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The map label for this gene is atoC [H]

Identifier: 159898887

GI number: 159898887

Start: 3013766

End: 3014923

Strand: Reverse

Name: atoC [H]

Synonym: Haur_2366

Alternate gene names: 159898887

Gene position: 3014923-3013766 (Counterclockwise)

Preceding gene: 159898888

Following gene: 159898885

Centisome position: 47.5

GC content: 53.8

Gene sequence:

>1158_bases
ATGACCAAACGCCTCTTAGTTATCGACGATGAAGCCAATTTACGCTGGGTGCTTAGCGAGGCCTTGAGCGACCAAGGCTA
CGACGTAGTGGTGGCCGCGAATGCCAACGATGGCTTGGCTGCGATGAGCCGCCAACCTGCCGATGTGGTCATTCTCGATC
TCAAGTTGAAGGGCATGGATGGCTTGGCAACCTTGGCCCGCTTGCGCGAACGCTGGCCTGAAGTCGTTGTCTTGATCTTG
ACGGCGTATGGCACAGTGGCCAGCGCGGTTGAGGCTATGCAACTGGGCGCTGCTGATTATTTGCGCAAGCCCTTTGATTT
GGAAGAAATTGGTTTCAAATTGCAACGAGCCTTGGAACGAGCTGCGCTACAACAAGAACTACGGCGTTTACGCCAACAAC
AGCAACAGCGCATGGTCAACGATTTGATCGGCAGTCATCCAGCATGGGTGGCTTGTCGTCAACAGCTTGAACGCATGATC
GATCGCTTGCCCGTGTTGGTTTTGGTGGGAGATGCGGGCGTGGGCAAGGCCCAATTGGCGCGGTATGCCCATGCTATCAG
CCAGCGCCAGCAGGCACCGCTGATTGAGCTTGATGCTGGCTTATTGAACGAATCGATGCTTGAGGCGGCGCTGGACGAGG
CGGGCCAAGGCAGTATCATTATTCGCCGTGGTTTAGGGTGGTTGGATTGGTTACTCGCTCGAAAACTTGCGGCATGTGTA
CTCTTGACTAGCCTTGAAGCGCCGAATCAAACGGTTCCAACGCTGCATCTCCCCACGCTTAATCAGCGCCGTAGCGACAT
TGGCTTGTTAGCGGATTATTGGCTTGGACAGCAGATGCTTAGTCCTCAGGCGCTCCAAAAACTAGAGCAAAGTCAATGGA
ACGCCAATCTGCCCGAATTGCGCCATGTCCTTGAACGTGCAGCTGTCGCGGCTAATGGTCAGCTAATTCAGTCCGAGCAT
TTGCCACACGATTTGCCTAGTGCTACTGCCGAACCAATCACACTGCCCGCAAGCGGCTTGCAACTTGAGGTGGTCGAACG
CAGTTTATTGCAACAGGCCTTGCAACAAGCCAATGGTAATAAAACCCGCGCCGCTGAATTATTGGGCTTATCGCGCCATC
AATTACTCTATCGGCTAGAAAAACATGGCCTTAGCTAG

Upstream 100 bases:

>100_bases
GCGTAGCTGAACATAGCGGCTCAATTCGGCTTGAGCCTGCGCCTGATCGCGGCACCTTAGCCCGTTTGCGCTTGCCACTT
GTGAACCAAGGAGCTGAGCA

Downstream 100 bases:

>100_bases
CCATTGATCACTTCGCCACCATTGGGATGCAAAATTTGCCCAGCCATATATGATGCATCGTCGCTTGCTAGAAATACATA
ACAATTGGCGACTTCTTCAG

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTKRLLVIDDEANLRWVLSEALSDQGYDVVVAANANDGLAAMSRQPADVVILDLKLKGMDGLATLARLRERWPEVVVLIL
TAYGTVASAVEAMQLGAADYLRKPFDLEEIGFKLQRALERAALQQELRRLRQQQQQRMVNDLIGSHPAWVACRQQLERMI
DRLPVLVLVGDAGVGKAQLARYAHAISQRQQAPLIELDAGLLNESMLEAALDEAGQGSIIIRRGLGWLDWLLARKLAACV
LLTSLEAPNQTVPTLHLPTLNQRRSDIGLLADYWLGQQMLSPQALQKLEQSQWNANLPELRHVLERAAVAANGQLIQSEH
LPHDLPSATAEPITLPASGLQLEVVERSLLQQALQQANGNKTRAAELLGLSRHQLLYRLEKHGLS

Sequences:

>Translated_385_residues
MTKRLLVIDDEANLRWVLSEALSDQGYDVVVAANANDGLAAMSRQPADVVILDLKLKGMDGLATLARLRERWPEVVVLIL
TAYGTVASAVEAMQLGAADYLRKPFDLEEIGFKLQRALERAALQQELRRLRQQQQQRMVNDLIGSHPAWVACRQQLERMI
DRLPVLVLVGDAGVGKAQLARYAHAISQRQQAPLIELDAGLLNESMLEAALDEAGQGSIIIRRGLGWLDWLLARKLAACV
LLTSLEAPNQTVPTLHLPTLNQRRSDIGLLADYWLGQQMLSPQALQKLEQSQWNANLPELRHVLERAAVAANGQLIQSEH
LPHDLPSATAEPITLPASGLQLEVVERSLLQQALQQANGNKTRAAELLGLSRHQLLYRLEKHGLS
>Mature_384_residues
TKRLLVIDDEANLRWVLSEALSDQGYDVVVAANANDGLAAMSRQPADVVILDLKLKGMDGLATLARLRERWPEVVVLILT
AYGTVASAVEAMQLGAADYLRKPFDLEEIGFKLQRALERAALQQELRRLRQQQQQRMVNDLIGSHPAWVACRQQLERMID
RLPVLVLVGDAGVGKAQLARYAHAISQRQQAPLIELDAGLLNESMLEAALDEAGQGSIIIRRGLGWLDWLLARKLAACVL
LTSLEAPNQTVPTLHLPTLNQRRSDIGLLADYWLGQQMLSPQALQKLEQSQWNANLPELRHVLERAAVAANGQLIQSEHL
PHDLPSATAEPITLPASGLQLEVVERSLLQQALQQANGNKTRAAELLGLSRHQLLYRLEKHGLS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=453, Percent_Identity=30.6843267108168, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1790437, Length=442, Percent_Identity=28.5067873303167, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1790299, Length=226, Percent_Identity=35.3982300884956, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788905, Length=216, Percent_Identity=31.4814814814815, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI87081872, Length=321, Percent_Identity=27.7258566978193, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1789809, Length=119, Percent_Identity=33.6134453781513, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789402, Length=127, Percent_Identity=40.1574803149606, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787375, Length=119, Percent_Identity=33.6134453781513, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788394, Length=126, Percent_Identity=30.1587301587302, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786911, Length=117, Percent_Identity=37.6068376068376, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786784, Length=119, Percent_Identity=32.7731092436975, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787487, Length=140, Percent_Identity=29.2857142857143, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790552, Length=123, Percent_Identity=34.1463414634146, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790863, Length=120, Percent_Identity=29.1666666666667, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 42587; Mature: 42456

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRLLVIDDEANLRWVLSEALSDQGYDVVVAANANDGLAAMSRQPADVVILDLKLKGMD
CCCEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCCCEEEEEEEECCCC
GLATLARLRERWPEVVVLILTAYGTVASAVEAMQLGAADYLRKPFDLEEIGFKLQRALER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHH
AALQQELRRLRQQQQQRMVNDLIGSHPAWVACRQQLERMIDRLPVLVLVGDAGVGKAQLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHH
RYAHAISQRQQAPLIELDAGLLNESMLEAALDEAGQGSIIIRRGLGWLDWLLARKLAACV
HHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHH
LLTSLEAPNQTVPTLHLPTLNQRRSDIGLLADYWLGQQMLSPQALQKLEQSQWNANLPEL
HHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHH
RHVLERAAVAANGQLIQSEHLPHDLPSATAEPITLPASGLQLEVVERSLLQQALQQANGN
HHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCC
KTRAAELLGLSRHQLLYRLEKHGLS
HHHHHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKRLLVIDDEANLRWVLSEALSDQGYDVVVAANANDGLAAMSRQPADVVILDLKLKGMD
CCEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCCCCCEEEEEEEECCCC
GLATLARLRERWPEVVVLILTAYGTVASAVEAMQLGAADYLRKPFDLEEIGFKLQRALER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHH
AALQQELRRLRQQQQQRMVNDLIGSHPAWVACRQQLERMIDRLPVLVLVGDAGVGKAQLA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHH
RYAHAISQRQQAPLIELDAGLLNESMLEAALDEAGQGSIIIRRGLGWLDWLLARKLAACV
HHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHH
LLTSLEAPNQTVPTLHLPTLNQRRSDIGLLADYWLGQQMLSPQALQKLEQSQWNANLPEL
HHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHH
RHVLERAAVAANGQLIQSEHLPHDLPSATAEPITLPASGLQLEVVERSLLQQALQQANGN
HHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCC
KTRAAELLGLSRHQLLYRLEKHGLS
HHHHHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]