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The map label for this gene is rsbRA [H]

Identifier: 159898843

GI number: 159898843

Start: 2962969

End: 2964534

Strand: Reverse

Name: rsbRA [H]

Synonym: Haur_2322

Alternate gene names: 159898843

Gene position: 2964534-2962969 (Counterclockwise)

Preceding gene: 159898844

Following gene: 159898841

Centisome position: 46.71

GC content: 50.96

Gene sequence:

>1566_bases
ATGCGGGCACGGGTTCGCCAACGAGTTACCTGGATTATCTTGCTTGCGGCGTTGTTGCCGTTATTAGCGGTGTGGGCAAT
CGCCTTGACGATTAGCTATCGAGCGCAGCAGCGTTCGGCGCAAAATCAACAAGTGGCGCTCACTAACCTAGCCGCTGAAG
ATTATCGACGCTTTGTGCTGAATAGTATGGATGAGTTGCGCGGCGCTGCTGAAACGCTTGGGAATAATGGGAATCCCAGT
CAGTTGAGCGATTTGCAGTTGGGTTCGCAAGTGCTATTTGGCTCAAGTTTTTCTGAAGTTGGGGTGTATAGCCTGAATGG
CGAACGAATCGCAGTGGCGGCACGCTTGCGCGGCGTGCGCATGCCCGAATCGTTGGCAGGCTCACCATTATTGCAAATGG
TGCAAAATCGCCAAGTTGCGATTGAAAACCCTGCGCCCTTGCAAGCCCTCTCCTTGCCACTTGCTCCCAGCGAAGTGCCG
CACTTTCGGATGGCCTTGCCAATTTTGGGCAATGCCAACGCCCAATTAATTCTGGTCGCCGATATCAGCATGGATCGAAT
TTGGGAAACGACTTCGCGGATAGAATCAGCCGCCCAGATGCGGGTGTTGGTGGTTAATCAACAAGGCCAATTAATTAGCG
CCGCCAATACCCAAGCGCTAATCGAGAATCAAGATTTATCCAGCTTACCCTTGCTGCAAACTGGCAATTCGATTGAAACC
TATCGTAGCCCATTTGGCGAAGAAGTTTTAGGTGTGCGCACCTCGCTTGATCCTACCGATTGGATTTTGATCGTTGAACG
ACCGCTTGAGGTTATTTATAGTAATGTTCAAACCTTGGCAATTAGTTTGTTGATTGTGATTGGGATTGCCTTGCCGATTG
TGGCGGCGATTGGTTGGTATGTTGGGCGGCGATTGGCCTTGCCCGTGCAAAAATTATATGCGAGCGTTACCCGTTTTACC
GATGATCCCAATGCCTATACTCCGGTGCACCTCAACACCCGCGACGAATTGGCTAGCCTTGGCGAGGCCTTCAATACGAT
GGTGGTTGGCCTCAATGCCTCGCAAACACGGCTTTCTAAAATGAATGAAGAGCTTGAAACGCTGGTTGTGACCAGAACTG
GCGAGTTGAATCAGGCGTTGGCTGAGGTGCAAGCCCAAAATCTTGAACAAGAACGCTTGCTCGAAACCGTGCGCCGTTTG
AGCATGCCAACCATCCCAATTACTAAGCATATGCTGGTGATGCCGTTGGTTGGTGAATTTAGCGCTAATCGGGCTGGCGA
TATTAATGCAACGCTGCTCAAATCGATCGAACAACAACAAGCCAAAGTTGTAATTATGGATATTACCGGCGTGCCAGTTG
TCGATCAATCGGTGGCGCGAGCCTTGATCAGTGCTTCGCATGCAGCGCAATTGCTGGGAGCGCGGGTGATTTTGGCGGGG
ATTCGCCCCGATATGGCCGAAACCTTGGTTAATTTACAGCTTGATCTTTCAGTGATTGATACGGAGGCAACCTTGGCCCA
AGCCTTTAGCCGTGGCACTGAGTATTTGCAAAAGCGTCGGCGCTAA

Upstream 100 bases:

>100_bases
TTTGGATAAACTTGATCCTAGCCAATTGCCCTAAATCGATCTGAGCACGTCGTTCGATCCAACGTCGCAAAGCACCATTT
CAGCAGAGGTAGGAATACAT

Downstream 100 bases:

>100_bases
ATTGAAAATCAATTATGCTCTGGTTCGTTGCGAATGTAGAGTTGCTTGAGTAGCGGTGTAAATACGCGGTAAAAGCGTTC
GAGGGTGTCGATCATCCAAA

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MRARVRQRVTWIILLAALLPLLAVWAIALTISYRAQQRSAQNQQVALTNLAAEDYRRFVLNSMDELRGAAETLGNNGNPS
QLSDLQLGSQVLFGSSFSEVGVYSLNGERIAVAARLRGVRMPESLAGSPLLQMVQNRQVAIENPAPLQALSLPLAPSEVP
HFRMALPILGNANAQLILVADISMDRIWETTSRIESAAQMRVLVVNQQGQLISAANTQALIENQDLSSLPLLQTGNSIET
YRSPFGEEVLGVRTSLDPTDWILIVERPLEVIYSNVQTLAISLLIVIGIALPIVAAIGWYVGRRLALPVQKLYASVTRFT
DDPNAYTPVHLNTRDELASLGEAFNTMVVGLNASQTRLSKMNEELETLVVTRTGELNQALAEVQAQNLEQERLLETVRRL
SMPTIPITKHMLVMPLVGEFSANRAGDINATLLKSIEQQQAKVVIMDITGVPVVDQSVARALISASHAAQLLGARVILAG
IRPDMAETLVNLQLDLSVIDTEATLAQAFSRGTEYLQKRRR

Sequences:

>Translated_521_residues
MRARVRQRVTWIILLAALLPLLAVWAIALTISYRAQQRSAQNQQVALTNLAAEDYRRFVLNSMDELRGAAETLGNNGNPS
QLSDLQLGSQVLFGSSFSEVGVYSLNGERIAVAARLRGVRMPESLAGSPLLQMVQNRQVAIENPAPLQALSLPLAPSEVP
HFRMALPILGNANAQLILVADISMDRIWETTSRIESAAQMRVLVVNQQGQLISAANTQALIENQDLSSLPLLQTGNSIET
YRSPFGEEVLGVRTSLDPTDWILIVERPLEVIYSNVQTLAISLLIVIGIALPIVAAIGWYVGRRLALPVQKLYASVTRFT
DDPNAYTPVHLNTRDELASLGEAFNTMVVGLNASQTRLSKMNEELETLVVTRTGELNQALAEVQAQNLEQERLLETVRRL
SMPTIPITKHMLVMPLVGEFSANRAGDINATLLKSIEQQQAKVVIMDITGVPVVDQSVARALISASHAAQLLGARVILAG
IRPDMAETLVNLQLDLSVIDTEATLAQAFSRGTEYLQKRRR
>Mature_521_residues
MRARVRQRVTWIILLAALLPLLAVWAIALTISYRAQQRSAQNQQVALTNLAAEDYRRFVLNSMDELRGAAETLGNNGNPS
QLSDLQLGSQVLFGSSFSEVGVYSLNGERIAVAARLRGVRMPESLAGSPLLQMVQNRQVAIENPAPLQALSLPLAPSEVP
HFRMALPILGNANAQLILVADISMDRIWETTSRIESAAQMRVLVVNQQGQLISAANTQALIENQDLSSLPLLQTGNSIET
YRSPFGEEVLGVRTSLDPTDWILIVERPLEVIYSNVQTLAISLLIVIGIALPIVAAIGWYVGRRLALPVQKLYASVTRFT
DDPNAYTPVHLNTRDELASLGEAFNTMVVGLNASQTRLSKMNEELETLVVTRTGELNQALAEVQAQNLEQERLLETVRRL
SMPTIPITKHMLVMPLVGEFSANRAGDINATLLKSIEQQQAKVVIMDITGVPVVDQSVARALISASHAAQLLGARVILAG
IRPDMAETLVNLQLDLSVIDTEATLAQAFSRGTEYLQKRRR

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 57035; Mature: 57035

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50885 HAMP ; PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARVRQRVTWIILLAALLPLLAVWAIALTISYRAQQRSAQNQQVALTNLAAEDYRRFVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHH
NSMDELRGAAETLGNNGNPSQLSDLQLGSQVLFGSSFSEVGVYSLNGERIAVAARLRGVR
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHEECCCCCCCCEEEECCCEEEEEEHHCCCC
MPESLAGSPLLQMVQNRQVAIENPAPLQALSLPLAPSEVPHFRMALPILGNANAQLILVA
CCHHHCCCHHHHHHCCCCEEECCCCCCHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
DISMDRIWETTSRIESAAQMRVLVVNQQGQLISAANTQALIENQDLSSLPLLQTGNSIET
ECCHHHHHHHHHHHHHHHHEEEEEECCCCCEEECCCCHHHHCCCCCCCCCCCCCCCCHHH
YRSPFGEEVLGVRTSLDPTDWILIVERPLEVIYSNVQTLAISLLIVIGIALPIVAAIGWY
HHCCCCHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGRRLALPVQKLYASVTRFTDDPNAYTPVHLNTRDELASLGEAFNTMVVGLNASQTRLSK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHEEEECCCHHHHHHH
MNEELETLVVTRTGELNQALAEVQAQNLEQERLLETVRRLSMPTIPITKHMLVMPLVGEF
HHHHHHEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
SANRAGDINATLLKSIEQQQAKVVIMDITGVPVVDQSVARALISASHAAQLLGARVILAG
CCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEC
IRPDMAETLVNLQLDLSVIDTEATLAQAFSRGTEYLQKRRR
CCCHHHHHHHHHEEEEEEECHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRARVRQRVTWIILLAALLPLLAVWAIALTISYRAQQRSAQNQQVALTNLAAEDYRRFVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHH
NSMDELRGAAETLGNNGNPSQLSDLQLGSQVLFGSSFSEVGVYSLNGERIAVAARLRGVR
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHEECCCCCCCCEEEECCCEEEEEEHHCCCC
MPESLAGSPLLQMVQNRQVAIENPAPLQALSLPLAPSEVPHFRMALPILGNANAQLILVA
CCHHHCCCHHHHHHCCCCEEECCCCCCHHHCCCCCCCCCCCCEEEEEEECCCCEEEEEEE
DISMDRIWETTSRIESAAQMRVLVVNQQGQLISAANTQALIENQDLSSLPLLQTGNSIET
ECCHHHHHHHHHHHHHHHHEEEEEECCCCCEEECCCCHHHHCCCCCCCCCCCCCCCCHHH
YRSPFGEEVLGVRTSLDPTDWILIVERPLEVIYSNVQTLAISLLIVIGIALPIVAAIGWY
HHCCCCHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGRRLALPVQKLYASVTRFTDDPNAYTPVHLNTRDELASLGEAFNTMVVGLNASQTRLSK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHHHHHHEEEECCCHHHHHHH
MNEELETLVVTRTGELNQALAEVQAQNLEQERLLETVRRLSMPTIPITKHMLVMPLVGEF
HHHHHHEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
SANRAGDINATLLKSIEQQQAKVVIMDITGVPVVDQSVARALISASHAAQLLGARVILAG
CCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEC
IRPDMAETLVNLQLDLSVIDTEATLAQAFSRGTEYLQKRRR
CCCHHHHHHHHHEEEEEEECHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]