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The map label for this gene is hisA

Identifier: 159896689

GI number: 159896689

Start: 187107

End: 187829

Strand: Direct

Name: hisA

Synonym: Haur_0156

Alternate gene names: 159896689

Gene position: 187107-187829 (Clockwise)

Preceding gene: 159896688

Following gene: 159896690

Centisome position: 2.95

GC content: 55.19

Gene sequence:

>723_bases
ATGCAACTTATACCAGCAATCGATTTGCGCGATGGCCGTTGTGTGCGGCTGGTGCAAGGTGATTTTGAACAAACCACCGT
CTATGGCGATGATCCGGTGGCGGTCGCGCAGCAGTGGGAAGCAGCCGGCGCTGCCCGTATTCACATTGTTGATCTTGATG
GAGCCAAAGCTGGTCGCCCAACTCAAACCAGCACGATTGCTGCAATCACCAAAGCGGTCAGTGTGCCTGTGCAACTTGGT
GGTGGCTTGCGCGATGCCGCCAGTATTGCCGCCGCTTTTGAGCTTGGCGTGAGCGATGTGATTTTGGGCACGGTAGCGGT
GCGCAACCCTGAATTGGTGGCCGAATTGGTGCGCCAATATGGTAAGGCGATTACGATTGGTATCGATGCCCGCAATGGGG
TCGTGGCGACCGAAGGCTGGCTGGCGAGCAGCCGTCAACGCGCAACTGAACTAGCTGAACAAATGGGTCAACTCGGAGTT
GCGCGGATCATCTATACTGATATTAGCCGTGATGGCACCTTGAGCGAACCAAATTATGCTCAAACTGCCGCCTTGGTAAC
CCCCAATGGCCCAGCAATTATCGCTTCTGGCGGCATCGCCCGCGTTGAACATTTGGCGCGTTTGGCTGAACTGGGCATTA
GCGGGGCAATTATTGGCACGGCACTTTATACAGGCCATATCGATCTGGCCTCGGCAATTCAAACGATTGAACACGGAGGC
TAA

Upstream 100 bases:

>100_bases
TGATAGAGCGCAGCAGGATCGTATAAAACTGGGCTGGTTTGGCAAACATAGCCGATCCCCAACCCCCAAAACCCGATCCC
CAATGACTTTTAGGAGAACC

Downstream 100 bases:

>100_bases
ACGTGTCGTCATCGAAACAAGATATTACTGCTCGTTATGAAGAGGAGCGTTTACGCGCCCAAGAGCAATCGCAATTGCTC
TATCTCCAGAATCAAATCGA

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MQLIPAIDLRDGRCVRLVQGDFEQTTVYGDDPVAVAQQWEAAGAARIHIVDLDGAKAGRPTQTSTIAAITKAVSVPVQLG
GGLRDAASIAAAFELGVSDVILGTVAVRNPELVAELVRQYGKAITIGIDARNGVVATEGWLASSRQRATELAEQMGQLGV
ARIIYTDISRDGTLSEPNYAQTAALVTPNGPAIIASGGIARVEHLARLAELGISGAIIGTALYTGHIDLASAIQTIEHGG

Sequences:

>Translated_240_residues
MQLIPAIDLRDGRCVRLVQGDFEQTTVYGDDPVAVAQQWEAAGAARIHIVDLDGAKAGRPTQTSTIAAITKAVSVPVQLG
GGLRDAASIAAAFELGVSDVILGTVAVRNPELVAELVRQYGKAITIGIDARNGVVATEGWLASSRQRATELAEQMGQLGV
ARIIYTDISRDGTLSEPNYAQTAALVTPNGPAIIASGGIARVEHLARLAELGISGAIIGTALYTGHIDLASAIQTIEHGG
>Mature_240_residues
MQLIPAIDLRDGRCVRLVQGDFEQTTVYGDDPVAVAQQWEAAGAARIHIVDLDGAKAGRPTQTSTIAAITKAVSVPVQLG
GGLRDAASIAAAFELGVSDVILGTVAVRNPELVAELVRQYGKAITIGIDARNGVVATEGWLASSRQRATELAEQMGQLGV
ARIIYTDISRDGTLSEPNYAQTAALVTPNGPAIIASGGIARVEHLARLAELGISGAIIGTALYTGHIDLASAIQTIEHGG

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=245, Percent_Identity=36.734693877551, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788336, Length=240, Percent_Identity=23.3333333333333, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_HERA2 (A9B5I3)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001542936.1
- ProteinModelPortal:   A9B5I3
- SMR:   A9B5I3
- GeneID:   5732065
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_0156
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- BioCyc:   HAUR316274:HAUR_0156-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 24854; Mature: 24854

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLIPAIDLRDGRCVRLVQGDFEQTTVYGDDPVAVAQQWEAAGAARIHIVDLDGAKAGRP
CCCCCCEECCCCCEEEEEECCCCCEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCC
TQTSTIAAITKAVSVPVQLGGGLRDAASIAAAFELGVSDVILGTVAVRNPELVAELVRQY
CCHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHCCHHHHHHHHHEECCHHHHHHHHHHH
GKAITIGIDARNGVVATEGWLASSRQRATELAEQMGQLGVARIIYTDISRDGTLSEPNYA
CCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCCCC
QTAALVTPNGPAIIASGGIARVEHLARLAELGISGAIIGTALYTGHIDLASAIQTIEHGG
CEEEEECCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEHHHHEECCCHHHHHHHHHHCCC
>Mature Secondary Structure
MQLIPAIDLRDGRCVRLVQGDFEQTTVYGDDPVAVAQQWEAAGAARIHIVDLDGAKAGRP
CCCCCCEECCCCCEEEEEECCCCCEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCC
TQTSTIAAITKAVSVPVQLGGGLRDAASIAAAFELGVSDVILGTVAVRNPELVAELVRQY
CCHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHCCHHHHHHHHHEECCHHHHHHHHHHH
GKAITIGIDARNGVVATEGWLASSRQRATELAEQMGQLGVARIIYTDISRDGTLSEPNYA
CCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCCCC
QTAALVTPNGPAIIASGGIARVEHLARLAELGISGAIIGTALYTGHIDLASAIQTIEHGG
CEEEEECCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEHHHHEECCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA