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The map label for this gene is srrB [H]

Identifier: 159900448

GI number: 159900448

Start: 4926913

End: 4928181

Strand: Direct

Name: srrB [H]

Synonym: Haur_3933

Alternate gene names: 159900448

Gene position: 4926913-4928181 (Clockwise)

Preceding gene: 159900447

Following gene: 159900451

Centisome position: 77.63

GC content: 52.72

Gene sequence:

>1269_bases
ATGCTTAATCGATTGCGTTGGCGCTTAACCTTAATTTATGCTTGCACAGCCTTGCTGCTGTTGGCGGCAGTTGGCGGTAG
CGTTTATTGGATGACCGTGCGCTATTTTCGCTTTGCTACCGAACGGGCCTTGCTTGAACGCATGACCTTGGAATTTGAGC
AATTGGCAGCGCCCTTGCCGCCCGCCCTGCAAGCCTATCGCCCCCAGCAATTGCCCGATGAACGGCCCGTTGATAATGGA
ACACTGGCTAGCACGTTCGTTTTTACCATCGACCAAAACGGCCAAGTCTTCAACCCAAACCCGTGGAACCCGCCAATTCA
GCCTGATCAAGCGGCGATTGAGGCCGCCAAGGCTGGCAAACTTGATCTGCGCACCATCAACTTGGCTGATGGAACTCAAG
TCGCTTTGTTGACTGAAAAATTGACTCGCAGCGATGGCCCAGCTTTTTTGCAAGTTGGGCGGGTGCTCAACGAGCAAGAA
GCCGCCTTGAGCACCTTGTTAAAAGGCTTGGTGGCTTTATGGGCTGGAAGTGTAGTGGTTTTGGGCTGGTTTGGTTGGTG
GTTGGCCGGGCGATCGTTGCGGCCAGCCCAACAAGCTTGGGAACGCCAACAAGCGTTTATCGCCAATGCCAGCCATGAAC
TGCGTGCTCCTCTGACCTTGATGCGAGCCAGCAGCGAAATTGCCCTGCGCGAATCGACCGACCCTGCCGAGCAACAAGAA
TTGCTTGAAGATATTTTGGCCGAAACCTATCACATGGCACGTTTGGTTGAAGATTTGCTGTTGCTCTCGCGGCTTGATGC
TGCCAAAACCCATCTTCAGCGCGAAACGATCGATCTGGCTGAGTTATGCCAGGATGTGGCTAAGGATGCTGGACGCTTGG
CACACGATGCTGGGGTGGAGGTTCGTGTGGCGCATGCCGAGGGTCAGATCAAAGTTGATCGCACCCGTTTGCGCCAAGTG
TTATTAATTTTGCTGGATAACGCAATTGCCCATACGCCGCGTGGTGGGAGCGTAGTGATCCATGCTGAACGCAAGCAAAC
TAGCTATCAAATTAGCGTAATCGACACGGGCAAAGGCATTGAGCCTAAACATCTCAAGCATATTTTCGAGCGTTTTTATC
GGGTTGATAGCGCTCGGATCGCTGGCGGACGTGGTAATGGGCTTGGTTTATCAATTGCTCAAGCGCTGATTCAAGCCCAC
AATGGCACGATTGAGGCCCAAAGCAACGTGGGCACTGGCACAACAATGTTGATCAACTTGCCAAAATAA

Upstream 100 bases:

>100_bases
GATGTCTATATCTCGTATTTGCGGCGCAAACTTGAGCAACCAACCAAACGTGACCCAATTCAAACCGTGCGCGGGGTTGG
CTATCGTTGGGTGAGCGACC

Downstream 100 bases:

>100_bases
GCTATCACAAAATCAAAGCCCACGCTCATAGAGCGCGGGCCAATAGGCTGATGCTGATTCATTGATCATCAACTACAGCC
AAGCCACCAACACATAGTAA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MLNRLRWRLTLIYACTALLLLAAVGGSVYWMTVRYFRFATERALLERMTLEFEQLAAPLPPALQAYRPQQLPDERPVDNG
TLASTFVFTIDQNGQVFNPNPWNPPIQPDQAAIEAAKAGKLDLRTINLADGTQVALLTEKLTRSDGPAFLQVGRVLNEQE
AALSTLLKGLVALWAGSVVVLGWFGWWLAGRSLRPAQQAWERQQAFIANASHELRAPLTLMRASSEIALRESTDPAEQQE
LLEDILAETYHMARLVEDLLLLSRLDAAKTHLQRETIDLAELCQDVAKDAGRLAHDAGVEVRVAHAEGQIKVDRTRLRQV
LLILLDNAIAHTPRGGSVVIHAERKQTSYQISVIDTGKGIEPKHLKHIFERFYRVDSARIAGGRGNGLGLSIAQALIQAH
NGTIEAQSNVGTGTTMLINLPK

Sequences:

>Translated_422_residues
MLNRLRWRLTLIYACTALLLLAAVGGSVYWMTVRYFRFATERALLERMTLEFEQLAAPLPPALQAYRPQQLPDERPVDNG
TLASTFVFTIDQNGQVFNPNPWNPPIQPDQAAIEAAKAGKLDLRTINLADGTQVALLTEKLTRSDGPAFLQVGRVLNEQE
AALSTLLKGLVALWAGSVVVLGWFGWWLAGRSLRPAQQAWERQQAFIANASHELRAPLTLMRASSEIALRESTDPAEQQE
LLEDILAETYHMARLVEDLLLLSRLDAAKTHLQRETIDLAELCQDVAKDAGRLAHDAGVEVRVAHAEGQIKVDRTRLRQV
LLILLDNAIAHTPRGGSVVIHAERKQTSYQISVIDTGKGIEPKHLKHIFERFYRVDSARIAGGRGNGLGLSIAQALIQAH
NGTIEAQSNVGTGTTMLINLPK
>Mature_422_residues
MLNRLRWRLTLIYACTALLLLAAVGGSVYWMTVRYFRFATERALLERMTLEFEQLAAPLPPALQAYRPQQLPDERPVDNG
TLASTFVFTIDQNGQVFNPNPWNPPIQPDQAAIEAAKAGKLDLRTINLADGTQVALLTEKLTRSDGPAFLQVGRVLNEQE
AALSTLLKGLVALWAGSVVVLGWFGWWLAGRSLRPAQQAWERQQAFIANASHELRAPLTLMRASSEIALRESTDPAEQQE
LLEDILAETYHMARLVEDLLLLSRLDAAKTHLQRETIDLAELCQDVAKDAGRLAHDAGVEVRVAHAEGQIKVDRTRLRQV
LLILLDNAIAHTPRGGSVVIHAERKQTSYQISVIDTGKGIEPKHLKHIFERFYRVDSARIAGGRGNGLGLSIAQALIQAH
NGTIEAQSNVGTGTTMLINLPK

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=225, Percent_Identity=35.1111111111111, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=32.7272727272727, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788393, Length=221, Percent_Identity=32.1266968325792, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790861, Length=213, Percent_Identity=30.9859154929577, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790436, Length=264, Percent_Identity=27.2727272727273, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790346, Length=239, Percent_Identity=30.9623430962343, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788549, Length=223, Percent_Identity=32.2869955156951, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789403, Length=208, Percent_Identity=33.1730769230769, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=27.7777777777778, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1789149, Length=228, Percent_Identity=29.3859649122807, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=28.1385281385281, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788713, Length=223, Percent_Identity=23.7668161434978, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788279, Length=226, Percent_Identity=27.4336283185841, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=26.7241379310345, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87082128, Length=223, Percent_Identity=26.9058295964126, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787894, Length=221, Percent_Identity=28.5067873303167, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87081816, Length=236, Percent_Identity=27.9661016949153, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789808, Length=220, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790300, Length=247, Percent_Identity=29.1497975708502, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46622; Mature: 46622

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNRLRWRLTLIYACTALLLLAAVGGSVYWMTVRYFRFATERALLERMTLEFEQLAAPLP
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PALQAYRPQQLPDERPVDNGTLASTFVFTIDQNGQVFNPNPWNPPIQPDQAAIEAAKAGK
HHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEECCCCCCCCCCCCHHHHHHHCCCC
LDLRTINLADGTQVALLTEKLTRSDGPAFLQVGRVLNEQEAALSTLLKGLVALWAGSVVV
EEEEEEECCCCCEEEHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCHHHH
LGWFGWWLAGRSLRPAQQAWERQQAFIANASHELRAPLTLMRASSEIALRESTDPAEQQE
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHHCCCCEEEECCCCCHHHHH
LLEDILAETYHMARLVEDLLLLSRLDAAKTHLQRETIDLAELCQDVAKDAGRLAHDAGVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VRVAHAEGQIKVDRTRLRQVLLILLDNAIAHTPRGGSVVIHAERKQTSYQISVIDTGKGI
EEEEECCCCEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEECCCCC
EPKHLKHIFERFYRVDSARIAGGRGNGLGLSIAQALIQAHNGTIEAQSNVGTGTTMLINL
CHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEC
PK
CC
>Mature Secondary Structure
MLNRLRWRLTLIYACTALLLLAAVGGSVYWMTVRYFRFATERALLERMTLEFEQLAAPLP
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PALQAYRPQQLPDERPVDNGTLASTFVFTIDQNGQVFNPNPWNPPIQPDQAAIEAAKAGK
HHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCCCCEECCCCCCCCCCCCHHHHHHHCCCC
LDLRTINLADGTQVALLTEKLTRSDGPAFLQVGRVLNEQEAALSTLLKGLVALWAGSVVV
EEEEEEECCCCCEEEHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCHHHH
LGWFGWWLAGRSLRPAQQAWERQQAFIANASHELRAPLTLMRASSEIALRESTDPAEQQE
HHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHHCCCCEEEECCCCCHHHHH
LLEDILAETYHMARLVEDLLLLSRLDAAKTHLQRETIDLAELCQDVAKDAGRLAHDAGVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VRVAHAEGQIKVDRTRLRQVLLILLDNAIAHTPRGGSVVIHAERKQTSYQISVIDTGKGI
EEEEECCCCEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEEEECCCCC
EPKHLKHIFERFYRVDSARIAGGRGNGLGLSIAQALIQAHNGTIEAQSNVGTGTTMLINL
CHHHHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEC
PK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA