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The map label for this gene is lon [H]

Identifier: 159897212

GI number: 159897212

Start: 784033

End: 786465

Strand: Reverse

Name: lon [H]

Synonym: Haur_0683

Alternate gene names: 159897212

Gene position: 786465-784033 (Counterclockwise)

Preceding gene: 159897213

Following gene: 159897208

Centisome position: 12.39

GC content: 50.72

Gene sequence:

>2433_bases
ATGACCCGAGAAAAAGACCGCCCTCGTACAGGTACCGAGCGCACTTTACCGTTGGTGGTATTGGGCGAAATTGTGATCAT
GCCGCACATGACTGTGCCGCTCCAGGTTGGGCAGGGCAAGTCTTATCGGGCCATGGAACAAGCCATGGAAGACGATCAAC
ATGTTTTGTTGATCTTTGTTTCTGAGGCTGAAATTGAAGCTTATAAGGGCCACGAACCCCAACAACTACCCAAAGTTGGC
GTGGTCGCACGCTTGGAAGATTTCTCCCAATTGCCCGATGGCACGGTAAAAATTGTGCTCGAAGGGATTACCCGCGCTGA
GATTGTTGATTGTGTTCAGAGCGATCCCTTCTATCGGGTAGCTTGCCGCTACTTGCCCGATCAGGAACCCAAAGGCATCG
AAGTCGATGCATTGATGGATACGGTCAAACAACAAATTACTGAATTTGTCGATTATTTAGGCGAAATTCCTCAAGAAGCA
GTTGCCTTTGTGCACCGAATCACGACACCTGGCCATTTGGCCGATTTGGTGACTTATGGCCCAGCCTTCTCATTCCAAGA
TCGCTTGGAATTGTTGAATGAAATGGAGCCATTGGCTCGTTTGAATCGGGTGCAAGTGATTTTGGCCCGTCAATTAGAGC
TGTTGCGGCTCCGCGCCAAAATTCAATCCGACACCAAAGAAGTGCTCGATCAAGGCCAAAAAGAGTATTTCTTACGCGAA
CAAATGCGGGTGATTCGCCGTGAACTAGGCGAAGATGACGATGGCGATGATCCAATTGATGAATTGCGCCGCAAAGTCAA
CGAACTCAACGCGCCGCAATATGTCAAAGATCAAGCCTTGCACGAAATTAAGCGCCTCGCTCAACAAGGCATGAATTCGC
CCGAAGCTGGCGTGATTCGTACCTACCTTGATTGGATTATCGCTTTGCCGTGGAATGCCGATCAAGTCGCCGCGATTTCG
CTGGTGCAATCGCGCCAAGTGCTTGATGAAGATCATTATGGCTTGGAAAAAGTCAAAGAGCGAATTTTGGAATATCTGGC
GGTGCGCAAGCTCGCTGGTAGCAAAATGCGTTCGCCAATTTTGTGCTTCGTCGGCCCGCCAGGCGTGGGTAAAACCAGCC
TTGGTCGCTCGATTGCTCGGGCCTTGGATCGTCCATTCGTGCGCCAGTCGCTGGGTGGGGTACACGACGAGGCCGAAATT
CGCGGTCACCGCCGAACTTACATCGGAGCCATGCCAGGCCGGATTATTCAAGGCATGAAAACCGCCAAATCGCGTCAAGC
AGTCTTTATGCTTGATGAAATCGATAAAATTGGCAATGATTTCCGTGGTGACCCAACTTCGGCATTGCTAGAAGTGCTTG
ATCCTGAGCAAAACAACACGTTCTCAGATCACTATTTGGAAATTCCATTTGATTTGAGCCAAGTGGTGTTTGTGGCAACC
GCTAACCAACTTGAGCCAATTCCAGCGCCGCTGCGCGACCGGATGGAAATTATCGAGATTGGCGGCTATACCGAGGACGA
AAAACTAGCGATTGCTCAAGGCTTCTTGCTGCCCAAGCAACGCGAGTTCCATGGACTCGAAAGCAGCCAGTTGGAATTAA
CCGATGCTGCGATCTTGAAGTTGATTCGCGAATATACCCGCGAAGCTGGTGTGCGTAACCTTGAGCGCGAAGTTGCGGCC
TTGTGTCGCAAAATTGCCCGTAAGGTAGCTGAATCGCAGGATGAAGAAGCACCACAAGAAGGCAAGAAGCGCCGTAAGAA
GGCCAAAAAAGCCGAGCCAACCAAGTTCTTGATTGACGCTGCTGATGTGCCAATCTACCTTGGACCTGAACATTTCAGCT
TTGGAATGGCCGAAGTTTCCGATCAAATTGGGGTCGCGACTGGAGTTGCTTGGACACCAACGGGCGGCGATATTCTTTCC
TTCGAAGTTTTGCCATTGACTGGCAAAGGCGAATTGCGCCTCACTGGTCAATTGGGCGATGTGATGAAGGAATCGGCCCA
AGCAGCCATGTCGTATGTGCGATATCGCGCCAAAGAGTTGGGCATCGAGCCAAATTACTTCGACGAGCATTCGATCCATA
TTCACGTGCCCGAGGGTGCAGTGCCCAAAGATGGCCCATCGGCTGGGATTACATTGACGATTGCGTTGATCTCCGCGATG
ACTGGCCGAGCGGTGCGCCGCGATGTGGCAATGACAGGCGAAGTCACCTTGCGCGGGCGGGTCTTGCCGATTGGTGGCTT
GAAAGAAAAAACATTGGCCGCTCATCGTGCAGGCATCAAAACTTTTATCTTACCCAAGGAAAACGCCAAAGATATTGTTG
ATCTGCCTGAAAAAGTGCGCCAAGATCTGCAATTGATTCCGGTCGAAACCATGGATGAAGTGCTGACAATTGCATTGATG
CCATTTATTCGCCAAGACGTGATCGCCAGCTAA

Upstream 100 bases:

>100_bases
GCCGTTAAGATAAGTTAGCGTATACTATAAAGACGTATTATGATGCTTTTAACCCACTCTGTGTGGCCATTCTGCCACAA
CGAAATGAGGGATTTTTGAT

Downstream 100 bases:

>100_bases
ATTAAGCTGATCACAATCAAAAACGCCCCTTGCCTAGATATTTTAGGTGAGGGGCGTTTTTTAAGGCGGAAGTCAAAAAT
CAAAAGGCAAAAGAAAGCAT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 810; Mature: 809

Protein sequence:

>810_residues
MTREKDRPRTGTERTLPLVVLGEIVIMPHMTVPLQVGQGKSYRAMEQAMEDDQHVLLIFVSEAEIEAYKGHEPQQLPKVG
VVARLEDFSQLPDGTVKIVLEGITRAEIVDCVQSDPFYRVACRYLPDQEPKGIEVDALMDTVKQQITEFVDYLGEIPQEA
VAFVHRITTPGHLADLVTYGPAFSFQDRLELLNEMEPLARLNRVQVILARQLELLRLRAKIQSDTKEVLDQGQKEYFLRE
QMRVIRRELGEDDDGDDPIDELRRKVNELNAPQYVKDQALHEIKRLAQQGMNSPEAGVIRTYLDWIIALPWNADQVAAIS
LVQSRQVLDEDHYGLEKVKERILEYLAVRKLAGSKMRSPILCFVGPPGVGKTSLGRSIARALDRPFVRQSLGGVHDEAEI
RGHRRTYIGAMPGRIIQGMKTAKSRQAVFMLDEIDKIGNDFRGDPTSALLEVLDPEQNNTFSDHYLEIPFDLSQVVFVAT
ANQLEPIPAPLRDRMEIIEIGGYTEDEKLAIAQGFLLPKQREFHGLESSQLELTDAAILKLIREYTREAGVRNLEREVAA
LCRKIARKVAESQDEEAPQEGKKRRKKAKKAEPTKFLIDAADVPIYLGPEHFSFGMAEVSDQIGVATGVAWTPTGGDILS
FEVLPLTGKGELRLTGQLGDVMKESAQAAMSYVRYRAKELGIEPNYFDEHSIHIHVPEGAVPKDGPSAGITLTIALISAM
TGRAVRRDVAMTGEVTLRGRVLPIGGLKEKTLAAHRAGIKTFILPKENAKDIVDLPEKVRQDLQLIPVETMDEVLTIALM
PFIRQDVIAS

Sequences:

>Translated_810_residues
MTREKDRPRTGTERTLPLVVLGEIVIMPHMTVPLQVGQGKSYRAMEQAMEDDQHVLLIFVSEAEIEAYKGHEPQQLPKVG
VVARLEDFSQLPDGTVKIVLEGITRAEIVDCVQSDPFYRVACRYLPDQEPKGIEVDALMDTVKQQITEFVDYLGEIPQEA
VAFVHRITTPGHLADLVTYGPAFSFQDRLELLNEMEPLARLNRVQVILARQLELLRLRAKIQSDTKEVLDQGQKEYFLRE
QMRVIRRELGEDDDGDDPIDELRRKVNELNAPQYVKDQALHEIKRLAQQGMNSPEAGVIRTYLDWIIALPWNADQVAAIS
LVQSRQVLDEDHYGLEKVKERILEYLAVRKLAGSKMRSPILCFVGPPGVGKTSLGRSIARALDRPFVRQSLGGVHDEAEI
RGHRRTYIGAMPGRIIQGMKTAKSRQAVFMLDEIDKIGNDFRGDPTSALLEVLDPEQNNTFSDHYLEIPFDLSQVVFVAT
ANQLEPIPAPLRDRMEIIEIGGYTEDEKLAIAQGFLLPKQREFHGLESSQLELTDAAILKLIREYTREAGVRNLEREVAA
LCRKIARKVAESQDEEAPQEGKKRRKKAKKAEPTKFLIDAADVPIYLGPEHFSFGMAEVSDQIGVATGVAWTPTGGDILS
FEVLPLTGKGELRLTGQLGDVMKESAQAAMSYVRYRAKELGIEPNYFDEHSIHIHVPEGAVPKDGPSAGITLTIALISAM
TGRAVRRDVAMTGEVTLRGRVLPIGGLKEKTLAAHRAGIKTFILPKENAKDIVDLPEKVRQDLQLIPVETMDEVLTIALM
PFIRQDVIAS
>Mature_809_residues
TREKDRPRTGTERTLPLVVLGEIVIMPHMTVPLQVGQGKSYRAMEQAMEDDQHVLLIFVSEAEIEAYKGHEPQQLPKVGV
VARLEDFSQLPDGTVKIVLEGITRAEIVDCVQSDPFYRVACRYLPDQEPKGIEVDALMDTVKQQITEFVDYLGEIPQEAV
AFVHRITTPGHLADLVTYGPAFSFQDRLELLNEMEPLARLNRVQVILARQLELLRLRAKIQSDTKEVLDQGQKEYFLREQ
MRVIRRELGEDDDGDDPIDELRRKVNELNAPQYVKDQALHEIKRLAQQGMNSPEAGVIRTYLDWIIALPWNADQVAAISL
VQSRQVLDEDHYGLEKVKERILEYLAVRKLAGSKMRSPILCFVGPPGVGKTSLGRSIARALDRPFVRQSLGGVHDEAEIR
GHRRTYIGAMPGRIIQGMKTAKSRQAVFMLDEIDKIGNDFRGDPTSALLEVLDPEQNNTFSDHYLEIPFDLSQVVFVATA
NQLEPIPAPLRDRMEIIEIGGYTEDEKLAIAQGFLLPKQREFHGLESSQLELTDAAILKLIREYTREAGVRNLEREVAAL
CRKIARKVAESQDEEAPQEGKKRRKKAKKAEPTKFLIDAADVPIYLGPEHFSFGMAEVSDQIGVATGVAWTPTGGDILSF
EVLPLTGKGELRLTGQLGDVMKESAQAAMSYVRYRAKELGIEPNYFDEHSIHIHVPEGAVPKDGPSAGITLTIALISAMT
GRAVRRDVAMTGEVTLRGRVLPIGGLKEKTLAAHRAGIKTFILPKENAKDIVDLPEKVRQDLQLIPVETMDEVLTIALMP
FIRQDVIAS

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=835, Percent_Identity=39.7604790419162, Blast_Score=555, Evalue=1e-158,
Organism=Homo sapiens, GI21396489, Length=646, Percent_Identity=42.4148606811146, Blast_Score=518, Evalue=1e-147,
Organism=Escherichia coli, GI1786643, Length=786, Percent_Identity=46.6921119592875, Blast_Score=707, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=699, Percent_Identity=40.2002861230329, Blast_Score=488, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17556486, Length=547, Percent_Identity=40.5850091407678, Blast_Score=439, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319449, Length=708, Percent_Identity=40.6779661016949, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24666867, Length=650, Percent_Identity=43.3846153846154, Blast_Score=522, Evalue=1e-148,
Organism=Drosophila melanogaster, GI221513036, Length=650, Percent_Identity=43.3846153846154, Blast_Score=521, Evalue=1e-148,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 90614; Mature: 90482

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTREKDRPRTGTERTLPLVVLGEIVIMPHMTVPLQVGQGKSYRAMEQAMEDDQHVLLIFV
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEE
SEAEIEAYKGHEPQQLPKVGVVARLEDFSQLPDGTVKIVLEGITRAEIVDCVQSDPFYRV
ECCHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCCCEEHHHHHCHHHHHHHHHCCCCHHHH
ACRYLPDQEPKGIEVDALMDTVKQQITEFVDYLGEIPQEAVAFVHRITTPGHLADLVTYG
HHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHCC
PAFSFQDRLELLNEMEPLARLNRVQVILARQLELLRLRAKIQSDTKEVLDQGQKEYFLRE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QMRVIRRELGEDDDGDDPIDELRRKVNELNAPQYVKDQALHEIKRLAQQGMNSPEAGVIR
HHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
TYLDWIIALPWNADQVAAISLVQSRQVLDEDHYGLEKVKERILEYLAVRKLAGSKMRSPI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCE
LCFVGPPGVGKTSLGRSIARALDRPFVRQSLGGVHDEAEIRGHRRTYIGAMPGRIIQGMK
EEEECCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHH
TAKSRQAVFMLDEIDKIGNDFRGDPTSALLEVLDPEQNNTFSDHYLEIPFDLSQVVFVAT
HHCCCCCEEHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHEEE
ANQLEPIPAPLRDRMEIIEIGGYTEDEKLAIAQGFLLPKQREFHGLESSQLELTDAAILK
CCCCCCCCCCHHHCHHEEEECCCCCCCHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHH
LIREYTREAGVRNLEREVAALCRKIARKVAESQDEEAPQEGKKRRKKAKKAEPTKFLIDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEC
ADVPIYLGPEHFSFGMAEVSDQIGVATGVAWTPTGGDILSFEVLPLTGKGELRLTGQLGD
CCCCEEECCCHHHCCHHHHHHHHHHHCCCEECCCCCCEEEEEEEEECCCCCEEEECHHHH
VMKESAQAAMSYVRYRAKELGIEPNYFDEHSIHIHVPEGAVPKDGPSAGITLTIALISAM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHH
TGRAVRRDVAMTGEVTLRGRVLPIGGLKEKTLAAHRAGIKTFILPKENAKDIVDLPEKVR
HHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCHHHCCHHHHH
QDLQLIPVETMDEVLTIALMPFIRQDVIAS
CCCEECCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TREKDRPRTGTERTLPLVVLGEIVIMPHMTVPLQVGQGKSYRAMEQAMEDDQHVLLIFV
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEE
SEAEIEAYKGHEPQQLPKVGVVARLEDFSQLPDGTVKIVLEGITRAEIVDCVQSDPFYRV
ECCHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCCCEEHHHHHCHHHHHHHHHCCCCHHHH
ACRYLPDQEPKGIEVDALMDTVKQQITEFVDYLGEIPQEAVAFVHRITTPGHLADLVTYG
HHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHCC
PAFSFQDRLELLNEMEPLARLNRVQVILARQLELLRLRAKIQSDTKEVLDQGQKEYFLRE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QMRVIRRELGEDDDGDDPIDELRRKVNELNAPQYVKDQALHEIKRLAQQGMNSPEAGVIR
HHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHH
TYLDWIIALPWNADQVAAISLVQSRQVLDEDHYGLEKVKERILEYLAVRKLAGSKMRSPI
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCE
LCFVGPPGVGKTSLGRSIARALDRPFVRQSLGGVHDEAEIRGHRRTYIGAMPGRIIQGMK
EEEECCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHH
TAKSRQAVFMLDEIDKIGNDFRGDPTSALLEVLDPEQNNTFSDHYLEIPFDLSQVVFVAT
HHCCCCCEEHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHEEE
ANQLEPIPAPLRDRMEIIEIGGYTEDEKLAIAQGFLLPKQREFHGLESSQLELTDAAILK
CCCCCCCCCCHHHCHHEEEECCCCCCCHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHH
LIREYTREAGVRNLEREVAALCRKIARKVAESQDEEAPQEGKKRRKKAKKAEPTKFLIDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEC
ADVPIYLGPEHFSFGMAEVSDQIGVATGVAWTPTGGDILSFEVLPLTGKGELRLTGQLGD
CCCCEEECCCHHHCCHHHHHHHHHHHCCCEECCCCCCEEEEEEEEECCCCCEEEECHHHH
VMKESAQAAMSYVRYRAKELGIEPNYFDEHSIHIHVPEGAVPKDGPSAGITLTIALISAM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHH
TGRAVRRDVAMTGEVTLRGRVLPIGGLKEKTLAAHRAGIKTFILPKENAKDIVDLPEKVR
HHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCHHHCCHHHHH
QDLQLIPVETMDEVLTIALMPFIRQDVIAS
CCCEECCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA