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The map label for this gene is ahcY [H]

Identifier: 159898873

GI number: 159898873

Start: 3000780

End: 3002042

Strand: Direct

Name: ahcY [H]

Synonym: Haur_2352

Alternate gene names: 159898873

Gene position: 3000780-3002042 (Clockwise)

Preceding gene: 159898872

Following gene: 159898874

Centisome position: 47.28

GC content: 51.54

Gene sequence:

>1263_bases
GTGGCTAAGGATTTCGATATTAAGGATATTAAGCTGGCCGACGAAGGCATGCGCCGCATCGCCTGGGCCGAGCAAGAAAT
GCCAGTCTTGCGCCAATTGCGCGAACGGTTCAGCAAAGAACGTCCACTTGAAGGCATCAAGATGTCGGCATGTTTGCACG
TTACCGCTGAAACCGCTAACTTGATGCGTGCGCTCCAAGCTGGTGGCGCTGATATTGTGTTGGCAGCTTCAAACCCACTT
TCAACCCAAGACGATGTTGCCGCAGCGCTGGTGCAATACGACGAAATCCCCGTCTATGCCATCAAGGGCGAAGATAACGC
AACCTATTACAATCACTTGAAAGCCGCCCTCGACCACGCTCCTCACATCACCATGGACGATGGTGCCGACCTCGTGAGCG
CCGTGTTGAAAGATCGCCGCGAATTGTTGCCAAACTTGATTGGCTCAACCGAAGAAACCACCACTGGTGTGATTCGGCTT
CGCGCGATGGCCAACCAAGGCGTGCTCGAATTCCCAGTGATCGCGGTTAACGATAGCCAAACCAAGCATTTGTTTGACAA
CCGCTATGGCACTGGCCAATCAACCCTCGACGGGATCATCCGCGCAACCAATGTGTTGATCGCTGGTAAAACCGTGGTTG
TGGCTGGTTACGGCTGGTGTTCAAAAGGGATCGCAATGCGTGCCCACGGTCTCGGCGCAAACGTGATTGTTACCGAAATC
GATTCAATCAAGGCGCTCGAAGCTGCAATGGACGGCTTCCGCGTGATGCCAATGGTTGATGCAGCTCGCATCGGCGATAT
CTTCATCACCGCAACTGGCGATATTCACGTGCTTGACGGCGAAGATTTCGCTGCAATGAAAGATGGCGCGATTGTTTGTA
ACTCAGGCCACTTCAATGTTGAAATCGATATTCCAGCCTTGGAAAAAATGGCAGTTGAAAAGAAACAACCACGCCAATTC
ATCGATCAATACGTTATGGCCGATGGTCGCCGCATCAACTTGTTGGGCGAAGGCCGCTTGATCAACTTGGCTTCGGCTGA
AGGTCACCCAAGCGCCGTAATGGATCAATCATTCGCCAACCAAGCTTTGGCCAGCGAATATCTCTTGACCAACAAAGGCA
AGTTGGAAAACAAAGTTTACGCCTTGCCAGTAGAAGTTGACCAAGAAATTGCTCGCTTGAAGCTTGCAGCAATGGGTATC
AGCATCGATATCTTGACCGAAGCTCAAGTAACCTACCTCAACTCATGGGAAGAAGGCACCTAG

Upstream 100 bases:

>100_bases
CACTCTTAGCTGAATTATTTGGCTAGACTGAATCTGGCAAATTGGGCATTTTTTGCCTTTTGCCTTTTGAATTTTGATTT
CTCTATTGAAGGAGTTTTTC

Downstream 100 bases:

>100_bases
TCTGATCGATCGTTTGAGGCTAGTTTAGACTAGTTCAACGATCTTATGCTAATGTGACTGAGGCCGAAGTGCATTAACCC
GCCTTCGGCTTCAGTATATA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MAKDFDIKDIKLADEGMRRIAWAEQEMPVLRQLRERFSKERPLEGIKMSACLHVTAETANLMRALQAGGADIVLAASNPL
STQDDVAAALVQYDEIPVYAIKGEDNATYYNHLKAALDHAPHITMDDGADLVSAVLKDRRELLPNLIGSTEETTTGVIRL
RAMANQGVLEFPVIAVNDSQTKHLFDNRYGTGQSTLDGIIRATNVLIAGKTVVVAGYGWCSKGIAMRAHGLGANVIVTEI
DSIKALEAAMDGFRVMPMVDAARIGDIFITATGDIHVLDGEDFAAMKDGAIVCNSGHFNVEIDIPALEKMAVEKKQPRQF
IDQYVMADGRRINLLGEGRLINLASAEGHPSAVMDQSFANQALASEYLLTNKGKLENKVYALPVEVDQEIARLKLAAMGI
SIDILTEAQVTYLNSWEEGT

Sequences:

>Translated_420_residues
MAKDFDIKDIKLADEGMRRIAWAEQEMPVLRQLRERFSKERPLEGIKMSACLHVTAETANLMRALQAGGADIVLAASNPL
STQDDVAAALVQYDEIPVYAIKGEDNATYYNHLKAALDHAPHITMDDGADLVSAVLKDRRELLPNLIGSTEETTTGVIRL
RAMANQGVLEFPVIAVNDSQTKHLFDNRYGTGQSTLDGIIRATNVLIAGKTVVVAGYGWCSKGIAMRAHGLGANVIVTEI
DSIKALEAAMDGFRVMPMVDAARIGDIFITATGDIHVLDGEDFAAMKDGAIVCNSGHFNVEIDIPALEKMAVEKKQPRQF
IDQYVMADGRRINLLGEGRLINLASAEGHPSAVMDQSFANQALASEYLLTNKGKLENKVYALPVEVDQEIARLKLAAMGI
SIDILTEAQVTYLNSWEEGT
>Mature_419_residues
AKDFDIKDIKLADEGMRRIAWAEQEMPVLRQLRERFSKERPLEGIKMSACLHVTAETANLMRALQAGGADIVLAASNPLS
TQDDVAAALVQYDEIPVYAIKGEDNATYYNHLKAALDHAPHITMDDGADLVSAVLKDRRELLPNLIGSTEETTTGVIRLR
AMANQGVLEFPVIAVNDSQTKHLFDNRYGTGQSTLDGIIRATNVLIAGKTVVVAGYGWCSKGIAMRAHGLGANVIVTEID
SIKALEAAMDGFRVMPMVDAARIGDIFITATGDIHVLDGEDFAAMKDGAIVCNSGHFNVEIDIPALEKMAVEKKQPRQFI
DQYVMADGRRINLLGEGRLINLASAEGHPSAVMDQSFANQALASEYLLTNKGKLENKVYALPVEVDQEIARLKLAAMGIS
IDILTEAQVTYLNSWEEGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=412, Percent_Identity=46.3592233009709, Blast_Score=342, Evalue=3e-94,
Organism=Homo sapiens, GI239937451, Length=390, Percent_Identity=46.9230769230769, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI298286489, Length=416, Percent_Identity=40.8653846153846, Blast_Score=291, Evalue=8e-79,
Organism=Homo sapiens, GI195539349, Length=416, Percent_Identity=40.8653846153846, Blast_Score=291, Evalue=9e-79,
Organism=Homo sapiens, GI195539337, Length=416, Percent_Identity=40.8653846153846, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI24308043, Length=416, Percent_Identity=40.8653846153846, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI21361647, Length=416, Percent_Identity=39.9038461538462, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17506425, Length=416, Percent_Identity=43.2692307692308, Blast_Score=322, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6320882, Length=437, Percent_Identity=41.6475972540046, Blast_Score=319, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24642172, Length=419, Percent_Identity=43.9140811455847, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24656245, Length=417, Percent_Identity=38.6091127098321, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI45553385, Length=413, Percent_Identity=38.9830508474576, Blast_Score=254, Evalue=7e-68,
Organism=Drosophila melanogaster, GI45553387, Length=413, Percent_Identity=38.9830508474576, Blast_Score=254, Evalue=8e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 45710; Mature: 45579

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00738 ADOHCYASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDFDIKDIKLADEGMRRIAWAEQEMPVLRQLRERFSKERPLEGIKMSACLHVTAETAN
CCCCCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEHHHHH
LMRALQAGGADIVLAASNPLSTQDDVAAALVQYDEIPVYAIKGEDNATYYNHLKAALDHA
HHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
PHITMDDGADLVSAVLKDRRELLPNLIGSTEETTTGVIRLRAMANQGVLEFPVIAVNDSQ
CEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECCCCCCEEEEEEEECCCC
TKHLFDNRYGTGQSTLDGIIRATNVLIAGKTVVVAGYGWCSKGIAMRAHGLGANVIVTEI
HHHHHCCCCCCCHHHHHHHHHHHEEEEECCEEEEEECCCCCCCCEEEECCCCCEEEEEEH
DSIKALEAAMDGFRVMPMVDAARIGDIFITATGDIHVLDGEDFAAMKDGAIVCNSGHFNV
HHHHHHHHHHCCEEEEEECCHHCCCCEEEEECCCEEEECCCCCEEECCCEEEECCCEEEE
EIDIPALEKMAVEKKQPRQFIDQYVMADGRRINLLGEGRLINLASAEGHPSAVMDQSFAN
EEECCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHH
QALASEYLLTNKGKLENKVYALPVEVDQEIARLKLAAMGISIDILTEAQVTYLNSWEEGT
HHHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCEEEEEEECCEEEEECCCCCCC
>Mature Secondary Structure 
AKDFDIKDIKLADEGMRRIAWAEQEMPVLRQLRERFSKERPLEGIKMSACLHVTAETAN
CCCCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEHHHHH
LMRALQAGGADIVLAASNPLSTQDDVAAALVQYDEIPVYAIKGEDNATYYNHLKAALDHA
HHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCC
PHITMDDGADLVSAVLKDRRELLPNLIGSTEETTTGVIRLRAMANQGVLEFPVIAVNDSQ
CEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECCCCCCEEEEEEEECCCC
TKHLFDNRYGTGQSTLDGIIRATNVLIAGKTVVVAGYGWCSKGIAMRAHGLGANVIVTEI
HHHHHCCCCCCCHHHHHHHHHHHEEEEECCEEEEEECCCCCCCCEEEECCCCCEEEEEEH
DSIKALEAAMDGFRVMPMVDAARIGDIFITATGDIHVLDGEDFAAMKDGAIVCNSGHFNV
HHHHHHHHHHCCEEEEEECCHHCCCCEEEEECCCEEEECCCCCEEECCCEEEECCCEEEE
EIDIPALEKMAVEKKQPRQFIDQYVMADGRRINLLGEGRLINLASAEGHPSAVMDQSFAN
EEECCHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHH
QALASEYLLTNKGKLENKVYALPVEVDQEIARLKLAAMGISIDILTEAQVTYLNSWEEGT
HHHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHCCEEEEEEECCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]