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The map label for this gene is ctaB [H]

Identifier: 159900225

GI number: 159900225

Start: 4662731

End: 4664062

Strand: Reverse

Name: ctaB [H]

Synonym: Haur_3708

Alternate gene names: 159900225

Gene position: 4664062-4662731 (Counterclockwise)

Preceding gene: 159900226

Following gene: 159900223

Centisome position: 73.49

GC content: 51.35

Gene sequence:

>1332_bases
ATGCCGGCTCTTGCCACCCCTGAACAACAAAATGAGGTTAGCGCAGCCATCAGCGAACGCTTGCCTGCCAAACCTCGCGA
TTCGTTCCGCCCAACGGCGGCGTTGACGGCGGTTTTTAGTGCTTTAACAACCATCAATAGCCTGTGGTGGGTTTTGAGTC
CACAGCATACGCTGGCTCCGGTCTTGTTTGCCTGGTTGTTGCTAACAGCCTTGCTGGGCTTGGTCTCGTTGGTTGGCTCA
TCACGCGCTGCTCATCGGCCCATTCAATGGCTCACTTGGCTCGCCCAACCGCTGGGCATCGCCGTGATTGCCTTGGTCAA
TACCACCTACGCCGATTGGGTTGGTTGGGCCAATTTGGCCTGTTCGGTTGCTACGACCATTATCACTGGTTTAGTCGCCT
ATATGGCTTACCACAGCGACATCAGCACACCCAAAGCCCAAGCCAACAGCAAATTGGCTGATTTTCGGGTGTTGATGAAG
TTTCGGATTATCTCGTTGCTGTTGTTGACCACCTTGATTCCCATGTATTTGGCTAATGGCGGCGAGTGGCCCAAATTCTA
TATCGTCGTTTTGACCTTACTTGGTGGTACGTTGGCAGCTGGTGGCGCTAACGCGATCAACATGTTCTACGATCGTGATA
TTGATGCAGTGATGAGCCGCACCAAAAAACGCCCATTGCCCAATAATCGTCTAACTCAATGGGAAGTTTTGGGCTTTGGC
CTGACCCTCAGCGTGTTGTCATTTTTGGTGCTCTTGCCCGTTAATTTGTTAACGGCAATTTTGGCAGTTAGCGGTATTTT
CTACTATGTGGTGATTTATACCATGTGGTTGAAGCGCACAACGGTGCAAAATATCGTGATCGGCGGCGCGGCGGGGGCGA
TTCCGCCAATGGTTGGTTGGGCGGCTGGCACTGATATTAATTTATTTGTGGATAGCCCAATTAAGTGGCTGCCCGCTGTG
TTTCTGTTTGCGATTGTGTTCTATTGGACACCACCGCATTTTTGGGCTTTGGCAATTATTCGCCGCGAAGATTATGCCAA
AGCTGGCGTGCCAATGTTGCCTGTGGTCAAGGGCGAAGCTGAAACCCGCCGCCAAATTGTGCTCTACACCTTTATTATGA
TTGCGCTTTCGTTTATGTTGGTGTCGTTGCAAGTGGTTGGTTTGCTCTACCTTGGCTTGGCGATGGTGCTTGGGGCAATC
TTCTTGTATTACGCCGCCAATATGATGCGCGACCATTCGCATGCTGCGGCTTGGAAGCTCTATCGCTATTCATTGCTCTA
TCTGGCGCTGCTCTTTGTGGCCATGGGCATCGACCGCGCTTTGCTTGGCTAA

Upstream 100 bases:

>100_bases
CTATATCTTTGAGAGAACATAATCAAACAATGGTATCATAGCGATCAGCCGTTCAACGTGAACGGCCTGTTTGTTAGTGC
GTACAAAGGAACCGAGGCCT

Downstream 100 bases:

>100_bases
AACTGCCTTAGAGGATGAGTTTTTAAGGGTAGATTCTTAACAATCATTGAAGATCACCACCCTTCCGTCCCGCCTCGAGG
CGGGAGACGCAGGGGGCTTT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MPALATPEQQNEVSAAISERLPAKPRDSFRPTAALTAVFSALTTINSLWWVLSPQHTLAPVLFAWLLLTALLGLVSLVGS
SRAAHRPIQWLTWLAQPLGIAVIALVNTTYADWVGWANLACSVATTIITGLVAYMAYHSDISTPKAQANSKLADFRVLMK
FRIISLLLLTTLIPMYLANGGEWPKFYIVVLTLLGGTLAAGGANAINMFYDRDIDAVMSRTKKRPLPNNRLTQWEVLGFG
LTLSVLSFLVLLPVNLLTAILAVSGIFYYVVIYTMWLKRTTVQNIVIGGAAGAIPPMVGWAAGTDINLFVDSPIKWLPAV
FLFAIVFYWTPPHFWALAIIRREDYAKAGVPMLPVVKGEAETRRQIVLYTFIMIALSFMLVSLQVVGLLYLGLAMVLGAI
FLYYAANMMRDHSHAAAWKLYRYSLLYLALLFVAMGIDRALLG

Sequences:

>Translated_443_residues
MPALATPEQQNEVSAAISERLPAKPRDSFRPTAALTAVFSALTTINSLWWVLSPQHTLAPVLFAWLLLTALLGLVSLVGS
SRAAHRPIQWLTWLAQPLGIAVIALVNTTYADWVGWANLACSVATTIITGLVAYMAYHSDISTPKAQANSKLADFRVLMK
FRIISLLLLTTLIPMYLANGGEWPKFYIVVLTLLGGTLAAGGANAINMFYDRDIDAVMSRTKKRPLPNNRLTQWEVLGFG
LTLSVLSFLVLLPVNLLTAILAVSGIFYYVVIYTMWLKRTTVQNIVIGGAAGAIPPMVGWAAGTDINLFVDSPIKWLPAV
FLFAIVFYWTPPHFWALAIIRREDYAKAGVPMLPVVKGEAETRRQIVLYTFIMIALSFMLVSLQVVGLLYLGLAMVLGAI
FLYYAANMMRDHSHAAAWKLYRYSLLYLALLFVAMGIDRALLG
>Mature_442_residues
PALATPEQQNEVSAAISERLPAKPRDSFRPTAALTAVFSALTTINSLWWVLSPQHTLAPVLFAWLLLTALLGLVSLVGSS
RAAHRPIQWLTWLAQPLGIAVIALVNTTYADWVGWANLACSVATTIITGLVAYMAYHSDISTPKAQANSKLADFRVLMKF
RIISLLLLTTLIPMYLANGGEWPKFYIVVLTLLGGTLAAGGANAINMFYDRDIDAVMSRTKKRPLPNNRLTQWEVLGFGL
TLSVLSFLVLLPVNLLTAILAVSGIFYYVVIYTMWLKRTTVQNIVIGGAAGAIPPMVGWAAGTDINLFVDSPIKWLPAVF
LFAIVFYWTPPHFWALAIIRREDYAKAGVPMLPVVKGEAETRRQIVLYTFIMIALSFMLVSLQVVGLLYLGLAMVLGAIF
LYYAANMMRDHSHAAAWKLYRYSLLYLALLFVAMGIDRALLG

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=201, Percent_Identity=36.81592039801, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786631, Length=278, Percent_Identity=32.0143884892086, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71998235, Length=250, Percent_Identity=30, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6325085, Length=239, Percent_Identity=30.9623430962343, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19921064, Length=292, Percent_Identity=31.1643835616438, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003780
- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF02628 COX15-CtaA; PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 48812; Mature: 48680

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALATPEQQNEVSAAISERLPAKPRDSFRPTAALTAVFSALTTINSLWWVLSPQHTLAP
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VLFAWLLLTALLGLVSLVGSSRAAHRPIQWLTWLAQPLGIAVIALVNTTYADWVGWANLA
HHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CSVATTIITGLVAYMAYHSDISTPKAQANSKLADFRVLMKFRIISLLLLTTLIPMYLANG
HHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GEWPKFYIVVLTLLGGTLAAGGANAINMFYDRDIDAVMSRTKKRPLPNNRLTQWEVLGFG
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHH
LTLSVLSFLVLLPVNLLTAILAVSGIFYYVVIYTMWLKRTTVQNIVIGGAAGAIPPMVGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHCC
AAGTDINLFVDSPIKWLPAVFLFAIVFYWTPPHFWALAIIRREDYAKAGVPMLPVVKGEA
CCCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCH
ETRRQIVLYTFIMIALSFMLVSLQVVGLLYLGLAMVLGAIFLYYAANMMRDHSHAAAWKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRYSLLYLALLFVAMGIDRALLG
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PALATPEQQNEVSAAISERLPAKPRDSFRPTAALTAVFSALTTINSLWWVLSPQHTLAP
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VLFAWLLLTALLGLVSLVGSSRAAHRPIQWLTWLAQPLGIAVIALVNTTYADWVGWANLA
HHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CSVATTIITGLVAYMAYHSDISTPKAQANSKLADFRVLMKFRIISLLLLTTLIPMYLANG
HHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GEWPKFYIVVLTLLGGTLAAGGANAINMFYDRDIDAVMSRTKKRPLPNNRLTQWEVLGFG
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCHHHHHHH
LTLSVLSFLVLLPVNLLTAILAVSGIFYYVVIYTMWLKRTTVQNIVIGGAAGAIPPMVGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHCC
AAGTDINLFVDSPIKWLPAVFLFAIVFYWTPPHFWALAIIRREDYAKAGVPMLPVVKGEA
CCCCCEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCH
ETRRQIVLYTFIMIALSFMLVSLQVVGLLYLGLAMVLGAIFLYYAANMMRDHSHAAAWKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRYSLLYLALLFVAMGIDRALLG
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA