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The map label for this gene is gyaR [H]

Identifier: 159898549

GI number: 159898549

Start: 2517622

End: 2518584

Strand: Reverse

Name: gyaR [H]

Synonym: Haur_2025

Alternate gene names: 159898549

Gene position: 2518584-2517622 (Counterclockwise)

Preceding gene: 159898550

Following gene: 159898548

Centisome position: 39.68

GC content: 50.47

Gene sequence:

>963_bases
ATGACAAAACTACGCTGTGCAATTCTTGACGATTATCAACACGCCGCCTTGGCGATGGCTGATTGGTCAGTGGTAGCCGA
ACAGGTTGAAGTAGAGATTTTTTCTAACTATTTCAGCGAACAAACCGCGTTAATTCAAGCAATCCACGATTGTGAGATTG
TGGTAATTATGCGCGAACGAACACCATTTAAAGCTGATTTACTAGCCCAATTGCCAAACCTCAAGCTGTTGATCACTTCG
GGTATGCGAAATGCCTCGATCGATGTGGCAGCAGCCCAAGCCCAAGGGGTGGTGGTTTGTGGCACGGCGAGCCGTTCCGA
GCCACCAGCCGAATTAACCTGGGCACTGATTTTAGGCTTGGCTCGCCAGATTGTGCCTGAAAATCTGGCTTTACGCACCA
ATGGCCCATGGCAACAAAGCGTTGGCATGGATTTGGCGGGCCAGCGTTTGGGCTTATTAGGCTTAGGCAAAATTGGCAGC
AACGTTGCCAAAGTCGCCCAAGCATTTGGTATGGACGTGTTGGCGTGGAGCCAAAACCTCACTGCTGAGCGCACTCAAGC
GCTAGGTGTTCAGCTCGCTGTATCCAAAGAACAGCTGCTTGAACAGAGTGATATTGTTTCGATTCACTTAGTGTTAGGCG
AACGGACGCACGGTTTAATCGGCGCTGCCGAACTCCAGCGCATGCGCCGTCATGCCTACCTGATCAACACATCTCGCGCA
GCGATTGTCGATCAAGCTGCCTTGATTCAGGCTTTGGAACAGGGATGGATTGGTGGCGCAGGCTTAGATGTGTTTGAGAT
TGAGCCGCTGCCAGCCCAACACCCATTTCGTAGCTTGCCAAATGTCTTAGCCACACCGCACTTGGGCTATGTATCCCAAC
GCAACTACAAAGCCTATTTTGGCGAGGCGATTGAAGATATTCAGGCTTTTTTAGCAGGCGCACCAATTCGCCAATTAAGT
TAA

Upstream 100 bases:

>100_bases
ATTTGGTCAATGACCCCTTTCAAGGCCTTGTGATCGAGCAAGGTACGCTGCGTTTACCGCAAACTCCAGGTTTAGGATTA
ACCATTCAAGGAGCAATCGA

Downstream 100 bases:

>100_bases
AGCGGCTAAAGAGTTTTAGATTGTGTGCATAATGGAGTTGATTAACCAATGAAACCGCAACGACAGATGAAACTTGGGGC
TTTTCTGCCAGCACCTGGCC

Product: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTKLRCAILDDYQHAALAMADWSVVAEQVEVEIFSNYFSEQTALIQAIHDCEIVVIMRERTPFKADLLAQLPNLKLLITS
GMRNASIDVAAAQAQGVVVCGTASRSEPPAELTWALILGLARQIVPENLALRTNGPWQQSVGMDLAGQRLGLLGLGKIGS
NVAKVAQAFGMDVLAWSQNLTAERTQALGVQLAVSKEQLLEQSDIVSIHLVLGERTHGLIGAAELQRMRRHAYLINTSRA
AIVDQAALIQALEQGWIGGAGLDVFEIEPLPAQHPFRSLPNVLATPHLGYVSQRNYKAYFGEAIEDIQAFLAGAPIRQLS

Sequences:

>Translated_320_residues
MTKLRCAILDDYQHAALAMADWSVVAEQVEVEIFSNYFSEQTALIQAIHDCEIVVIMRERTPFKADLLAQLPNLKLLITS
GMRNASIDVAAAQAQGVVVCGTASRSEPPAELTWALILGLARQIVPENLALRTNGPWQQSVGMDLAGQRLGLLGLGKIGS
NVAKVAQAFGMDVLAWSQNLTAERTQALGVQLAVSKEQLLEQSDIVSIHLVLGERTHGLIGAAELQRMRRHAYLINTSRA
AIVDQAALIQALEQGWIGGAGLDVFEIEPLPAQHPFRSLPNVLATPHLGYVSQRNYKAYFGEAIEDIQAFLAGAPIRQLS
>Mature_319_residues
TKLRCAILDDYQHAALAMADWSVVAEQVEVEIFSNYFSEQTALIQAIHDCEIVVIMRERTPFKADLLAQLPNLKLLITSG
MRNASIDVAAAQAQGVVVCGTASRSEPPAELTWALILGLARQIVPENLALRTNGPWQQSVGMDLAGQRLGLLGLGKIGSN
VAKVAQAFGMDVLAWSQNLTAERTQALGVQLAVSKEQLLEQSDIVSIHLVLGERTHGLIGAAELQRMRRHAYLINTSRAA
IVDQAALIQALEQGWIGGAGLDVFEIEPLPAQHPFRSLPNVLATPHLGYVSQRNYKAYFGEAIEDIQAFLAGAPIRQLS

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=264, Percent_Identity=34.0909090909091, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI61743967, Length=257, Percent_Identity=35.408560311284, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4557497, Length=257, Percent_Identity=35.408560311284, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI145580578, Length=238, Percent_Identity=36.9747899159664, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4557499, Length=238, Percent_Identity=36.9747899159664, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI145580575, Length=238, Percent_Identity=36.9747899159664, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI6912396, Length=250, Percent_Identity=30.8, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI87082289, Length=258, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1789279, Length=282, Percent_Identity=31.5602836879433, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787645, Length=281, Percent_Identity=29.1814946619217, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081824, Length=166, Percent_Identity=33.1325301204819, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=265, Percent_Identity=36.6037735849057, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=276, Percent_Identity=26.8115942028986, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=276, Percent_Identity=31.8840579710145, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=262, Percent_Identity=32.0610687022901, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=244, Percent_Identity=30.327868852459, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=280, Percent_Identity=28.9285714285714, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6324980, Length=160, Percent_Identity=30.625, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646446, Length=238, Percent_Identity=36.1344537815126, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24646448, Length=238, Percent_Identity=36.1344537815126, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24646452, Length=238, Percent_Identity=36.1344537815126, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24646450, Length=238, Percent_Identity=36.1344537815126, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI62472511, Length=238, Percent_Identity=36.1344537815126, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI19921140, Length=241, Percent_Identity=34.4398340248963, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574286, Length=314, Percent_Identity=28.343949044586, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28571528, Length=248, Percent_Identity=32.258064516129, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI45552429, Length=264, Percent_Identity=27.6515151515151, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585514, Length=264, Percent_Identity=27.6515151515151, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28574282, Length=264, Percent_Identity=27.6515151515151, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI45551003, Length=264, Percent_Identity=27.6515151515151, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28574284, Length=264, Percent_Identity=27.6515151515151, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24585516, Length=149, Percent_Identity=30.8724832214765, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34732; Mature: 34601

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLRCAILDDYQHAALAMADWSVVAEQVEVEIFSNYFSEQTALIQAIHDCEIVVIMRER
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
TPFKADLLAQLPNLKLLITSGMRNASIDVAAAQAQGVVVCGTASRSEPPAELTWALILGL
CCCHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHH
ARQIVPENLALRTNGPWQQSVGMDLAGQRLGLLGLGKIGSNVAKVAQAFGMDVLAWSQNL
HHHHCCCCEEEECCCCCHHHCCCCCCCCCCCEEECCHHCHHHHHHHHHHCCHHEECCCCC
TAERTQALGVQLAVSKEQLLEQSDIVSIHLVLGERTHGLIGAAELQRMRRHAYLINTSRA
CHHHHHHHCEEEEECHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHEEEECCHH
AIVDQAALIQALEQGWIGGAGLDVFEIEPLPAQHPFRSLPNVLATPHLGYVSQRNYKAYF
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCHHHCCHHHCCCCCCCCCCCCHHHHH
GEAIEDIQAFLAGAPIRQLS
HHHHHHHHHHHCCCCHHHCC
>Mature Secondary Structure 
TKLRCAILDDYQHAALAMADWSVVAEQVEVEIFSNYFSEQTALIQAIHDCEIVVIMRER
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
TPFKADLLAQLPNLKLLITSGMRNASIDVAAAQAQGVVVCGTASRSEPPAELTWALILGL
CCCHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHH
ARQIVPENLALRTNGPWQQSVGMDLAGQRLGLLGLGKIGSNVAKVAQAFGMDVLAWSQNL
HHHHCCCCEEEECCCCCHHHCCCCCCCCCCCEEECCHHCHHHHHHHHHHCCHHEECCCCC
TAERTQALGVQLAVSKEQLLEQSDIVSIHLVLGERTHGLIGAAELQRMRRHAYLINTSRA
CHHHHHHHCEEEEECHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHEEEECCHH
AIVDQAALIQALEQGWIGGAGLDVFEIEPLPAQHPFRSLPNVLATPHLGYVSQRNYKAYF
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCHHHCCHHHCCCCCCCCCCCCHHHHH
GEAIEDIQAFLAGAPIRQLS
HHHHHHHHHHHCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]