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The map label for this gene is ddl

Identifier: 159900023

GI number: 159900023

Start: 4415445

End: 4416530

Strand: Reverse

Name: ddl

Synonym: Haur_3506

Alternate gene names: 159900023

Gene position: 4416530-4415445 (Counterclockwise)

Preceding gene: 159900024

Following gene: 159900022

Centisome position: 69.59

GC content: 53.31

Gene sequence:

>1086_bases
ATGACAAAACGGCGGGTTGGAATTGTTTTTGGCGGGAAATCGGGCGAGCACGAAGTGTCGTTGAAATCGGCGCGGGCCGT
GATGAATGCGCTTGATCCTGAAAAATATACCGTGATTCCGATTGGAATCACCCGTAATGGCCAATGGCTCAGCGGCGGTG
ATCCGTTGTTGGCCTTGGAGCAACAGGCCGACCAAAAGATGCTTGGCCGTACACCGCAAGCTGGTGTCGTCAGCGAAACA
GCGATTGTGCAAAGTGCTGGCAGTTTGCCCGAACAAACCAACGTTGCGGCTTTGGATGTGATTATTCCAGTCTTGCATGG
CCCATTTGGCGAGGATGGCACGATTCAAGGGGTGTTTGAGTTCGCCAATCTGCCCTATGTTGGCTGTGGAGTTTTGGCGG
CTTCAGTTGGGATGGATAAAGGCTTGATGAAATCGGCTTTTGCCGCCGCTGGTTTGCCCCAAGTGCCCTGGCAGTTGGTT
TTGCGCCGTGATTGGCAAACCCAGCCCGAAGCTGTCTACGAGCGGCTTGAGGCTACGTTGCACTATCCAATGTTTGTTAA
GCCCGCCAACTTAGGTAGCAGCGTTGGTATTAGCAAAGTCAGCAATCGAGCTGAATTGGCGACTGGCATGGCCGAGGCCG
CTGGTTATGATCGGCGAATTGTAGTCGAGCAAGGCATCAATGCCCGTGAAATTGAAGTCGCAATTTTGGGCAACGACGAT
CCCAAGCCCTCAGTGCCAGGCGAAGTGCTGCCTGCCAACGATTTTTACGACTATGCCGATAAATACCTTGAAGGCCAAAC
CCAATTTGCAATTCCGGCGGAGCTTGATGCTGCGACCAGCGAACAGCTGCGCGAGATGGCAGTTACCGCCTTCAAAGCGA
TTGACGGGGCTGGCTTGGCGCGGGTCGATTTCTTTGTCGAGCGCGAAACTGGCGCGATCTATATCAACGAAATTAATACC
TTCCCTGGCTTTACGGCGATGAGCCAATATCCCAAATTGTGGGAAGCTACGGGCCTTGGCTATAGCGAATTACTCGATCG
GCTGATCGATTTGGCGATTGAGCGTTATCACGAGCGAGGCCGATGA

Upstream 100 bases:

>100_bases
TTTTGCGGGTGGCCGAATATGCCCAAACCGAAGTGCTCAAACAATTTGGTATCGAACTCGAATTAGAAGTTCGCGTGATC
ACCAGTGAGGATCAATCGTT

Downstream 100 bases:

>100_bases
GTAATCCACGTCGCACAAGCCGCTTGATTAGCCGCAAACCGCGTGGGCGTGCGCCGCTGGGCGTGCGTACCACCACGCCG
ATGGTGCGCCCAACGGCACG

Product: D-alanine--D-alanine ligase

Products: NA

Alternate protein names: D-Ala-D-Ala ligase; D-alanylalanine synthetase

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTKRRVGIVFGGKSGEHEVSLKSARAVMNALDPEKYTVIPIGITRNGQWLSGGDPLLALEQQADQKMLGRTPQAGVVSET
AIVQSAGSLPEQTNVAALDVIIPVLHGPFGEDGTIQGVFEFANLPYVGCGVLAASVGMDKGLMKSAFAAAGLPQVPWQLV
LRRDWQTQPEAVYERLEATLHYPMFVKPANLGSSVGISKVSNRAELATGMAEAAGYDRRIVVEQGINAREIEVAILGNDD
PKPSVPGEVLPANDFYDYADKYLEGQTQFAIPAELDAATSEQLREMAVTAFKAIDGAGLARVDFFVERETGAIYINEINT
FPGFTAMSQYPKLWEATGLGYSELLDRLIDLAIERYHERGR

Sequences:

>Translated_361_residues
MTKRRVGIVFGGKSGEHEVSLKSARAVMNALDPEKYTVIPIGITRNGQWLSGGDPLLALEQQADQKMLGRTPQAGVVSET
AIVQSAGSLPEQTNVAALDVIIPVLHGPFGEDGTIQGVFEFANLPYVGCGVLAASVGMDKGLMKSAFAAAGLPQVPWQLV
LRRDWQTQPEAVYERLEATLHYPMFVKPANLGSSVGISKVSNRAELATGMAEAAGYDRRIVVEQGINAREIEVAILGNDD
PKPSVPGEVLPANDFYDYADKYLEGQTQFAIPAELDAATSEQLREMAVTAFKAIDGAGLARVDFFVERETGAIYINEINT
FPGFTAMSQYPKLWEATGLGYSELLDRLIDLAIERYHERGR
>Mature_360_residues
TKRRVGIVFGGKSGEHEVSLKSARAVMNALDPEKYTVIPIGITRNGQWLSGGDPLLALEQQADQKMLGRTPQAGVVSETA
IVQSAGSLPEQTNVAALDVIIPVLHGPFGEDGTIQGVFEFANLPYVGCGVLAASVGMDKGLMKSAFAAAGLPQVPWQLVL
RRDWQTQPEAVYERLEATLHYPMFVKPANLGSSVGISKVSNRAELATGMAEAAGYDRRIVVEQGINAREIEVAILGNDDP
KPSVPGEVLPANDFYDYADKYLEGQTQFAIPAELDAATSEQLREMAVTAFKAIDGAGLARVDFFVERETGAIYINEINTF
PGFTAMSQYPKLWEATGLGYSELLDRLIDLAIERYHERGR

Specific function: Cell wall formation

COG id: COG1181

COG function: function code M; D-alanine-D-alanine ligase and related ATP-grasp enzymes

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Escherichia coli, GI1786579, Length=367, Percent_Identity=42.7792915531335, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI1786280, Length=348, Percent_Identity=31.0344827586207, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DDL_HERA2 (A9B406)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001546270.1
- ProteinModelPortal:   A9B406
- SMR:   A9B406
- GeneID:   5735367
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_3506
- HOGENOM:   HBG427092
- OMA:   FTDISMY
- BioCyc:   HAUR316274:HAUR_3506-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00047
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR000291
- InterPro:   IPR005905
- InterPro:   IPR011095
- InterPro:   IPR011127
- InterPro:   IPR013817
- InterPro:   IPR016185
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.20
- TIGRFAMs:   TIGR01205

Pfam domain/function: PF07478 Dala_Dala_lig_C; PF01820 Dala_Dala_lig_N; SSF52440 PreATP-grasp-like

EC number: =6.3.2.4

Molecular weight: Translated: 39104; Mature: 38973

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS50975 ATP_GRASP; PS00843 DALA_DALA_LIGASE_1; PS00844 DALA_DALA_LIGASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRRVGIVFGGKSGEHEVSLKSARAVMNALDPEKYTVIPIGITRNGQWLSGGDPLLALE
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEECCCCCEEEEH
QQADQKMLGRTPQAGVVSETAIVQSAGSLPEQTNVAALDVIIPVLHGPFGEDGTIQGVFE
HHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
FANLPYVGCGVLAASVGMDKGLMKSAFAAAGLPQVPWQLVLRRDWQTQPEAVYERLEATL
HCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHC
HYPMFVKPANLGSSVGISKVSNRAELATGMAEAAGYDRRIVVEQGINAREIEVAILGNDD
CCCEEEEECCCCCCCCHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEECCCC
PKPSVPGEVLPANDFYDYADKYLEGQTQFAIPAELDAATSEQLREMAVTAFKAIDGAGLA
CCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
RVDFFVERETGAIYINEINTFPGFTAMSQYPKLWEATGLGYSELLDRLIDLAIERYHERG
EEEEEEEECCCEEEEEECCCCCCCHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
R
C
>Mature Secondary Structure 
TKRRVGIVFGGKSGEHEVSLKSARAVMNALDPEKYTVIPIGITRNGQWLSGGDPLLALE
CCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEECCCCCEEEEH
QQADQKMLGRTPQAGVVSETAIVQSAGSLPEQTNVAALDVIIPVLHGPFGEDGTIQGVFE
HHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
FANLPYVGCGVLAASVGMDKGLMKSAFAAAGLPQVPWQLVLRRDWQTQPEAVYERLEATL
HCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHC
HYPMFVKPANLGSSVGISKVSNRAELATGMAEAAGYDRRIVVEQGINAREIEVAILGNDD
CCCEEEEECCCCCCCCHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEECCCC
PKPSVPGEVLPANDFYDYADKYLEGQTQFAIPAELDAATSEQLREMAVTAFKAIDGAGLA
CCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEE
RVDFFVERETGAIYINEINTFPGFTAMSQYPKLWEATGLGYSELLDRLIDLAIERYHERG
EEEEEEEECCCEEEEEECCCCCCCHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA