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The map label for this gene is macA [H]

Identifier: 159898126

GI number: 159898126

Start: 1858512

End: 1860437

Strand: Direct

Name: macA [H]

Synonym: Haur_1602

Alternate gene names: 159898126

Gene position: 1858512-1860437 (Clockwise)

Preceding gene: 159898122

Following gene: 159898127

Centisome position: 29.28

GC content: 52.13

Gene sequence:

>1926_bases
ATGGCTGAAAGCTCAGCACAGCCCAAAAAACGTGGCTATAAATGGTTTGTTATTGGCGGCGCGGTCTTATTAGCGCTGGT
GTTAATGCCGTTTGTCTTTGGTGGCGATGATCCATCGACCGTCTCGGCCAGCACTACCACGACGATTCAGCGCGGTCGTT
TGGTTTCATCGGTGCTTGGCAGCGGAACGATTAACCCCAAGCAAAGCCTTGATCTTACCTTTCAAACGACTGGAATTGTC
AGCACCGTCTTGGTCAGCGAAGGCCAACAGGTGGTAGCAGGCCAGATGCTGGCTGAGCTTGATGATCGTAATTTGGCATT
AAGCGTGCTTTCCGCTGAAGCCAATTTGCAAAGTGCCCAAGCCCGTTTGCGCCAAACCCAAGAGGGCAATGCTCGCCCAG
AGGATTTGGCCGCTTCGCAAGCCAGCGTTGATAATGCGAAGGCCAATTTGCAAAAGACCGTAACTGGCAATGCTACCGCT
GCTGATATTGCCTCGGCCCAAGCCAGTGTTGCTAACGCCGAAGCCCAATTACGCAAAGCCAAAAATGGCACCGCTACGCC
AGCTGATTTGGCCAATGCCGAAGCCTCAGTCCGTTCAGCCCAAGCCAAGCTTGATGATCTGCGGGCTGGCCCCAAACCAG
AAAAGGTTTCCAGCGCCCAAGCCACGCTTGATCAGGCTAAATCAAGCTTAGAGCAAGTGAAATCTGATGCTTCGAAGGCC
AAAAATCAAGCCTCACTTGATCGTGATACCGCCGCCAATGCGGTGCGTAACGCCCAAACCAGCCTCAGCCAAGTGTATTG
GGAAACCCACGATGCTGATGGGAATTGGAAGAAAAAGCCCGATGATTTTGGCTATCAAACCGATGTGGATCGCTATAACA
ATGCCGTGCGCGATGAACAAGATGCCCAAACCAAGCTCGACGCGGCCCAATTGGCCTATGACAATGCCGTAACCCAAGAA
GGTTTGGATATTGCTAATGCTGAGGCCAAAGTGCGTGATGCTGAAGTGCAATTGCAAACTGTGCTCAAAGGTGCAACCGC
GCTCGAAATTACCCAAGCTGAGGCCGCGCTCGACCAAGCCAAAGCTAACCTCGATAAACTCAAACAAGGCGGAACCGCTG
ATGATGTCGCGGCAGCCCAAGCCAACCTCGACCAAGCTAAAGCCAATTTGCGCAAATTGACCCAAGGTGGCACGGCGGCT
GATGTTGCGGCAGCCCGAGCCAATGTTGATCAAGCCGAAGCCAACCTTGATAAATTAACAGCCCCACCAACTGATACTGA
TTTGGCGATTCAAGAAGCAGCAGTTTCACAAAGCGAGCAATCGTTAAAACAAGCGCAATTACAACGTGATAATGCGACCT
TGCGTGCTCCTTTTGCTGGCGTGATTACCTCGGTTTCGATTGTGCCTGGTGGCCCTTCGAGCGGTGCGGTGATGCATATT
CTTGATCGTAGTGGCTTGTATGTAGAGCTGAATTTGAGCGAAACTGATGTGGCATTAGTTACGCTGAATCAAAAAGTTGA
GTTAACGATTGATGCGCTCGATGCCTGGAGCGCCGAGGGTACGGTCAGTTATATCTCGCCGGTGGCCGAAGTATCGAACG
GCGTGGTGATTTATCGGGTCAAAATTAGCGTGCCTAGCAACGACCCAATGGTTAAAGTTGGCATGACCGTCAACACCAAC
ATTATTCTCAGCGAAAAAAGTGATGTATTGCTGGTGCCAAATTCAGCCTTGTTGCCCAAAGGTAGCGGACGGGTGGTGCA
AGTGCCCGATGGCGCTGGTGTACGTGAGGTCGATGTGGTGACTGGCATCAGCGATGGCTCATTTACCGAAGTGTTGAGTG
GCTTGAATGAAGGCGATACGATCATCGCCGTGCCAACTGCCGCCTCGGATAGTGGCAATGGTGGGTTATTCGGCGGAGGC
CGCTGA

Upstream 100 bases:

>100_bases
CACCAAAACGTGCGAATGAATGATCGAAATAAAGATCGATGCTGATCGCGCCGGAATTCACTACAGTATAGCTAGAAATT
GTCGCATAAGGAGATTTCCG

Downstream 100 bases:

>100_bases
TGATTAGTTTGAGCGATATTCACAAAACCTACCAAATGGGTGATGTGCTGGTGGCAGCGCTGCAAGGCGTGAGTTTCAGC
ATCGACAAGGGCGATTTTGT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MAESSAQPKKRGYKWFVIGGAVLLALVLMPFVFGGDDPSTVSASTTTTIQRGRLVSSVLGSGTINPKQSLDLTFQTTGIV
STVLVSEGQQVVAGQMLAELDDRNLALSVLSAEANLQSAQARLRQTQEGNARPEDLAASQASVDNAKANLQKTVTGNATA
ADIASAQASVANAEAQLRKAKNGTATPADLANAEASVRSAQAKLDDLRAGPKPEKVSSAQATLDQAKSSLEQVKSDASKA
KNQASLDRDTAANAVRNAQTSLSQVYWETHDADGNWKKKPDDFGYQTDVDRYNNAVRDEQDAQTKLDAAQLAYDNAVTQE
GLDIANAEAKVRDAEVQLQTVLKGATALEITQAEAALDQAKANLDKLKQGGTADDVAAAQANLDQAKANLRKLTQGGTAA
DVAAARANVDQAEANLDKLTAPPTDTDLAIQEAAVSQSEQSLKQAQLQRDNATLRAPFAGVITSVSIVPGGPSSGAVMHI
LDRSGLYVELNLSETDVALVTLNQKVELTIDALDAWSAEGTVSYISPVAEVSNGVVIYRVKISVPSNDPMVKVGMTVNTN
IILSEKSDVLLVPNSALLPKGSGRVVQVPDGAGVREVDVVTGISDGSFTEVLSGLNEGDTIIAVPTAASDSGNGGLFGGG
R

Sequences:

>Translated_641_residues
MAESSAQPKKRGYKWFVIGGAVLLALVLMPFVFGGDDPSTVSASTTTTIQRGRLVSSVLGSGTINPKQSLDLTFQTTGIV
STVLVSEGQQVVAGQMLAELDDRNLALSVLSAEANLQSAQARLRQTQEGNARPEDLAASQASVDNAKANLQKTVTGNATA
ADIASAQASVANAEAQLRKAKNGTATPADLANAEASVRSAQAKLDDLRAGPKPEKVSSAQATLDQAKSSLEQVKSDASKA
KNQASLDRDTAANAVRNAQTSLSQVYWETHDADGNWKKKPDDFGYQTDVDRYNNAVRDEQDAQTKLDAAQLAYDNAVTQE
GLDIANAEAKVRDAEVQLQTVLKGATALEITQAEAALDQAKANLDKLKQGGTADDVAAAQANLDQAKANLRKLTQGGTAA
DVAAARANVDQAEANLDKLTAPPTDTDLAIQEAAVSQSEQSLKQAQLQRDNATLRAPFAGVITSVSIVPGGPSSGAVMHI
LDRSGLYVELNLSETDVALVTLNQKVELTIDALDAWSAEGTVSYISPVAEVSNGVVIYRVKISVPSNDPMVKVGMTVNTN
IILSEKSDVLLVPNSALLPKGSGRVVQVPDGAGVREVDVVTGISDGSFTEVLSGLNEGDTIIAVPTAASDSGNGGLFGGG
R
>Mature_640_residues
AESSAQPKKRGYKWFVIGGAVLLALVLMPFVFGGDDPSTVSASTTTTIQRGRLVSSVLGSGTINPKQSLDLTFQTTGIVS
TVLVSEGQQVVAGQMLAELDDRNLALSVLSAEANLQSAQARLRQTQEGNARPEDLAASQASVDNAKANLQKTVTGNATAA
DIASAQASVANAEAQLRKAKNGTATPADLANAEASVRSAQAKLDDLRAGPKPEKVSSAQATLDQAKSSLEQVKSDASKAK
NQASLDRDTAANAVRNAQTSLSQVYWETHDADGNWKKKPDDFGYQTDVDRYNNAVRDEQDAQTKLDAAQLAYDNAVTQEG
LDIANAEAKVRDAEVQLQTVLKGATALEITQAEAALDQAKANLDKLKQGGTADDVAAAQANLDQAKANLRKLTQGGTAAD
VAAARANVDQAEANLDKLTAPPTDTDLAIQEAAVSQSEQSLKQAQLQRDNATLRAPFAGVITSVSIVPGGPSSGAVMHIL
DRSGLYVELNLSETDVALVTLNQKVELTIDALDAWSAEGTVSYISPVAEVSNGVVIYRVKISVPSNDPMVKVGMTVNTNI
ILSEKSDVLLVPNSALLPKGSGRVVQVPDGAGVREVDVVTGISDGSFTEVLSGLNEGDTIIAVPTAASDSGNGGLFGGGR

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=219, Percent_Identity=28.310502283105, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 66710; Mature: 66578

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESSAQPKKRGYKWFVIGGAVLLALVLMPFVFGGDDPSTVSASTTTTIQRGRLVSSVLG
CCCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHC
SGTINPKQSLDLTFQTTGIVSTVLVSEGQQVVAGQMLAELDDRNLALSVLSAEANLQSAQ
CCCCCCCCCEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECHHHHHHHH
ARLRQTQEGNARPEDLAASQASVDNAKANLQKTVTGNATAADIASAQASVANAEAQLRKA
HHHHHHHCCCCCCHHHHHHHHHCCHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
KNGTATPADLANAEASVRSAQAKLDDLRAGPKPEKVSSAQATLDQAKSSLEQVKSDASKA
CCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KNQASLDRDTAANAVRNAQTSLSQVYWETHDADGNWKKKPDDFGYQTDVDRYNNAVRDEQ
HHHHHCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCH
DAQTKLDAAQLAYDNAVTQEGLDIANAEAKVRDAEVQLQTVLKGATALEITQAEAALDQA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHH
KANLDKLKQGGTADDVAAAQANLDQAKANLRKLTQGGTAADVAAARANVDQAEANLDKLT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHCCHHHCC
APPTDTDLAIQEAAVSQSEQSLKQAQLQRDNATLRAPFAGVITSVSIVPGGPSSGAVMHI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHEEEEEECCCCCCCCEEEE
LDRSGLYVELNLSETDVALVTLNQKVELTIDALDAWSAEGTVSYISPVAEVSNGVVIYRV
ECCCCEEEEEECCCCCEEEEEECCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEE
KISVPSNDPMVKVGMTVNTNIILSEKSDVLLVPNSALLPKGSGRVVQVPDGAGVREVDVV
EEECCCCCCEEEEEEEEECEEEEECCCCEEEECCCCCCCCCCCCEEECCCCCCCEEEEEE
TGISDGSFTEVLSGLNEGDTIIAVPTAASDSGNGGLFGGGR
ECCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AESSAQPKKRGYKWFVIGGAVLLALVLMPFVFGGDDPSTVSASTTTTIQRGRLVSSVLG
CCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHC
SGTINPKQSLDLTFQTTGIVSTVLVSEGQQVVAGQMLAELDDRNLALSVLSAEANLQSAQ
CCCCCCCCCEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECHHHHHHHH
ARLRQTQEGNARPEDLAASQASVDNAKANLQKTVTGNATAADIASAQASVANAEAQLRKA
HHHHHHHCCCCCCHHHHHHHHHCCHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
KNGTATPADLANAEASVRSAQAKLDDLRAGPKPEKVSSAQATLDQAKSSLEQVKSDASKA
CCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KNQASLDRDTAANAVRNAQTSLSQVYWETHDADGNWKKKPDDFGYQTDVDRYNNAVRDEQ
HHHHHCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCH
DAQTKLDAAQLAYDNAVTQEGLDIANAEAKVRDAEVQLQTVLKGATALEITQAEAALDQA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHH
KANLDKLKQGGTADDVAAAQANLDQAKANLRKLTQGGTAADVAAARANVDQAEANLDKLT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHCCHHHCC
APPTDTDLAIQEAAVSQSEQSLKQAQLQRDNATLRAPFAGVITSVSIVPGGPSSGAVMHI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHEEEEEECCCCCCCCEEEE
LDRSGLYVELNLSETDVALVTLNQKVELTIDALDAWSAEGTVSYISPVAEVSNGVVIYRV
ECCCCEEEEEECCCCCEEEEEECCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEE
KISVPSNDPMVKVGMTVNTNIILSEKSDVLLVPNSALLPKGSGRVVQVPDGAGVREVDVV
EEECCCCCCEEEEEEEEECEEEEECCCCEEEECCCCCCCCCCCCEEECCCCCCCEEEEEE
TGISDGSFTEVLSGLNEGDTIIAVPTAASDSGNGGLFGGGR
ECCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]