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The map label for this gene is atoC [H]

Identifier: 159897367

GI number: 159897367

Start: 948636

End: 950009

Strand: Direct

Name: atoC [H]

Synonym: Haur_0838

Alternate gene names: 159897367

Gene position: 948636-950009 (Clockwise)

Preceding gene: 159897366

Following gene: 159897370

Centisome position: 14.95

GC content: 49.71

Gene sequence:

>1374_bases
GTGACCAAAGCTACCGAACAACGACATATTTTAATTGCTGATGACGATCCAGGGATTCGTGGTCTGTTATGCGAGGTCTT
TGATGAAGAGGGCTATCTGACCGAACCTGCCGAGCATGGCGGCGAAGTTTTAGCCAAAATGACCAAGAAACATCCCTATG
ATCTGTTGATTATGGATGTGCGCATGCCTGGCCAAGATGGTTTAACCATTCTTGAGCAATTGCGCAAAAATGGCATCACC
ACCCCAGTGATTATGATGACGGCCCATGGTACTTCATCAACCGCGATTCGGGCGATTCAAATTGGTGCCTACGATTACGT
CATCAAGCCGTTTGATGTTGAAGAAGTAACTTTGGTCGTCAAACGCTTGTTTGATCATCAGCAATTGGCCTCAAAAGTGC
GCGAACTCGAAGCCAAAAGTTTTGATCCTCGTGACAAAATGATTGGCAATAGCCCAGCCATGCAGGAGATTTATAAGCAA
ATTGGGCGAGTTGCTCACACCGACGCGACCGTTTTGATTACGGGCGAAACTGGCACAGGTAAGGAAGTTTTGGCCAACCT
GATTCACGTGAATTCAGCACGGCGTAACGGGCCAATGGTTAAAGTCAATTGTGCCGCCTTGCCAGAATCGTTGCTCGAAA
GTGAATTGTTTGGCCATGAAAAAGGCGCGTTTACTGGGGCGGTCGCTCAGCGCAAGGGTCGCTTTGAATTAGCCCATAAA
GGCTCGATCTTCCTTGATGAAATTGGCGAAATGACCCTCGCTACCCAGAAAAAGTTGCTGCGCATTCTGCAAGAACGCGA
ATTTGAGCGGGTTGGTGGCACAACCACCGTGCGAGTTGATGTGCGAGTGATTGCGGCGACTAACCGTGATCTTGAAGCTG
ACGTGCGAGCTGGCACCTTTCGCGAAGATTTGTACTATCGTTTGAATGTGATCACGTTGCATTTACCAGCCCTGCGCCAA
CGAATTGGCGATATTCCCTTATTGGCTGAATTTTTCTTGGATAAATATCGTTACGCGCCCTCATCACCACCAGCTCGCAT
CTCTGAAGAGGCCATGGAGCGCCTGAATAACTACGATTGGCCAGGCAATGTGCGCCAACTTGAGCATGAGATCGAGCGAG
CGGTGATTTTGTCTCGCGGCAATGTGATTACCAGTGAGCATATGTCGTTGGTTCCATCATCGCGCTCGGCCTTGCAAGTT
GATATTGCTGCCCGTTTGCGCGAAAAATCGACGCTCGAGGAACTGCTGGCCGATGTTGAACGCTTGGCGTTGCAAGAAGC
GCTGGTTCAGCACGACGATGATCTCAAGGTGGCTGCTCGTAGCCTTGGCCTGAGCGAAGCTGAGTTCCAAAAGCGCCAAA
AGAAGTATAGTTAG

Upstream 100 bases:

>100_bases
AATTGATCGGGGCTACCAACGGATTGAACAGCGGCTGGCTGCGCTTGGAGCGCGGATCGAACGCCGTCCTGCTGAATAAT
GGCCTGTAAGGAGGGTCGGT

Downstream 100 bases:

>100_bases
TTGTGGGGCTATAGGCTATTTGTAATGGTTCATGCCCTCACCCCCAGTCCCTCTCCCACGGCGACGGGCGAAGGGGATCA
CTCCTAGAGCAATTCCCCCT

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTKATEQRHILIADDDPGIRGLLCEVFDEEGYLTEPAEHGGEVLAKMTKKHPYDLLIMDVRMPGQDGLTILEQLRKNGIT
TPVIMMTAHGTSSTAIRAIQIGAYDYVIKPFDVEEVTLVVKRLFDHQQLASKVRELEAKSFDPRDKMIGNSPAMQEIYKQ
IGRVAHTDATVLITGETGTGKEVLANLIHVNSARRNGPMVKVNCAALPESLLESELFGHEKGAFTGAVAQRKGRFELAHK
GSIFLDEIGEMTLATQKKLLRILQEREFERVGGTTTVRVDVRVIAATNRDLEADVRAGTFREDLYYRLNVITLHLPALRQ
RIGDIPLLAEFFLDKYRYAPSSPPARISEEAMERLNNYDWPGNVRQLEHEIERAVILSRGNVITSEHMSLVPSSRSALQV
DIAARLREKSTLEELLADVERLALQEALVQHDDDLKVAARSLGLSEAEFQKRQKKYS

Sequences:

>Translated_457_residues
MTKATEQRHILIADDDPGIRGLLCEVFDEEGYLTEPAEHGGEVLAKMTKKHPYDLLIMDVRMPGQDGLTILEQLRKNGIT
TPVIMMTAHGTSSTAIRAIQIGAYDYVIKPFDVEEVTLVVKRLFDHQQLASKVRELEAKSFDPRDKMIGNSPAMQEIYKQ
IGRVAHTDATVLITGETGTGKEVLANLIHVNSARRNGPMVKVNCAALPESLLESELFGHEKGAFTGAVAQRKGRFELAHK
GSIFLDEIGEMTLATQKKLLRILQEREFERVGGTTTVRVDVRVIAATNRDLEADVRAGTFREDLYYRLNVITLHLPALRQ
RIGDIPLLAEFFLDKYRYAPSSPPARISEEAMERLNNYDWPGNVRQLEHEIERAVILSRGNVITSEHMSLVPSSRSALQV
DIAARLREKSTLEELLADVERLALQEALVQHDDDLKVAARSLGLSEAEFQKRQKKYS
>Mature_456_residues
TKATEQRHILIADDDPGIRGLLCEVFDEEGYLTEPAEHGGEVLAKMTKKHPYDLLIMDVRMPGQDGLTILEQLRKNGITT
PVIMMTAHGTSSTAIRAIQIGAYDYVIKPFDVEEVTLVVKRLFDHQQLASKVRELEAKSFDPRDKMIGNSPAMQEIYKQI
GRVAHTDATVLITGETGTGKEVLANLIHVNSARRNGPMVKVNCAALPESLLESELFGHEKGAFTGAVAQRKGRFELAHKG
SIFLDEIGEMTLATQKKLLRILQEREFERVGGTTTVRVDVRVIAATNRDLEADVRAGTFREDLYYRLNVITLHLPALRQR
IGDIPLLAEFFLDKYRYAPSSPPARISEEAMERLNNYDWPGNVRQLEHEIERAVILSRGNVITSEHMSLVPSSRSALQVD
IAARLREKSTLEELLADVERLALQEALVQHDDDLKVAARSLGLSEAEFQKRQKKYS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=453, Percent_Identity=47.9028697571744, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1790299, Length=463, Percent_Identity=40.8207343412527, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1790437, Length=386, Percent_Identity=45.0777202072539, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI1788905, Length=378, Percent_Identity=43.1216931216931, Blast_Score=294, Evalue=9e-81,
Organism=Escherichia coli, GI1789087, Length=238, Percent_Identity=58.8235294117647, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI87082117, Length=238, Percent_Identity=57.9831932773109, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI87082152, Length=424, Percent_Identity=38.9150943396226, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1786524, Length=322, Percent_Identity=43.4782608695652, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1789233, Length=327, Percent_Identity=40.3669724770642, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI87081872, Length=323, Percent_Identity=40.8668730650155, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1787583, Length=329, Percent_Identity=37.9939209726444, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1789828, Length=283, Percent_Identity=36.7491166077738, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI87081858, Length=218, Percent_Identity=33.4862385321101, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789809, Length=122, Percent_Identity=31.9672131147541, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786599, Length=151, Percent_Identity=29.1390728476821, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788394, Length=131, Percent_Identity=30.5343511450382, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790863, Length=138, Percent_Identity=28.9855072463768, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787487, Length=162, Percent_Identity=29.6296296296296, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788713, Length=163, Percent_Identity=28.8343558282209, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082012, Length=125, Percent_Identity=32.8, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787229, Length=124, Percent_Identity=30.6451612903226, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1787375, Length=134, Percent_Identity=29.1044776119403, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790860, Length=115, Percent_Identity=33.9130434782609, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788191, Length=126, Percent_Identity=31.7460317460317, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790552, Length=115, Percent_Identity=31.304347826087, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI145693157, Length=113, Percent_Identity=33.6283185840708, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI1786784, Length=117, Percent_Identity=32.4786324786325, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51243; Mature: 51112

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKATEQRHILIADDDPGIRGLLCEVFDEEGYLTEPAEHGGEVLAKMTKKHPYDLLIMDV
CCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEE
RMPGQDGLTILEQLRKNGITTPVIMMTAHGTSSTAIRAIQIGAYDYVIKPFDVEEVTLVV
ECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECCEEEEECCCCHHHHHHHH
KRLFDHQQLASKVRELEAKSFDPRDKMIGNSPAMQEIYKQIGRVAHTDATVLITGETGTG
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
KEVLANLIHVNSARRNGPMVKVNCAALPESLLESELFGHEKGAFTGAVAQRKGRFELAHK
HHHHHHHHHHCCCCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEC
GSIFLDEIGEMTLATQKKLLRILQEREFERVGGTTTVRVDVRVIAATNRDLEADVRAGTF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCCH
REDLYYRLNVITLHLPALRQRIGDIPLLAEFFLDKYRYAPSSPPARISEEAMERLNNYDW
HHHHHEEEEEEEEECHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
PGNVRQLEHEIERAVILSRGNVITSEHMSLVPSSRSALQVDIAARLREKSTLEELLADVE
CCHHHHHHHHHHHHHHHCCCCEEECHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RLALQEALVQHDDDLKVAARSLGLSEAEFQKRQKKYS
HHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TKATEQRHILIADDDPGIRGLLCEVFDEEGYLTEPAEHGGEVLAKMTKKHPYDLLIMDV
CCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEE
RMPGQDGLTILEQLRKNGITTPVIMMTAHGTSSTAIRAIQIGAYDYVIKPFDVEEVTLVV
ECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEECCEEEEECCCCHHHHHHHH
KRLFDHQQLASKVRELEAKSFDPRDKMIGNSPAMQEIYKQIGRVAHTDATVLITGETGTG
HHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
KEVLANLIHVNSARRNGPMVKVNCAALPESLLESELFGHEKGAFTGAVAQRKGRFELAHK
HHHHHHHHHHCCCCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEC
GSIFLDEIGEMTLATQKKLLRILQEREFERVGGTTTVRVDVRVIAATNRDLEADVRAGTF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCCCCCCCCH
REDLYYRLNVITLHLPALRQRIGDIPLLAEFFLDKYRYAPSSPPARISEEAMERLNNYDW
HHHHHEEEEEEEEECHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
PGNVRQLEHEIERAVILSRGNVITSEHMSLVPSSRSALQVDIAARLREKSTLEELLADVE
CCHHHHHHHHHHHHHHHCCCCEEECHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
RLALQEALVQHDDDLKVAARSLGLSEAEFQKRQKKYS
HHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]