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The map label for this gene is psaA [H]

Identifier: 159899365

GI number: 159899365

Start: 3610294

End: 3611301

Strand: Reverse

Name: psaA [H]

Synonym: Haur_2846

Alternate gene names: 159899365

Gene position: 3611301-3610294 (Counterclockwise)

Preceding gene: 159899369

Following gene: 159899364

Centisome position: 56.9

GC content: 50.4

Gene sequence:

>1008_bases
ATGCGGCGCTGGTGGATTATTAGCTTCCTTTCGCTGTTTATCTTGGCAAGTTGCGGTGCTGAACAAGCCGCCCCAACCAC
CCAAGGCCAAACCGCCAAACTCAACGTCGTCAGTACGGTTTCGCCAATTACCAATATTATCTACAACATTGCAGGCGATA
AAATTAGCCTAACCGGAATTGTGCCTGAGGGTGTGAATTCCCACACCTTCGAGCCAGTGCCTTCAGATGCCAAAACCTTG
GCCGAGGCCGACTTAATCTTTATCAATGGCCTTAATTTAGAGGAACCAACCCACAAATTGGCCGAAGCCAACAAACAACC
AAGTGCCGAAATTATCTTGCTGGGCGAGCAAACGATCACGCCTGAGCAATATGTCTACGATTTCTCGTTTCCTAAAGAGG
CTGGTAGCCCCAACCCGCACCTCTGGACACACCCGCTGCATGGCTTGCGCTACGCCGAAATTGTGCGTGATGCCTTGGTG
CGCCGCGACCCGAGCAACGCTGAGTATTACAACGCCAATTATGCCAGCTTCAAAACCCGCATCGAAGCCTTTGATCTGGC
AGTTAAAAAAACGATCGAGAGTATCCCGGCTGAAAATCGCAAATTGCTGACCTACCACGATTCATGGGCTTATTTCGCCC
CGCACTATGGCATGACCGTGATTGGGGCAATTCAGCCTGCTGATTTTGCCGAGCCATCGGCCAAAGATGTTGCCGATTTG
ATCACGCAGATTCGTGAGCAAAAAGTGCCAGCGATTTTTGGCTCGGAAGTTTTTCCATCGCCAGTATTAGAGCAAATTGG
CCGCGAAACAGGCGTAAAATATATTGATAGCCTGCGCGACGACGATTTACCTGGCGAGGTCGGGGCTGCCAATCACTCAT
ATTTAGGCTTGCTGACCGAAGATCTGCGGATTATGGCCGAAAATTTGGGTGGCGACCCCAGCTTGATTGCCAATTTCGAT
ACCAGCAATATTCCTGGCAGCGATAGCAGCGTCGTTCAACAACAATAG

Upstream 100 bases:

>100_bases
GAAGCAGCGTTTTTGCAGAGAATAGTAGTATATCCGAGATAGCCAAACGATCGATGGTAGAATACTCGTTGGATTCATGT
AGTCGAGGATGGATAACGCT

Downstream 100 bases:

>100_bases
GGAGTAGTTTGGATGCAGCCAATTATTGAGTTGCGCGATGTTGGGTTGCGCTATGCCGACCGTTTGGTGCTTGATCAAAT
TAATATTCATCTGCACCATG

Product: periplasmic solute binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: Pneumococcal surface adhesin A [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MRRWWIISFLSLFILASCGAEQAAPTTQGQTAKLNVVSTVSPITNIIYNIAGDKISLTGIVPEGVNSHTFEPVPSDAKTL
AEADLIFINGLNLEEPTHKLAEANKQPSAEIILLGEQTITPEQYVYDFSFPKEAGSPNPHLWTHPLHGLRYAEIVRDALV
RRDPSNAEYYNANYASFKTRIEAFDLAVKKTIESIPAENRKLLTYHDSWAYFAPHYGMTVIGAIQPADFAEPSAKDVADL
ITQIREQKVPAIFGSEVFPSPVLEQIGRETGVKYIDSLRDDDLPGEVGAANHSYLGLLTEDLRIMAENLGGDPSLIANFD
TSNIPGSDSSVVQQQ

Sequences:

>Translated_335_residues
MRRWWIISFLSLFILASCGAEQAAPTTQGQTAKLNVVSTVSPITNIIYNIAGDKISLTGIVPEGVNSHTFEPVPSDAKTL
AEADLIFINGLNLEEPTHKLAEANKQPSAEIILLGEQTITPEQYVYDFSFPKEAGSPNPHLWTHPLHGLRYAEIVRDALV
RRDPSNAEYYNANYASFKTRIEAFDLAVKKTIESIPAENRKLLTYHDSWAYFAPHYGMTVIGAIQPADFAEPSAKDVADL
ITQIREQKVPAIFGSEVFPSPVLEQIGRETGVKYIDSLRDDDLPGEVGAANHSYLGLLTEDLRIMAENLGGDPSLIANFD
TSNIPGSDSSVVQQQ
>Mature_335_residues
MRRWWIISFLSLFILASCGAEQAAPTTQGQTAKLNVVSTVSPITNIIYNIAGDKISLTGIVPEGVNSHTFEPVPSDAKTL
AEADLIFINGLNLEEPTHKLAEANKQPSAEIILLGEQTITPEQYVYDFSFPKEAGSPNPHLWTHPLHGLRYAEIVRDALV
RRDPSNAEYYNANYASFKTRIEAFDLAVKKTIESIPAENRKLLTYHDSWAYFAPHYGMTVIGAIQPADFAEPSAKDVADL
ITQIREQKVPAIFGSEVFPSPVLEQIGRETGVKYIDSLRDDDLPGEVGAANHSYLGLLTEDLRIMAENLGGDPSLIANFD
TSNIPGSDSSVVQQQ

Specific function: Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection [H]

COG id: COG0803

COG function: function code P; ABC-type metal ion transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Cell membrane; Lipid-anchor [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081990, Length=298, Percent_Identity=25.503355704698, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127
- InterPro:   IPR006129
- InterPro:   IPR006128 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 36799; Mature: 36799

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRWWIISFLSLFILASCGAEQAAPTTQGQTAKLNVVSTVSPITNIIYNIAGDKISLTGI
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHCCCCEEEEEEE
VPEGVNSHTFEPVPSDAKTLAEADLIFINGLNLEEPTHKLAEANKQPSAEIILLGEQTIT
CCCCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCHHHHHHHCCCCCCCEEEEECCCCCC
PEQYVYDFSFPKEAGSPNPHLWTHPLHGLRYAEIVRDALVRRDPSNAEYYNANYASFKTR
HHHEEEECCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHH
IEAFDLAVKKTIESIPAENRKLLTYHDSWAYFAPHYGMTVIGAIQPADFAEPSAKDVADL
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCEECCCCCCEEEEECCCCCCCCCCHHHHHHH
ITQIREQKVPAIFGSEVFPSPVLEQIGRETGVKYIDSLRDDDLPGEVGAANHSYLGLLTE
HHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
DLRIMAENLGGDPSLIANFDTSNIPGSDSSVVQQQ
HHHHHHHHCCCCCCEEEECCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MRRWWIISFLSLFILASCGAEQAAPTTQGQTAKLNVVSTVSPITNIIYNIAGDKISLTGI
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEHHHHHHHHHHHHCCCCEEEEEEE
VPEGVNSHTFEPVPSDAKTLAEADLIFINGLNLEEPTHKLAEANKQPSAEIILLGEQTIT
CCCCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCHHHHHHHCCCCCCCEEEEECCCCCC
PEQYVYDFSFPKEAGSPNPHLWTHPLHGLRYAEIVRDALVRRDPSNAEYYNANYASFKTR
HHHEEEECCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHH
IEAFDLAVKKTIESIPAENRKLLTYHDSWAYFAPHYGMTVIGAIQPADFAEPSAKDVADL
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCEECCCCCCEEEEECCCCCCCCCCHHHHHHH
ITQIREQKVPAIFGSEVFPSPVLEQIGRETGVKYIDSLRDDDLPGEVGAANHSYLGLLTE
HHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
DLRIMAENLGGDPSLIANFDTSNIPGSDSSVVQQQ
HHHHHHHHCCCCCCEEEECCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8945574; 9767595; 11463916; 9379902 [H]