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The map label for this gene is upp [H]

Identifier: 159896909

GI number: 159896909

Start: 450474

End: 451094

Strand: Reverse

Name: upp [H]

Synonym: Haur_0377

Alternate gene names: 159896909

Gene position: 451094-450474 (Counterclockwise)

Preceding gene: 159896914

Following gene: 159896908

Centisome position: 7.11

GC content: 51.05

Gene sequence:

>621_bases
ATGGGCTTGCATGTATCGTCACATCCATTGGTATTACATAAATTGGCTTTACTACGCCGGGTAGAAAGCGAACCAAAGAA
ATTTCGCGAATTGGTGCGGGAAATTTCGCAATTTTTGGTCTATGAAGCAACGGCAGATATGCCACTCGCGCCCTATACAA
TTCAAACACCGCTCTCAACCATGCAAGGTCATGCCATCGGTGCTCGCATCGGCTTGATTCCGATTTTACGCGCTGGCTTG
GGCATGGTCGAGCCAGTTATCGACCTTTTGCCAACCGCCCATGTATGGCATTTGGGTCTCTATCGCGACCACAACACGCT
TGAGCCAGTCACCTATTACAACAAATTGCCAGCTCAGCCAGATATTGATGTCTGTTTGATTCTCGACCCCATGTTGGCAA
CTGGCGGCTCGGCTGTTGCTGCGGTCGATATTTTGAAGGCTTGGGGCGCAGCTAAAATTAAATTCTTGGGGTTAATCGCC
GCACCTGAAGGGGTAGAACGCTTGCAAACTGCTCACCCCGACGTGGAGATTCATTTGGCGGCGCTTGACGAGCGATTGAA
CGAGCAAGGCTATATCGTGCCAGGCTTGGGCGATGCTGGCGACCGCCAATTTGGAACGTAG

Upstream 100 bases:

>100_bases
AGGTGCAATGTGACGGGTTGATTTAACCACGCCTAAGAGGGGTTTGTCAAGATGGGATACAATAACCACGATCTGCTGTT
TTTTAGTATGAGGTTGTGTT

Downstream 100 bases:

>100_bases
GCTAGAATGCAAATCTTAGTCACAGGCGCTACTGGTTTTTTGGGTGCGCACACCGCGTTGGCTCTGCAAAAAGCTGGGCA
TACGGTGCTGGGTTTGGGCC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MGLHVSSHPLVLHKLALLRRVESEPKKFRELVREISQFLVYEATADMPLAPYTIQTPLSTMQGHAIGARIGLIPILRAGL
GMVEPVIDLLPTAHVWHLGLYRDHNTLEPVTYYNKLPAQPDIDVCLILDPMLATGGSAVAAVDILKAWGAAKIKFLGLIA
APEGVERLQTAHPDVEIHLAALDERLNEQGYIVPGLGDAGDRQFGT

Sequences:

>Translated_206_residues
MGLHVSSHPLVLHKLALLRRVESEPKKFRELVREISQFLVYEATADMPLAPYTIQTPLSTMQGHAIGARIGLIPILRAGL
GMVEPVIDLLPTAHVWHLGLYRDHNTLEPVTYYNKLPAQPDIDVCLILDPMLATGGSAVAAVDILKAWGAAKIKFLGLIA
APEGVERLQTAHPDVEIHLAALDERLNEQGYIVPGLGDAGDRQFGT
>Mature_205_residues
GLHVSSHPLVLHKLALLRRVESEPKKFRELVREISQFLVYEATADMPLAPYTIQTPLSTMQGHAIGARIGLIPILRAGLG
MVEPVIDLLPTAHVWHLGLYRDHNTLEPVTYYNKLPAQPDIDVCLILDPMLATGGSAVAAVDILKAWGAAKIKFLGLIAA
PEGVERLQTAHPDVEIHLAALDERLNEQGYIVPGLGDAGDRQFGT

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=208, Percent_Identity=29.3269230769231, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI57863312, Length=208, Percent_Identity=29.3269230769231, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI87082118, Length=201, Percent_Identity=50.7462686567164, Blast_Score=207, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17539894, Length=173, Percent_Identity=26.0115606936416, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17539892, Length=173, Percent_Identity=26.0115606936416, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321920, Length=173, Percent_Identity=36.4161849710983, Blast_Score=111, Evalue=9e-26,
Organism=Drosophila melanogaster, GI28573516, Length=201, Percent_Identity=29.3532338308458, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28573514, Length=201, Percent_Identity=29.3532338308458, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28573512, Length=201, Percent_Identity=29.3532338308458, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45550449, Length=201, Percent_Identity=29.3532338308458, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22455; Mature: 22324

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLHVSSHPLVLHKLALLRRVESEPKKFRELVREISQFLVYEATADMPLAPYTIQTPLST
CCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHH
MQGHAIGARIGLIPILRAGLGMVEPVIDLLPTAHVWHLGLYRDHNTLEPVTYYNKLPAQP
HCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHEEEEECCCCCCCCHHHHHCCCCCC
DIDVCLILDPMLATGGSAVAAVDILKAWGAAKIKFLGLIAAPEGVERLQTAHPDVEIHLA
CCCEEEEECHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHCCCCEEEEHH
ALDERLNEQGYIVPGLGDAGDRQFGT
HHHHHHCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure 
GLHVSSHPLVLHKLALLRRVESEPKKFRELVREISQFLVYEATADMPLAPYTIQTPLST
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHH
MQGHAIGARIGLIPILRAGLGMVEPVIDLLPTAHVWHLGLYRDHNTLEPVTYYNKLPAQP
HCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHEEEEECCCCCCCCHHHHHCCCCCC
DIDVCLILDPMLATGGSAVAAVDILKAWGAAKIKFLGLIAAPEGVERLQTAHPDVEIHLA
CCCEEEEECHHHHCCCCHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHCCCCEEEEHH
ALDERLNEQGYIVPGLGDAGDRQFGT
HHHHHHCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA