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The map label for this gene is 159900059

Identifier: 159900059

GI number: 159900059

Start: 4457652

End: 4459568

Strand: Reverse

Name: 159900059

Synonym: Haur_3542

Alternate gene names: NA

Gene position: 4459568-4457652 (Counterclockwise)

Preceding gene: 159900070

Following gene: 159900058

Centisome position: 70.27

GC content: 50.39

Gene sequence:

>1917_bases
ATGCAACGAACCGTTCGCATGGGCTTGCTACTGTTGTTGGCTTTTGGATTAATGCCCTTGATTCAACGCCCAGCGCAGGC
AGCGACCCTCGATGATCAGATTATTGCCGATGAAATTCTGGTAACGTTTAATGATGGCTATCGTGTCAGTGCGAATGGGG
CATTCTTTGAAGGTTCTAAGGCATTGAAAAATGGCCTAGGCATTGGGCCATTACTTTCGACCCAAATGCTTGATGGGGCT
GGTCAAGTGGCAATGTTGAAGCTCCCCGCAGGCGCAAATGGCGATGCTAAAATTGCCCAATTGCTCAAAAATCCAGCAGT
GCGCTACGCCGAATACAACGCTGTGCGTGAGATTCTGGTCGATCCCAATGATGAATATTACTCAGAACAATGGGGCTTGC
CCAAAATTGGCGCTAATGCGGCTTGGGACATGACCCAAGGCAACGGCTTGGTGATTGCCATTATTGATACTGGGGTTTCA
CCAACCCACCCTGATTTGGCTGGCCATGTGTTGCCTGGCTACAATGCCTTGCAAAATAATAGCAATAGCCAAGATGATCA
AGGCCACGGTACGGCCATGGCTGGGATTGCTGCTGCCCTAACCAATAATGGTCAAGGTGTAGCTGGGGTTTGTTGGAACT
GCCAAATCCTGCCAGTTAAAGTGCTGAACAGTCGTGGTCAAGGCACAGCGGCAGATATTGTCGAAGGCATGTATTGGGCT
GCTGATAATGGCGCACGCATCATTAGTATGAGTTTGGGTGGCCCACGGGGTACGCAAGCCGAGCAAGATGCAGTTAATTA
TATTTATAGCAAAAATATTCCACTCTTTGCCTCATCTGGCAATTCGGGCGATGAGGGCAACCCACGCATGTATCCAGCCG
CTTTTGATCATGTAATTGCGGTTGGGGCAACCACGACCCAAGATCGGGTTGCAAGTTTCTCATCGTATGGCGATTATGTG
GATATTGCTGCTCCAGGCGTAAATATTGTGACGACTGGATGGGATGGTGGCGATACCTATGAAATGGGCAGTGGCACATC
GCCAGCTTGTCCGTTTGTGGCAGCAACTGCGGCCTTGGCGCTGAGTGTTTGGCCTGAGCTTACGGTCGATCAAATTGAAA
AATTGATCACTGGCAGTGCTGTTGATATTTTGACTCCTGGTAAAGATGTCTATAGTGGGTTTGGCCGACTGGATACCTAC
AAAACGGTGCAAAATGCGGTTTTGCGCACGATTCCTGGCGAACCACAACCCCAACCACCAGCACCACCAGCGCCGCAACC
ACCAACTCCAGAACCACAACCAGGTAACCCTGCGTTTGTGCCTGTGGGAGCGCCCCCATTGCCAGCACCGGTCGGCGAAG
TCTACTTCCCTGAAACTGGCCATAACTTGCGTGGCGAGTTCAAAAACTACTGGGATCGTAATGGTGGCTTGGCAGTCTTT
GGCTTCCCAATTAGCGAAGAATTTACCGAACAAACTCCTGAAGGTTCGTTTACGGTGCAATACTTCGAACGCCAACGCTT
TGAATTTCACCCTGAAAAAGCTGCACCCTACAACGTGTTGCTGGGTCGCTTAGGCGATGCTGTGCTGCGGGATCGTGGCG
ACGATTGGGCCAACTTCCCCAAAACTGGGCCAGAAAATGGCTGTCTCTATTTCGATCAAACCCAGCACAAAATTTGTGGC
GAGTTCCGCAAATATTGGGAAACCAATGGGCTGAATGATCCTGCTTTGAACAAATATGATCGCAGCTTGCAATTGTTTGG
CTTGCCATTATCCGAGCCAATGACCGAAACCAATCGGGATGGGGCAACCGTCACGACCCAATGGTTTGAGCGCGGCCGCT
TTGAGTATCACGAAGGTCAAGGCGTGCTGTTAGGTTTGTTGGCCAAAGAATATGCCAACAATCGCAGTTGGCGCTAA

Upstream 100 bases:

>100_bases
TTTGGCATATTGTCGATTTGGCGTGGCTGCTGGTATAATGCAAGCTTGTAGAGGAGAGCTACCTCTCCCCATATATTTAA
CTGAATGAGTGAGGCAACGT

Downstream 100 bases:

>100_bases
TCGCGTTTAGAATGGCTGAAGCCAGCTTGTCTCTTGGGCTGGCTTCAGTATCACATAAATAGGGAAACGCCGCTCGATTC
GGTTGTGAGAGAATTTGCCA

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MQRTVRMGLLLLLAFGLMPLIQRPAQAATLDDQIIADEILVTFNDGYRVSANGAFFEGSKALKNGLGIGPLLSTQMLDGA
GQVAMLKLPAGANGDAKIAQLLKNPAVRYAEYNAVREILVDPNDEYYSEQWGLPKIGANAAWDMTQGNGLVIAIIDTGVS
PTHPDLAGHVLPGYNALQNNSNSQDDQGHGTAMAGIAAALTNNGQGVAGVCWNCQILPVKVLNSRGQGTAADIVEGMYWA
ADNGARIISMSLGGPRGTQAEQDAVNYIYSKNIPLFASSGNSGDEGNPRMYPAAFDHVIAVGATTTQDRVASFSSYGDYV
DIAAPGVNIVTTGWDGGDTYEMGSGTSPACPFVAATAALALSVWPELTVDQIEKLITGSAVDILTPGKDVYSGFGRLDTY
KTVQNAVLRTIPGEPQPQPPAPPAPQPPTPEPQPGNPAFVPVGAPPLPAPVGEVYFPETGHNLRGEFKNYWDRNGGLAVF
GFPISEEFTEQTPEGSFTVQYFERQRFEFHPEKAAPYNVLLGRLGDAVLRDRGDDWANFPKTGPENGCLYFDQTQHKICG
EFRKYWETNGLNDPALNKYDRSLQLFGLPLSEPMTETNRDGATVTTQWFERGRFEYHEGQGVLLGLLAKEYANNRSWR

Sequences:

>Translated_638_residues
MQRTVRMGLLLLLAFGLMPLIQRPAQAATLDDQIIADEILVTFNDGYRVSANGAFFEGSKALKNGLGIGPLLSTQMLDGA
GQVAMLKLPAGANGDAKIAQLLKNPAVRYAEYNAVREILVDPNDEYYSEQWGLPKIGANAAWDMTQGNGLVIAIIDTGVS
PTHPDLAGHVLPGYNALQNNSNSQDDQGHGTAMAGIAAALTNNGQGVAGVCWNCQILPVKVLNSRGQGTAADIVEGMYWA
ADNGARIISMSLGGPRGTQAEQDAVNYIYSKNIPLFASSGNSGDEGNPRMYPAAFDHVIAVGATTTQDRVASFSSYGDYV
DIAAPGVNIVTTGWDGGDTYEMGSGTSPACPFVAATAALALSVWPELTVDQIEKLITGSAVDILTPGKDVYSGFGRLDTY
KTVQNAVLRTIPGEPQPQPPAPPAPQPPTPEPQPGNPAFVPVGAPPLPAPVGEVYFPETGHNLRGEFKNYWDRNGGLAVF
GFPISEEFTEQTPEGSFTVQYFERQRFEFHPEKAAPYNVLLGRLGDAVLRDRGDDWANFPKTGPENGCLYFDQTQHKICG
EFRKYWETNGLNDPALNKYDRSLQLFGLPLSEPMTETNRDGATVTTQWFERGRFEYHEGQGVLLGLLAKEYANNRSWR
>Mature_638_residues
MQRTVRMGLLLLLAFGLMPLIQRPAQAATLDDQIIADEILVTFNDGYRVSANGAFFEGSKALKNGLGIGPLLSTQMLDGA
GQVAMLKLPAGANGDAKIAQLLKNPAVRYAEYNAVREILVDPNDEYYSEQWGLPKIGANAAWDMTQGNGLVIAIIDTGVS
PTHPDLAGHVLPGYNALQNNSNSQDDQGHGTAMAGIAAALTNNGQGVAGVCWNCQILPVKVLNSRGQGTAADIVEGMYWA
ADNGARIISMSLGGPRGTQAEQDAVNYIYSKNIPLFASSGNSGDEGNPRMYPAAFDHVIAVGATTTQDRVASFSSYGDYV
DIAAPGVNIVTTGWDGGDTYEMGSGTSPACPFVAATAALALSVWPELTVDQIEKLITGSAVDILTPGKDVYSGFGRLDTY
KTVQNAVLRTIPGEPQPQPPAPPAPQPPTPEPQPGNPAFVPVGAPPLPAPVGEVYFPETGHNLRGEFKNYWDRNGGLAVF
GFPISEEFTEQTPEGSFTVQYFERQRFEFHPEKAAPYNVLLGRLGDAVLRDRGDDWANFPKTGPENGCLYFDQTQHKICG
EFRKYWETNGLNDPALNKYDRSLQLFGLPLSEPMTETNRDGATVTTQWFERGRFEYHEGQGVLLGLLAKEYANNRSWR

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI76443679, Length=375, Percent_Identity=28.2666666666667, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI31317307, Length=257, Percent_Identity=26.8482490272374, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI4505579, Length=330, Percent_Identity=25.7575757575758, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71983555, Length=319, Percent_Identity=23.8244514106583, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320775, Length=342, Percent_Identity=31.8713450292398, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324576, Length=342, Percent_Identity=29.2397660818713, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319893, Length=275, Percent_Identity=29.0909090909091, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45550681, Length=254, Percent_Identity=25.1968503937008, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 68769; Mature: 68769

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00136 SUBTILASE_ASP ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRTVRMGLLLLLAFGLMPLIQRPAQAATLDDQIIADEILVTFNDGYRVSANGAFFEGSK
CCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHEECEEEEEECCCEEEECCCCEECCCH
ALKNGLGIGPLLSTQMLDGAGQVAMLKLPAGANGDAKIAQLLKNPAVRYAEYNAVREILV
HHHCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHC
DPNDEYYSEQWGLPKIGANAAWDMTQGNGLVIAIIDTGVSPTHPDLAGHVLPGYNALQNN
CCCHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHCCC
SNSQDDQGHGTAMAGIAAALTNNGQGVAGVCWNCQILPVKVLNSRGQGTAADIVEGMYWA
CCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCEEEEEHEECCCCCCHHHHHHCCEEEE
ADNGARIISMSLGGPRGTQAEQDAVNYIYSKNIPLFASSGNSGDEGNPRMYPAAFDHVIA
ECCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCEECHHHHCCEEE
VGATTTQDRVASFSSYGDYVDIAAPGVNIVTTGWDGGDTYEMGSGTSPACPFVAATAALA
ECCCCCHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCEECCCCCCCCCHHHHHHHHHH
LSVWPELTVDQIEKLITGSAVDILTPGKDVYSGFGRLDTYKTVQNAVLRTIPGEPQPQPP
HHHCCCCCHHHHHHHHCCCCEEEECCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
APPAPQPPTPEPQPGNPAFVPVGAPPLPAPVGEVYFPETGHNLRGEFKNYWDRNGGLAVF
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEECCCCCCCCCCHHHHHHCCCCCEEEE
GFPISEEFTEQTPEGSFTVQYFERQRFEFHPEKAAPYNVLLGRLGDAVLRDRGDDWANFP
ECCCCHHHHHCCCCCCEEEEEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
KTGPENGCLYFDQTQHKICGEFRKYWETNGLNDPALNKYDRSLQLFGLPLSEPMTETNRD
CCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEECCCCCCCCCCCCCC
GATVTTQWFERGRFEYHEGQGVLLGLLAKEYANNRSWR
CCEEEHHHHHCCCCEEECCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQRTVRMGLLLLLAFGLMPLIQRPAQAATLDDQIIADEILVTFNDGYRVSANGAFFEGSK
CCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHEECEEEEEECCCEEEECCCCEECCCH
ALKNGLGIGPLLSTQMLDGAGQVAMLKLPAGANGDAKIAQLLKNPAVRYAEYNAVREILV
HHHCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHC
DPNDEYYSEQWGLPKIGANAAWDMTQGNGLVIAIIDTGVSPTHPDLAGHVLPGYNALQNN
CCCHHHHHHHCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHCCC
SNSQDDQGHGTAMAGIAAALTNNGQGVAGVCWNCQILPVKVLNSRGQGTAADIVEGMYWA
CCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCEEEEEHEECCCCCCHHHHHHCCEEEE
ADNGARIISMSLGGPRGTQAEQDAVNYIYSKNIPLFASSGNSGDEGNPRMYPAAFDHVIA
ECCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCCEECHHHHCCEEE
VGATTTQDRVASFSSYGDYVDIAAPGVNIVTTGWDGGDTYEMGSGTSPACPFVAATAALA
ECCCCCHHHHHHHHHCCCEEEEECCCCEEEEECCCCCCCEECCCCCCCCCHHHHHHHHHH
LSVWPELTVDQIEKLITGSAVDILTPGKDVYSGFGRLDTYKTVQNAVLRTIPGEPQPQPP
HHHCCCCCHHHHHHHHCCCCEEEECCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
APPAPQPPTPEPQPGNPAFVPVGAPPLPAPVGEVYFPETGHNLRGEFKNYWDRNGGLAVF
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCEECCCCCCCCCCHHHHHHCCCCCEEEE
GFPISEEFTEQTPEGSFTVQYFERQRFEFHPEKAAPYNVLLGRLGDAVLRDRGDDWANFP
ECCCCHHHHHCCCCCCEEEEEEHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
KTGPENGCLYFDQTQHKICGEFRKYWETNGLNDPALNKYDRSLQLFGLPLSEPMTETNRD
CCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEECCCCCCCCCCCCCC
GATVTTQWFERGRFEYHEGQGVLLGLLAKEYANNRSWR
CCEEEHHHHHCCCCEEECCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]