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The map label for this gene is appC [H]

Identifier: 159900016

GI number: 159900016

Start: 4406840

End: 4407811

Strand: Reverse

Name: appC [H]

Synonym: Haur_3499

Alternate gene names: 159900016

Gene position: 4407811-4406840 (Counterclockwise)

Preceding gene: 159900017

Following gene: 159900015

Centisome position: 69.45

GC content: 48.97

Gene sequence:

>972_bases
ATGGCTGTTTCAACAACGCAAGTCGAAGCTCATGAGCCTAAAAAAGAAGAATATGAGCGTCCATGGCTTGAGGTGCTCAA
ACGGTTTACCCGCCACCGCTTTGCGGTTGGAAGTGTTGTCGTTTTGTCTTTGATGATTTTGGCGGTTACTTTTGGGCCGT
TGTTTATGCCTTTTGGCGAAACCGATAGCGCCGTTACCAAGAAAGACCAACCGCCAGGCACCGAATATACCTTGCCCAAA
GATCTTTATTACAATAGTATCGGTGGCGAGGTTCGGACTCCCAAAGGTACAACCCTGACCTTCTGGCTTGGCTCGGATAA
TATTGGCCGCGATTTGCTGACGCGTTTGCTCTATGCTGGGCGGGTTTCGCTGTATATCGCGGTTGCCGTTACCTTACTGA
GCGAATTAATCGGCATCATCGTTGGTGTGATGAGTGGCTATTTTGGGGGCTTGGTCGATGCATTCGCTATGCGCTTTGTA
GACTTCCTCAACACCTTGCCGTTGCTGCCAATTCTCTTGATTATTTCAACGATCTTAGAACCAACGATCAATCTGTTGAT
TTTGATTCTGGTGTTCTTTAGTTGGACGGGCGGCGCACGTTTGATGCGTGGCCAAATCTTGAGTTTGCGTGAACAAGAAT
ATGTTTCAGCATCACGTGCTTTGGGTGCTTCCAACTTGCGGATTATGTTCCGCCACCTTGTGCCAAATGCCTTAGCTCCC
AACATTGTCAATGCCTCGTTGGCCTTGAGTGGTGTGATGATCACCGAGGCTGCTCTCAGCTTCTTGGGCTTCGGCGTGAA
ACTGCCCGCCGCATCATGGGGCAATATGCTCAAAGGTGTTAATACGACCATTCTTGAAAAATATACATGGCAAGCCTTCT
TCCCGGGGCTGGCAATCTTTATTTGTTCATTGTGCTTCAATTTCATTGGCGATGGCTTGCGCGACGCTCTTGACCCACGC
GCCAAACGCTAA

Upstream 100 bases:

>100_bases
GCGGATGTGCTCTATACCATTGTTGACCCACGAATTCGACTTGACTAGTTGCTACTGGTAGGGTGCGATTGGTTTCATTA
ACCTTGTGAAAGGAAGATCC

Downstream 100 bases:

>100_bases
CCTGTAATTCTTGCTAGATAGGGGCATGCTTGTGGCTCAATCCGATGTTTTGTTGAAACTCAAGGGTGTCAAAACCTACT
TTTTCACCGATGAAGGCACT

Product: binding-protein-dependent transport systems inner membrane component

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MAVSTTQVEAHEPKKEEYERPWLEVLKRFTRHRFAVGSVVVLSLMILAVTFGPLFMPFGETDSAVTKKDQPPGTEYTLPK
DLYYNSIGGEVRTPKGTTLTFWLGSDNIGRDLLTRLLYAGRVSLYIAVAVTLLSELIGIIVGVMSGYFGGLVDAFAMRFV
DFLNTLPLLPILLIISTILEPTINLLILILVFFSWTGGARLMRGQILSLREQEYVSASRALGASNLRIMFRHLVPNALAP
NIVNASLALSGVMITEAALSFLGFGVKLPAASWGNMLKGVNTTILEKYTWQAFFPGLAIFICSLCFNFIGDGLRDALDPR
AKR

Sequences:

>Translated_323_residues
MAVSTTQVEAHEPKKEEYERPWLEVLKRFTRHRFAVGSVVVLSLMILAVTFGPLFMPFGETDSAVTKKDQPPGTEYTLPK
DLYYNSIGGEVRTPKGTTLTFWLGSDNIGRDLLTRLLYAGRVSLYIAVAVTLLSELIGIIVGVMSGYFGGLVDAFAMRFV
DFLNTLPLLPILLIISTILEPTINLLILILVFFSWTGGARLMRGQILSLREQEYVSASRALGASNLRIMFRHLVPNALAP
NIVNASLALSGVMITEAALSFLGFGVKLPAASWGNMLKGVNTTILEKYTWQAFFPGLAIFICSLCFNFIGDGLRDALDPR
AKR
>Mature_322_residues
AVSTTQVEAHEPKKEEYERPWLEVLKRFTRHRFAVGSVVVLSLMILAVTFGPLFMPFGETDSAVTKKDQPPGTEYTLPKD
LYYNSIGGEVRTPKGTTLTFWLGSDNIGRDLLTRLLYAGRVSLYIAVAVTLLSELIGIIVGVMSGYFGGLVDAFAMRFVD
FLNTLPLLPILLIISTILEPTINLLILILVFFSWTGGARLMRGQILSLREQEYVSASRALGASNLRIMFRHLVPNALAPN
IVNASLALSGVMITEAALSFLGFGVKLPAASWGNMLKGVNTTILEKYTWQAFFPGLAIFICSLCFNFIGDGLRDALDPRA
KR

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789964, Length=245, Percent_Identity=41.6326530612245, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1787498, Length=327, Percent_Identity=34.5565749235474, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1787054, Length=310, Percent_Identity=30.3225806451613, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1787760, Length=286, Percent_Identity=31.1188811188811, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1789889, Length=251, Percent_Identity=35.0597609561753, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788505, Length=218, Percent_Identity=33.4862385321101, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1787549, Length=296, Percent_Identity=30.7432432432432, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 35573; Mature: 35442

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSTTQVEAHEPKKEEYERPWLEVLKRFTRHRFAVGSVVVLSLMILAVTFGPLFMPFGE
CCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TDSAVTKKDQPPGTEYTLPKDLYYNSIGGEVRTPKGTTLTFWLGSDNIGRDLLTRLLYAG
CCCHHCCCCCCCCCCCCCCHHHHHHCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHH
RVSLYIAVAVTLLSELIGIIVGVMSGYFGGLVDAFAMRFVDFLNTLPLLPILLIISTILE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PTINLLILILVFFSWTGGARLMRGQILSLREQEYVSASRALGASNLRIMFRHLVPNALAP
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHCC
NIVNASLALSGVMITEAALSFLGFGVKLPAASWGNMLKGVNTTILEKYTWQAFFPGLAIF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ICSLCFNFIGDGLRDALDPRAKR
HHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AVSTTQVEAHEPKKEEYERPWLEVLKRFTRHRFAVGSVVVLSLMILAVTFGPLFMPFGE
CCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TDSAVTKKDQPPGTEYTLPKDLYYNSIGGEVRTPKGTTLTFWLGSDNIGRDLLTRLLYAG
CCCHHCCCCCCCCCCCCCCHHHHHHCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHH
RVSLYIAVAVTLLSELIGIIVGVMSGYFGGLVDAFAMRFVDFLNTLPLLPILLIISTILE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PTINLLILILVFFSWTGGARLMRGQILSLREQEYVSASRALGASNLRIMFRHLVPNALAP
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHCC
NIVNASLALSGVMITEAALSFLGFGVKLPAASWGNMLKGVNTTILEKYTWQAFFPGLAIF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
ICSLCFNFIGDGLRDALDPRAKR
HHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]