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The map label for this gene is htrA [H]

Identifier: 159896879

GI number: 159896879

Start: 418341

End: 419447

Strand: Direct

Name: htrA [H]

Synonym: Haur_0347

Alternate gene names: 159896879

Gene position: 418341-419447 (Clockwise)

Preceding gene: 159896878

Following gene: 159896880

Centisome position: 6.59

GC content: 50.5

Gene sequence:

>1107_bases
ATGAGTAATCCCAAACGTACCGTCGGCATCGGCGGATTGATTATTGCCGCCCTCGCACTTTCAGGGGTTGGTGGTGGTTT
AGTCGGTGGTGTCGCAGGCTATCGCTTAGCCCAAGTTGATCAAACGGCAACGGCAGTGGCGGTCACGCCAACCAGCGCCA
CCCAACAAACGACCGATAATCTGACTGCGCAACCAGTTGTTGCCAGCACGAATGATGCAGTTGTCCAAACCGTTGCCAAG
GCCTCACCAGCAGTCGTAAAAATTATTAGTACGGTGGTTGGCGGTCAGGCCAGCGGTTCAGGCGCAATTATCAATGAAGA
TGGCTATATCATCACCAATAATCATGTGGTCGAAGGTCAAAGTCGCTTGCAAGTAATTTATTCTGATGGAACCAGCCACA
ATGCCGAGTTGATCGGCACTGATGCTTTTTCGGATATCGCCGTGATTCGGGTGCTCGATGCCGTGCCAGCCACAATTTCC
TTAGGCGATTCGGATAGTTTGCAGCCTGGCGAAACGGTCGTGGCCATTGGCAGTCCGCTTGGTAAATTCCAAAATAGTGT
GACGGTTGGAGTGGTCAGCGCTCTTGACCGCACAATTGATAGCATGGAAGGCCTAATTCAAACTGACGCAGCGATTAACC
ATGGCAATAGTGGCGGCCCACTGATCAACCTCAAAGGCGAAATTGTTGGGATCAATACGTTGGTTGTGCGCGGTGATATT
GGTAGTATCGATGAAGCTCAAGGCCTAGGTTTTGCTGTCCCATCAAATATTGTGCGCGAAGTCAGCGATGCTTTGATTGC
CAATGGCCAAGTTATTCGACCATATATAGGCATTCGCTACGAATTGCTTTCGCCCGAAACCGCCGAACTGGGGATTGCCA
ATGATAAAGGTGCTTTCGTGACCAATGTTGATGAAGGTACACCTGCTCGGCGAGCTGGCATTAGCCGTGGCGATATTATT
CTCGCAGTCAACGGCGAAGAAATTACTCAACGCCACTCATTGCAGCGCCTGCTGTTGCAATATAAACCAGGCGATACCGT
AACGGTCACAATCGAGCGTAATGACCAACAACAGGAAGTGCAAATTACCCTCGCTGAACGCCCATAA

Upstream 100 bases:

>100_bases
GATTTTCTAAACCACCATTTAGCCTGCATTAGCCTGCTTTTTAGCTAAACATTGCTACAATACAAGCAGCAAAACAAGCT
CTCTGCAACCAGGAGTCGTT

Downstream 100 bases:

>100_bases
TCGCCTAATAAACCCAGCTCGCTTCAAGCCCTTCGTTCCCAAAACGAGGGGCTTTTTGGTTGTGGCACGCTGCTTGCCCT
TTACACAGCGTTTAGAATAC

Product: 2-alkenal reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSNPKRTVGIGGLIIAALALSGVGGGLVGGVAGYRLAQVDQTATAVAVTPTSATQQTTDNLTAQPVVASTNDAVVQTVAK
ASPAVVKIISTVVGGQASGSGAIINEDGYIITNNHVVEGQSRLQVIYSDGTSHNAELIGTDAFSDIAVIRVLDAVPATIS
LGDSDSLQPGETVVAIGSPLGKFQNSVTVGVVSALDRTIDSMEGLIQTDAAINHGNSGGPLINLKGEIVGINTLVVRGDI
GSIDEAQGLGFAVPSNIVREVSDALIANGQVIRPYIGIRYELLSPETAELGIANDKGAFVTNVDEGTPARRAGISRGDII
LAVNGEEITQRHSLQRLLLQYKPGDTVTVTIERNDQQQEVQITLAERP

Sequences:

>Translated_368_residues
MSNPKRTVGIGGLIIAALALSGVGGGLVGGVAGYRLAQVDQTATAVAVTPTSATQQTTDNLTAQPVVASTNDAVVQTVAK
ASPAVVKIISTVVGGQASGSGAIINEDGYIITNNHVVEGQSRLQVIYSDGTSHNAELIGTDAFSDIAVIRVLDAVPATIS
LGDSDSLQPGETVVAIGSPLGKFQNSVTVGVVSALDRTIDSMEGLIQTDAAINHGNSGGPLINLKGEIVGINTLVVRGDI
GSIDEAQGLGFAVPSNIVREVSDALIANGQVIRPYIGIRYELLSPETAELGIANDKGAFVTNVDEGTPARRAGISRGDII
LAVNGEEITQRHSLQRLLLQYKPGDTVTVTIERNDQQQEVQITLAERP
>Mature_367_residues
SNPKRTVGIGGLIIAALALSGVGGGLVGGVAGYRLAQVDQTATAVAVTPTSATQQTTDNLTAQPVVASTNDAVVQTVAKA
SPAVVKIISTVVGGQASGSGAIINEDGYIITNNHVVEGQSRLQVIYSDGTSHNAELIGTDAFSDIAVIRVLDAVPATISL
GDSDSLQPGETVVAIGSPLGKFQNSVTVGVVSALDRTIDSMEGLIQTDAAINHGNSGGPLINLKGEIVGINTLVVRGDIG
SIDEAQGLGFAVPSNIVREVSDALIANGQVIRPYIGIRYELLSPETAELGIANDKGAFVTNVDEGTPARRAGISRGDIIL
AVNGEEITQRHSLQRLLLQYKPGDTVTVTIERNDQQQEVQITLAERP

Specific function: May be involved in processing, maturation, or secretion of extracellular enzymes [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=302, Percent_Identity=38.7417218543046, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI4506141, Length=282, Percent_Identity=38.6524822695035, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI24308541, Length=278, Percent_Identity=35.2517985611511, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI7019477, Length=287, Percent_Identity=37.6306620209059, Blast_Score=135, Evalue=9e-32,
Organism=Escherichia coli, GI1786356, Length=276, Percent_Identity=40.9420289855072, Blast_Score=184, Evalue=7e-48,
Organism=Escherichia coli, GI1789629, Length=272, Percent_Identity=39.7058823529412, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789630, Length=311, Percent_Identity=34.4051446945338, Blast_Score=154, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24646839, Length=293, Percent_Identity=33.7883959044369, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 37925; Mature: 37794

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPKRTVGIGGLIIAALALSGVGGGLVGGVAGYRLAQVDQTATAVAVTPTSATQQTTDN
CCCCCCEECHHHHHHHHHHHCCCCCHHHHHHHCCEEEECCCCCEEEEECCCCCCCHHCCC
LTAQPVVASTNDAVVQTVAKASPAVVKIISTVVGGQASGSGAIINEDGYIITNNHVVEGQ
CCCCCEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEECCCCEEEECCEEECCC
SRLQVIYSDGTSHNAELIGTDAFSDIAVIRVLDAVPATISLGDSDSLQPGETVVAIGSPL
CEEEEEEECCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEECCCH
GKFQNSVTVGVVSALDRTIDSMEGLIQTDAAINHGNSGGPLINLKGEIVGINTLVVRGDI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEEEEEEECCC
GSIDEAQGLGFAVPSNIVREVSDALIANGQVIRPYIGIRYELLSPETAELGIANDKGAFV
CCCCCCCCCCEECCHHHHHHHHHHHHCCCEEEECEECEEEEECCCCCCEEECCCCCCCEE
TNVDEGTPARRAGISRGDIILAVNGEEITQRHSLQRLLLQYKPGDTVTVTIERNDQQQEV
EECCCCCCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHEECCCCEEEEEEECCCCCEEE
QITLAERP
EEEEECCC
>Mature Secondary Structure 
SNPKRTVGIGGLIIAALALSGVGGGLVGGVAGYRLAQVDQTATAVAVTPTSATQQTTDN
CCCCCEECHHHHHHHHHHHCCCCCHHHHHHHCCEEEECCCCCEEEEECCCCCCCHHCCC
LTAQPVVASTNDAVVQTVAKASPAVVKIISTVVGGQASGSGAIINEDGYIITNNHVVEGQ
CCCCCEEECCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEECCCCEEEECCEEECCC
SRLQVIYSDGTSHNAELIGTDAFSDIAVIRVLDAVPATISLGDSDSLQPGETVVAIGSPL
CEEEEEEECCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCEEEEECCCH
GKFQNSVTVGVVSALDRTIDSMEGLIQTDAAINHGNSGGPLINLKGEIVGINTLVVRGDI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEEEEEEECCC
GSIDEAQGLGFAVPSNIVREVSDALIANGQVIRPYIGIRYELLSPETAELGIANDKGAFV
CCCCCCCCCCEECCHHHHHHHHHHHHCCCEEEECEECEEEEECCCCCCEEECCCCCCCEE
TNVDEGTPARRAGISRGDIILAVNGEEITQRHSLQRLLLQYKPGDTVTVTIERNDQQQEV
EECCCCCCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHEECCCCEEEEEEECCCCCEEE
QITLAERP
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 10692364; 11133960; 11555295 [H]