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The map label for this gene is yngG [H]

Identifier: 159897291

GI number: 159897291

Start: 865391

End: 866374

Strand: Reverse

Name: yngG [H]

Synonym: Haur_0762

Alternate gene names: 159897291

Gene position: 866374-865391 (Counterclockwise)

Preceding gene: 159897292

Following gene: 159897290

Centisome position: 13.65

GC content: 53.76

Gene sequence:

>984_bases
ATGATTCCCTTAACTAACCTGCCCAGCACTGTCAGCATCCGCGAAGTTGGCCCCCGCGATGGCTTGCAAAATGAGGATCG
TATCCTCACCACCGAGCAAAAAATCCTGTTAATCAATGCCCTCAATAATTCCGGCTTGCGCCAAATTGAAGTTGGTTCGT
TTGTCAACCCGCGCTATGTGCCACAAATGGCCGATACCGCCGAGGTATTCGCGCGAATTGAGCGCCGCCCCGATGTGATT
TATAGCGCGATTGCGCCCAATTTACGTGGGGCACAACGGGCGATCGAGGCCCGCGCCGATTCGGTGCAGGTCTTTTTGAG
CGCTTCCGAGAGCCATAATCAAAGCAATGTGCGCATGAGCATCAACGAATCGCTGGCTGCTGCCGCCGATATTGCCTTAG
CGCTCAAAGAAGCTTCGATTGAATTTGAGGCGGTACTTTCGGTGGTGTTTGGCTGTCCCTTTGAAAACGATGTACCGATC
GAGCGGGTTGTAACCATGACTGAACGGCTCTTGGCCCTCGGAGCCAGCCAAATTACGCTTGGTGATACCACGGGCATGGC
GCATCCTCGCTTGGTACAAGCGGTGGTGCGAGCATTGCGTGAGCGCTTTCCCCAAGCACCCTTACGTTTGCACCCGCATA
GCGCTCGTGGCGCAGGTTTGGCCAATGTTTTGGCGGCCCTCGAAGTTGGGATTGATCGAATCGATGCGAGCATCGGCGGG
ATCGGCGGTTGTCCTTTTGCGCCAGGTGCACCAGGCAATATTTGCACCGAAGACACCGTACATATGCTCCACGAAATGGG
CATCAATACTGGCCTCGATATTCCAAAATTGGTTTCATGTGCCAAATTGATTGAAAGCTTGCTAGGCCATGAAGTGCCTG
GTCAAGTGATCAAAGGCGGCATTTGTGGCCATATTCCAGGTGGCACGATGCGCCCATGGAACGAAACCGAAATCCTTGGT
CAGCAAGCTAGCCGCACAGTTTAA

Upstream 100 bases:

>100_bases
AATTGTTATTTATCCAAAACGCTAATCAATGGCGATTAGCGCTCGTGTTCAGCGGGTGTTGTACTCCAACGCCCGCTAGC
ACATAGCCAAGGAGTCGATG

Downstream 100 bases:

>100_bases
GCAAACACAACCCATCCAGTCAGCACCTTGATTGGATGGGTTTTAAATTCCCCGGTCTACAAGCGATATCAACAAGCCTA
ACCCACAGGCTAGCACAAAG

Product: pyruvate carboxyltransferase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MIPLTNLPSTVSIREVGPRDGLQNEDRILTTEQKILLINALNNSGLRQIEVGSFVNPRYVPQMADTAEVFARIERRPDVI
YSAIAPNLRGAQRAIEARADSVQVFLSASESHNQSNVRMSINESLAAAADIALALKEASIEFEAVLSVVFGCPFENDVPI
ERVVTMTERLLALGASQITLGDTTGMAHPRLVQAVVRALRERFPQAPLRLHPHSARGAGLANVLAALEVGIDRIDASIGG
IGGCPFAPGAPGNICTEDTVHMLHEMGINTGLDIPKLVSCAKLIESLLGHEVPGQVIKGGICGHIPGGTMRPWNETEILG
QQASRTV

Sequences:

>Translated_327_residues
MIPLTNLPSTVSIREVGPRDGLQNEDRILTTEQKILLINALNNSGLRQIEVGSFVNPRYVPQMADTAEVFARIERRPDVI
YSAIAPNLRGAQRAIEARADSVQVFLSASESHNQSNVRMSINESLAAAADIALALKEASIEFEAVLSVVFGCPFENDVPI
ERVVTMTERLLALGASQITLGDTTGMAHPRLVQAVVRALRERFPQAPLRLHPHSARGAGLANVLAALEVGIDRIDASIGG
IGGCPFAPGAPGNICTEDTVHMLHEMGINTGLDIPKLVSCAKLIESLLGHEVPGQVIKGGICGHIPGGTMRPWNETEILG
QQASRTV
>Mature_327_residues
MIPLTNLPSTVSIREVGPRDGLQNEDRILTTEQKILLINALNNSGLRQIEVGSFVNPRYVPQMADTAEVFARIERRPDVI
YSAIAPNLRGAQRAIEARADSVQVFLSASESHNQSNVRMSINESLAAAADIALALKEASIEFEAVLSVVFGCPFENDVPI
ERVVTMTERLLALGASQITLGDTTGMAHPRLVQAVVRALRERFPQAPLRLHPHSARGAGLANVLAALEVGIDRIDASIGG
IGGCPFAPGAPGNICTEDTVHMLHEMGINTGLDIPKLVSCAKLIESLLGHEVPGQVIKGGICGHIPGGTMRPWNETEILG
QQASRTV

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI109150427, Length=281, Percent_Identity=40.5693950177936, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI109150422, Length=281, Percent_Identity=40.5693950177936, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI62198232, Length=293, Percent_Identity=39.9317406143345, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI260654708, Length=131, Percent_Identity=38.1679389312977, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1786261, Length=334, Percent_Identity=21.5568862275449, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17510563, Length=285, Percent_Identity=35.7894736842105, Blast_Score=194, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6320071, Length=224, Percent_Identity=25.8928571428571, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320019, Length=224, Percent_Identity=25.8928571428571, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24582381, Length=293, Percent_Identity=38.9078498293515, Blast_Score=223, Evalue=1e-58,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 34973; Mature: 34973

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPLTNLPSTVSIREVGPRDGLQNEDRILTTEQKILLINALNNSGLRQIEVGSFVNPRYV
CCCCCCCCCCEEEEECCCCCCCCCCCCEEECCCEEEEEEECCCCCCCEEECCCCCCCCCC
PQMADTAEVFARIERRPDVIYSAIAPNLRGAQRAIEARADSVQVFLSASESHNQSNVRMS
CCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEE
INESLAAAADIALALKEASIEFEAVLSVVFGCPFENDVPIERVVTMTERLLALGASQITL
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
GDTTGMAHPRLVQAVVRALRERFPQAPLRLHPHSARGAGLANVLAALEVGIDRIDASIGG
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
IGGCPFAPGAPGNICTEDTVHMLHEMGINTGLDIPKLVSCAKLIESLLGHEVPGQVIKGG
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCC
ICGHIPGGTMRPWNETEILGQQASRTV
CCCCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MIPLTNLPSTVSIREVGPRDGLQNEDRILTTEQKILLINALNNSGLRQIEVGSFVNPRYV
CCCCCCCCCCEEEEECCCCCCCCCCCCEEECCCEEEEEEECCCCCCCEEECCCCCCCCCC
PQMADTAEVFARIERRPDVIYSAIAPNLRGAQRAIEARADSVQVFLSASESHNQSNVRMS
CCHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEE
INESLAAAADIALALKEASIEFEAVLSVVFGCPFENDVPIERVVTMTERLLALGASQITL
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
GDTTGMAHPRLVQAVVRALRERFPQAPLRLHPHSARGAGLANVLAALEVGIDRIDASIGG
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
IGGCPFAPGAPGNICTEDTVHMLHEMGINTGLDIPKLVSCAKLIESLLGHEVPGQVIKGG
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCC
ICGHIPGGTMRPWNETEILGQQASRTV
CCCCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]