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The map label for this gene is ltrA [H]

Identifier: 159896668

GI number: 159896668

Start: 166364

End: 168046

Strand: Direct

Name: ltrA [H]

Synonym: Haur_0135

Alternate gene names: 159896668

Gene position: 166364-168046 (Clockwise)

Preceding gene: 159896667

Following gene: 159896669

Centisome position: 2.62

GC content: 53.54

Gene sequence:

>1683_bases
ATGATGGCAGAAACCTCTGCTGGTGCGGCCTCCCGCAGTGAGGTCGAGTGGCATGCCATTAACTGGCAACACGTGAACCA
AACTGTGCGTCGGCTGCAATCCCGTATCGTGAAGGCAACACAGGCGGGACGCTATGGCAAGGTGAAAGCTTTGCAACGGC
TCCTGACCCACTCGTTCAGCGGCAAAGCCCTTGCCGTGCGACGAGTGACGGAAAACCAAGGCAAACGGACACCGGGAGTG
GATCAGGTCATCTGGGACACCCCCGAAAAGAAAGCAACGGCCATCCGATCGTTGCGACGACGTGGCTATCAGCCGCGTCC
GTTGCGACGCATCTACATTCCAAAGAAGCATGGAAAACGACGACCCCTTGGCATCCCAACGATGCACGACCGAGCCATGC
AGGCACTCCACCTGCTTGCGCTTGCTCCCATCGCGGAAACAACCGCTGACCCAAACTCCTATGGATTTCGGTCAGAACGG
GCACCAGCAGATGCCATTGGGCAATGCTTTGTTGCACTCGCGAAACGGAAGGCACCAACGTGGATTCTGGAAGGCGACAT
CCGATCATGCTTCGACCGAATTAGCCACGACTGGCTTTTGGCTCATGTCCCAATGGATAAAGCCATCCTTCAGAAATGGT
TAAAGGCCGGGTACATGGAAGGAACAACGCTCTACCCCACCGAGCACGGCACACCGCAGGGCGGGATTATCTCGCCAGTA
TTAGCCAATCTCGCGCTGGATGGCCTCGAACGAATCCTCTTGGAGCATTGCCCCAGAAGGACAGTTCGCGGTATTGCCGC
AAAAGTCAATCTTGTGCGGTATGCGGATGACTTCATTATCACAGGCAGATCGCGAGAACTGCTCGAACAGACAGTCAAAC
CGCTGGTAGAAGCATTCCTCAAGGAACGAGGTCTGGAACTCGCACCGGAGAAAACGCGGATCACGACCATTGAGGAAGGC
TTTGATTTTCTTGGACAGAATGTACGCAAGTACAAGGGGATACTGCTGATTAAGCCCTCAACGGCGAGTCAACGGACATT
CCTCGCCACAATCCGAGCCACGATCAAAGCCAATATGGCCTTGGATGCCGAGAAGTTGATCCGGCTGCTCAATCCCATCA
TCTCGGGATGGACAGCCTATCACCATCATGTTGTCTCAAAGGCTGTGTTTCAATCTATGGGCCATGCAATTTATCAAGCG
CTATGGCGCTGGGCAAAACGAAGACATGCCAACAAACCAAAACGCTGGATCAAAGAGAAATACTTCCGACCAGTCAATGG
AAATCAGTGGGTGTTTTCGGGAGATAGTGCAGGTCGCCCAATACGTTTAGTTGCCGCAGGATACGTGCCGATTAAACGGC
ATGTCAAAATCCGAGCAGCGGCTAATCCATACGACCCAGCGTGGGAGATGTATTTTGAAACCCGACTTGGGGTAAAGATA
GCATCAACCCTCAAGGGACGACGACAACTCCTGCACTTGTGGAAACGACAAAACGGAATTTGCCCCTGTTGCCAAGAACC
GATCACAATGCTGACGGGATGGCACAACCATCACGTCATTCGGCGGATCGACGGCGGAACAGACACGGCGGAAAACCGTA
TGTTAGTCCACCCCACATGCCATACGCAAATCCATAGCCAGAGGTTAACCGAAGTGAAACCGTGTCTCGAAAGAGGCAAG
TGA

Upstream 100 bases:

>100_bases
ATAGGCGGTGAAACATCCCGCCACGCGAAAGCGGGCAGACTTCCGCTTTGGGTCTCTCCTCACGAGAGCTATTGTCGAAC
TGATTTAGGAGGACAAGCAA

Downstream 100 bases:

>100_bases
GAGGCTTGAGCCGGATGCGGGGAAACTCGCACGTCCGGTTCTTAGGGGGCGGGAGTGTAGTAATACGCTCCTGCTACCCG
ACAGATCATTTGCCTGAACG

Product: RNA-directed DNA polymerase

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MMAETSAGAASRSEVEWHAINWQHVNQTVRRLQSRIVKATQAGRYGKVKALQRLLTHSFSGKALAVRRVTENQGKRTPGV
DQVIWDTPEKKATAIRSLRRRGYQPRPLRRIYIPKKHGKRRPLGIPTMHDRAMQALHLLALAPIAETTADPNSYGFRSER
APADAIGQCFVALAKRKAPTWILEGDIRSCFDRISHDWLLAHVPMDKAILQKWLKAGYMEGTTLYPTEHGTPQGGIISPV
LANLALDGLERILLEHCPRRTVRGIAAKVNLVRYADDFIITGRSRELLEQTVKPLVEAFLKERGLELAPEKTRITTIEEG
FDFLGQNVRKYKGILLIKPSTASQRTFLATIRATIKANMALDAEKLIRLLNPIISGWTAYHHHVVSKAVFQSMGHAIYQA
LWRWAKRRHANKPKRWIKEKYFRPVNGNQWVFSGDSAGRPIRLVAAGYVPIKRHVKIRAAANPYDPAWEMYFETRLGVKI
ASTLKGRRQLLHLWKRQNGICPCCQEPITMLTGWHNHHVIRRIDGGTDTAENRMLVHPTCHTQIHSQRLTEVKPCLERGK

Sequences:

>Translated_560_residues
MMAETSAGAASRSEVEWHAINWQHVNQTVRRLQSRIVKATQAGRYGKVKALQRLLTHSFSGKALAVRRVTENQGKRTPGV
DQVIWDTPEKKATAIRSLRRRGYQPRPLRRIYIPKKHGKRRPLGIPTMHDRAMQALHLLALAPIAETTADPNSYGFRSER
APADAIGQCFVALAKRKAPTWILEGDIRSCFDRISHDWLLAHVPMDKAILQKWLKAGYMEGTTLYPTEHGTPQGGIISPV
LANLALDGLERILLEHCPRRTVRGIAAKVNLVRYADDFIITGRSRELLEQTVKPLVEAFLKERGLELAPEKTRITTIEEG
FDFLGQNVRKYKGILLIKPSTASQRTFLATIRATIKANMALDAEKLIRLLNPIISGWTAYHHHVVSKAVFQSMGHAIYQA
LWRWAKRRHANKPKRWIKEKYFRPVNGNQWVFSGDSAGRPIRLVAAGYVPIKRHVKIRAAANPYDPAWEMYFETRLGVKI
ASTLKGRRQLLHLWKRQNGICPCCQEPITMLTGWHNHHVIRRIDGGTDTAENRMLVHPTCHTQIHSQRLTEVKPCLERGK
>Mature_560_residues
MMAETSAGAASRSEVEWHAINWQHVNQTVRRLQSRIVKATQAGRYGKVKALQRLLTHSFSGKALAVRRVTENQGKRTPGV
DQVIWDTPEKKATAIRSLRRRGYQPRPLRRIYIPKKHGKRRPLGIPTMHDRAMQALHLLALAPIAETTADPNSYGFRSER
APADAIGQCFVALAKRKAPTWILEGDIRSCFDRISHDWLLAHVPMDKAILQKWLKAGYMEGTTLYPTEHGTPQGGIISPV
LANLALDGLERILLEHCPRRTVRGIAAKVNLVRYADDFIITGRSRELLEQTVKPLVEAFLKERGLELAPEKTRITTIEEG
FDFLGQNVRKYKGILLIKPSTASQRTFLATIRATIKANMALDAEKLIRLLNPIISGWTAYHHHVVSKAVFQSMGHAIYQA
LWRWAKRRHANKPKRWIKEKYFRPVNGNQWVFSGDSAGRPIRLVAAGYVPIKRHVKIRAAANPYDPAWEMYFETRLGVKI
ASTLKGRRQLLHLWKRQNGICPCCQEPITMLTGWHNHHVIRRIDGGTDTAENRMLVHPTCHTQIHSQRLTEVKPCLERGK

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226521, Length=321, Percent_Identity=24.6105919003115, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6226520, Length=317, Percent_Identity=26.1829652996845, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 63686; Mature: 63686

Theoretical pI: Translated: 11.01; Mature: 11.01

Prosite motif: PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAETSAGAASRSEVEWHAINWQHVNQTVRRLQSRIVKATQAGRYGKVKALQRLLTHSFS
CCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
GKALAVRRVTENQGKRTPGVDQVIWDTPEKKATAIRSLRRRGYQPRPLRRIYIPKKHGKR
CCEEEEEEHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCC
RPLGIPTMHDRAMQALHLLALAPIAETTADPNSYGFRSERAPADAIGQCFVALAKRKAPT
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
WILEGDIRSCFDRISHDWLLAHVPMDKAILQKWLKAGYMEGTTLYPTEHGTPQGGIISPV
EEEECHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCEECCCCCCCCCCCHHHHH
LANLALDGLERILLEHCPRRTVRGIAAKVNLVRYADDFIITGRSRELLEQTVKPLVEAFL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCEEEECCCHHHHHHHHHHHHHHHH
KERGLELAPEKTRITTIEEGFDFLGQNVRKYKGILLIKPSTASQRTFLATIRATIKANMA
HHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHCC
LDAEKLIRLLNPIISGWTAYHHHVVSKAVFQSMGHAIYQALWRWAKRRHANKPKRWIKEK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YFRPVNGNQWVFSGDSAGRPIRLVAAGYVPIKRHVKIRAAANPYDPAWEMYFETRLGVKI
HCCCCCCCEEEECCCCCCCCEEEEEECCCCHHHCEEEEECCCCCCCHHHHHHHHHCCHHH
ASTLKGRRQLLHLWKRQNGICPCCQEPITMLTGWHNHHVIRRIDGGTDTAENRMLVHPTC
HHHHHHHHHHHHHHHHCCCCCCCHHCHHHHHCCCCCCCEEEEECCCCCCCCCCEEECCCH
HTQIHSQRLTEVKPCLERGK
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMAETSAGAASRSEVEWHAINWQHVNQTVRRLQSRIVKATQAGRYGKVKALQRLLTHSFS
CCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
GKALAVRRVTENQGKRTPGVDQVIWDTPEKKATAIRSLRRRGYQPRPLRRIYIPKKHGKR
CCEEEEEEHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCC
RPLGIPTMHDRAMQALHLLALAPIAETTADPNSYGFRSERAPADAIGQCFVALAKRKAPT
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
WILEGDIRSCFDRISHDWLLAHVPMDKAILQKWLKAGYMEGTTLYPTEHGTPQGGIISPV
EEEECHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCEECCCCCCCCCCCHHHHH
LANLALDGLERILLEHCPRRTVRGIAAKVNLVRYADDFIITGRSRELLEQTVKPLVEAFL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCEEEECCCHHHHHHHHHHHHHHHH
KERGLELAPEKTRITTIEEGFDFLGQNVRKYKGILLIKPSTASQRTFLATIRATIKANMA
HHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHCC
LDAEKLIRLLNPIISGWTAYHHHVVSKAVFQSMGHAIYQALWRWAKRRHANKPKRWIKEK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YFRPVNGNQWVFSGDSAGRPIRLVAAGYVPIKRHVKIRAAANPYDPAWEMYFETRLGVKI
HCCCCCCCEEEECCCCCCCCEEEEEECCCCHHHCEEEEECCCCCCCHHHHHHHHHCCHHH
ASTLKGRRQLLHLWKRQNGICPCCQEPITMLTGWHNHHVIRRIDGGTDTAENRMLVHPTC
HHHHHHHHHHHHHHHHCCCCCCCHHCHHHHHCCCCCCCEEEEECCCCCCCCCCEEECCCH
HTQIHSQRLTEVKPCLERGK
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]