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The map label for this gene is garR [H]

Identifier: 159898431

GI number: 159898431

Start: 2301446

End: 2302351

Strand: Direct

Name: garR [H]

Synonym: Haur_1907

Alternate gene names: 159898431

Gene position: 2301446-2302351 (Clockwise)

Preceding gene: 159898430

Following gene: 159898432

Centisome position: 36.26

GC content: 53.97

Gene sequence:

>906_bases
ATGCAAAAACCACGAATTGGCCTGATTGGCTTGGGCGCGATGGGTGCTCCGATGGCGTCGAATTTGCTCCAAGCAGGCTA
TCAATTGACGGTTGGCGTGCATCAACGGCGCGAAGCTGCTGAACAGTTGGCTTTGCAAGGGGCAATCATCGCCGAAAGCT
ACCAAGCGTTGGGCGAAAACAGCGATATTGTGATTACGATGGTGCCTGATGCGCCCCAAGTTGAGGCCGCATTGCTTGGC
ACGAATGGTGCTGCATATGGCATGGCGGCGGGCAGCATCTGTATTGATATGAGCACAATTGCCCCCACCGCCAGTCGGGC
GATTGCTGCCAAACTTGCCGAACGCCAAATTGCCATGCTCGATGCGCCAGTTAGTGGTGGCCCAGCCCGTGCTAAAACTG
GCGAGTTGGCGATTATGGTGGGCGGCGAACCAAGCACATTCGAGCGCTGCCAAGCAGTTTTGGAGGTACTGGGCGGTGCG
GTCAGCTACATTGGCGCTAGTGGTTCTGGCTCAGTCGTTAAGCTTTGCAATAATCTGGCGATCAGCATTATTGCCATGGC
CAATATCGAAGCCTTAGCCTTTGGTGTTGCCAACGGGGTTGAAGCTGAAACGATTCGCAATGTGTTGTTGAATGCCACCG
CCTCAAACTATTTATTAGAGCGTTGGCTGCCTGAAACCGTGTTTAGCGGCGATTACAACAAAGGCTTTGCGGCTGAATTA
TTGGCCAAAGATTTAAACGCCGTGCTTGATACCGCCCGCGCCAGTGGTGTGCCATTGTGGGCTGGTGGCCTTGCCCAACA
AATGTGGATCGCCCAAAAAGCGCTTGACCCACGCTCGGATTACACCGCTCTAGCCCAGCGCTACGAAGCAATTATCGGAC
GCACGATCAAACCAAACTCGGAATAA

Upstream 100 bases:

>100_bases
CTTTTTTCGATGTTTAATCGCTTCAACGATGCCTTGGATATGGCGATTACTGAGCCAGGTTGGCCGGAAGCATAATTGGC
TTGGGTATTGAGGAATAATC

Downstream 100 bases:

>100_bases
GCCAAACCTGCCTTGCAACTAAACGATATGTGGAAGGAACCCTGAATGAATATAACCAGTCGCGAATGGGCTATGATTGA
AGACTTTTCGCGCCGGATCA

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MQKPRIGLIGLGAMGAPMASNLLQAGYQLTVGVHQRREAAEQLALQGAIIAESYQALGENSDIVITMVPDAPQVEAALLG
TNGAAYGMAAGSICIDMSTIAPTASRAIAAKLAERQIAMLDAPVSGGPARAKTGELAIMVGGEPSTFERCQAVLEVLGGA
VSYIGASGSGSVVKLCNNLAISIIAMANIEALAFGVANGVEAETIRNVLLNATASNYLLERWLPETVFSGDYNKGFAAEL
LAKDLNAVLDTARASGVPLWAGGLAQQMWIAQKALDPRSDYTALAQRYEAIIGRTIKPNSE

Sequences:

>Translated_301_residues
MQKPRIGLIGLGAMGAPMASNLLQAGYQLTVGVHQRREAAEQLALQGAIIAESYQALGENSDIVITMVPDAPQVEAALLG
TNGAAYGMAAGSICIDMSTIAPTASRAIAAKLAERQIAMLDAPVSGGPARAKTGELAIMVGGEPSTFERCQAVLEVLGGA
VSYIGASGSGSVVKLCNNLAISIIAMANIEALAFGVANGVEAETIRNVLLNATASNYLLERWLPETVFSGDYNKGFAAEL
LAKDLNAVLDTARASGVPLWAGGLAQQMWIAQKALDPRSDYTALAQRYEAIIGRTIKPNSE
>Mature_301_residues
MQKPRIGLIGLGAMGAPMASNLLQAGYQLTVGVHQRREAAEQLALQGAIIAESYQALGENSDIVITMVPDAPQVEAALLG
TNGAAYGMAAGSICIDMSTIAPTASRAIAAKLAERQIAMLDAPVSGGPARAKTGELAIMVGGEPSTFERCQAVLEVLGGA
VSYIGASGSGSVVKLCNNLAISIIAMANIEALAFGVANGVEAETIRNVLLNATASNYLLERWLPETVFSGDYNKGFAAEL
LAKDLNAVLDTARASGVPLWAGGLAQQMWIAQKALDPRSDYTALAQRYEAIIGRTIKPNSE

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=273, Percent_Identity=33.3333333333333, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI40556376, Length=285, Percent_Identity=24.5614035087719, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI145693186, Length=289, Percent_Identity=36.6782006920415, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=36.6782006920415, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1790315, Length=301, Percent_Identity=33.5548172757475, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1789092, Length=290, Percent_Identity=33.1034482758621, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17557316, Length=270, Percent_Identity=30.7407407407407, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24655230, Length=271, Percent_Identity=34.3173431734317, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI19922568, Length=271, Percent_Identity=34.3173431734317, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28574115, Length=259, Percent_Identity=24.7104247104247, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31230; Mature: 31230

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKPRIGLIGLGAMGAPMASNLLQAGYQLTVGVHQRREAAEQLALQGAIIAESYQALGEN
CCCCCEEEEECCCCCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SDIVITMVPDAPQVEAALLGTNGAAYGMAAGSICIDMSTIAPTASRAIAAKLAERQIAML
CCEEEEECCCCCCCEEEEEECCCCCHHHCCCCEEEEHHHCCCHHHHHHHHHHHHHHHHEE
DAPVSGGPARAKTGELAIMVGGEPSTFERCQAVLEVLGGAVSYIGASGSGSVVKLCNNLA
ECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHH
ISIIAMANIEALAFGVANGVEAETIRNVLLNATASNYLLERWLPETVFSGDYNKGFAAEL
EEEHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHH
LAKDLNAVLDTARASGVPLWAGGLAQQMWIAQKALDPRSDYTALAQRYEAIIGRTIKPNS
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
E
C
>Mature Secondary Structure
MQKPRIGLIGLGAMGAPMASNLLQAGYQLTVGVHQRREAAEQLALQGAIIAESYQALGEN
CCCCCEEEEECCCCCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SDIVITMVPDAPQVEAALLGTNGAAYGMAAGSICIDMSTIAPTASRAIAAKLAERQIAML
CCEEEEECCCCCCCEEEEEECCCCCHHHCCCCEEEEHHHCCCHHHHHHHHHHHHHHHHEE
DAPVSGGPARAKTGELAIMVGGEPSTFERCQAVLEVLGGAVSYIGASGSGSVVKLCNNLA
ECCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHH
ISIIAMANIEALAFGVANGVEAETIRNVLLNATASNYLLERWLPETVFSGDYNKGFAAEL
EEEHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHH
LAKDLNAVLDTARASGVPLWAGGLAQQMWIAQKALDPRSDYTALAQRYEAIIGRTIKPNS
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]