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The map label for this gene is gltA [H]

Identifier: 159898555

GI number: 159898555

Start: 2526773

End: 2528194

Strand: Reverse

Name: gltA [H]

Synonym: Haur_2031

Alternate gene names: 159898555

Gene position: 2528194-2526773 (Counterclockwise)

Preceding gene: 159898561

Following gene: 159898554

Centisome position: 39.84

GC content: 47.12

Gene sequence:

>1422_bases
ATGGTCAATCCACAAAAAATCACCAATAATCAAATTTCAGATATAACCAATCTGATTGCTCAGGTGCTGCAAATTCCAGA
ATATATGGTAACCGATCAACTTAGCTACCGTTCAATTATGCAATGGGATTCATTGGCGCATATTAACTTGATGTTGGCAT
TAGAAACAACCTATGGAGTGACAATCGAACCTGATACCATTGTTACACTTAGTTCTGTTGCCCAAATTAAGGCCTATATG
CAGGGGACGCTTCAGCCGACATCAACCCACACAGCAGGGATTGAAACTCAAACTGACGGTGGTGTGGTCTATCGTGGCCT
TGCAGGAGTAACCTTCGATCAGAGCCAGATCACGTTGATCGATGGCAAACAAGGCCGCTTGCAATATCGCGGCTATAGCA
TTCATGATTTGGTTGAGCAAACGACGTTTGAGGAAACAGCCTTTTTATTATTGAATGGGCAATTGCCAACAACCACTGAG
TTGGATCAATTTAAGCACCAGTTGGTGGCAGCACGAGAGATACCAGCAACGATTTTGGAGTTGATTCAGCTCCTAAAAGA
TGGCCATCCCACCGAAGTTTTGCGCACCTGCCTTTCGGCGCTTGCCACGTTCGATGCTGAGCGCCTTGATGGATCAGTTA
CTGCAACCAAAGCTCGGTCTATTCGACTGATTGCACAAATGCCCTGCTTGATTGCAGCTCATCATGCGATTCGCCAAGGA
AAAACACCAATCCAGCCCAACCCAACGCTTGATCATGCTGCTAATTTTCTCTACATGCTCCAAGGAACCATTCCGAGCCA
ACAGGCTCAGCAGATCGTGAATCAGATTCTGATTCTGCATGCTGATCATAGTGCCAATGCTTCAACCTTTGCAGCCCGAG
TTGTCGCAGGAACACGCTCAGACTGGTATGCAGCGCTCACTGCTGCAATTGCCGCCTTTGCAGGCCCACTCCATGGCGGG
GCCATCGAACAGGTCATTGCCATGATTCAAGCGATCGGTACTCCTGAGCGAGCTGCCGATTATGTAGCCAACTTACAAGC
CAACAATCAGCCAGTGATGGGTTTTGGGCATCGGGTCTATCAAACCGAAGATCCACGAGCACGTCATTTACGCAAAGCAG
CGCAGGCCTTGAGCGCACAAAGCGATAACAACTATTACGCGATTCTTGAAGCGGTTGTTCAAGCAATGCGTCCCTATATG
GCCAAAGGAATCGATGTGAATGTTGATTTTTATGCCAGTGTTATTTATCACCTTTTGGGTATTCCCTACGATCTGTTTGT
TCCAGCATTTATTGTTGGCCGAACCGTGGGCTGGTTGGCCCAAATTCAAGAGCAATATGCCAACAATATTTTGATTCGCC
CATTGCTTGCCTATGTTGGGCCAATTGATCAGCCCTATCCAGCATTGAGCCAACGTCAATAA

Upstream 100 bases:

>100_bases
TAGTTTATATACACACTTAATCATATAATATTGATTTAAGTATGTATCTATATCGTTGTGCCTTCAGTTAAGAATTGAGA
ATCAGGAGTTTAAACGTTCT

Downstream 100 bases:

>100_bases
CAAGTCTATAACACGCCTAACGCCTTATTGGAGAATAGATGATGATTGAGTTTAACCAGATGCTTGAAGTTGTGCCTCCA
TGCCAAAGCGAGCCAAACCA

Product: citrate (Si)-synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MVNPQKITNNQISDITNLIAQVLQIPEYMVTDQLSYRSIMQWDSLAHINLMLALETTYGVTIEPDTIVTLSSVAQIKAYM
QGTLQPTSTHTAGIETQTDGGVVYRGLAGVTFDQSQITLIDGKQGRLQYRGYSIHDLVEQTTFEETAFLLLNGQLPTTTE
LDQFKHQLVAAREIPATILELIQLLKDGHPTEVLRTCLSALATFDAERLDGSVTATKARSIRLIAQMPCLIAAHHAIRQG
KTPIQPNPTLDHAANFLYMLQGTIPSQQAQQIVNQILILHADHSANASTFAARVVAGTRSDWYAALTAAIAAFAGPLHGG
AIEQVIAMIQAIGTPERAADYVANLQANNQPVMGFGHRVYQTEDPRARHLRKAAQALSAQSDNNYYAILEAVVQAMRPYM
AKGIDVNVDFYASVIYHLLGIPYDLFVPAFIVGRTVGWLAQIQEQYANNILIRPLLAYVGPIDQPYPALSQRQ

Sequences:

>Translated_473_residues
MVNPQKITNNQISDITNLIAQVLQIPEYMVTDQLSYRSIMQWDSLAHINLMLALETTYGVTIEPDTIVTLSSVAQIKAYM
QGTLQPTSTHTAGIETQTDGGVVYRGLAGVTFDQSQITLIDGKQGRLQYRGYSIHDLVEQTTFEETAFLLLNGQLPTTTE
LDQFKHQLVAAREIPATILELIQLLKDGHPTEVLRTCLSALATFDAERLDGSVTATKARSIRLIAQMPCLIAAHHAIRQG
KTPIQPNPTLDHAANFLYMLQGTIPSQQAQQIVNQILILHADHSANASTFAARVVAGTRSDWYAALTAAIAAFAGPLHGG
AIEQVIAMIQAIGTPERAADYVANLQANNQPVMGFGHRVYQTEDPRARHLRKAAQALSAQSDNNYYAILEAVVQAMRPYM
AKGIDVNVDFYASVIYHLLGIPYDLFVPAFIVGRTVGWLAQIQEQYANNILIRPLLAYVGPIDQPYPALSQRQ
>Mature_473_residues
MVNPQKITNNQISDITNLIAQVLQIPEYMVTDQLSYRSIMQWDSLAHINLMLALETTYGVTIEPDTIVTLSSVAQIKAYM
QGTLQPTSTHTAGIETQTDGGVVYRGLAGVTFDQSQITLIDGKQGRLQYRGYSIHDLVEQTTFEETAFLLLNGQLPTTTE
LDQFKHQLVAAREIPATILELIQLLKDGHPTEVLRTCLSALATFDAERLDGSVTATKARSIRLIAQMPCLIAAHHAIRQG
KTPIQPNPTLDHAANFLYMLQGTIPSQQAQQIVNQILILHADHSANASTFAARVVAGTRSDWYAALTAAIAAFAGPLHGG
AIEQVIAMIQAIGTPERAADYVANLQANNQPVMGFGHRVYQTEDPRARHLRKAAQALSAQSDNNYYAILEAVVQAMRPYM
AKGIDVNVDFYASVIYHLLGIPYDLFVPAFIVGRTVGWLAQIQEQYANNILIRPLLAYVGPIDQPYPALSQRQ

Specific function: Catalyzes The Synthesis Of 2-Methylcitrate From Propionyl-CoA And Oxaloacetate. Also Catalyzes The Condensation Of Oxaloacetate With Acetyl-CoA But With A Lower Specificity. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=381, Percent_Identity=26.246719160105, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI1786527, Length=370, Percent_Identity=35.9459459459459, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1786939, Length=373, Percent_Identity=33.2439678284182, Blast_Score=196, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17555174, Length=375, Percent_Identity=24.5333333333333, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319850, Length=374, Percent_Identity=23.2620320855615, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325257, Length=390, Percent_Identity=25.3846153846154, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324328, Length=380, Percent_Identity=23.4210526315789, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356863, Length=417, Percent_Identity=25.6594724220624, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24640126, Length=388, Percent_Identity=23.7113402061856, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24640124, Length=388, Percent_Identity=23.7113402061856, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 51984; Mature: 51984

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50075 ACP_DOMAIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNPQKITNNQISDITNLIAQVLQIPEYMVTDQLSYRSIMQWDSLAHINLMLALETTYGV
CCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHCCHHEEEEEEEEECCCCC
TIEPDTIVTLSSVAQIKAYMQGTLQPTSTHTAGIETQTDGGVVYRGLAGVTFDQSQITLI
EECCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCEECCCEEEEE
DGKQGRLQYRGYSIHDLVEQTTFEETAFLLLNGQLPTTTELDQFKHQLVAAREIPATILE
ECCCCCEEECCCHHHHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHH
LIQLLKDGHPTEVLRTCLSALATFDAERLDGSVTATKARSIRLIAQMPCLIAAHHAIRQG
HHHHHHCCCHHHHHHHHHHHHHHCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCC
KTPIQPNPTLDHAANFLYMLQGTIPSQQAQQIVNQILILHADHSANASTFAARVVAGTRS
CCCCCCCCCHHHHHHHHHEEECCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHCCCC
DWYAALTAAIAAFAGPLHGGAIEQVIAMIQAIGTPERAADYVANLQANNQPVMGFGHRVY
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEE
QTEDPRARHLRKAAQALSAQSDNNYYAILEAVVQAMRPYMAKGIDVNVDFYASVIYHLLG
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
IPYDLFVPAFIVGRTVGWLAQIQEQYANNILIRPLLAYVGPIDQPYPALSQRQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MVNPQKITNNQISDITNLIAQVLQIPEYMVTDQLSYRSIMQWDSLAHINLMLALETTYGV
CCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHCCHHEEEEEEEEECCCCC
TIEPDTIVTLSSVAQIKAYMQGTLQPTSTHTAGIETQTDGGVVYRGLAGVTFDQSQITLI
EECCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCEECCCEEEEE
DGKQGRLQYRGYSIHDLVEQTTFEETAFLLLNGQLPTTTELDQFKHQLVAAREIPATILE
ECCCCCEEECCCHHHHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHH
LIQLLKDGHPTEVLRTCLSALATFDAERLDGSVTATKARSIRLIAQMPCLIAAHHAIRQG
HHHHHHCCCHHHHHHHHHHHHHHCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCC
KTPIQPNPTLDHAANFLYMLQGTIPSQQAQQIVNQILILHADHSANASTFAARVVAGTRS
CCCCCCCCCHHHHHHHHHEEECCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHCCCC
DWYAALTAAIAAFAGPLHGGAIEQVIAMIQAIGTPERAADYVANLQANNQPVMGFGHRVY
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCEEE
QTEDPRARHLRKAAQALSAQSDNNYYAILEAVVQAMRPYMAKGIDVNVDFYASVIYHLLG
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
IPYDLFVPAFIVGRTVGWLAQIQEQYANNILIRPLLAYVGPIDQPYPALSQRQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]