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The map label for this gene is hutH [H]

Identifier: 159898927

GI number: 159898927

Start: 3066641

End: 3068299

Strand: Reverse

Name: hutH [H]

Synonym: Haur_2406

Alternate gene names: 159898927

Gene position: 3068299-3066641 (Counterclockwise)

Preceding gene: 159898928

Following gene: 159898926

Centisome position: 48.35

GC content: 48.4

Gene sequence:

>1659_bases
ATGCGCCACCAAGTAACCCTAACAGGTGCAGGCCTAACCATTGAGGACGTTGTTCGCGTGGCTCGCCATCATCAACCTGT
TGGGCTAACCGATAACCCCGAGATTTTGCAGCGAATTGAGGATTCGTGTGCTTACATTAACGATGCTGTCAAAGCTAGCA
AGCCTGTGTATGGTGTAACAACTGGCTTTGGCGGTATGGCCGATGTGGTTATTTCGTCCGAGGAAGCTGCCGATTTGCAG
AATAATGCCATTTGGTATCACAAAACTGGCGCTGGCAAATTGTTGCCCTTGGCCGATGTACGGGCGGCGATGTTGCTACG
CGCCAATTCGCATATGCGCGGAGTTTCGGGCATTCGCTTGGAAATTATCCAACGCATGATGACGTTTTTGAATGCCAATG
TCACGCCGCATGTGCGCGAGTTTGGCTCAATTGGGGCTAGCGGCGATCTTGTGCCATTAATCAGCATTACCGGAGCCTTG
CTTGGCACAGATCCCGCCTTCCGCGTCGATTTTGATGGTGAGAATATTGATTGTCTTGAGGCTTTGGAACGGCTCAACTT
GCCACGCTTGGAATTATTGCCCAAAGAAGGCTTGGCCATGATGAATGGCACATCGGTGATGACTGGGATTGCTTCGAATG
TGCTGCATGATGCGCGGATTTTGCTGGGCTTGGCACTCAATATCCATGGGTTGATGATTCAAGGTTTGCAAGGCACCAAT
CAATCATTCCACCCGTTTATTCATCAGCATAAAGCCCATACTGGTCAAGTTTGGGCCGCCGACCATATGCTACAAATTTT
AGAAGGCTCGGCGTTATCGCGCGATGAGCTTGATGGACGACATGAATATCGCGAAGGCGATTTGATTCAAGATCGCTATT
CATTGCGCTGTTTACCGCAGTTTTTAGGGCCAATTATTGATGGCATGGCCTATATCACCCATCATTTGCGGGTCGAAATC
AACTCGGCCAATGATAATCCTTTAATTAACACCGAAGCTGGCGCAAGCTATCATGGCGGCAATTTCCTTGGTCAATATAT
TGGCGTGGGCATGGATCAATTGCGCTATTACATGGGCTTGATGGCTAAACACCTTGATGTGCAAATTGCCTTGTTGGTTT
CGCCACAGTTCAACAATGGCTTATCGGCCTCGTTGGTTGGCAACACCGACCGCAAGGTCAATATGGGCCTCAAAGGTTTG
CAAATTTCGGGCAACTCGATTATGCCAATTTTGGGCTTTTTGGGTAACTCGTTGGCTGATCGGTTTCCAACGCATGCTGA
GCAATTTAACCAAAATATCAATAGCCAAGGCTTTGGTTCGGCCAATTTGGCCCGCCAAACGATCGAAACCTTGCAACAAT
ATATTGCGATTGCCTTGATTTTTGGGGTGCAAGCGGTCGATTTACGCACCTTCAAGCGCACTGGGCACTATAACGCAGTT
GAAACGCTTTCGCCGATGACCGCCAAGCTCTACAGTGCGATGCGTGAAGTAGTGGGTAAGCCGATTTCGCACGAACGCCC
CTACATTTGGAACGACAACGAGCAAGCTTTAGAACAACATATCAGCGCGATTGTCAGCGACATCACCAACGATGGAATTA
TTCCCCAGGCAATTCAAGAAACCTTAGATAGTTTGCGCTCAATTATTTTATTTGCCTAA

Upstream 100 bases:

>100_bases
AGTGTTAAAGCGGCTCTTACGCAACGAGGCTGGAGCCTAAGTTCGAAAGGTTTAGGACATGTTAGAGCGACTATCGACAA
ATTCAACGTTGGAGAACCAA

Downstream 100 bases:

>100_bases
TATTCGCTTAAACAGCTGAATCAAGCAGTTGCGCCAATTTCTAGCCTGTTATGGCAGAAATTGGCGTAATCGGTTAATCG
AGTCATTCAGCTACAAAAAC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MRHQVTLTGAGLTIEDVVRVARHHQPVGLTDNPEILQRIEDSCAYINDAVKASKPVYGVTTGFGGMADVVISSEEAADLQ
NNAIWYHKTGAGKLLPLADVRAAMLLRANSHMRGVSGIRLEIIQRMMTFLNANVTPHVREFGSIGASGDLVPLISITGAL
LGTDPAFRVDFDGENIDCLEALERLNLPRLELLPKEGLAMMNGTSVMTGIASNVLHDARILLGLALNIHGLMIQGLQGTN
QSFHPFIHQHKAHTGQVWAADHMLQILEGSALSRDELDGRHEYREGDLIQDRYSLRCLPQFLGPIIDGMAYITHHLRVEI
NSANDNPLINTEAGASYHGGNFLGQYIGVGMDQLRYYMGLMAKHLDVQIALLVSPQFNNGLSASLVGNTDRKVNMGLKGL
QISGNSIMPILGFLGNSLADRFPTHAEQFNQNINSQGFGSANLARQTIETLQQYIAIALIFGVQAVDLRTFKRTGHYNAV
ETLSPMTAKLYSAMREVVGKPISHERPYIWNDNEQALEQHISAIVSDITNDGIIPQAIQETLDSLRSIILFA

Sequences:

>Translated_552_residues
MRHQVTLTGAGLTIEDVVRVARHHQPVGLTDNPEILQRIEDSCAYINDAVKASKPVYGVTTGFGGMADVVISSEEAADLQ
NNAIWYHKTGAGKLLPLADVRAAMLLRANSHMRGVSGIRLEIIQRMMTFLNANVTPHVREFGSIGASGDLVPLISITGAL
LGTDPAFRVDFDGENIDCLEALERLNLPRLELLPKEGLAMMNGTSVMTGIASNVLHDARILLGLALNIHGLMIQGLQGTN
QSFHPFIHQHKAHTGQVWAADHMLQILEGSALSRDELDGRHEYREGDLIQDRYSLRCLPQFLGPIIDGMAYITHHLRVEI
NSANDNPLINTEAGASYHGGNFLGQYIGVGMDQLRYYMGLMAKHLDVQIALLVSPQFNNGLSASLVGNTDRKVNMGLKGL
QISGNSIMPILGFLGNSLADRFPTHAEQFNQNINSQGFGSANLARQTIETLQQYIAIALIFGVQAVDLRTFKRTGHYNAV
ETLSPMTAKLYSAMREVVGKPISHERPYIWNDNEQALEQHISAIVSDITNDGIIPQAIQETLDSLRSIILFA
>Mature_552_residues
MRHQVTLTGAGLTIEDVVRVARHHQPVGLTDNPEILQRIEDSCAYINDAVKASKPVYGVTTGFGGMADVVISSEEAADLQ
NNAIWYHKTGAGKLLPLADVRAAMLLRANSHMRGVSGIRLEIIQRMMTFLNANVTPHVREFGSIGASGDLVPLISITGAL
LGTDPAFRVDFDGENIDCLEALERLNLPRLELLPKEGLAMMNGTSVMTGIASNVLHDARILLGLALNIHGLMIQGLQGTN
QSFHPFIHQHKAHTGQVWAADHMLQILEGSALSRDELDGRHEYREGDLIQDRYSLRCLPQFLGPIIDGMAYITHHLRVEI
NSANDNPLINTEAGASYHGGNFLGQYIGVGMDQLRYYMGLMAKHLDVQIALLVSPQFNNGLSASLVGNTDRKVNMGLKGL
QISGNSIMPILGFLGNSLADRFPTHAEQFNQNINSQGFGSANLARQTIETLQQYIAIALIFGVQAVDLRTFKRTGHYNAV
ETLSPMTAKLYSAMREVVGKPISHERPYIWNDNEQALEQHISAIVSDITNDGIIPQAIQETLDSLRSIILFA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=507, Percent_Identity=31.163708086785, Blast_Score=205, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI17567831, Length=520, Percent_Identity=30.9615384615385, Blast_Score=183, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 60443; Mature: 60443

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHQVTLTGAGLTIEDVVRVARHHQPVGLTDNPEILQRIEDSCAYINDAVKASKPVYGVT
CCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TGFGGMADVVISSEEAADLQNNAIWYHKTGAGKLLPLADVRAAMLLRANSHMRGVSGIRL
CCCCCHHHHEECCHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHH
EIIQRMMTFLNANVTPHVREFGSIGASGDLVPLISITGALLGTDPAFRVDFDGENIDCLE
HHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCCEEEEECCCCCHHHH
ALERLNLPRLELLPKEGLAMMNGTSVMTGIASNVLHDARILLGLALNIHGLMIQGLQGTN
HHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCC
QSFHPFIHQHKAHTGQVWAADHMLQILEGSALSRDELDGRHEYREGDLIQDRYSLRCLPQ
CCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHCCCCHHCCCCCCHHHHHHHHHHHH
FLGPIIDGMAYITHHLRVEINSANDNPLINTEAGASYHGGNFLGQYIGVGMDQLRYYMGL
HHHHHHHHHHHHHHEEEEEEECCCCCCEEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHH
MAKHLDVQIALLVSPQFNNGLSASLVGNTDRKVNMGLKGLQISGNSIMPILGFLGNSLAD
HHHHCCEEEEEEECCCCCCCCCEEEECCCCCEEECCCCEEEECCCCHHHHHHHHHHHHHH
RFPTHAEQFNQNINSQGFGSANLARQTIETLQQYIAIALIFGVQAVDLRTFKRTGHYNAV
HCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHH
ETLSPMTAKLYSAMREVVGKPISHERPYIWNDNEQALEQHISAIVSDITNDGIIPQAIQE
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
TLDSLRSIILFA
HHHHHHHHHHCC
>Mature Secondary Structure
MRHQVTLTGAGLTIEDVVRVARHHQPVGLTDNPEILQRIEDSCAYINDAVKASKPVYGVT
CCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEE
TGFGGMADVVISSEEAADLQNNAIWYHKTGAGKLLPLADVRAAMLLRANSHMRGVSGIRL
CCCCCHHHHEECCHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHH
EIIQRMMTFLNANVTPHVREFGSIGASGDLVPLISITGALLGTDPAFRVDFDGENIDCLE
HHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHCCCCCEEEEECCCCCHHHH
ALERLNLPRLELLPKEGLAMMNGTSVMTGIASNVLHDARILLGLALNIHGLMIQGLQGTN
HHHHCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCC
QSFHPFIHQHKAHTGQVWAADHMLQILEGSALSRDELDGRHEYREGDLIQDRYSLRCLPQ
CCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHCCCCHHCCCCCCHHHHHHHHHHHH
FLGPIIDGMAYITHHLRVEINSANDNPLINTEAGASYHGGNFLGQYIGVGMDQLRYYMGL
HHHHHHHHHHHHHHEEEEEEECCCCCCEEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHH
MAKHLDVQIALLVSPQFNNGLSASLVGNTDRKVNMGLKGLQISGNSIMPILGFLGNSLAD
HHHHCCEEEEEEECCCCCCCCCEEEECCCCCEEECCCCEEEECCCCHHHHHHHHHHHHHH
RFPTHAEQFNQNINSQGFGSANLARQTIETLQQYIAIALIFGVQAVDLRTFKRTGHYNAV
HCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHH
ETLSPMTAKLYSAMREVVGKPISHERPYIWNDNEQALEQHISAIVSDITNDGIIPQAIQE
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
TLDSLRSIILFA
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]