGTGATGATTGCCCGTGATATTGCTTTGGCTGAAGAAACAGGCGGGCGTTTACACATCTGCCATGTCAGC
ACCGCTGGCGGGGTGGAATTGATTCGGGCAGCTAAGGCTCGTGGCGTGCGCGTGACTGGCGAAGTTACGCCGCACCACTT
GACTATGACCGATCGCTGGGTGCTGGGCAGTATGGAGCCATGGGATGGCAAAGGCCCATACGATCCTTCGCAATTAGCAC
CTTACGATACCCGTACTCGTGTCAGCCCACCCTTGCGCACCAGCGAAGATGTGGCGGCGCTGATCGCAGGCTTACGCGAT
GGCACGATCGACGCAGTAGCCACTGACCATGCGCCGCATACCCATGTCGATAAAGAATGTGAGTATGGCTTTGCCTCCCC
AGGTTTCACTGGCTTGGAACTAGCCTTGCCCATGGTGTTGACCTTAGTTCAGACCATGCAGATCGATATTGTCGAATTAA
TTTCGCGGATGACAATTGGCCCAGCGGCAATTATCGATGTGCTGCCAATTTCGTTGGGGCCAAACGACCCCGCTACCTTG
ACGATTTTTGATCCAGCAGCAATTTGGAAGGTAACTCCAGAAGCCTTGGCATCGAAAGGCAAAAACAGCCCCTTGATGGG
TCAAGAGATGCGCGGCCAAGTGATGTTGACCATGATGGAAGGCCAAATCGTCTATCGCCGTGAGCAGTTTGGTGAATCCA
GTCGCCGCGAGCATGGTGGGGCCGTCGGCAAACTCAGCGGCGTATTCGACGAAGAAGAGTAA

Upstream 100 bases:

>100_bases
CACAAGAATCAAGTGGCGAAATTCTGAGCCGTAACGAAGCCCGCGATAAAATGGGCAGCGGTACGGCCAACGAATAAACG
CCCAATCAGTGGAGTTCTAC

Downstream 100 bases:

>100_bases
TTTTTAGAGGTAAGGGATTAAAATCGAGGTTATTACCGCTACGGTGCAGAGGATGCTGAGTTTGAGGTATTCTCACACTC
AGTCCTCTGTCCGCTGCGGG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MSRIVIKNGCIIDPARKTATVGDLVLENNRVREVIELAMAPDSYGDDVEFIDASGCFVTPGFIDIHTHLREPGFEGKETI
ATGMDAAVRGGYTTICPMPNTNPSLDSAPLIRQQFDIAARHGPIHVLPIGAVTLGREGKVLAPLVELAEAGAHGFSDDGS
PVWDAHIMRQALLYSKMTGRPVMNHCEDLSIVRGAPMNEGAVATRLGLSGWPAAGEEVMIARDIALAEETGGRLHICHVS
TAGGVELIRAAKARGVRVTGEVTPHHLTMTDRWVLGSMEPWDGKGPYDPSQLAPYDTRTRVSPPLRTSEDVAALIAGLRD
GTIDAVATDHAPHTHVDKECEYGFASPGFTGLELALPMVLTLVQTMQIDIVELISRMTIGPAAIIDVLPISLGPNDPATL
TIFDPAAIWKVTPEALASKGKNSPLMGQEMRGQVMLTMMEGQIVYRREQFGESSRREHGGAVGKLSGVFDEEE

Sequences:

>Translated_473_residues
MSRIVIKNGCIIDPARKTATVGDLVLENNRVREVIELAMAPDSYGDDVEFIDASGCFVTPGFIDIHTHLREPGFEGKETI
ATGMDAAVRGGYTTICPMPNTNPSLDSAPLIRQQFDIAARHGPIHVLPIGAVTLGREGKVLAPLVELAEAGAHGFSDDGS
PVWDAHIMRQALLYSKMTGRPVMNHCEDLSIVRGAPMNEGAVATRLGLSGWPAAGEEVMIARDIALAEETGGRLHICHVS
TAGGVELIRAAKARGVRVTGEVTPHHLTMTDRWVLGSMEPWDGKGPYDPSQLAPYDTRTRVSPPLRTSEDVAALIAGLRD
GTIDAVATDHAPHTHVDKECEYGFASPGFTGLELALPMVLTLVQTMQIDIVELISRMTIGPAAIIDVLPISLGPNDPATL
TIFDPAAIWKVTPEALASKGKNSPLMGQEMRGQVMLTMMEGQIVYRREQFGESSRREHGGAVGKLSGVFDEEE
>Mature_472_residues
SRIVIKNGCIIDPARKTATVGDLVLENNRVREVIELAMAPDSYGDDVEFIDASGCFVTPGFIDIHTHLREPGFEGKETIA
TGMDAAVRGGYTTICPMPNTNPSLDSAPLIRQQFDIAARHGPIHVLPIGAVTLGREGKVLAPLVELAEAGAHGFSDDGSP
VWDAHIMRQALLYSKMTGRPVMNHCEDLSIVRGAPMNEGAVATRLGLSGWPAAGEEVMIARDIALAEETGGRLHICHVST
AGGVELIRAAKARGVRVTGEVTPHHLTMTDRWVLGSMEPWDGKGPYDPSQLAPYDTRTRVSPPLRTSEDVAALIAGLRDG
TIDAVATDHAPHTHVDKECEYGFASPGFTGLELALPMVLTLVQTMQIDIVELISRMTIGPAAIIDVLPISLGPNDPATLT
IFDPAAIWKVTPEALASKGKNSPLMGQEMRGQVMLTMMEGQIVYRREQFGESSRREHGGAVGKLSGVFDEEE

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=426, Percent_Identity=30.0469483568075, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1786722, Length=473, Percent_Identity=28.1183932346723, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI87082175, Length=465, Percent_Identity=26.2365591397849, Blast_Score=102, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI193204318, Length=385, Percent_Identity=29.6103896103896, Blast_Score=131, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6322218, Length=471, Percent_Identity=25.6900212314225, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24642586, Length=415, Percent_Identity=30.1204819277108, Blast_Score=142, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 50769; Mature: 50638

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIVIKNGCIIDPARKTATVGDLVLENNRVREVIELAMAPDSYGDDVEFIDASGCFVTP
CCEEEEECCCEECCCHHHHHHHHHEECCCHHHHHHHHHHCCCCCCCCEEEEECCCCEECC
GFIDIHTHLREPGFEGKETIATGMDAAVRGGYTTICPMPNTNPSLDSAPLIRQQFDIAAR
CEEEEEHHHCCCCCCCHHHHHHCCCHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHC
HGPIHVLPIGAVTLGREGKVLAPLVELAEAGAHGFSDDGSPVWDAHIMRQALLYSKMTGR
CCCEEEEEECEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
PVMNHCEDLSIVRGAPMNEGAVATRLGLSGWPAAGEEVMIARDIALAEETGGRLHICHVS
HHHHHHHCCHHHCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEEEHHHCCCCEEEEEEEC
TAGGVELIRAAKARGVRVTGEVTPHHLTMTDRWVLGSMEPWDGKGPYDPSQLAPYDTRTR
CCCCHHHHHHHHHCCEEEECCCCCCEEEEECCEEECCCCCCCCCCCCCHHHCCCCCCCCC
VSPPLRTSEDVAALIAGLRDGTIDAVATDHAPHTHVDKECEYGFASPGFTGLELALPMVL
CCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
TLVQTMQIDIVELISRMTIGPAAIIDVLPISLGPNDPATLTIFDPAAIWKVTPEALASKG
HHHHHHHHHHHHHHHHHCCCHHHHHHEEEECCCCCCCCEEEEECCHHHEEECHHHHHCCC
KNSPLMGQEMRGQVMLTMMEGQIVYRREQFGESSRREHGGAVGKLSGVFDEEE
CCCCCCCHHCCCEEEEEEECCEEEEEHHHHCCHHHHHHCCCEEECCCCCCCCC
>Mature Secondary Structure 
SRIVIKNGCIIDPARKTATVGDLVLENNRVREVIELAMAPDSYGDDVEFIDASGCFVTP
CEEEEECCCEECCCHHHHHHHHHEECCCHHHHHHHHHHCCCCCCCCEEEEECCCCEECC
GFIDIHTHLREPGFEGKETIATGMDAAVRGGYTTICPMPNTNPSLDSAPLIRQQFDIAAR
CEEEEEHHHCCCCCCCHHHHHHCCCHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHC
HGPIHVLPIGAVTLGREGKVLAPLVELAEAGAHGFSDDGSPVWDAHIMRQALLYSKMTGR
CCCEEEEEECEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
PVMNHCEDLSIVRGAPMNEGAVATRLGLSGWPAAGEEVMIARDIALAEETGGRLHICHVS
HHHHHHHCCHHHCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEEEHHHCCCCEEEEEEEC
TAGGVELIRAAKARGVRVTGEVTPHHLTMTDRWVLGSMEPWDGKGPYDPSQLAPYDTRTR
CCCCHHHHHHHHHCCEEEECCCCCCEEEEECCEEECCCCCCCCCCCCCHHHCCCCCCCCC
VSPPLRTSEDVAALIAGLRDGTIDAVATDHAPHTHVDKECEYGFASPGFTGLELALPMVL
CCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
TLVQTMQIDIVELISRMTIGPAAIIDVLPISLGPNDPATLTIFDPAAIWKVTPEALASKG
HHHHHHHHHHHHHHHHHCCCHHHHHHEEEECCCCCCCCEEEEECCHHHEEECHHHHHCCC
KNSPLMGQEMRGQVMLTMMEGQIVYRREQFGESSRREHGGAVGKLSGVFDEEE
CCCCCCCHHCCCEEEEEEECCEEEEEHHHHCCHHHHHHCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA