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The map label for this gene is liaR [H]

Identifier: 159900171

GI number: 159900171

Start: 4595660

End: 4596325

Strand: Direct

Name: liaR [H]

Synonym: Haur_3654

Alternate gene names: 159900171

Gene position: 4595660-4596325 (Clockwise)

Preceding gene: 159900165

Following gene: 159900176

Centisome position: 72.41

GC content: 51.5

Gene sequence:

>666_bases
ATGGAAAGTATTAGCGTTTTTTTAGTCGATGATCATTTGGTTGTTCGCCAAGGCTTGCGCGATTTTCTCGAACTCCAAGA
TGATATTGAAGTTGTCGGCGATTCGGGAATGCCGGTTGAGGCAGTTGGCCAGATTAAGCAACTGTTGCCTGATGTGGTGA
TTATGGATTTGGTGATGCCTGAAATCGACGGGGTAGAAGCCACTCGCCGCGTCAAGGCCGTCAGCCCCACCACTCAAGTG
ATTGTTCTGACTTCGTTCTCTGATGATGAAAAAGTCTTTCCGGCAATCAAAGCAGGGGCAATATCCTACCTATTAAAAGA
TGTTAGCCCGTTGGAATTAGCGCGGGCTGTGCGTTCCGCCAAACGCGGCGAGGCGGTGTTGCACCCTGAAGTGGCCGCCA
AATTGATGCAAGAATTCTCTGCGCCGCGCAACAACGACCCCGATGCTGAAGCCCTGACCGAGCGCGAAATGGATGTTTTG
CGCCTGATCGCCCGCGGTCATTCCAACCGTGAAATTGCCGATTCGCTGATCATCAGTGAGAAAACTGTCAAAACCCACGT
CAGCAACATTTTGTCGAAATTGCACTTAGCGGATCGTACCCAAGCCGCGATTTATGCCCTACGCCAACGCCTCGTCCCCA
TGGATGATCCTTTACCTGGACGCTAG

Upstream 100 bases:

>100_bases
CTTTGGCCGCTTGGAAGTGAAAAAGTGGTGAGCAGTTGGCGTTCATTTGCCGATTGCGTGTACAATCAATAGAGCGCGAT
TCACTCACAATGAGGTTCTT

Downstream 100 bases:

>100_bases
TTTGGCGCAAGCCGCCGCTCAGTTGAGTGGCGGTTTTAGTTTTTTAGGCCGATTTTTCGTTAATTTTTTGCACATCCCAC
ACTATCTTACTCCATCGGCT

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MESISVFLVDDHLVVRQGLRDFLELQDDIEVVGDSGMPVEAVGQIKQLLPDVVIMDLVMPEIDGVEATRRVKAVSPTTQV
IVLTSFSDDEKVFPAIKAGAISYLLKDVSPLELARAVRSAKRGEAVLHPEVAAKLMQEFSAPRNNDPDAEALTEREMDVL
RLIARGHSNREIADSLIISEKTVKTHVSNILSKLHLADRTQAAIYALRQRLVPMDDPLPGR

Sequences:

>Translated_221_residues
MESISVFLVDDHLVVRQGLRDFLELQDDIEVVGDSGMPVEAVGQIKQLLPDVVIMDLVMPEIDGVEATRRVKAVSPTTQV
IVLTSFSDDEKVFPAIKAGAISYLLKDVSPLELARAVRSAKRGEAVLHPEVAAKLMQEFSAPRNNDPDAEALTEREMDVL
RLIARGHSNREIADSLIISEKTVKTHVSNILSKLHLADRTQAAIYALRQRLVPMDDPLPGR
>Mature_221_residues
MESISVFLVDDHLVVRQGLRDFLELQDDIEVVGDSGMPVEAVGQIKQLLPDVVIMDLVMPEIDGVEATRRVKAVSPTTQV
IVLTSFSDDEKVFPAIKAGAISYLLKDVSPLELARAVRSAKRGEAVLHPEVAAKLMQEFSAPRNNDPDAEALTEREMDVL
RLIARGHSNREIADSLIISEKTVKTHVSNILSKLHLADRTQAAIYALRQRLVPMDDPLPGR

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=207, Percent_Identity=39.1304347826087, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI1788222, Length=209, Percent_Identity=32.5358851674641, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1787473, Length=211, Percent_Identity=35.0710900473934, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1790102, Length=201, Percent_Identity=35.3233830845771, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786747, Length=212, Percent_Identity=28.3018867924528, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=23.5576923076923, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI87082052, Length=121, Percent_Identity=38.0165289256198, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1788546, Length=223, Percent_Identity=28.6995515695067, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787277, Length=85, Percent_Identity=41.1764705882353, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=27.2321428571429, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24377; Mature: 24377

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESISVFLVDDHLVVRQGLRDFLELQDDIEVVGDSGMPVEAVGQIKQLLPDVVIMDLVMP
CCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
EIDGVEATRRVKAVSPTTQVIVLTSFSDDEKVFPAIKAGAISYLLKDVSPLELARAVRSA
CCCCCHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KRGEAVLHPEVAAKLMQEFSAPRNNDPDAEALTEREMDVLRLIARGHSNREIADSLIISE
HCCCCEECHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KTVKTHVSNILSKLHLADRTQAAIYALRQRLVPMDDPLPGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MESISVFLVDDHLVVRQGLRDFLELQDDIEVVGDSGMPVEAVGQIKQLLPDVVIMDLVMP
CCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
EIDGVEATRRVKAVSPTTQVIVLTSFSDDEKVFPAIKAGAISYLLKDVSPLELARAVRSA
CCCCCHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KRGEAVLHPEVAAKLMQEFSAPRNNDPDAEALTEREMDVLRLIARGHSNREIADSLIISE
HCCCCEECHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
KTVKTHVSNILSKLHLADRTQAAIYALRQRLVPMDDPLPGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]