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The map label for this gene is 159899018

Identifier: 159899018

GI number: 159899018

Start: 3193783

End: 3194712

Strand: Direct

Name: 159899018

Synonym: Haur_2499

Alternate gene names: NA

Gene position: 3193783-3194712 (Clockwise)

Preceding gene: 159899016

Following gene: 159899019

Centisome position: 50.32

GC content: 53.87

Gene sequence:

>930_bases
ATGCGCCTTGCTATTGTCGATTCGCATACTGCTGGCGAACCAACCCGCATCGTGATTGCTGGTGGCCCCGATCTTGGCGG
CGGAACCGTTGCCCAACAACGCGACGTACTGACCCAACACCACGATTGGCTGCGCTCGGCGGTCGTCAACGAACCACGCG
GCTCAGATGTGTTGGTTGGGGCGCTGTTATGCCCGCCAAGCGATCAACGTTGCTGCACTGGGGTGATCTTCTTTAATAAT
GTTGGCTATTTGGGCATGTGCGGCCATGGCACAATCGGCTTAGTCGCAACCCTCGCCCATCTTGGCAACATTGAGGTTGG
CGAGCATCTGATTGAAACGCCCGTTGGGATTGTTAGTGCTACGTTGCATGCTGACGGCCAAGCAACGATCGAAAATGTGC
CAAGCTATCGTTATCGCGCCAACGTTCCAGTCGATCTGCCAAATCATGGTCGAATTCATGGTGATATTGCTTGGGGCGGC
AATTGGTTTTTCTTGGTCAACGATCATGGCCAAGATTTGCAATTGGCCAATGTTGAGCAACTAACTGCATTTAGCTGGCA
GATTCGCCAAGCGCTCGAAGCCGCAGGCATCACTGGCGCAGACAATGGGCTGATTGATCATATTGAATTATTCGGGGCCG
CCGCCGAGGGAGCCAACAGCCGTAGTTTTGTGCTCTGCCCAGGCAAGGCCTACGACCGTTCGCCCTGTGGCACAGGTACA
AGTGCCAAATTGGCCTGCCTCGCCGCCGATGGCAAATTAGCACCCAACACGCCTTGGGTCCAAGAAAGTATCATCGGCAG
TCGCTTTCAAGCCGAATATCACCACCATGAACAGGCGATTATTCCCAAAATTACGGGATCAGCCTTTGTCACGCTCGAAG
GCCAGTTGATTTTGCACGAAGCCGATCCATTTCGCTGGGGTATTCAATGA

Upstream 100 bases:

>100_bases
GGGGTGCAGGGGATGAAAACCCCTGCGTTTCCCGCCTTGAGGCGGGACGGAAGGGTGGCGAACTACGAGTTACGTTAAAT
CATGTTAATAAGGAGCACCA

Downstream 100 bases:

>100_bases
GCAGCGTGATCATTGTTGGCGGCGGGATTGTTGGTTGTGCGGTGGCGCTGGAGTTGACGCAGGCAGGCTGGCAAGTCACA
CTGATTGAACGCGATTGCCT

Product: proline racemase

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; PaHyPRE [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MRLAIVDSHTAGEPTRIVIAGGPDLGGGTVAQQRDVLTQHHDWLRSAVVNEPRGSDVLVGALLCPPSDQRCCTGVIFFNN
VGYLGMCGHGTIGLVATLAHLGNIEVGEHLIETPVGIVSATLHADGQATIENVPSYRYRANVPVDLPNHGRIHGDIAWGG
NWFFLVNDHGQDLQLANVEQLTAFSWQIRQALEAAGITGADNGLIDHIELFGAAAEGANSRSFVLCPGKAYDRSPCGTGT
SAKLACLAADGKLAPNTPWVQESIIGSRFQAEYHHHEQAIIPKITGSAFVTLEGQLILHEADPFRWGIQ

Sequences:

>Translated_309_residues
MRLAIVDSHTAGEPTRIVIAGGPDLGGGTVAQQRDVLTQHHDWLRSAVVNEPRGSDVLVGALLCPPSDQRCCTGVIFFNN
VGYLGMCGHGTIGLVATLAHLGNIEVGEHLIETPVGIVSATLHADGQATIENVPSYRYRANVPVDLPNHGRIHGDIAWGG
NWFFLVNDHGQDLQLANVEQLTAFSWQIRQALEAAGITGADNGLIDHIELFGAAAEGANSRSFVLCPGKAYDRSPCGTGT
SAKLACLAADGKLAPNTPWVQESIIGSRFQAEYHHHEQAIIPKITGSAFVTLEGQLILHEADPFRWGIQ
>Mature_309_residues
MRLAIVDSHTAGEPTRIVIAGGPDLGGGTVAQQRDVLTQHHDWLRSAVVNEPRGSDVLVGALLCPPSDQRCCTGVIFFNN
VGYLGMCGHGTIGLVATLAHLGNIEVGEHLIETPVGIVSATLHADGQATIENVPSYRYRANVPVDLPNHGRIHGDIAWGG
NWFFLVNDHGQDLQLANVEQLTAFSWQIRQALEAAGITGADNGLIDHIELFGAAAEGANSRSFVLCPGKAYDRSPCGTGT
SAKLACLAADGKLAPNTPWVQESIIGSRFQAEYHHHEQAIIPKITGSAFVTLEGQLILHEADPFRWGIQ

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=334, Percent_Identity=29.0419161676647, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 32981; Mature: 32981

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLAIVDSHTAGEPTRIVIAGGPDLGGGTVAQQRDVLTQHHDWLRSAVVNEPRGSDVLVG
CEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
ALLCPPSDQRCCTGVIFFNNVGYLGMCGHGTIGLVATLAHLGNIEVGEHLIETPVGIVSA
EEECCCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEE
TLHADGQATIENVPSYRYRANVPVDLPNHGRIHGDIAWGGNWFFLVNDHGQDLQLANVEQ
EEECCCCHHHHCCCCEEEEECCCEECCCCCEEEEEEEECCEEEEEECCCCCCEEECCHHH
LTAFSWQIRQALEAAGITGADNGLIDHIELFGAAAEGANSRSFVLCPGKAYDRSPCGTGT
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCC
SAKLACLAADGKLAPNTPWVQESIIGSRFQAEYHHHEQAIIPKITGSAFVTLEGQLILHE
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECEEECCCEEEEEECEEEEEE
ADPFRWGIQ
CCCEECCCC
>Mature Secondary Structure
MRLAIVDSHTAGEPTRIVIAGGPDLGGGTVAQQRDVLTQHHDWLRSAVVNEPRGSDVLVG
CEEEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
ALLCPPSDQRCCTGVIFFNNVGYLGMCGHGTIGLVATLAHLGNIEVGEHLIETPVGIVSA
EEECCCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEE
TLHADGQATIENVPSYRYRANVPVDLPNHGRIHGDIAWGGNWFFLVNDHGQDLQLANVEQ
EEECCCCHHHHCCCCEEEEECCCEECCCCCEEEEEEEECCEEEEEECCCCCCEEECCHHH
LTAFSWQIRQALEAAGITGADNGLIDHIELFGAAAEGANSRSFVLCPGKAYDRSPCGTGT
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCC
SAKLACLAADGKLAPNTPWVQESIIGSRFQAEYHHHEQAIIPKITGSAFVTLEGQLILHE
CCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECEEECCCEEEEEECEEEEEE
ADPFRWGIQ
CCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]