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The map label for this gene is ddaH [H]

Identifier: 159896657

GI number: 159896657

Start: 156515

End: 157291

Strand: Reverse

Name: ddaH [H]

Synonym: Haur_0124

Alternate gene names: 159896657

Gene position: 157291-156515 (Counterclockwise)

Preceding gene: 159896670

Following gene: 159896648

Centisome position: 2.48

GC content: 52.64

Gene sequence:

>777_bases
ATGCCAACCGCAATTGTGCGTCCGGTTAGTCCGGCGATTCAACAGTGTGAATTGACCCATCTTGAACGTCAGCCAATTGA
TTTTAGCCGCGCTCAGAGCCAACATGCCAGCTATTGCACCACGCTGGCGGCCAACGGCTATCAGGTTGTCGAACTCAGTG
TAGCCGAAGATTTGGCCGATTCAGTGTTTGTAGAAGATACGGCCTTGGTCTTGCCAGAGCTGGCGATCATTACGCGGCCT
GGCGCTGCATCACGCCGCCCAGAGTTGGCAGCTATGGCCGCCGTATTGCAAAATTACCGCCAACTAGCATGGCTGAGCGA
ACCAGCTACCCTCGATGGCGGCGATGTAGTAGTTTTGGGCAAAACGATTTGGATTGGGCTTTCGAGCCGCAGCAATCAGG
CAGCGGTCGAGCAGGTGCAGGCAGTAACCAAGGCTTTTGGCTATCGTGTCCAAGGGGTTGAATTAGGCCAATGTTTGCAT
CTGAAAACTGCTGTTTGTGCAGTTGATAGCAATACCGTCTTGCTCAACCCACAGTGGGTCGAACCGCAAGTATTTGCTGA
ATATCAGGTAATCGAAGTTGACCCGCGTGAAGAATTTGCGGCGAATGTGGTGCAACTGCACTATGGGCGTTTACTCTACG
ATCAGGCCTATTCGGCAACTGCTGAACGCTTACGCCAGCGGGGCTATCAATTAATTTTGGTGGATAACAGCGAGTTGACG
AAGGCTGAGGGCGCGTTGACCTGTTGCAGCGTACTGATTCACGAAACTGAGGGCTAA

Upstream 100 bases:

>100_bases
ATGCAAATGCTATTGTTATTATACGGTAAACCATCGTAGAACGACTGCCTGTGGTACATACGTGGATCTTTAGAAGTAGC
CAAGGAGGATAGCAATTTCT

Downstream 100 bases:

>100_bases
AACACCATCAGCGGGAACGGCAGTAGCCATTCCCGCTGATCGCTGGTAACAATTAGGCAGTTGCTTGAGCAACATTCACA
TCGAGCGGAATCCCAGGACC

Product: dimethylargininase

Products: NA

Alternate protein names: Dimethylargininase; Dimethylarginine dimethylaminohydrolase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MPTAIVRPVSPAIQQCELTHLERQPIDFSRAQSQHASYCTTLAANGYQVVELSVAEDLADSVFVEDTALVLPELAIITRP
GAASRRPELAAMAAVLQNYRQLAWLSEPATLDGGDVVVLGKTIWIGLSSRSNQAAVEQVQAVTKAFGYRVQGVELGQCLH
LKTAVCAVDSNTVLLNPQWVEPQVFAEYQVIEVDPREEFAANVVQLHYGRLLYDQAYSATAERLRQRGYQLILVDNSELT
KAEGALTCCSVLIHETEG

Sequences:

>Translated_258_residues
MPTAIVRPVSPAIQQCELTHLERQPIDFSRAQSQHASYCTTLAANGYQVVELSVAEDLADSVFVEDTALVLPELAIITRP
GAASRRPELAAMAAVLQNYRQLAWLSEPATLDGGDVVVLGKTIWIGLSSRSNQAAVEQVQAVTKAFGYRVQGVELGQCLH
LKTAVCAVDSNTVLLNPQWVEPQVFAEYQVIEVDPREEFAANVVQLHYGRLLYDQAYSATAERLRQRGYQLILVDNSELT
KAEGALTCCSVLIHETEG
>Mature_257_residues
PTAIVRPVSPAIQQCELTHLERQPIDFSRAQSQHASYCTTLAANGYQVVELSVAEDLADSVFVEDTALVLPELAIITRPG
AASRRPELAAMAAVLQNYRQLAWLSEPATLDGGDVVVLGKTIWIGLSSRSNQAAVEQVQAVTKAFGYRVQGVELGQCLHL
KTAVCAVDSNTVLLNPQWVEPQVFAEYQVIEVDPREEFAANVVQLHYGRLLYDQAYSATAERLRQRGYQLILVDNSELTK
AEGALTCCSVLIHETEG

Specific function: Hydrolyzes asymmetrically methylated arginine with preference for dimethylated arginine over monomethylated arginine [H]

COG id: COG1834

COG function: function code E; N-Dimethylarginine dimethylaminohydrolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DDAH family [H]

Homologues:

Organism=Homo sapiens, GI6912328, Length=270, Percent_Identity=35.1851851851852, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI197313763, Length=163, Percent_Identity=31.2883435582822, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI18859791, Length=251, Percent_Identity=27.8884462151394, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003198 [H]

Pfam domain/function: PF02274 Amidinotransf [H]

EC number: =3.5.3.18 [H]

Molecular weight: Translated: 28238; Mature: 28107

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTAIVRPVSPAIQQCELTHLERQPIDFSRAQSQHASYCTTLAANGYQVVELSVAEDLAD
CCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHH
SVFVEDTALVLPELAIITRPGAASRRPELAAMAAVLQNYRQLAWLSEPATLDGGDVVVLG
HHHHCHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
KTIWIGLSSRSNQAAVEQVQAVTKAFGYRVQGVELGQCLHLKTAVCAVDSNTVLLNPQWV
EEEEEEECCCCCHHHHHHHHHHHHHHCCEECCEECCCCHHHHEEEEEECCCEEEECCCCC
EPQVFAEYQVIEVDPREEFAANVVQLHYGRLLYDQAYSATAERLRQRGYQLILVDNSELT
CCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
KAEGALTCCSVLIHETEG
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PTAIVRPVSPAIQQCELTHLERQPIDFSRAQSQHASYCTTLAANGYQVVELSVAEDLAD
CCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHH
SVFVEDTALVLPELAIITRPGAASRRPELAAMAAVLQNYRQLAWLSEPATLDGGDVVVLG
HHHHCHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
KTIWIGLSSRSNQAAVEQVQAVTKAFGYRVQGVELGQCLHLKTAVCAVDSNTVLLNPQWV
EEEEEEECCCCCHHHHHHHHHHHHHHCCEECCEECCCCHHHHEEEEEECCCEEEECCCCC
EPQVFAEYQVIEVDPREEFAANVVQLHYGRLLYDQAYSATAERLRQRGYQLILVDNSELT
CCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
KAEGALTCCSVLIHETEG
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]