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The map label for this gene is lgrC [H]

Identifier: 159898402

GI number: 159898402

Start: 2237957

End: 2239396

Strand: Direct

Name: lgrC [H]

Synonym: Haur_1878

Alternate gene names: 159898402

Gene position: 2237957-2239396 (Clockwise)

Preceding gene: 159898401

Following gene: 159898403

Centisome position: 35.26

GC content: 49.1

Gene sequence:

>1440_bases
ATGAAAGTTGAGAATTTAGAAGATATCTATGGTTTGTCGCCTATGCAAAAGGGGATGCTTTTTCATACCCTGCTTGTACC
CAATTCGAGTGCCTACCAAAATCAATCAGTTTGGCAACTTGAGGGCCAGCTGAATCTGGCAGCCTTTGAATGGGCTTGGC
AACAGGTTATCCAGCGCCATTCAGTGCTGCGGACTGCCTTCTTTTGGGAAGATCTTGAGGAGCCGCTGCAAGTGGTGTTG
CGCCAAGTTACGCTACCATTGCAGATCATGGATTGGCGGGAATACTCGGCTGAGCAGCAAGCCCAACAATTGGAGCCTTG
GCTAGCGGCAGATTTAGCCCAAGGCTTTCAATTAACTGCCGCACCCTTGCTACGCTTGAGCTTGATTCAAATCGGCCCGA
CCAGCTATTGGTTTTGTTGGAGCCGCCATCATCTCTTGCTTGATGGTTGGTCGCAGGCGATTGTGCTGAAGGATTTGTTT
ACCTTCTATGAGGTCTATTGCTATGGCGAGCAAGCCAGCTTTAATCAGCAGGCAGTTTTAGGCCCACGCCGCCCGTATGG
CGAATACATTGCTTGGCTTCAACAGCAGGATCAGGCCAAGGCGGAGGCTTTTTGGCAACAACTGTTGAATAATTGGGCGG
GGCCAGCGCGACTTAGTTTTGCTCGTCAAGGTCGTTCGCAGCACAGTTATGCTACCCAGCTGCTCCAGCTGGCAAGCGAA
TTAACTAGCCAAGTTCAAATGGTGATGCAGCAGGCCGAATTAACCATCAATAGCTTAATTCAGGGTGTGTGGGTTTGTCT
CTTAGGTCAATATAGCAATCAACATGATGTACTGTTTGGGGTGACGGTTTCAGGCCGTCCGCCGAGCCTGCCAGCAATTG
AAAGCATGGTTGGTTTGTTTATCAATACGCTGCCGTTGCGAGCTCAAATTCAGCCTGAGCAGCTGTTTCTCGATTTGCTC
AAACAGGTGCAAAGCCAGCAGTTGGCCATGAGCCAATATGAGTATAGCTCGTTGGTTGATATTCAAGGCTGGGCCAAATT
GCCGCGTGAACAAGCCATGTTCGAGACAGTCGTCGTGTTTGAAAATTACCCGATGGATACGGCGGCTTTTACCCAGCACT
CAAGCCTTAAGCTCGATTTGCAGCGCACCTTTGTGCAAAATAGCATGCCATTGACCTTACGGGCAATCCCAGGCGATCAG
CTAACCCTCGATGTGCTCTACGATACTGAGCGTTTTACCGTAACCCAGATCGAACGAGTATTGCACGATTGTCAGTTGGT
GTTGCAAGCCATTGCTGCCACGCCAATGATTGCCGTTGCTGAGATTATGCACCATTTACAACAAGCTGAAGACCAATTTC
AACAATTGGAAGAGCAACGATTAAGAGATGCTAATGCTCAGAAACTCAAAACGATCAAGCGCCGTTCGGTCGTTTCATAA

Upstream 100 bases:

>100_bases
GCTGGTGGTTATACCCCTTCGGATTTTCCATCGGCCAACTTAAACCAAAAGAATTTGGATAGCTTTATCGCCAAATTACG
CAACAGCGAGAACAGCACTC

Downstream 100 bases:

>100_bases
CTGGGGTTGTACCTCGCTGTTGGTCTCTATCTCGATATCGATCACGAAAGGGCTGGATCATGCAAACAGGCTCCATTGAA
GGATTTCGCCTCTCTCCCCA

Product: condensation domain-containing protein

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent D-valine adenylase; D-ValA; D-valine activase; Valine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan adenylase; TrpA; Tryptophan activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent tryptophan/phenylalanine/tyrosine adenylase; Trp/Phe/TyrA; Tryptophan/phenylalanine/tyrosine activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing] [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MKVENLEDIYGLSPMQKGMLFHTLLVPNSSAYQNQSVWQLEGQLNLAAFEWAWQQVIQRHSVLRTAFFWEDLEEPLQVVL
RQVTLPLQIMDWREYSAEQQAQQLEPWLAADLAQGFQLTAAPLLRLSLIQIGPTSYWFCWSRHHLLLDGWSQAIVLKDLF
TFYEVYCYGEQASFNQQAVLGPRRPYGEYIAWLQQQDQAKAEAFWQQLLNNWAGPARLSFARQGRSQHSYATQLLQLASE
LTSQVQMVMQQAELTINSLIQGVWVCLLGQYSNQHDVLFGVTVSGRPPSLPAIESMVGLFINTLPLRAQIQPEQLFLDLL
KQVQSQQLAMSQYEYSSLVDIQGWAKLPREQAMFETVVVFENYPMDTAAFTQHSSLKLDLQRTFVQNSMPLTLRAIPGDQ
LTLDVLYDTERFTVTQIERVLHDCQLVLQAIAATPMIAVAEIMHHLQQAEDQFQQLEEQRLRDANAQKLKTIKRRSVVS

Sequences:

>Translated_479_residues
MKVENLEDIYGLSPMQKGMLFHTLLVPNSSAYQNQSVWQLEGQLNLAAFEWAWQQVIQRHSVLRTAFFWEDLEEPLQVVL
RQVTLPLQIMDWREYSAEQQAQQLEPWLAADLAQGFQLTAAPLLRLSLIQIGPTSYWFCWSRHHLLLDGWSQAIVLKDLF
TFYEVYCYGEQASFNQQAVLGPRRPYGEYIAWLQQQDQAKAEAFWQQLLNNWAGPARLSFARQGRSQHSYATQLLQLASE
LTSQVQMVMQQAELTINSLIQGVWVCLLGQYSNQHDVLFGVTVSGRPPSLPAIESMVGLFINTLPLRAQIQPEQLFLDLL
KQVQSQQLAMSQYEYSSLVDIQGWAKLPREQAMFETVVVFENYPMDTAAFTQHSSLKLDLQRTFVQNSMPLTLRAIPGDQ
LTLDVLYDTERFTVTQIERVLHDCQLVLQAIAATPMIAVAEIMHHLQQAEDQFQQLEEQRLRDANAQKLKTIKRRSVVS
>Mature_479_residues
MKVENLEDIYGLSPMQKGMLFHTLLVPNSSAYQNQSVWQLEGQLNLAAFEWAWQQVIQRHSVLRTAFFWEDLEEPLQVVL
RQVTLPLQIMDWREYSAEQQAQQLEPWLAADLAQGFQLTAAPLLRLSLIQIGPTSYWFCWSRHHLLLDGWSQAIVLKDLF
TFYEVYCYGEQASFNQQAVLGPRRPYGEYIAWLQQQDQAKAEAFWQQLLNNWAGPARLSFARQGRSQHSYATQLLQLASE
LTSQVQMVMQQAELTINSLIQGVWVCLLGQYSNQHDVLFGVTVSGRPPSLPAIESMVGLFINTLPLRAQIQPEQLFLDLL
KQVQSQQLAMSQYEYSSLVDIQGWAKLPREQAMFETVVVFENYPMDTAAFTQHSSLKLDLQRTFVQNSMPLTLRAIPGDQ
LTLDVLYDTERFTVTQIERVLHDCQLVLQAIAATPMIAVAEIMHHLQQAEDQFQQLEEQRLRDANAQKLKTIKRRSVVS

Specific function: Activates the 7th to 12th amino acids (Val, D-Val, Trp, D-Leu, Xaa and D-Leu) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 8th (D-Val), the 10th (D- Leu) an

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR023213
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 55091; Mature: 55091

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVENLEDIYGLSPMQKGMLFHTLLVPNSSAYQNQSVWQLEGQLNLAAFEWAWQQVIQRH
CCCCCCHHHHCCCHHHHCCEEEEEECCCCCCCCCCCEEEECCCEEHHHHHHHHHHHHHHH
SVLRTAFFWEDLEEPLQVVLRQVTLPLQIMDWREYSAEQQAQQLEPWLAADLAQGFQLTA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHCHHHHHHHHCCCCHHH
APLLRLSLIQIGPTSYWFCWSRHHLLLDGWSQAIVLKDLFTFYEVYCYGEQASFNQQAVL
HHHHHHHHHEECCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCC
GPRRPYGEYIAWLQQQDQAKAEAFWQQLLNNWAGPARLSFARQGRSQHSYATQLLQLASE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
LTSQVQMVMQQAELTINSLIQGVWVCLLGQYSNQHDVLFGVTVSGRPPSLPAIESMVGLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHH
INTLPLRAQIQPEQLFLDLLKQVQSQQLAMSQYEYSSLVDIQGWAKLPREQAMFETVVVF
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHCCHHHHHHHHHHEE
ENYPMDTAAFTQHSSLKLDLQRTFVQNSMPLTLRAIPGDQLTLDVLYDTERFTVTQIERV
ECCCCCHHHHCCCCCEEHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHH
LHDCQLVLQAIAATPMIAVAEIMHHLQQAEDQFQQLEEQRLRDANAQKLKTIKRRSVVS
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVENLEDIYGLSPMQKGMLFHTLLVPNSSAYQNQSVWQLEGQLNLAAFEWAWQQVIQRH
CCCCCCHHHHCCCHHHHCCEEEEEECCCCCCCCCCCEEEECCCEEHHHHHHHHHHHHHHH
SVLRTAFFWEDLEEPLQVVLRQVTLPLQIMDWREYSAEQQAQQLEPWLAADLAQGFQLTA
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHCHHHHHHHHCCCCHHH
APLLRLSLIQIGPTSYWFCWSRHHLLLDGWSQAIVLKDLFTFYEVYCYGEQASFNQQAVL
HHHHHHHHHEECCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHEECCCCCCCCCCCC
GPRRPYGEYIAWLQQQDQAKAEAFWQQLLNNWAGPARLSFARQGRSQHSYATQLLQLASE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
LTSQVQMVMQQAELTINSLIQGVWVCLLGQYSNQHDVLFGVTVSGRPPSLPAIESMVGLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHH
INTLPLRAQIQPEQLFLDLLKQVQSQQLAMSQYEYSSLVDIQGWAKLPREQAMFETVVVF
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHCCHHHHHHHHHHEE
ENYPMDTAAFTQHSSLKLDLQRTFVQNSMPLTLRAIPGDQLTLDVLYDTERFTVTQIERV
ECCCCCHHHHCCCCCEEHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHH
LHDCQLVLQAIAATPMIAVAEIMHHLQQAEDQFQQLEEQRLRDANAQKLKTIKRRSVVS
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA