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The map label for this gene is fabF [H]

Identifier: 159898891

GI number: 159898891

Start: 3017667

End: 3018935

Strand: Reverse

Name: fabF [H]

Synonym: Haur_2370

Alternate gene names: 159898891

Gene position: 3018935-3017667 (Counterclockwise)

Preceding gene: 159898892

Following gene: 159898890

Centisome position: 47.57

GC content: 54.85

Gene sequence:

>1269_bases
ATGCGTCGTGTTGTCATTACCGGAATGGGGATCGTTTCGCCGTTGGGTTGCGGAGTAGATGTCGTTTGGCAACGCCTATT
AGCTGGACAATCGGGAATTGGCCCTTTGCCTGAGCAGATTAGCGCCGGCTTGGCCAGTACAATTGGCGGCATGGTGCCAA
GTTTGGCTGATGATCCACAGGCTGGTTTCGAGCCAAGTGCCGTTGCCAATAGCAAAGAGCTGCGTAAAATGGATCGCTTT
ATTGTGCTTGGTTTGGCTGCTGCCGCCGAGGCACTCAAGCAAGCTCAGTGGCAACCACAAACTGAAGAAGCCCAAGAGCG
AACTGCGACCTTGATTGCGTCGTGCGTTGGTGGCTTTTCGACCATCACCCAAGCAGTGCGCACTTTAGATAGCAAAGGCC
CGCAACGGCTCTCACCCTTTACCGTGCCTGCCTTTCTGATCAACCTTGCAGCGGGTCATATTTCAATTCGCCATGGCTTT
CGTGGGCCAATCGCCGCCCCCGTGACTGCTTGTGCTGCTAGTTTGCAGGCAATCGGCGATGGTGCCCGCTTAATTCATAG
TGGCGAGGCCGATGTAGCGGTCTGTGGTGGCACTGAAGCTGCACTTGATCCGGTTAGCTTGGGTGGCTTTGCCGCTGCGC
GAGCATTAGCAACCGAATTTAACGATCGCCCAAGCTTGGCATCGCGCCCGTTCGACCAAGCCCGCGATGGCTTTGTGATG
AGCGAAGGTGCTGGCGTTTTGGTGTTAGAAGATTTGGAACATGCCTTAGCCCGTGGAGCAACGCCATTAGTCGAGGTCGT
TGGTTATGGCACAACCGCCGATGCCTACCACATTACATCTGGCCCCGAAGATGGCTCTGGCGCGGCGCGGGCAATGCGTT
TAGCCTTGCGCCAGGCCCAAATCTCTGCTCGCGATGTTCAACATTTGAATGCTCATGCTACCTCAACCCAAGTGGGCGAT
CGTGGCGAACTGGCGGCGATTAAGCAGGTATTTGGTGAAAACTCTGGTTTAGCCGTGAGCGCCACCAAATCGTCAACTGG
CCACTTGTTGGGGGCTGCAGGCGCGGTTGAAGCAATTTTTACGGCCTTGGCAATTCGCGACCAAATTGCGCCAGCCACAT
TAAACCTAGACGATCCTGATCCGGCGAGTGAGGGCATCGACTTAGTAGCGAAGCAGCCTCGCCCAATGCCAATTGAATAT
GCCTTATCGAACGGGTTTGGCTTTGGTGGAGTCAATGCCAGTGTCATTCTTAAACGTTGGCAAGGCTAA

Upstream 100 bases:

>100_bases
ATGTTCTATATTCTCATCCCCACCCCTCAGCCCGATCAAAACTGCGGTATAGTGGTGAGGCGGTTGCTACAATGCGCAGC
AACCTAGTTAAGGAATCACT

Downstream 100 bases:

>100_bases
GTTTAATTGTGAAGGATGAGGGATGCAGAGGAGAAGGGTTTATAAAAGGATGAAGGATAAAGGATGAAGGATGAGTCTAT
ATCTTTGGCATAATCAAATA

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MRRVVITGMGIVSPLGCGVDVVWQRLLAGQSGIGPLPEQISAGLASTIGGMVPSLADDPQAGFEPSAVANSKELRKMDRF
IVLGLAAAAEALKQAQWQPQTEEAQERTATLIASCVGGFSTITQAVRTLDSKGPQRLSPFTVPAFLINLAAGHISIRHGF
RGPIAAPVTACAASLQAIGDGARLIHSGEADVAVCGGTEAALDPVSLGGFAAARALATEFNDRPSLASRPFDQARDGFVM
SEGAGVLVLEDLEHALARGATPLVEVVGYGTTADAYHITSGPEDGSGAARAMRLALRQAQISARDVQHLNAHATSTQVGD
RGELAAIKQVFGENSGLAVSATKSSTGHLLGAAGAVEAIFTALAIRDQIAPATLNLDDPDPASEGIDLVAKQPRPMPIEY
ALSNGFGFGGVNASVILKRWQG

Sequences:

>Translated_422_residues
MRRVVITGMGIVSPLGCGVDVVWQRLLAGQSGIGPLPEQISAGLASTIGGMVPSLADDPQAGFEPSAVANSKELRKMDRF
IVLGLAAAAEALKQAQWQPQTEEAQERTATLIASCVGGFSTITQAVRTLDSKGPQRLSPFTVPAFLINLAAGHISIRHGF
RGPIAAPVTACAASLQAIGDGARLIHSGEADVAVCGGTEAALDPVSLGGFAAARALATEFNDRPSLASRPFDQARDGFVM
SEGAGVLVLEDLEHALARGATPLVEVVGYGTTADAYHITSGPEDGSGAARAMRLALRQAQISARDVQHLNAHATSTQVGD
RGELAAIKQVFGENSGLAVSATKSSTGHLLGAAGAVEAIFTALAIRDQIAPATLNLDDPDPASEGIDLVAKQPRPMPIEY
ALSNGFGFGGVNASVILKRWQG
>Mature_422_residues
MRRVVITGMGIVSPLGCGVDVVWQRLLAGQSGIGPLPEQISAGLASTIGGMVPSLADDPQAGFEPSAVANSKELRKMDRF
IVLGLAAAAEALKQAQWQPQTEEAQERTATLIASCVGGFSTITQAVRTLDSKGPQRLSPFTVPAFLINLAAGHISIRHGF
RGPIAAPVTACAASLQAIGDGARLIHSGEADVAVCGGTEAALDPVSLGGFAAARALATEFNDRPSLASRPFDQARDGFVM
SEGAGVLVLEDLEHALARGATPLVEVVGYGTTADAYHITSGPEDGSGAARAMRLALRQAQISARDVQHLNAHATSTQVGD
RGELAAIKQVFGENSGLAVSATKSSTGHLLGAAGAVEAIFTALAIRDQIAPATLNLDDPDPASEGIDLVAKQPRPMPIEY
ALSNGFGFGGVNASVILKRWQG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=419, Percent_Identity=43.6754176610979, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI223972627, Length=221, Percent_Identity=34.3891402714932, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI41872631, Length=430, Percent_Identity=26.7441860465116, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1787337, Length=420, Percent_Identity=47.3809523809524, Blast_Score=344, Evalue=7e-96,
Organism=Escherichia coli, GI1788663, Length=424, Percent_Identity=33.7264150943396, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71983541, Length=425, Percent_Identity=38.5882352941176, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=44.3609022556391, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=355, Percent_Identity=28.169014084507, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=279, Percent_Identity=26.8817204301075, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=450, Percent_Identity=37.5555555555556, Blast_Score=282, Evalue=8e-77,
Organism=Drosophila melanogaster, GI24644341, Length=426, Percent_Identity=42.9577464788732, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI221330659, Length=279, Percent_Identity=27.9569892473118, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19920632, Length=279, Percent_Identity=27.9569892473118, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24581345, Length=424, Percent_Identity=22.4056603773585, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43420; Mature: 43420

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGMGIVSPLGCGVDVVWQRLLAGQSGIGPLPEQISAGLASTIGGMVPSLADDPQ
CCEEEEECCCHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
AGFEPSAVANSKELRKMDRFIVLGLAAAAEALKQAQWQPQTEEAQERTATLIASCVGGFS
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHH
TITQAVRTLDSKGPQRLSPFTVPAFLINLAAGHISIRHGFRGPIAAPVTACAASLQAIGD
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHCC
GARLIHSGEADVAVCGGTEAALDPVSLGGFAAARALATEFNDRPSLASRPFDQARDGFVM
CHHEEECCCCCEEEECCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCEEE
SEGAGVLVLEDLEHALARGATPLVEVVGYGTTADAYHITSGPEDGSGAARAMRLALRQAQ
ECCCCEEEHHHHHHHHHCCCCHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHH
ISARDVQHLNAHATSTQVGDRGELAAIKQVFGENSGLAVSATKSSTGHLLGAAGAVEAIF
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCEEEHHHHHHHHH
TALAIRDQIAPATLNLDDPDPASEGIDLVAKQPRPMPIEYALSNGFGFGGVNASVILKRW
HHHHHHHHCCCCEECCCCCCCCHHCCHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHEEC
QG
CC
>Mature Secondary Structure
MRRVVITGMGIVSPLGCGVDVVWQRLLAGQSGIGPLPEQISAGLASTIGGMVPSLADDPQ
CCEEEEECCCHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
AGFEPSAVANSKELRKMDRFIVLGLAAAAEALKQAQWQPQTEEAQERTATLIASCVGGFS
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHH
TITQAVRTLDSKGPQRLSPFTVPAFLINLAAGHISIRHGFRGPIAAPVTACAASLQAIGD
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHCC
GARLIHSGEADVAVCGGTEAALDPVSLGGFAAARALATEFNDRPSLASRPFDQARDGFVM
CHHEEECCCCCEEEECCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCEEE
SEGAGVLVLEDLEHALARGATPLVEVVGYGTTADAYHITSGPEDGSGAARAMRLALRQAQ
ECCCCEEEHHHHHHHHHCCCCHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHH
ISARDVQHLNAHATSTQVGDRGELAAIKQVFGENSGLAVSATKSSTGHLLGAAGAVEAIF
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCEEEHHHHHHHHH
TALAIRDQIAPATLNLDDPDPASEGIDLVAKQPRPMPIEYALSNGFGFGGVNASVILKRW
HHHHHHHHCCCCEECCCCCCCCHHCCHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHEEC
QG
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]