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The map label for this gene is mvaA [H]

Identifier: 159900056

GI number: 159900056

Start: 4453279

End: 4454604

Strand: Reverse

Name: mvaA [H]

Synonym: Haur_3539

Alternate gene names: 159900056

Gene position: 4454604-4453279 (Counterclockwise)

Preceding gene: 159900057

Following gene: 159900052

Centisome position: 70.19

GC content: 52.34

Gene sequence:

>1326_bases
ATGAAAGCAAAAAATAGCCGTTTACAAGGATTCTACCAACTTTCGCCGCTCGATCGTTTGCAAGCCGTGGGGGCTTTCGA
TGGCTTGAATAACGATGATTTGCGAGCGTTACATGGCGCTGGCAGTTTAACCATCGAACGCGCCGATAAAATGATTGAAA
ATGTGGTTGGAACCTATAGTTTGCCCTTAGGCATTGCCACCAACTTCCAAATTAATGGCAAAGATACCTTGATCCCGATG
GTTGTTGAAGAACCATCAATTGTGGCTGGGGCTTCGTTTGCCGCTAAATTGGCCCGCGAAGGCGGCGGGTTTACCACCAG
TAGCACCGAATCATTGATGATTGGTCAAATTCAACTCGTGCATATCGCCGATCACGCCGCAGCCAGCGAAATTATTTTGC
GCAATAAAGCCGATTTGCTGGCAATTGCCAATCGTCAAAGCACCTCGTTGGTAGCCTTGGGTGGCGGTGCCAAAGATGTT
GAAGTGCATTCGTTCCCTGCTAGCCCAATGGGGCCGATGTTGGTGGTGCACTTAATCGTCGATTGTTTGGATGCGATGGG
GGCAAATGCAATCAATGCGATGGCAGAAGCCGTTGCCCCACGGCTCGAAGCATTAACTGGCGGTCGCGCTTACTTACGCA
TTCTCTCGAACTTGAGCGATCGGCGTTTGGCAACTGCCCGTTGTGTTATTCCCGCCCGCGCCTTGGATCGCTCGGACTTG
CGTGGTGAAGATGTGATCGAGGGGATTTTGTGGGCCTATGCCTTCGCCGCTGTTGATCCCTATCGCGCTACTACCCATAA
CAAAGGTATTTTGAACGGGATCGATCCGGTGTTGTTGGCAACAGGCCAAGATTGGCGGGCCATCGAATCAGGTGCGCATG
CCTATGCTGCGCGTGATGGCCGCTATACCTCGTTGACCACTTGGGAGCAAGATGCCGAAGGCAATTTGGTTGGCACATTG
ACCATGCCGTTGGCAGTTGGAATTGTGGGTGGCGCAGTTAAGGTGCATCCAACAGCTGCTGCGGCCTTGAAGTTGTTGAA
TGTTAGTTCAGCCCGCGAATTGGCTGAAATGTGTGTCTGTGCAGGCTTGGCCTCAAACTTGGCGGCGATGCGAGCTTTGG
CAACCGAAGGCATTCAGCGTGGCCATATGAGCTTGCATGCACGCCAAATCGCTATGAGTGCTGGAGCAGCGCCTGCCTTG
GTCGAAGAAGTGGCCGAGCGTTTGATTGCTGAGCGTTGCATCAAGCCAGCTCGTGCCGCCGAAATTGTGCGCGAAATGCA
TGATATGTTTGCATTGCAACGAATTGAGGTTGGAGTTCCCTGCTAA

Upstream 100 bases:

>100_bases
TTTGGCAGCTTTTTCGCTAGGTTTGGCATGCGTCACATGCTACACTTCAGCCGTCTACAACATGCCGATCCATTTTTGGC
GACAGAGGAGCTTCGTTCTT

Downstream 100 bases:

>100_bases
TCAAACCTGCTCCTTAAGCCAAAAGGCCAGCACCTCGTAGACAAGGTGCTGGCCAAATTATTTAATCTTGCAAGCGTTTT
TTAGCCTTCAACCAGTGTGG

Product: hydroxymethylglutaryl-CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKAKNSRLQGFYQLSPLDRLQAVGAFDGLNNDDLRALHGAGSLTIERADKMIENVVGTYSLPLGIATNFQINGKDTLIPM
VVEEPSIVAGASFAAKLAREGGGFTTSSTESLMIGQIQLVHIADHAAASEIILRNKADLLAIANRQSTSLVALGGGAKDV
EVHSFPASPMGPMLVVHLIVDCLDAMGANAINAMAEAVAPRLEALTGGRAYLRILSNLSDRRLATARCVIPARALDRSDL
RGEDVIEGILWAYAFAAVDPYRATTHNKGILNGIDPVLLATGQDWRAIESGAHAYAARDGRYTSLTTWEQDAEGNLVGTL
TMPLAVGIVGGAVKVHPTAAAALKLLNVSSARELAEMCVCAGLASNLAAMRALATEGIQRGHMSLHARQIAMSAGAAPAL
VEEVAERLIAERCIKPARAAEIVREMHDMFALQRIEVGVPC

Sequences:

>Translated_441_residues
MKAKNSRLQGFYQLSPLDRLQAVGAFDGLNNDDLRALHGAGSLTIERADKMIENVVGTYSLPLGIATNFQINGKDTLIPM
VVEEPSIVAGASFAAKLAREGGGFTTSSTESLMIGQIQLVHIADHAAASEIILRNKADLLAIANRQSTSLVALGGGAKDV
EVHSFPASPMGPMLVVHLIVDCLDAMGANAINAMAEAVAPRLEALTGGRAYLRILSNLSDRRLATARCVIPARALDRSDL
RGEDVIEGILWAYAFAAVDPYRATTHNKGILNGIDPVLLATGQDWRAIESGAHAYAARDGRYTSLTTWEQDAEGNLVGTL
TMPLAVGIVGGAVKVHPTAAAALKLLNVSSARELAEMCVCAGLASNLAAMRALATEGIQRGHMSLHARQIAMSAGAAPAL
VEEVAERLIAERCIKPARAAEIVREMHDMFALQRIEVGVPC
>Mature_441_residues
MKAKNSRLQGFYQLSPLDRLQAVGAFDGLNNDDLRALHGAGSLTIERADKMIENVVGTYSLPLGIATNFQINGKDTLIPM
VVEEPSIVAGASFAAKLAREGGGFTTSSTESLMIGQIQLVHIADHAAASEIILRNKADLLAIANRQSTSLVALGGGAKDV
EVHSFPASPMGPMLVVHLIVDCLDAMGANAINAMAEAVAPRLEALTGGRAYLRILSNLSDRRLATARCVIPARALDRSDL
RGEDVIEGILWAYAFAAVDPYRATTHNKGILNGIDPVLLATGQDWRAIESGAHAYAARDGRYTSLTTWEQDAEGNLVGTL
TMPLAVGIVGGAVKVHPTAAAALKLLNVSSARELAEMCVCAGLASNLAAMRALATEGIQRGHMSLHARQIAMSAGAAPAL
VEEVAERLIAERCIKPARAAEIVREMHDMFALQRIEVGVPC

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 46592; Mature: 46592

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAKNSRLQGFYQLSPLDRLQAVGAFDGLNNDDLRALHGAGSLTIERADKMIENVVGTYS
CCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHCCCCEEHHHHHHHHHHHHCCCC
LPLGIATNFQINGKDTLIPMVVEEPSIVAGASFAAKLAREGGGFTTSSTESLMIGQIQLV
CCCEEEEEEEECCCCCEEEEEECCCCEEECHHHHHHHHHCCCCCCCCCCCCEEECEEEEE
HIADHAAASEIILRNKADLLAIANRQSTSLVALGGGAKDVEVHSFPASPMGPMLVVHLIV
EECCHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCEEEECCCCCCHHHHHHHHHH
DCLDAMGANAINAMAEAVAPRLEALTGGRAYLRILSNLSDRRLATARCVIPARALDRSDL
HHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHEEECHHHCCCCCC
RGEDVIEGILWAYAFAAVDPYRATTHNKGILNGIDPVLLATGQDWRAIESGAHAYAARDG
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHCCCCEEEECCC
RYTSLTTWEQDAEGNLVGTLTMPLAVGIVGGAVKVHPTAAAALKLLNVSSARELAEMCVC
CEEEEECCCCCCCCCEEEEEHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
AGLASNLAAMRALATEGIQRGHMSLHARQIAMSAGAAPALVEEVAERLIAERCIKPARAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHH
EIVREMHDMFALQRIEVGVPC
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKAKNSRLQGFYQLSPLDRLQAVGAFDGLNNDDLRALHGAGSLTIERADKMIENVVGTYS
CCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHCCCCEEHHHHHHHHHHHHCCCC
LPLGIATNFQINGKDTLIPMVVEEPSIVAGASFAAKLAREGGGFTTSSTESLMIGQIQLV
CCCEEEEEEEECCCCCEEEEEECCCCEEECHHHHHHHHHCCCCCCCCCCCCEEECEEEEE
HIADHAAASEIILRNKADLLAIANRQSTSLVALGGGAKDVEVHSFPASPMGPMLVVHLIV
EECCHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCEEEECCCCCCHHHHHHHHHH
DCLDAMGANAINAMAEAVAPRLEALTGGRAYLRILSNLSDRRLATARCVIPARALDRSDL
HHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHEEECHHHCCCCCC
RGEDVIEGILWAYAFAAVDPYRATTHNKGILNGIDPVLLATGQDWRAIESGAHAYAARDG
CHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHCCCCEEEECCC
RYTSLTTWEQDAEGNLVGTLTMPLAVGIVGGAVKVHPTAAAALKLLNVSSARELAEMCVC
CEEEEECCCCCCCCCEEEEEHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHH
AGLASNLAAMRALATEGIQRGHMSLHARQIAMSAGAAPALVEEVAERLIAERCIKPARAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHH
EIVREMHDMFALQRIEVGVPC
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]