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The map label for this gene is moaA [H]

Identifier: 159896860

GI number: 159896860

Start: 391538

End: 392572

Strand: Direct

Name: moaA [H]

Synonym: Haur_0327

Alternate gene names: 159896860

Gene position: 391538-392572 (Clockwise)

Preceding gene: 159896859

Following gene: 159896861

Centisome position: 6.17

GC content: 53.33

Gene sequence:

>1035_bases
ATGATGCCGATTGAATTGTTGGAAAAACCTCAAACCCTGCAAACGCGCAGCAATGCCCCCGCCCACGATGCCCACGGGCG
GCGGATTAATTATCTGCGGATTTCATTAACCGACCGCTGCAATTTTCGCTGCTTCTATTGTATGCCTGAATGGGGCATGC
AGTTTGCCCCCAAGCCCGAACTGCTCACCAATGCTGAGTTGATTCGCTTGGTGCGCATTATGGCCCAAACTGGCTTTGAA
AAGATTCGCTTGACTGGTGGCGAGCCAACCTTGCGCCGCGATTTGGTTGGGTTGGTCGAGGCGATTGCCAATACCCCAGG
AATTAGCGAAGTTTCGATGACCACCAATGCCTTATTATTGGCCCCAATCGCCCAGCAATTGGCCGATGCAGGCCTCAAGC
GAGTTAATATCAGCATCGATTCACTCAACCCCGAAAGCTTCCGCAAAATCACGCGTGGCGGCGATTTGACGCGAGTTTGG
GCTGGAATCGAAGCCGCCGAGCAGGCTGGGCTGACTCCATTAAAACTCAATTGTGTGGTTGTGCGCGGAGTCAACGATCA
CGAAGTGCTTGATTTGGCGCGGCTGACGATCGATAAACCTTGGCAAATGCGCTTTATCGAAGTCATGCCGTTGGTTGGCG
TGGCTGAGGTGGCTGATAACGGGGTTGTGCCGAGCAACCAACTAATTGCGCAAATTGAGGCTGAATTTGGCCTCGATTTT
CTTGGTTGGTATGGAGCTGATCCTGCCCGCACCTATCAAATTCCTGGAGCACAAGGCAAACTTGGCTTTATTAGCTCAAT
TAGTGACCCGTTTTGTGCTACTTGCAACCGCATGCGTCTTACCGCCGATGGCAAATTACACCTGTGTTTGCTGCGTGATA
ATGAGCTTGATCTGCGAGCTGCACTCCGGGGCAGCGGCAGCGACGAAGAGCTAGAAGCCTTGATCCGCCATGCCGTCTGG
ATCAAACCATGGGGCCATGGGCTGCCGGATGGAGTTAAGCCGACCGTGCGCGGCATGTCAGAACTCGGTGGTTAA

Upstream 100 bases:

>100_bases
GTATTGAAACCATGGTGGCGGCCTAGCGCCTTGCCACTGGCAACGCTTCAATGACGCATGGCTGCTGCTATGCGTCATTG
TTGTCTGAAAGAGCAAGCCG

Downstream 100 bases:

>100_bases
AGTAGGTTAAAAATTCGCTAGTAAAGCAACCACAACGCTGCTATAATGCCATCCTACGATCGGTAGTAGGTGAAATCGAT
CGTAGGATGGCTCGTTTTTA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MMPIELLEKPQTLQTRSNAPAHDAHGRRINYLRISLTDRCNFRCFYCMPEWGMQFAPKPELLTNAELIRLVRIMAQTGFE
KIRLTGGEPTLRRDLVGLVEAIANTPGISEVSMTTNALLLAPIAQQLADAGLKRVNISIDSLNPESFRKITRGGDLTRVW
AGIEAAEQAGLTPLKLNCVVVRGVNDHEVLDLARLTIDKPWQMRFIEVMPLVGVAEVADNGVVPSNQLIAQIEAEFGLDF
LGWYGADPARTYQIPGAQGKLGFISSISDPFCATCNRMRLTADGKLHLCLLRDNELDLRAALRGSGSDEELEALIRHAVW
IKPWGHGLPDGVKPTVRGMSELGG

Sequences:

>Translated_344_residues
MMPIELLEKPQTLQTRSNAPAHDAHGRRINYLRISLTDRCNFRCFYCMPEWGMQFAPKPELLTNAELIRLVRIMAQTGFE
KIRLTGGEPTLRRDLVGLVEAIANTPGISEVSMTTNALLLAPIAQQLADAGLKRVNISIDSLNPESFRKITRGGDLTRVW
AGIEAAEQAGLTPLKLNCVVVRGVNDHEVLDLARLTIDKPWQMRFIEVMPLVGVAEVADNGVVPSNQLIAQIEAEFGLDF
LGWYGADPARTYQIPGAQGKLGFISSISDPFCATCNRMRLTADGKLHLCLLRDNELDLRAALRGSGSDEELEALIRHAVW
IKPWGHGLPDGVKPTVRGMSELGG
>Mature_344_residues
MMPIELLEKPQTLQTRSNAPAHDAHGRRINYLRISLTDRCNFRCFYCMPEWGMQFAPKPELLTNAELIRLVRIMAQTGFE
KIRLTGGEPTLRRDLVGLVEAIANTPGISEVSMTTNALLLAPIAQQLADAGLKRVNISIDSLNPESFRKITRGGDLTRVW
AGIEAAEQAGLTPLKLNCVVVRGVNDHEVLDLARLTIDKPWQMRFIEVMPLVGVAEVADNGVVPSNQLIAQIEAEFGLDF
LGWYGADPARTYQIPGAQGKLGFISSISDPFCATCNRMRLTADGKLHLCLLRDNELDLRAALRGSGSDEELEALIRHAVW
IKPWGHGLPDGVKPTVRGMSELGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=306, Percent_Identity=42.156862745098, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI22027536, Length=306, Percent_Identity=42.156862745098, Blast_Score=247, Evalue=1e-65,
Organism=Escherichia coli, GI1786999, Length=328, Percent_Identity=35.6707317073171, Blast_Score=204, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI32566329, Length=323, Percent_Identity=44.8916408668731, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI32566331, Length=318, Percent_Identity=44.9685534591195, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17561210, Length=323, Percent_Identity=43.9628482972136, Blast_Score=270, Evalue=7e-73,
Organism=Drosophila melanogaster, GI28574490, Length=322, Percent_Identity=43.167701863354, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI28574488, Length=322, Percent_Identity=43.167701863354, Blast_Score=248, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37869; Mature: 37869

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPIELLEKPQTLQTRSNAPAHDAHGRRINYLRISLTDRCNFRCFYCMPEWGMQFAPKPE
CCCHHHHCCCCHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCC
LLTNAELIRLVRIMAQTGFEKIRLTGGEPTLRRDLVGLVEAIANTPGISEVSMTTNALLL
HHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHHHH
APIAQQLADAGLKRVNISIDSLNPESFRKITRGGDLTRVWAGIEAAEQAGLTPLKLNCVV
HHHHHHHHHCCCEEEEEEEECCCHHHHHHHHCCCCEEEEHHCHHHHHHCCCCEEEEEEEE
VRGVNDHEVLDLARLTIDKPWQMRFIEVMPLVGVAEVADNGVVPSNQLIAQIEAEFGLDF
EECCCCHHHHHHHHHHCCCCHHEEHHHHHCHHHHHHHHCCCCCCCCHHHEEEEHHHCCEE
LGWYGADPARTYQIPGAQGKLGFISSISDPFCATCNRMRLTADGKLHLCLLRDNELDLRA
HHHCCCCCCEEEECCCCCCCCCCHHCCCCCHHHCCCCEEEEECCCEEEEEEECCCCCCHH
ALRGSGSDEELEALIRHAVWIKPWGHGLPDGVKPTVRGMSELGG
HHCCCCCHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MMPIELLEKPQTLQTRSNAPAHDAHGRRINYLRISLTDRCNFRCFYCMPEWGMQFAPKPE
CCCHHHHCCCCHHHHCCCCCCCCCCCCEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCC
LLTNAELIRLVRIMAQTGFEKIRLTGGEPTLRRDLVGLVEAIANTPGISEVSMTTNALLL
HHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEECCCCHHHH
APIAQQLADAGLKRVNISIDSLNPESFRKITRGGDLTRVWAGIEAAEQAGLTPLKLNCVV
HHHHHHHHHCCCEEEEEEEECCCHHHHHHHHCCCCEEEEHHCHHHHHHCCCCEEEEEEEE
VRGVNDHEVLDLARLTIDKPWQMRFIEVMPLVGVAEVADNGVVPSNQLIAQIEAEFGLDF
EECCCCHHHHHHHHHHCCCCHHEEHHHHHCHHHHHHHHCCCCCCCCHHHEEEEHHHCCEE
LGWYGADPARTYQIPGAQGKLGFISSISDPFCATCNRMRLTADGKLHLCLLRDNELDLRA
HHHCCCCCCEEEECCCCCCCCCCHHCCCCCHHHCCCCEEEEECCCEEEEEEECCCCCCHH
ALRGSGSDEELEALIRHAVWIKPWGHGLPDGVKPTVRGMSELGG
HHCCCCCHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA