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The map label for this gene is fabZ

Identifier: 159898865

GI number: 159898865

Start: 2991499

End: 2991924

Strand: Reverse

Name: fabZ

Synonym: Haur_2344

Alternate gene names: 159898865

Gene position: 2991924-2991499 (Counterclockwise)

Preceding gene: 159898876

Following gene: 159898864

Centisome position: 47.14

GC content: 48.83

Gene sequence:

>426_bases
ATGCTGACCGTTGAAGATATTTTGGCAATTTTGCCCCATCGCCCGCCATTTCTGTTGGTTGACCGCATTTTAGAGATCGA
AGATGGCCTGCGAGCAGTGGGCTTGAAAAACGTCACCATGAACGAGCCATTTTTCGTGGGCCATTTTCCAGGTCGGCCTG
TGATGCCTGGCGTATTGATTGTCGAAGCCCTAGCTCAAGTTGGGGCGGTAATCATTTTGCGCCAGCCAGAGTATGTTGGC
AAAATTGTGATGTTTGCTGGGATTGATGATTTTCGTTTCAAGCGCCCAGTTACGCCTGGTGATACACTTAAATTAGAAGT
AAGCCTTGATAAAATGCGCCGTCGCATTGGCAAAGGCCAGGCTAAGGCCACGGTTGATGGCACAGTGGTTGCCGAAGGTG
GGCTAATGTTTGCAATTGTTGATTAG

Upstream 100 bases:

>100_bases
CGTCAACGGATTTGCCGCTGGCTTTAGGCTCGGTTACACTAAGGCCTAGGCTATCTGAGAGCTTTGTGAGAGGTTTTGAA
AGCCGCTAGGAGTATACGCA

Downstream 100 bases:

>100_bases
AAGATTGCCGTAAACATTCGCCTACAGAAGGAGTCTGTTGTGGATACGTTCAATGTTGAGCTACGAGATAAGCTCATTCT
GGTGGTTGATGATGAACCAC

Product: beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ

Products: trans-Delta2-enoyl-acyl-ACP; H2O [C]

Alternate protein names: (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MLTVEDILAILPHRPPFLLVDRILEIEDGLRAVGLKNVTMNEPFFVGHFPGRPVMPGVLIVEALAQVGAVIILRQPEYVG
KIVMFAGIDDFRFKRPVTPGDTLKLEVSLDKMRRRIGKGQAKATVDGTVVAEGGLMFAIVD

Sequences:

>Translated_141_residues
MLTVEDILAILPHRPPFLLVDRILEIEDGLRAVGLKNVTMNEPFFVGHFPGRPVMPGVLIVEALAQVGAVIILRQPEYVG
KIVMFAGIDDFRFKRPVTPGDTLKLEVSLDKMRRRIGKGQAKATVDGTVVAEGGLMFAIVD
>Mature_141_residues
MLTVEDILAILPHRPPFLLVDRILEIEDGLRAVGLKNVTMNEPFFVGHFPGRPVMPGVLIVEALAQVGAVIILRQPEYVG
KIVMFAGIDDFRFKRPVTPGDTLKLEVSLDKMRRRIGKGQAKATVDGTVVAEGGLMFAIVD

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabZ subfamily

Homologues:

Organism=Escherichia coli, GI1786377, Length=139, Percent_Identity=50.3597122302158, Blast_Score=143, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABZ_HERA2 (A9AYK6)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001545112.1
- ProteinModelPortal:   A9AYK6
- SMR:   A9AYK6
- GeneID:   5736878
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_2344
- HOGENOM:   HBG433282
- OMA:   KERRGVA
- BioCyc:   HAUR316274:HAUR_2344-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- TIGRFAMs:   TIGR01750

Pfam domain/function: PF07977 FabA

EC number: 4.2.1.- [C]

Molecular weight: Translated: 15462; Mature: 15462

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: ACT_SITE 48-48

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVEDILAILPHRPPFLLVDRILEIEDGLRAVGLKNVTMNEPFFVGHFPGRPVMPGVLI
CCCHHHHHHHCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCCEEEEECCCCCCCCHHHH
VEALAQVGAVIILRQPEYVGKIVMFAGIDDFRFKRPVTPGDTLKLEVSLDKMRRRIGKGQ
HHHHHHCCEEEEEECCHHHCEEEEEECCCCHHCCCCCCCCCEEEEEEEHHHHHHHHCCCC
AKATVDGTVVAEGGLMFAIVD
CCEEECCEEEECCCEEEEEEC
>Mature Secondary Structure
MLTVEDILAILPHRPPFLLVDRILEIEDGLRAVGLKNVTMNEPFFVGHFPGRPVMPGVLI
CCCHHHHHHHCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCCEEEEECCCCCCCCHHHH
VEALAQVGAVIILRQPEYVGKIVMFAGIDDFRFKRPVTPGDTLKLEVSLDKMRRRIGKGQ
HHHHHHCCEEEEEECCHHHCEEEEEECCCCHHCCCCCCCCCEEEEEEEHHHHHHHHCCCC
AKATVDGTVVAEGGLMFAIVD
CCEEECCEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-3-hydroxy-acyl-ACP [C]

Specific reaction: D-3-hydroxy-acyl-ACP = trans-Delta2-enoyl-acyl-ACP + H2O [C]

General reaction: Carbon-Oxygen Lyases; Hydro-Lyases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA