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The map label for this gene is phoR [H]

Identifier: 159898432

GI number: 159898432

Start: 2302397

End: 2303860

Strand: Direct

Name: phoR [H]

Synonym: Haur_1908

Alternate gene names: 159898432

Gene position: 2302397-2303860 (Clockwise)

Preceding gene: 159898431

Following gene: 159898433

Centisome position: 36.28

GC content: 50.0

Gene sequence:

>1464_bases
ATGAATATAACCAGTCGCGAATGGGCTATGATTGAAGACTTTTCGCGCCGGATCACAACCGAAGCGCCACAATCGTTGGT
TGCCTTGGCTCAATCACTGAGTGCGGCATTTCAAGTTGACGTAACGATTTGGAGCCGCACTGCTTCTGGTGAATATCATT
GTGTTACGCCAAGCGCAGGCCAGCCCGAAGGCCTGATGATGAGCGCTGAGCAGGCATTAAACGTCGAAAAAGCTACCTTG
ATTTTTGTTTATGAAGCGTTTTACGCCGCCAAATTTAATCCTGCGCACAATTTCAGCCCAGCTCAAGTAATGATTATTCA
GGCCTTGCTGGAAGGCTGGATCGGGCGTTTGCGCACCAGCTATGTCGAGCCGCATGAGCACGAAAACCTTGGTGATCTGC
ATCAATCGTTGTTGCAAAGCATTATCGATGTGTTGCCAGAAGGTGTCGTTGTCGGTTTAGCGCCTGATGGTCAGTTGATT
TTGGCCAATCGTCAGGCCGAGCAATTGTGGCAACACCCACTGCATTCGGTGCCAGTTGAGGGTTATAGCCATTTTGGCCT
GTATAAACCTGATGGCACGCGCTTGCCGGCTGGCGATTCGGGGATTGCCCGCGTGCTGCGCACTGGGGAGCCATTTCTCA
AACATGATTTAATTTTGCGTCGCCCCGATGGCAGTGAAATTCCAATTTTGGCTAATACCTCGCCGATTCACGATAATCGC
GGTAATTTGATCGGCGCGGTCGCCGTCTTTCAAGATATCACTGGCTGGAAATTGCAAGAAAGTGATCGCGATAATGCCAT
TGCTACTATCGTGCATGATTTAAAAAATCCCCTGACGACGATTCGTGGCAGTGCCGATTTGCTGTTGCGGCGGGCTAAAA
CTGAAAATCGCAGCGAACGCGAGTTAAATCGCTTGCAATCAATTATCGCTCAATCCGATCGTATGCGTGATTATCTGTCG
TTATTGGTTGATGTTGCGCGAATCAACGCTGGCGAAACCTTAATCAGCCCATGCTTATTGGATTTTGGTGAGTTGGTCGG
CCAATTAATTGCCACGATCAATGGCGGTTTAGCTAATCCCCGCATCAACGTGGAGCTTCTAGCTAGGCCGTTGGTGCGGG
TTGACCCAATTTGGATGGAGCGAGTGATTTGGAATTTGCTCGATAATGCCCTGAAATATAGCGCCGATGATACCAATATC
GATGTACGCTTAGAGCTTGAGCACGACCAAGTGCTGCTGAGCATTCGCGATGCGGGCCTTGGTATCGATCCCCAAGATCT
TGAGCGAATTTTCGAGCGCTTTACGCGTGGGCGGCATACGCAACGGGTTGGTGGCACTGGTCTTGGTTTGTATACTGTTC
GGGCTGTTGTGCGAGCGCATGGCGGCAGTATTGTTGTTGAATCGGAAGGCCTAGGCCGTGGTAGTTGTCTTACCGTAAGC
CTTCCCGTTGAATCAAACGAATAA

Upstream 100 bases:

>100_bases
AGCCCAGCGCTACGAAGCAATTATCGGACGCACGATCAAACCAAACTCGGAATAAGCCAAACCTGCCTTGCAACTAAACG
ATATGTGGAAGGAACCCTGA

Downstream 100 bases:

>100_bases
CATTCACGACCTATTGGCCTGGATCTTGCTACGTGGTCTGGTTTATGCATTTTAAAGTGTTCCGAGGAGCAAACGCTAAT
GATCCGCGATCATTGGCGTT

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MNITSREWAMIEDFSRRITTEAPQSLVALAQSLSAAFQVDVTIWSRTASGEYHCVTPSAGQPEGLMMSAEQALNVEKATL
IFVYEAFYAAKFNPAHNFSPAQVMIIQALLEGWIGRLRTSYVEPHEHENLGDLHQSLLQSIIDVLPEGVVVGLAPDGQLI
LANRQAEQLWQHPLHSVPVEGYSHFGLYKPDGTRLPAGDSGIARVLRTGEPFLKHDLILRRPDGSEIPILANTSPIHDNR
GNLIGAVAVFQDITGWKLQESDRDNAIATIVHDLKNPLTTIRGSADLLLRRAKTENRSERELNRLQSIIAQSDRMRDYLS
LLVDVARINAGETLISPCLLDFGELVGQLIATINGGLANPRINVELLARPLVRVDPIWMERVIWNLLDNALKYSADDTNI
DVRLELEHDQVLLSIRDAGLGIDPQDLERIFERFTRGRHTQRVGGTGLGLYTVRAVVRAHGGSIVVESEGLGRGSCLTVS
LPVESNE

Sequences:

>Translated_487_residues
MNITSREWAMIEDFSRRITTEAPQSLVALAQSLSAAFQVDVTIWSRTASGEYHCVTPSAGQPEGLMMSAEQALNVEKATL
IFVYEAFYAAKFNPAHNFSPAQVMIIQALLEGWIGRLRTSYVEPHEHENLGDLHQSLLQSIIDVLPEGVVVGLAPDGQLI
LANRQAEQLWQHPLHSVPVEGYSHFGLYKPDGTRLPAGDSGIARVLRTGEPFLKHDLILRRPDGSEIPILANTSPIHDNR
GNLIGAVAVFQDITGWKLQESDRDNAIATIVHDLKNPLTTIRGSADLLLRRAKTENRSERELNRLQSIIAQSDRMRDYLS
LLVDVARINAGETLISPCLLDFGELVGQLIATINGGLANPRINVELLARPLVRVDPIWMERVIWNLLDNALKYSADDTNI
DVRLELEHDQVLLSIRDAGLGIDPQDLERIFERFTRGRHTQRVGGTGLGLYTVRAVVRAHGGSIVVESEGLGRGSCLTVS
LPVESNE
>Mature_487_residues
MNITSREWAMIEDFSRRITTEAPQSLVALAQSLSAAFQVDVTIWSRTASGEYHCVTPSAGQPEGLMMSAEQALNVEKATL
IFVYEAFYAAKFNPAHNFSPAQVMIIQALLEGWIGRLRTSYVEPHEHENLGDLHQSLLQSIIDVLPEGVVVGLAPDGQLI
LANRQAEQLWQHPLHSVPVEGYSHFGLYKPDGTRLPAGDSGIARVLRTGEPFLKHDLILRRPDGSEIPILANTSPIHDNR
GNLIGAVAVFQDITGWKLQESDRDNAIATIVHDLKNPLTTIRGSADLLLRRAKTENRSERELNRLQSIIAQSDRMRDYLS
LLVDVARINAGETLISPCLLDFGELVGQLIATINGGLANPRINVELLARPLVRVDPIWMERVIWNLLDNALKYSADDTNI
DVRLELEHDQVLLSIRDAGLGIDPQDLERIFERFTRGRHTQRVGGTGLGLYTVRAVVRAHGGSIVVESEGLGRGSCLTVS
LPVESNE

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=33.4782608695652, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI48994928, Length=400, Percent_Identity=25.75, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786783, Length=224, Percent_Identity=27.6785714285714, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788713, Length=231, Percent_Identity=23.3766233766234, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693157, Length=272, Percent_Identity=27.9411764705882, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=28.6363636363636, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788549, Length=352, Percent_Identity=26.1363636363636, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790346, Length=254, Percent_Identity=26.7716535433071, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=28.0193236714976, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786600, Length=244, Percent_Identity=25.4098360655738, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789149, Length=245, Percent_Identity=28.1632653061224, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787894, Length=230, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=235, Percent_Identity=27.6595744680851, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87082128, Length=236, Percent_Identity=27.9661016949153, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=109, Percent_Identity=37.6146788990826, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788279, Length=217, Percent_Identity=24.4239631336406, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53813; Mature: 53813

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITSREWAMIEDFSRRITTEAPQSLVALAQSLSAAFQVDVTIWSRTASGEYHCVTPSAG
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEEEEEECCCCCEEEECCCCC
QPEGLMMSAEQALNVEKATLIFVYEAFYAAKFNPAHNFSPAQVMIIQALLEGWIGRLRTS
CCCCEEECHHHHCCCCHHEEEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YVEPHEHENLGDLHQSLLQSIIDVLPEGVVVGLAPDGQLILANRQAEQLWQHPLHSVPVE
CCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCHHHHHHHCCHHCCCCC
GYSHFGLYKPDGTRLPAGDSGIARVLRTGEPFLKHDLILRRPDGSEIPILANTSPIHDNR
CCCCCCEECCCCCCCCCCCHHHHHHHHCCCCHHHCCEEEECCCCCCCCEEECCCCCCCCC
GNLIGAVAVFQDITGWKLQESDRDNAIATIVHDLKNPLTTIRGSADLLLRRAKTENRSER
CCEEEHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHH
ELNRLQSIIAQSDRMRDYLSLLVDVARINAGETLISPCLLDFGELVGQLIATINGGLANP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RINVELLARPLVRVDPIWMERVIWNLLDNALKYSADDTNIDVRLELEHDQVLLSIRDAGL
EEEHHHHHCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCCC
GIDPQDLERIFERFTRGRHTQRVGGTGLGLYTVRAVVRAHGGSIVVESEGLGRGSCLTVS
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEE
LPVESNE
ECCCCCC
>Mature Secondary Structure
MNITSREWAMIEDFSRRITTEAPQSLVALAQSLSAAFQVDVTIWSRTASGEYHCVTPSAG
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEEEEEECCCCCEEEECCCCC
QPEGLMMSAEQALNVEKATLIFVYEAFYAAKFNPAHNFSPAQVMIIQALLEGWIGRLRTS
CCCCEEECHHHHCCCCHHEEEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YVEPHEHENLGDLHQSLLQSIIDVLPEGVVVGLAPDGQLILANRQAEQLWQHPLHSVPVE
CCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCHHHHHHHCCHHCCCCC
GYSHFGLYKPDGTRLPAGDSGIARVLRTGEPFLKHDLILRRPDGSEIPILANTSPIHDNR
CCCCCCEECCCCCCCCCCCHHHHHHHHCCCCHHHCCEEEECCCCCCCCEEECCCCCCCCC
GNLIGAVAVFQDITGWKLQESDRDNAIATIVHDLKNPLTTIRGSADLLLRRAKTENRSER
CCEEEHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHH
ELNRLQSIIAQSDRMRDYLSLLVDVARINAGETLISPCLLDFGELVGQLIATINGGLANP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RINVELLARPLVRVDPIWMERVIWNLLDNALKYSADDTNIDVRLELEHDQVLLSIRDAGL
EEEHHHHHCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCCC
GIDPQDLERIFERFTRGRHTQRVGGTGLGLYTVRAVVRAHGGSIVVESEGLGRGSCLTVS
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEE
LPVESNE
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]