Click here to switch to the map view.

The map label for this gene is melR [H]

Identifier: 159897403

GI number: 159897403

Start: 995166

End: 996056

Strand: Direct

Name: melR [H]

Synonym: Haur_0874

Alternate gene names: 159897403

Gene position: 995166-996056 (Clockwise)

Preceding gene: 159897402

Following gene: 159897404

Centisome position: 15.68

GC content: 47.92

Gene sequence:

>891_bases
ATGACGTATGGCCCACCAGCGCACACAAGTTTTGATCATTCAAGCATTACGCATCAACAACAGGCCGTTCGGCAGGTCGT
TGAAACGATGCGGCAGAATTTCTGGAATCCTATGTCGCTGAATGATATGGCTGAAATGGCTAACTTCAGTCCATGTTATT
TCAACCAAGTATTTCGTTCGATTGTGGGAATTCCGCCCAGCCGCTATTTGACGGCACTCCGGATAGATGCCGCCAAACGT
CTTTTGATCGATACGACCCTGCGGGTGATCGATATTTGCTACGAGGTTGGCTATAACAGCCTCGGAACCTTTAGTTCACG
TTTTACCGAGTTGGTAGGTATTTCACCGCAAGGGTTTCGCGAGTTAGCCGATCAAGACAATTGGCGCTTGTTTCAGGCGT
TTCTCCAAGCCCAAAAACGAGCATTACCAAGCGTATTTCATTCACACAAACAAATCGCTATGGGTTCGGTTTATGCCCCT
CAAGCAACCCAAACACCCGTTGCGATTAAAACCAAGCGGCCAGCAACACCCACCCTAATTGGCTTGTATCCCTTACCAAT
GCCTCAAGGCAAGCCGATTGCCTATACGATTGCGCCTGCATCCCGCTTATATATGCTTCCACCCGTTGCCGATGGCCGTT
ATTACGTTTTTGCAACAGCATTCGAGTGGTCGCAAGACCCTCGATCGTTTTTATTACTCGATTGGCAACGAGAAGATCTT
TTGGTTGGCATGGGTGATCGGCCCTTATGGGTTCGTAATGGTCGCTATCAAAACCATATTGATCTCAATCTGCGCCCAAT
GCAGCCAACTGATCCGCCCCTTCTTAGCGCATTGTTTTATTTTATGGTACTTGCTCAGCAACAGCTTGAGCTTTTTGTCC
AAAGGAGTTAG

Upstream 100 bases:

>100_bases
GCAAACTCTGGTTCGATGGTGATAATGCTTGGCAAACTTGGCAGACTCCACTTCAGCAAGAAGTCTTGGGATCAGGCTCC
TAGCGAAGGAACTATAGCGT

Downstream 100 bases:

>100_bases
TCCATGACCTCAAGTGCAACTGAAAAAGCCTTGTTAGAACCAGCCGACGATGTTCCAGTGATCCGAGGATTGCCGAATAT
CCAAACAAACCAGTACACAA

Product: AraC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MTYGPPAHTSFDHSSITHQQQAVRQVVETMRQNFWNPMSLNDMAEMANFSPCYFNQVFRSIVGIPPSRYLTALRIDAAKR
LLIDTTLRVIDICYEVGYNSLGTFSSRFTELVGISPQGFRELADQDNWRLFQAFLQAQKRALPSVFHSHKQIAMGSVYAP
QATQTPVAIKTKRPATPTLIGLYPLPMPQGKPIAYTIAPASRLYMLPPVADGRYYVFATAFEWSQDPRSFLLLDWQREDL
LVGMGDRPLWVRNGRYQNHIDLNLRPMQPTDPPLLSALFYFMVLAQQQLELFVQRS

Sequences:

>Translated_296_residues
MTYGPPAHTSFDHSSITHQQQAVRQVVETMRQNFWNPMSLNDMAEMANFSPCYFNQVFRSIVGIPPSRYLTALRIDAAKR
LLIDTTLRVIDICYEVGYNSLGTFSSRFTELVGISPQGFRELADQDNWRLFQAFLQAQKRALPSVFHSHKQIAMGSVYAP
QATQTPVAIKTKRPATPTLIGLYPLPMPQGKPIAYTIAPASRLYMLPPVADGRYYVFATAFEWSQDPRSFLLLDWQREDL
LVGMGDRPLWVRNGRYQNHIDLNLRPMQPTDPPLLSALFYFMVLAQQQLELFVQRS
>Mature_295_residues
TYGPPAHTSFDHSSITHQQQAVRQVVETMRQNFWNPMSLNDMAEMANFSPCYFNQVFRSIVGIPPSRYLTALRIDAAKRL
LIDTTLRVIDICYEVGYNSLGTFSSRFTELVGISPQGFRELADQDNWRLFQAFLQAQKRALPSVFHSHKQIAMGSVYAPQ
ATQTPVAIKTKRPATPTLIGLYPLPMPQGKPIAYTIAPASRLYMLPPVADGRYYVFATAFEWSQDPRSFLLLDWQREDLL
VGMGDRPLWVRNGRYQNHIDLNLRPMQPTDPPLLSALFYFMVLAQQQLELFVQRS

Specific function: Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site [H]

COG id: COG2207

COG function: function code K; AraC-type DNA-binding domain-containing proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790559, Length=108, Percent_Identity=32.4074074074074, Blast_Score=71, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008917
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR020449
- InterPro:   IPR018060
- InterPro:   IPR014710 [H]

Pfam domain/function: PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 33852; Mature: 33721

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYGPPAHTSFDHSSITHQQQAVRQVVETMRQNFWNPMSLNDMAEMANFSPCYFNQVFRS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHH
IVGIPPSRYLTALRIDAAKRLLIDTTLRVIDICYEVGYNSLGTFSSRFTELVGISPQGFR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHH
ELADQDNWRLFQAFLQAQKRALPSVFHSHKQIAMGSVYAPQATQTPVAIKTKRPATPTLI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCCEEE
GLYPLPMPQGKPIAYTIAPASRLYMLPPVADGRYYVFATAFEWSQDPRSFLLLDWQREDL
EEECCCCCCCCCEEEEECCCCEEEECCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCE
LVGMGDRPLWVRNGRYQNHIDLNLRPMQPTDPPLLSALFYFMVLAQQQLELFVQRS
EEECCCCCEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TYGPPAHTSFDHSSITHQQQAVRQVVETMRQNFWNPMSLNDMAEMANFSPCYFNQVFRS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHH
IVGIPPSRYLTALRIDAAKRLLIDTTLRVIDICYEVGYNSLGTFSSRFTELVGISPQGFR
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHH
ELADQDNWRLFQAFLQAQKRALPSVFHSHKQIAMGSVYAPQATQTPVAIKTKRPATPTLI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCCCCEEE
GLYPLPMPQGKPIAYTIAPASRLYMLPPVADGRYYVFATAFEWSQDPRSFLLLDWQREDL
EEECCCCCCCCCEEEEECCCCEEEECCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCE
LVGMGDRPLWVRNGRYQNHIDLNLRPMQPTDPPLLSALFYFMVLAQQQLELFVQRS
EEECCCCCEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]