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The map label for this gene is ribH

Identifier: 159898110

GI number: 159898110

Start: 1840900

End: 1841361

Strand: Direct

Name: ribH

Synonym: Haur_1586

Alternate gene names: 159898110

Gene position: 1840900-1841361 (Clockwise)

Preceding gene: 159898109

Following gene: 159898111

Centisome position: 29.01

GC content: 49.13

Gene sequence:

>462_bases
ATGAATGTGATTGAAGGAAATTTGATCGGCACAGGCCTACGAGTGGCAATTGTGATTGCCCGCTGGAATGATTTTATCGG
CGGAAATTTGCTCGAAGGCGCGGTCAATACACTCAAACGCCATGGGGTTAACGACGATGATATTAGCGTGGCATGGTGTC
CTGGCTCGTATGAGATTCCGCTGGTGGTCAAGAAAATTGCTGAACGTGGCCAACACGATGCAATTATCACGCTTGGCGCA
GTTATTCGTGGCGCAACCTCGCATTATGAAGTTGTGGTCAATGCCGTTTCCAGTGGCGTGACCAAAGTTATGCACGATAC
CGGAATTCCAGTATTGTTGGGCGTGCTGACCACTGATACGATTGAACAAGCGATTGAGCGAGCTGGCACGAAAGCTGGTA
ACAAAGGCTCAGAGTGTGCAGTTGCGGCGATTGAAATGGCCAATTTGCTCAAACAACTCTAG

Upstream 100 bases:

>100_bases
ATGGCGCTCGCAAATCGGCTAAATCGCGACCAAACGTCGAGGTGCTCGATGGCGAAACCCTGCTGGAGATCAACGGCTAA
TTTGGTTTTGAGGAATGGGC

Downstream 100 bases:

>100_bases
TTTGAACATGGGGTTTTGAAACTGACGCGAGAGGTCAACCAAATTTGCTGGTTGGCCTCTCGGTATGTTTAGGTAGTTGC
TGCTATAATGGTGCGGCACT

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MNVIEGNLIGTGLRVAIVIARWNDFIGGNLLEGAVNTLKRHGVNDDDISVAWCPGSYEIPLVVKKIAERGQHDAIITLGA
VIRGATSHYEVVVNAVSSGVTKVMHDTGIPVLLGVLTTDTIEQAIERAGTKAGNKGSECAVAAIEMANLLKQL

Sequences:

>Translated_153_residues
MNVIEGNLIGTGLRVAIVIARWNDFIGGNLLEGAVNTLKRHGVNDDDISVAWCPGSYEIPLVVKKIAERGQHDAIITLGA
VIRGATSHYEVVVNAVSSGVTKVMHDTGIPVLLGVLTTDTIEQAIERAGTKAGNKGSECAVAAIEMANLLKQL
>Mature_153_residues
MNVIEGNLIGTGLRVAIVIARWNDFIGGNLLEGAVNTLKRHGVNDDDISVAWCPGSYEIPLVVKKIAERGQHDAIITLGA
VIRGATSHYEVVVNAVSSGVTKVMHDTGIPVLLGVLTTDTIEQAIERAGTKAGNKGSECAVAAIEMANLLKQL

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=154, Percent_Identity=55.8441558441558, Blast_Score=177, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324429, Length=147, Percent_Identity=34.0136054421769, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_HERA2 (A9B4R4)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001544357.1
- ProteinModelPortal:   A9B4R4
- SMR:   A9B4R4
- GeneID:   5733473
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_1586
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- BioCyc:   HAUR316274:HAUR_1586-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16111; Mature: 16111

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVIEGNLIGTGLRVAIVIARWNDFIGGNLLEGAVNTLKRHGVNDDDISVAWCPGSYEIP
CCCCCCCEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHH
LVVKKIAERGQHDAIITLGAVIRGATSHYEVVVNAVSSGVTKVMHDTGIPVLLGVLTTDT
HHHHHHHHCCCCCCEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IEQAIERAGTKAGNKGSECAVAAIEMANLLKQL
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNVIEGNLIGTGLRVAIVIARWNDFIGGNLLEGAVNTLKRHGVNDDDISVAWCPGSYEIP
CCCCCCCEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHH
LVVKKIAERGQHDAIITLGAVIRGATSHYEVVVNAVSSGVTKVMHDTGIPVLLGVLTTDT
HHHHHHHHCCCCCCEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IEQAIERAGTKAGNKGSECAVAAIEMANLLKQL
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA