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The map label for this gene is 159898724

Identifier: 159898724

GI number: 159898724

Start: 2799137

End: 2800336

Strand: Reverse

Name: 159898724

Synonym: Haur_2203

Alternate gene names: NA

Gene position: 2800336-2799137 (Counterclockwise)

Preceding gene: 159898729

Following gene: 159898718

Centisome position: 44.12

GC content: 51.92

Gene sequence:

>1200_bases
ATGTTGATCTTGGCGGTTAGTGCGTTTGCTGGCTCAAATTCATCATTCGCCCAGTCACGCGATGTAGAAAAACCCGTCGA
TATTGGCGATGCCGTTGGTCTCGACCTCAATGCCCCTGCTGTTCCTGGTCAGTTTGTCATCAAATTCAAGAATTCAACCT
CAAAAGCTAGCCGCGCCAATAGCTTGAGTGCCTTGGGCGCAGTGCAAATCGATCGGATCGAAGCGCTTGACGCTGAAGTC
GTCGAATTCGCTAGCTTGAAGAGCAACGATAGTTTGGCAATGCGCCAAGCCATGGTTGAAAGCTTGCTCAAAGATGGCAA
CATCGAATATGCCGAACCCAACTTTATCTATACTTCAACCTACACTCCCAACGACCCAGGTCGTAGCTCACAATGGGCAT
GGGGTGTAACCCAAGCATACACTGGTTGGGATATCACGCGCGGTAGCAGCAGCGTTGTCGTTGCGGTTGTTGACACTGGG
ATTCAAAGCACTCACCCTGATTTGGATGCCAAAATTGTCGCTGGCTACGACTACATCGATAATGACTCAACGCCAAATGA
TGGAAATGGCCACGGTACGCACGTCGCTGGGACGGTTGCTGCTGAAACCAACAATAGCACTGGTGGCGCAGGAACCTGCC
CCAACTGTCGCTTGATGGGCGTTCGCGTCTTGAATAACAGCGGTAGCGGTACCTTGGCTGGTGTGGCCAATGGCATCACC
TACGCTGCTAACAATGGCGCAAAGGTCATCAACTTAAGCCTTGGTGGCGGTGGTTCAACGGCCTTGCAAAATGCCGTCAA
CTACGCTTGGGGCCGTGGAGTATTCTTGGCTTGTGCCGCTGGTAACAGCAACACCTCAAGCACCACCAGCGCTTACCCAG
CTGCGTATACCAACTGTTTTGCGGTTGCATCAACGACTTCAACCGATGCCCGCTCATCATTCTCAAACTATGGTACATGG
GTCGAAGTGGCTGCCCCTGGTTCGAGCATCTACTCAACCTGGATTAACAGTGGCTACAACACGATCAATGGTACCTCAAT
GGCTACCCCACACGTTGCCGGTTTGGCTGGCTTGTTGTCATCACAAGGCTTGACCAACAGCCAAATCAAGAGCAAAATCT
GCTCAAGCTCCGACCAAATTAGCGGGACTGGCACGCGCTGGACTTGCGGTCGGATCAACATCTACAAAGCTGTTCAATAG

Upstream 100 bases:

>100_bases
TGTAGGTACAGCCGCTGTTGGTTTGGTACTGCACGATTTTGGTTAAAAAATCAACCCACATGTTGAGGAGGCAACTTTGA
AGCGTCTGTTTGTTTCGAGC

Downstream 100 bases:

>100_bases
TTCGACTCTCATCTGACGGAATAAGTGGTCAGCTGACCGCTTGGTGTGTGGAAGTGTTCAATTGATCCTGTAAAAACCTA
AGCAACCTATCAGATCAAAA

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MLILAVSAFAGSNSSFAQSRDVEKPVDIGDAVGLDLNAPAVPGQFVIKFKNSTSKASRANSLSALGAVQIDRIEALDAEV
VEFASLKSNDSLAMRQAMVESLLKDGNIEYAEPNFIYTSTYTPNDPGRSSQWAWGVTQAYTGWDITRGSSSVVVAVVDTG
IQSTHPDLDAKIVAGYDYIDNDSTPNDGNGHGTHVAGTVAAETNNSTGGAGTCPNCRLMGVRVLNNSGSGTLAGVANGIT
YAANNGAKVINLSLGGGGSTALQNAVNYAWGRGVFLACAAGNSNTSSTTSAYPAAYTNCFAVASTTSTDARSSFSNYGTW
VEVAAPGSSIYSTWINSGYNTINGTSMATPHVAGLAGLLSSQGLTNSQIKSKICSSSDQISGTGTRWTCGRINIYKAVQ

Sequences:

>Translated_399_residues
MLILAVSAFAGSNSSFAQSRDVEKPVDIGDAVGLDLNAPAVPGQFVIKFKNSTSKASRANSLSALGAVQIDRIEALDAEV
VEFASLKSNDSLAMRQAMVESLLKDGNIEYAEPNFIYTSTYTPNDPGRSSQWAWGVTQAYTGWDITRGSSSVVVAVVDTG
IQSTHPDLDAKIVAGYDYIDNDSTPNDGNGHGTHVAGTVAAETNNSTGGAGTCPNCRLMGVRVLNNSGSGTLAGVANGIT
YAANNGAKVINLSLGGGGSTALQNAVNYAWGRGVFLACAAGNSNTSSTTSAYPAAYTNCFAVASTTSTDARSSFSNYGTW
VEVAAPGSSIYSTWINSGYNTINGTSMATPHVAGLAGLLSSQGLTNSQIKSKICSSSDQISGTGTRWTCGRINIYKAVQ
>Mature_399_residues
MLILAVSAFAGSNSSFAQSRDVEKPVDIGDAVGLDLNAPAVPGQFVIKFKNSTSKASRANSLSALGAVQIDRIEALDAEV
VEFASLKSNDSLAMRQAMVESLLKDGNIEYAEPNFIYTSTYTPNDPGRSSQWAWGVTQAYTGWDITRGSSSVVVAVVDTG
IQSTHPDLDAKIVAGYDYIDNDSTPNDGNGHGTHVAGTVAAETNNSTGGAGTCPNCRLMGVRVLNNSGSGTLAGVANGIT
YAANNGAKVINLSLGGGGSTALQNAVNYAWGRGVFLACAAGNSNTSSTTSAYPAAYTNCFAVASTTSTDARSSFSNYGTW
VEVAAPGSSIYSTWINSGYNTINGTSMATPHVAGLAGLLSSQGLTNSQIKSKICSSSDQISGTGTRWTCGRINIYKAVQ

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI31317307, Length=311, Percent_Identity=26.3665594855305, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4506775, Length=283, Percent_Identity=27.208480565371, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI76443679, Length=123, Percent_Identity=37.3983739837398, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25141268, Length=241, Percent_Identity=24.4813278008299, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320775, Length=398, Percent_Identity=29.8994974874372, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6324576, Length=229, Percent_Identity=37.9912663755458, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6319893, Length=388, Percent_Identity=29.3814432989691, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45550681, Length=286, Percent_Identity=24.1258741258741, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 41164; Mature: 41164

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLILAVSAFAGSNSSFAQSRDVEKPVDIGDAVGLDLNAPAVPGQFVIKFKNSTSKASRAN
CEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHC
SLSALGAVQIDRIEALDAEVVEFASLKSNDSLAMRQAMVESLLKDGNIEYAEPNFIYTST
CHHHHCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEEEEC
YTPNDPGRSSQWAWGVTQAYTGWDITRGSSSVVVAVVDTGIQSTHPDLDAKIVAGYDYID
CCCCCCCCCCCEEECCCEEECCCEEECCCCCEEEEEEECCCCCCCCCCCEEEEECCEECC
NDSTPNDGNGHGTHVAGTVAAETNNSTGGAGTCPNCRLMGVRVLNNSGSGTLAGVANGIT
CCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCEEEEECCCCEE
YAANNGAKVINLSLGGGGSTALQNAVNYAWGRGVFLACAAGNSNTSSTTSAYPAAYTNCF
EEECCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCEE
AVASTTSTDARSSFSNYGTWVEVAAPGSSIYSTWINSGYNTINGTSMATPHVAGLAGLLS
EEEECCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
SQGLTNSQIKSKICSSSDQISGTGTRWTCGRINIYKAVQ
CCCCCHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEECC
>Mature Secondary Structure
MLILAVSAFAGSNSSFAQSRDVEKPVDIGDAVGLDLNAPAVPGQFVIKFKNSTSKASRAN
CEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHC
SLSALGAVQIDRIEALDAEVVEFASLKSNDSLAMRQAMVESLLKDGNIEYAEPNFIYTST
CHHHHCCEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEEEEC
YTPNDPGRSSQWAWGVTQAYTGWDITRGSSSVVVAVVDTGIQSTHPDLDAKIVAGYDYID
CCCCCCCCCCCEEECCCEEECCCEEECCCCCEEEEEEECCCCCCCCCCCEEEEECCEECC
NDSTPNDGNGHGTHVAGTVAAETNNSTGGAGTCPNCRLMGVRVLNNSGSGTLAGVANGIT
CCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCEEEEECCCCEE
YAANNGAKVINLSLGGGGSTALQNAVNYAWGRGVFLACAAGNSNTSSTTSAYPAAYTNCF
EEECCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHCEE
AVASTTSTDARSSFSNYGTWVEVAAPGSSIYSTWINSGYNTINGTSMATPHVAGLAGLLS
EEEECCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
SQGLTNSQIKSKICSSSDQISGTGTRWTCGRINIYKAVQ
CCCCCHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]