Click here to switch to the map view.

The map label for this gene is qor [C]

Identifier: 159897243

GI number: 159897243

Start: 820209

End: 821213

Strand: Reverse

Name: qor [C]

Synonym: Haur_0714

Alternate gene names: 159897243

Gene position: 821213-820209 (Counterclockwise)

Preceding gene: 159897244

Following gene: 159897241

Centisome position: 12.94

GC content: 50.05

Gene sequence:

>1005_bases
ATGATGAAAGCCTTCTTCATCGAGCGCTATGGAAACAAGGATCGTGTGCGGGCTGGCGATCTGCCAATTCCAGAACTGCG
GGATACTGATTTATTGATTCAGATCCACGCCGCTGGCGTTAACCCGTTGGATAACAAAATCAGGGATGGCGAGTTCAAAG
CTATCTTGCCATATCGCTTCCCACTTATTTTGGGCAATGATGTCGCTGGGGTTGTGGTTAAGGTCGGAGCAAAGGTACAG
CGATTCAAGCTAGGCGATGAGGTCTATGCTCGGCCAGCTGCCGACCGCATTGGAACCTTTGCCGAATTCATTGCAATCAA
CGAAGCTGATGTCGCGATCAAGCCCAAAAAACTGAGCATGGCCGAAGCAGCTTCCTTCCCGTTGGTTGGCCTAACCGCTT
GGCAAGCCTTGATTGAGCAAGCACAGCTCAAAAAAGGCCAAAAAATCTTCATCCAGGCCGGTTCTGGCGGAGTTGGGACA
ATTGCAATTCAGCTGGCCAAACATGTGGGAGCGATTGTCGCAACAACCACGAGCAAGGCAAATTTCGATTTTGTGAAGCG
CCTTGGGGCCGATATTGTGATTGATTACAAGACCGAGGATTTCGAAACAATCCTGAAGGACTATGATGTAGTCTTGAATA
GTCAAGAGGGAGCGATCGTCGAAAAATCGCTTCGCGTGTTAAAGCCTGGCGGAACGCTAATCTCGATTTCAGGGCCGCCT
GATCCCACGTTTGCGCAAGAAATTGGCGCGAAGTGGCCTATTCGCATGCTTTTGCGCTTTTTGAGCTATCGCATTCGCAA
AAAAGCTAAACAACGGCAAGTACGCTATTCATTTCTGTTTATGCGGGCGCACAGCGAGCAGCTAAGCGAACTTAGTTCGT
TGATCGACGCTGGAATTATCCACCCCGTTGTGGATCGGAGCTTTGCCTTTGAAGCAACCAAAGAGGCCTTGGACTACGTT
GAAACAGGCCGCGTAAAAGGCAAGGTCGTCATCACGATGCGCTAG

Upstream 100 bases:

>100_bases
AAGACCGCTGCCTAGGCTCGTGAACTGCGAACGGCAGCACGCTGATAGGAAACGAAATTCCCATCAGCAGCACCAAATAC
AACAATAGGAGCAACACATT

Downstream 100 bases:

>100_bases
CCGCGCTTTGTTTAGTAGATGGGCACATTTTTCTGTTAAATGATGTCCATCTATGGATGTTGATTAAGCGTCATTCCTAG
CGCCTTCGCTGCCAGCTGAT

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MMKAFFIERYGNKDRVRAGDLPIPELRDTDLLIQIHAAGVNPLDNKIRDGEFKAILPYRFPLILGNDVAGVVVKVGAKVQ
RFKLGDEVYARPAADRIGTFAEFIAINEADVAIKPKKLSMAEAASFPLVGLTAWQALIEQAQLKKGQKIFIQAGSGGVGT
IAIQLAKHVGAIVATTTSKANFDFVKRLGADIVIDYKTEDFETILKDYDVVLNSQEGAIVEKSLRVLKPGGTLISISGPP
DPTFAQEIGAKWPIRMLLRFLSYRIRKKAKQRQVRYSFLFMRAHSEQLSELSSLIDAGIIHPVVDRSFAFEATKEALDYV
ETGRVKGKVVITMR

Sequences:

>Translated_334_residues
MMKAFFIERYGNKDRVRAGDLPIPELRDTDLLIQIHAAGVNPLDNKIRDGEFKAILPYRFPLILGNDVAGVVVKVGAKVQ
RFKLGDEVYARPAADRIGTFAEFIAINEADVAIKPKKLSMAEAASFPLVGLTAWQALIEQAQLKKGQKIFIQAGSGGVGT
IAIQLAKHVGAIVATTTSKANFDFVKRLGADIVIDYKTEDFETILKDYDVVLNSQEGAIVEKSLRVLKPGGTLISISGPP
DPTFAQEIGAKWPIRMLLRFLSYRIRKKAKQRQVRYSFLFMRAHSEQLSELSSLIDAGIIHPVVDRSFAFEATKEALDYV
ETGRVKGKVVITMR
>Mature_334_residues
MMKAFFIERYGNKDRVRAGDLPIPELRDTDLLIQIHAAGVNPLDNKIRDGEFKAILPYRFPLILGNDVAGVVVKVGAKVQ
RFKLGDEVYARPAADRIGTFAEFIAINEADVAIKPKKLSMAEAASFPLVGLTAWQALIEQAQLKKGQKIFIQAGSGGVGT
IAIQLAKHVGAIVATTTSKANFDFVKRLGADIVIDYKTEDFETILKDYDVVLNSQEGAIVEKSLRVLKPGGTLISISGPP
DPTFAQEIGAKWPIRMLLRFLSYRIRKKAKQRQVRYSFLFMRAHSEQLSELSSLIDAGIIHPVVDRSFAFEATKEALDYV
ETGRVKGKVVITMR

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=358, Percent_Identity=33.2402234636872, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI194239674, Length=348, Percent_Identity=26.7241379310345, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI13236495, Length=348, Percent_Identity=26.7241379310345, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI22538446, Length=345, Percent_Identity=27.2463768115942, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI22538444, Length=345, Percent_Identity=27.2463768115942, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI194239676, Length=205, Percent_Identity=31.7073170731707, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI28557745, Length=334, Percent_Identity=29.6407185628743, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI24308257, Length=344, Percent_Identity=26.7441860465116, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI18379349, Length=317, Percent_Identity=25.2365930599369, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI67078404, Length=249, Percent_Identity=26.9076305220884, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI90669511, Length=184, Percent_Identity=30.4347826086957, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI67078406, Length=213, Percent_Identity=28.6384976525822, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790485, Length=305, Percent_Identity=28.5245901639344, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71987554, Length=367, Percent_Identity=29.4277929155313, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17507255, Length=208, Percent_Identity=35.5769230769231, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71988145, Length=219, Percent_Identity=27.8538812785388, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=273, Percent_Identity=26.3736263736264, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17536829, Length=270, Percent_Identity=28.1481481481481, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323729, Length=272, Percent_Identity=26.1029411764706, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=263, Percent_Identity=27.3764258555133, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=277, Percent_Identity=25.2707581227437, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319520, Length=244, Percent_Identity=31.1475409836066, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=272, Percent_Identity=25, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323801, Length=346, Percent_Identity=24.5664739884393, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324195, Length=242, Percent_Identity=32.6446280991736, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24581341, Length=365, Percent_Identity=27.6712328767123, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24581339, Length=367, Percent_Identity=28.0653950953678, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI221330659, Length=238, Percent_Identity=28.9915966386555, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19920632, Length=238, Percent_Identity=28.9915966386555, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550423, Length=226, Percent_Identity=28.7610619469027, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36932; Mature: 36932

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKAFFIERYGNKDRVRAGDLPIPELRDTDLLIQIHAAGVNPLDNKIRDGEFKAILPYRF
CCCEEEEHHCCCCCCEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEECCEEC
PLILGNDVAGVVVKVGAKVQRFKLGDEVYARPAADRIGTFAEFIAINEADVAIKPKKLSM
EEEECCCHHHHHEECCCCEEEEECCCHHHCCCCHHHHHHHHHHHEECCCCEEECCCHHCH
AEAASFPLVGLTAWQALIEQAQLKKGQKIFIQAGSGGVGTIAIQLAKHVGAIVATTTSKA
HHHCCCCEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCEEEEECCCCC
NFDFVKRLGADIVIDYKTEDFETILKDYDVVLNSQEGAIVEKSLRVLKPGGTLISISGPP
CHHHHHHCCCCEEEEECCCHHHHHHHHHHHEEECCCCCHHHHHHHEECCCCCEEEECCCC
DPTFAQEIGAKWPIRMLLRFLSYRIRKKAKQRQVRYSFLFMRAHSEQLSELSSLIDAGII
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHCCH
HPVVDRSFAFEATKEALDYVETGRVKGKVVITMR
HHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEC
>Mature Secondary Structure
MMKAFFIERYGNKDRVRAGDLPIPELRDTDLLIQIHAAGVNPLDNKIRDGEFKAILPYRF
CCCEEEEHHCCCCCCEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEECCEEC
PLILGNDVAGVVVKVGAKVQRFKLGDEVYARPAADRIGTFAEFIAINEADVAIKPKKLSM
EEEECCCHHHHHEECCCCEEEEECCCHHHCCCCHHHHHHHHHHHEECCCCEEECCCHHCH
AEAASFPLVGLTAWQALIEQAQLKKGQKIFIQAGSGGVGTIAIQLAKHVGAIVATTTSKA
HHHCCCCEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCEEEEECCCCC
NFDFVKRLGADIVIDYKTEDFETILKDYDVVLNSQEGAIVEKSLRVLKPGGTLISISGPP
CHHHHHHCCCCEEEEECCCHHHHHHHHHHHEEECCCCCHHHHHHHEECCCCCEEEECCCC
DPTFAQEIGAKWPIRMLLRFLSYRIRKKAKQRQVRYSFLFMRAHSEQLSELSSLIDAGII
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHCCH
HPVVDRSFAFEATKEALDYVETGRVKGKVVITMR
HHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA