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The map label for this gene is rsbRA [H]

Identifier: 159898731

GI number: 159898731

Start: 2808396

End: 2810138

Strand: Reverse

Name: rsbRA [H]

Synonym: Haur_2210

Alternate gene names: 159898731

Gene position: 2810138-2808396 (Counterclockwise)

Preceding gene: 159898732

Following gene: 159898730

Centisome position: 44.28

GC content: 50.26

Gene sequence:

>1743_bases
ATGCTCCATAGTTTACGCAGGCAAGTTATTGTTATCCTCTTATTGGGAACATCGCTCTTGGCGTTGCTCAATTTAGCAAT
TAATGCTCGTGGCTTGGTGGCAGTGCGCAACCAAGCCACCAACGATAGCACCGCCGCGCTGCAAGCCCAAGCTGAACAAT
ATCTCCTGCGCATTGCCCAAAGCCATGCTGCTAGCACTGGGCAAACAGTCCGCGGTGTGCAACAATTAGCGGTTACCACC
CGCACCTATTTGCAACAACCAACTAATCAAATTCCAAACTTGCCTGAGTTGAACGTAGCACGTAATGGCCGTCAATATGC
CAGCGGGGCAACCACGGTCTTGGTGATTGCTAATCCTGATCAGACTCAAGCATTAGCTGACATTCGCTATAGTCAACGGC
TCGAAGATGTTTTGCCAAGCTTGCAAATCAGCGTGCCTGAAATTGTGCGCATCTCATATCTGACGGCCAACACCTTGCGC
ACCTATCCCAACATGACTCCCAATGATCCGCCAGCGGATTGGTTGCCTAGCCAAGAGGCGGCGTATCAAGCAAGTTTGCC
TGAGAATAACCCGAGTCGCGCCTTAGTCTGGACAGAGGTACATCAATCGATTGATCAATCGCAAGCGTTGATCTCGGTTG
CGGCACCAGTTTATGCCAACGCCGATTTTTTGGGCACCGTCAGCGTCGATGTTAGCCTTGATCGGTTGAGTTTCTATCTC
AAGGGATTAATCATCGATCAATCGAGCTTTGCTTTTTTGATTACCCGTAATGGTGAAGTTGTGGCGGTTACCGAGGCTGG
CCAGGGCGGGATTGTTCAGCAAATTTTGACCAATCAAGCTAACATGCCCAGTTCATCAATGATCAGCGATCTGCAAGCGG
GTCGCGATGGAGTAACCACAGTCCGCTTGAGTGGGCGCGGCTATGTGGTAGCCTATGCGGCAATTAGCGGTATTCCATGG
GGTTTAGGCTTGGCTTCGCCCTTGGATGAAATTACGGCGCGAACCACTGAAACCGCCAACCAAATTGCCACGATCACCAA
CCAAAGCCTTGGATTGAGCATCGGTTTGGCTTTGATTGCGGTTATTTTGTTTGGTTTTGGAATGGCATTGATTCTGCGCC
GCCAATTTCTTAAGCCGCTGACTGGCTTAATTGGGGCAACCAATCGGGTTGCCGATGGCGATCTCCAGCCAATTGAGGTT
GAGAGCAATAATGAATTAGGCCAGTTAGCCAGCTCATTTAATAGCATGACTGCTGCTTTACAGGTTTCGCGCCAAGAAAC
CGAGGCCAAAGAGGCTGCCCGTGAAGCTGCAATGCAGCGCTTGAGTGAAGTGGTGGTTAATCTCGAACACTCACTTGCTG
AACGCCAACAGTTATCGCAACTGCTGCGTGATGTTGCCTCACCAGTCATCCCAATTCTAAAAGGGGTGTTGGTGATGCCA
TTGATTGGCAGTTTGGATGGCGAACGGGTGCAACAAGCCACCTCAATTCTCTTAACCCGAGTTGAACGCGAACGCGCCCG
CAAAGTGTTGATTGATATTACGGGTGTGCCAATGATGGATGAGCAAGCTGCTCAAGCGTTGTTGACTATGATGAATGGCT
TGCGTTTGTTGGGAGCCAGTGTGATTTTGGTAGGGGTTGCTCCTGAAGTTGCCCAAATTCTGACTACCTTGTCGGTGGAT
TTGAGTTCAGTCCAGACCTCAGCCGATTTGCGTACAGCCGTTGCCCAACTAAGTCGTTCGTAA

Upstream 100 bases:

>100_bases
ATCGCTCACCAGCTTTGATCCGACGACTTCGATCCCACCCGAAACGTTCAAAATTACGCTGCGTGTGTCGCAATAGGTTG
TTGTAGGTGGAGGATGGACG

Downstream 100 bases:

>100_bases
ATTTGTGTAGCTTGCTATCAGACCCATGCATCGTGCATGGGTTCTTGATTTAATCTTAGGAGTTTCGTGTGACCTTTGAT
TTTACTGGGCCAATTTGGTT

Product: anti-sigma-factor antagonist

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MLHSLRRQVIVILLLGTSLLALLNLAINARGLVAVRNQATNDSTAALQAQAEQYLLRIAQSHAASTGQTVRGVQQLAVTT
RTYLQQPTNQIPNLPELNVARNGRQYASGATTVLVIANPDQTQALADIRYSQRLEDVLPSLQISVPEIVRISYLTANTLR
TYPNMTPNDPPADWLPSQEAAYQASLPENNPSRALVWTEVHQSIDQSQALISVAAPVYANADFLGTVSVDVSLDRLSFYL
KGLIIDQSSFAFLITRNGEVVAVTEAGQGGIVQQILTNQANMPSSSMISDLQAGRDGVTTVRLSGRGYVVAYAAISGIPW
GLGLASPLDEITARTTETANQIATITNQSLGLSIGLALIAVILFGFGMALILRRQFLKPLTGLIGATNRVADGDLQPIEV
ESNNELGQLASSFNSMTAALQVSRQETEAKEAAREAAMQRLSEVVVNLEHSLAERQQLSQLLRDVASPVIPILKGVLVMP
LIGSLDGERVQQATSILLTRVERERARKVLIDITGVPMMDEQAAQALLTMMNGLRLLGASVILVGVAPEVAQILTTLSVD
LSSVQTSADLRTAVAQLSRS

Sequences:

>Translated_580_residues
MLHSLRRQVIVILLLGTSLLALLNLAINARGLVAVRNQATNDSTAALQAQAEQYLLRIAQSHAASTGQTVRGVQQLAVTT
RTYLQQPTNQIPNLPELNVARNGRQYASGATTVLVIANPDQTQALADIRYSQRLEDVLPSLQISVPEIVRISYLTANTLR
TYPNMTPNDPPADWLPSQEAAYQASLPENNPSRALVWTEVHQSIDQSQALISVAAPVYANADFLGTVSVDVSLDRLSFYL
KGLIIDQSSFAFLITRNGEVVAVTEAGQGGIVQQILTNQANMPSSSMISDLQAGRDGVTTVRLSGRGYVVAYAAISGIPW
GLGLASPLDEITARTTETANQIATITNQSLGLSIGLALIAVILFGFGMALILRRQFLKPLTGLIGATNRVADGDLQPIEV
ESNNELGQLASSFNSMTAALQVSRQETEAKEAAREAAMQRLSEVVVNLEHSLAERQQLSQLLRDVASPVIPILKGVLVMP
LIGSLDGERVQQATSILLTRVERERARKVLIDITGVPMMDEQAAQALLTMMNGLRLLGASVILVGVAPEVAQILTTLSVD
LSSVQTSADLRTAVAQLSRS
>Mature_580_residues
MLHSLRRQVIVILLLGTSLLALLNLAINARGLVAVRNQATNDSTAALQAQAEQYLLRIAQSHAASTGQTVRGVQQLAVTT
RTYLQQPTNQIPNLPELNVARNGRQYASGATTVLVIANPDQTQALADIRYSQRLEDVLPSLQISVPEIVRISYLTANTLR
TYPNMTPNDPPADWLPSQEAAYQASLPENNPSRALVWTEVHQSIDQSQALISVAAPVYANADFLGTVSVDVSLDRLSFYL
KGLIIDQSSFAFLITRNGEVVAVTEAGQGGIVQQILTNQANMPSSSMISDLQAGRDGVTTVRLSGRGYVVAYAAISGIPW
GLGLASPLDEITARTTETANQIATITNQSLGLSIGLALIAVILFGFGMALILRRQFLKPLTGLIGATNRVADGDLQPIEV
ESNNELGQLASSFNSMTAALQVSRQETEAKEAAREAAMQRLSEVVVNLEHSLAERQQLSQLLRDVASPVIPILKGVLVMP
LIGSLDGERVQQATSILLTRVERERARKVLIDITGVPMMDEQAAQALLTMMNGLRLLGASVILVGVAPEVAQILTTLSVD
LSSVQTSADLRTAVAQLSRS

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 62198; Mature: 62198

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50885 HAMP ; PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHSLRRQVIVILLLGTSLLALLNLAINARGLVAVRNQATNDSTAALQAQAEQYLLRIAQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
SHAASTGQTVRGVQQLAVTTRTYLQQPTNQIPNLPELNVARNGRQYASGATTVLVIANPD
HHCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCHHCCCCCEEEEEECCC
QTQALADIRYSQRLEDVLPSLQISVPEIVRISYLTANTLRTYPNMTPNDPPADWLPSQEA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEHHHHHHHHHCCCCCCCCCCCCCCCCCHH
AYQASLPENNPSRALVWTEVHQSIDQSQALISVAAPVYANADFLGTVSVDVSLDRLSFYL
CEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEEEEEEHHHHHHHH
KGLIIDQSSFAFLITRNGEVVAVTEAGQGGIVQQILTNQANMPSSSMISDLQAGRDGVTT
HHHEEECCCEEEEEECCCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCEE
VRLSGRGYVVAYAAISGIPWGLGLASPLDEITARTTETANQIATITNQSLGLSIGLALIA
EEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VILFGFGMALILRRQFLKPLTGLIGATNRVADGDLQPIEVESNNELGQLASSFNSMTAAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHH
QVSRQETEAKEAAREAAMQRLSEVVVNLEHSLAERQQLSQLLRDVASPVIPILKGVLVMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGSLDGERVQQATSILLTRVERERARKVLIDITGVPMMDEQAAQALLTMMNGLRLLGAS
HHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
VILVGVAPEVAQILTTLSVDLSSVQTSADLRTAVAQLSRS
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLHSLRRQVIVILLLGTSLLALLNLAINARGLVAVRNQATNDSTAALQAQAEQYLLRIAQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHH
SHAASTGQTVRGVQQLAVTTRTYLQQPTNQIPNLPELNVARNGRQYASGATTVLVIANPD
HHCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCHHCCCCCEEEEEECCC
QTQALADIRYSQRLEDVLPSLQISVPEIVRISYLTANTLRTYPNMTPNDPPADWLPSQEA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEHHHHHHHHHCCCCCCCCCCCCCCCCCHH
AYQASLPENNPSRALVWTEVHQSIDQSQALISVAAPVYANADFLGTVSVDVSLDRLSFYL
CEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEEEEEEHHHHHHHH
KGLIIDQSSFAFLITRNGEVVAVTEAGQGGIVQQILTNQANMPSSSMISDLQAGRDGVTT
HHHEEECCCEEEEEECCCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCEE
VRLSGRGYVVAYAAISGIPWGLGLASPLDEITARTTETANQIATITNQSLGLSIGLALIA
EEECCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VILFGFGMALILRRQFLKPLTGLIGATNRVADGDLQPIEVESNNELGQLASSFNSMTAAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHH
QVSRQETEAKEAAREAAMQRLSEVVVNLEHSLAERQQLSQLLRDVASPVIPILKGVLVMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGSLDGERVQQATSILLTRVERERARKVLIDITGVPMMDEQAAQALLTMMNGLRLLGAS
HHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
VILVGVAPEVAQILTTLSVDLSSVQTSADLRTAVAQLSRS
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]