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The map label for this gene is acsA [H]

Identifier: 15922466

GI number: 15922466

Start: 2140210

End: 2141940

Strand: Direct

Name: acsA [H]

Synonym: ST2139

Alternate gene names: 15922466

Gene position: 2140210-2141940 (Clockwise)

Preceding gene: 15922465

Following gene: 15922467

Centisome position: 79.42

GC content: 32.81

Gene sequence:

>1731_bases
ATGGGTTATGCCAAAACTAGTAGTAGAATAGATATGGATTATTTCACTCTTTATCAATATTCAATAGAAAACCCAGAAAA
ATATTGGAGTTCTTTTGCTAATAAATTAGAATGGTTTTCTAAGTGGAATAGTGTTATAATAAGGGACAAATACATCGCAA
AATGGTTTGTTAATGGTAAAACTAATATAGCCTATAATTCCGTCAATACACATCAAGGCAAGGCACTAATTTGGTATGGA
GAAGACGGAAAAAGAATAGAAATAACATATGATGAACTAAATAGGCTAAGTAACTCTATTGCAAACTTACTTAAAAAGAG
GGGAATTAAAAAAGGTATGAGGATTGCTATTTATTCACCCAATTCTATACTAACATTGGCCTCAATTTTAGGAACAGCTA
AAATTGGTGCTATTTATACCCTTATCTTTGCTGGACTAGGTATTGAGGCTATAAAATCTAGGCTTAATGATTTTAATCCA
GACCTTGTCATATCATCAAGAAAGACCTTTAGGAGAGGAAAAGAAATACCCCTATTAATAGAAGGGGATATTAATTTTGA
AAGAAATGATGAAGATGAAATCCGCAAACTTTTAGATAGCGATGAAGTAAAAGTGGAAGAAATAGAAGCTAATGAACCAT
TAAAAGTGATGTACACTTCTGGTACTACGGGTAAGCCTAAAGGAGTAATTTTGCCTCATGGTGCGTGGATGGTAGGAGAT
TATACAGTATTTGATTTACTTTTTGGACTAAAACCTGGTGATAAGGTCCTAACTACTACAGATGTCGGCTGGATAACTTT
CTCTAGAATAATGTATGGTACTTTACTTCATGGTTCTACTTTTATATTTATGGAAGGAGCTCCAGATTATCCTAAAGATA
GATTAGTTAAAATAATTGAAGAAGAGCAACCCAAAGTACTATTCACTTCTCCCACTTTAATAAGATTGTTGATGAAATAT
GATATAAAACTTCCAAGAGTAGAATATATTGCTACTGCAGGAGAGATATTTGATGAAAAAAGCTGGAATTATGCATTAGA
AATTGCAGATAAAGTTACTGATGTATATGGACAAAGCGAATTGGGCTATGTAGTAGGAATACCTTATTCACTAGAGAGCA
TAAAACCGAAGATAGGATATGCAGGTGTACCTTTTCCTGGTATAGTCTTAGATACATTGGATGATGAGGGGAAGGCAGTG
AGAAACAAACCTGGCTATCTAGTTGCAAAAACTCCTTTTCCAACTCAATTTATAGGAATATTAAATAATGAAAAGAAATT
TACAGAATATTTTGAGAAATTTGGTTTCCATGATACCGGAGATTTAGCAATATTTGATGGAACTTATATAAAGATAGTAG
GAAGAGCAGACGATATGATTAAAGTTGCAGGGCATAGAATTACAAGTGGAGAAGTTGAAAGTATAATAGCTAGTATTGAT
GGAGTGAAAGATGTAGCAGTAGTAGGTATTCCAGACGAAATTAGAGGTGAAAAGCTGGCAATCTTTGTAGTTGGAAAAGT
AGATAAAGAGGAAATTAAAAGAAAAGTTCTTGATGCATTAGGACCAATTTATATTATTCATGATGTTTATGTCGTAGAAA
AGTTACCTAAATCTAGAAGTGGCAAGACTGTAAGAAGAATTTTAAGAGATATACTTTTAAATAAGGAAATTGATGCTTCA
ATACTTGAAGACCCAGAAGTCGTAAAGGAGATTAAGGATGAAATTTCATGA

Upstream 100 bases:

>100_bases
TAACTACTGAATTGAAAGACCAAGACATTATAATCTCAACTGCAGAACTAACATTTGCCCATGGTTTCAGTATTCCTTAT
GAAATATTTAAATCTAATAA

Downstream 100 bases:

>100_bases
AGACTTTAGAAATTTAGTACCAGTGACAAAAGAATACGTTTATTTAAATCATGCTGCAATATCTCCTATACCTTTACCTA
TATTATATGAAAGCTTGAGA

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 576; Mature: 575

Protein sequence:

>576_residues
MGYAKTSSRIDMDYFTLYQYSIENPEKYWSSFANKLEWFSKWNSVIIRDKYIAKWFVNGKTNIAYNSVNTHQGKALIWYG
EDGKRIEITYDELNRLSNSIANLLKKRGIKKGMRIAIYSPNSILTLASILGTAKIGAIYTLIFAGLGIEAIKSRLNDFNP
DLVISSRKTFRRGKEIPLLIEGDINFERNDEDEIRKLLDSDEVKVEEIEANEPLKVMYTSGTTGKPKGVILPHGAWMVGD
YTVFDLLFGLKPGDKVLTTTDVGWITFSRIMYGTLLHGSTFIFMEGAPDYPKDRLVKIIEEEQPKVLFTSPTLIRLLMKY
DIKLPRVEYIATAGEIFDEKSWNYALEIADKVTDVYGQSELGYVVGIPYSLESIKPKIGYAGVPFPGIVLDTLDDEGKAV
RNKPGYLVAKTPFPTQFIGILNNEKKFTEYFEKFGFHDTGDLAIFDGTYIKIVGRADDMIKVAGHRITSGEVESIIASID
GVKDVAVVGIPDEIRGEKLAIFVVGKVDKEEIKRKVLDALGPIYIIHDVYVVEKLPKSRSGKTVRRILRDILLNKEIDAS
ILEDPEVVKEIKDEIS

Sequences:

>Translated_576_residues
MGYAKTSSRIDMDYFTLYQYSIENPEKYWSSFANKLEWFSKWNSVIIRDKYIAKWFVNGKTNIAYNSVNTHQGKALIWYG
EDGKRIEITYDELNRLSNSIANLLKKRGIKKGMRIAIYSPNSILTLASILGTAKIGAIYTLIFAGLGIEAIKSRLNDFNP
DLVISSRKTFRRGKEIPLLIEGDINFERNDEDEIRKLLDSDEVKVEEIEANEPLKVMYTSGTTGKPKGVILPHGAWMVGD
YTVFDLLFGLKPGDKVLTTTDVGWITFSRIMYGTLLHGSTFIFMEGAPDYPKDRLVKIIEEEQPKVLFTSPTLIRLLMKY
DIKLPRVEYIATAGEIFDEKSWNYALEIADKVTDVYGQSELGYVVGIPYSLESIKPKIGYAGVPFPGIVLDTLDDEGKAV
RNKPGYLVAKTPFPTQFIGILNNEKKFTEYFEKFGFHDTGDLAIFDGTYIKIVGRADDMIKVAGHRITSGEVESIIASID
GVKDVAVVGIPDEIRGEKLAIFVVGKVDKEEIKRKVLDALGPIYIIHDVYVVEKLPKSRSGKTVRRILRDILLNKEIDAS
ILEDPEVVKEIKDEIS
>Mature_575_residues
GYAKTSSRIDMDYFTLYQYSIENPEKYWSSFANKLEWFSKWNSVIIRDKYIAKWFVNGKTNIAYNSVNTHQGKALIWYGE
DGKRIEITYDELNRLSNSIANLLKKRGIKKGMRIAIYSPNSILTLASILGTAKIGAIYTLIFAGLGIEAIKSRLNDFNPD
LVISSRKTFRRGKEIPLLIEGDINFERNDEDEIRKLLDSDEVKVEEIEANEPLKVMYTSGTTGKPKGVILPHGAWMVGDY
TVFDLLFGLKPGDKVLTTTDVGWITFSRIMYGTLLHGSTFIFMEGAPDYPKDRLVKIIEEEQPKVLFTSPTLIRLLMKYD
IKLPRVEYIATAGEIFDEKSWNYALEIADKVTDVYGQSELGYVVGIPYSLESIKPKIGYAGVPFPGIVLDTLDDEGKAVR
NKPGYLVAKTPFPTQFIGILNNEKKFTEYFEKFGFHDTGDLAIFDGTYIKIVGRADDMIKVAGHRITSGEVESIIASIDG
VKDVAVVGIPDEIRGEKLAIFVVGKVDKEEIKRKVLDALGPIYIIHDVYVVEKLPKSRSGKTVRRILRDILLNKEIDASI
LEDPEVVKEIKDEIS

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=648, Percent_Identity=31.1728395061728, Blast_Score=271, Evalue=9e-73,
Organism=Homo sapiens, GI28416953, Length=620, Percent_Identity=30.4838709677419, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI13375727, Length=631, Percent_Identity=32.0126782884311, Blast_Score=268, Evalue=2e-71,
Organism=Homo sapiens, GI253970489, Length=397, Percent_Identity=35.264483627204, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI31982927, Length=629, Percent_Identity=23.0524642289348, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI38505220, Length=511, Percent_Identity=27.2015655577299, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI42544132, Length=525, Percent_Identity=24.5714285714286, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI58082049, Length=516, Percent_Identity=26.3565891472868, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI115511026, Length=503, Percent_Identity=24.4532803180915, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI157311624, Length=517, Percent_Identity=24.9516441005803, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI157311622, Length=517, Percent_Identity=24.9516441005803, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI122937307, Length=514, Percent_Identity=26.0700389105058, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI187761345, Length=394, Percent_Identity=25.1269035532995, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI187761343, Length=394, Percent_Identity=25.1269035532995, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI42544134, Length=363, Percent_Identity=20.3856749311295, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1790505, Length=626, Percent_Identity=32.1086261980831, Blast_Score=285, Evalue=6e-78,
Organism=Escherichia coli, GI1786529, Length=627, Percent_Identity=30.3030303030303, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI145693145, Length=529, Percent_Identity=23.6294896030246, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI221142682, Length=518, Percent_Identity=24.1312741312741, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788107, Length=519, Percent_Identity=25.2408477842004, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71983001, Length=635, Percent_Identity=28.1889763779528, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71982997, Length=635, Percent_Identity=28.1889763779528, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17569507, Length=620, Percent_Identity=22.4193548387097, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71985884, Length=377, Percent_Identity=26.2599469496021, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71996755, Length=484, Percent_Identity=22.9338842975207, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17560140, Length=351, Percent_Identity=24.7863247863248, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17559526, Length=546, Percent_Identity=26.007326007326, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=500, Percent_Identity=24.4, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17557194, Length=514, Percent_Identity=23.5408560311284, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538037, Length=503, Percent_Identity=24.2544731610338, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25141359, Length=510, Percent_Identity=24.5098039215686, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17551278, Length=488, Percent_Identity=23.5655737704918, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323182, Length=641, Percent_Identity=31.3572542901716, Blast_Score=253, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6319264, Length=638, Percent_Identity=30.8777429467085, Blast_Score=248, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6319699, Length=365, Percent_Identity=25.7534246575342, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24667955, Length=639, Percent_Identity=31.1424100156495, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI21355225, Length=635, Percent_Identity=30.8661417322835, Blast_Score=248, Evalue=1e-65,
Organism=Drosophila melanogaster, GI62472339, Length=548, Percent_Identity=31.7518248175182, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24667959, Length=508, Percent_Identity=31.2992125984252, Blast_Score=222, Evalue=6e-58,
Organism=Drosophila melanogaster, GI24648260, Length=548, Percent_Identity=23.3576642335766, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21356947, Length=495, Percent_Identity=21.010101010101, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355181, Length=499, Percent_Identity=25.8517034068136, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24653035, Length=511, Percent_Identity=24.6575342465753, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24581924, Length=541, Percent_Identity=23.1053604436229, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161076582, Length=515, Percent_Identity=24.2718446601942, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648676, Length=397, Percent_Identity=25.1889168765743, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648257, Length=360, Percent_Identity=23.8888888888889, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 64988; Mature: 64857

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYAKTSSRIDMDYFTLYQYSIENPEKYWSSFANKLEWFSKWNSVIIRDKYIAKWFVNGK
CCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCC
TNIAYNSVNTHQGKALIWYGEDGKRIEITYDELNRLSNSIANLLKKRGIKKGMRIAIYSP
CEEEEECCCCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
NSILTLASILGTAKIGAIYTLIFAGLGIEAIKSRLNDFNPDLVISSRKTFRRGKEIPLLI
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCHHHHCCCCCCEEE
EGDINFERNDEDEIRKLLDSDEVKVEEIEANEPLKVMYTSGTTGKPKGVILPHGAWMVGD
ECCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCCCCCEEEEECCCEEECC
YTVFDLLFGLKPGDKVLTTTDVGWITFSRIMYGTLLHGSTFIFMEGAPDYPKDRLVKIIE
HHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHH
EEQPKVLFTSPTLIRLLMKYDIKLPRVEYIATAGEIFDEKSWNYALEIADKVTDVYGQSE
CCCCCEEEECHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCC
LGYVVGIPYSLESIKPKIGYAGVPFPGIVLDTLDDEGKAVRNKPGYLVAKTPFPTQFIGI
CCEEEECCCCHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCHHHEE
LNNEKKFTEYFEKFGFHDTGDLAIFDGTYIKIVGRADDMIKVAGHRITSGEVESIIASID
CCCCHHHHHHHHHCCCCCCCCEEEECCEEEEEEECCCCCHHHCCCCCCCHHHHHHHHHHC
GVKDVAVVGIPDEIRGEKLAIFVVGKVDKEEIKRKVLDALGPIYIIHDVYVVEKLPKSRS
CCCCEEEEECCHHHCCCEEEEEEEECCCHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCC
GKTVRRILRDILLNKEIDASILEDPEVVKEIKDEIS
CHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
GYAKTSSRIDMDYFTLYQYSIENPEKYWSSFANKLEWFSKWNSVIIRDKYIAKWFVNGK
CCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCC
TNIAYNSVNTHQGKALIWYGEDGKRIEITYDELNRLSNSIANLLKKRGIKKGMRIAIYSP
CEEEEECCCCCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
NSILTLASILGTAKIGAIYTLIFAGLGIEAIKSRLNDFNPDLVISSRKTFRRGKEIPLLI
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCHHHHCCCCCCEEE
EGDINFERNDEDEIRKLLDSDEVKVEEIEANEPLKVMYTSGTTGKPKGVILPHGAWMVGD
ECCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCCCCCCEEEEECCCEEECC
YTVFDLLFGLKPGDKVLTTTDVGWITFSRIMYGTLLHGSTFIFMEGAPDYPKDRLVKIIE
HHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHH
EEQPKVLFTSPTLIRLLMKYDIKLPRVEYIATAGEIFDEKSWNYALEIADKVTDVYGQSE
CCCCCEEEECHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCCCCC
LGYVVGIPYSLESIKPKIGYAGVPFPGIVLDTLDDEGKAVRNKPGYLVAKTPFPTQFIGI
CCEEEECCCCHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCCHHHEE
LNNEKKFTEYFEKFGFHDTGDLAIFDGTYIKIVGRADDMIKVAGHRITSGEVESIIASID
CCCCHHHHHHHHHCCCCCCCCEEEECCEEEEEEECCCCCHHHCCCCCCCHHHHHHHHHHC
GVKDVAVVGIPDEIRGEKLAIFVVGKVDKEEIKRKVLDALGPIYIIHDVYVVEKLPKSRS
CCCCEEEEECCHHHCCCEEEEEEEECCCHHHHHHHHHHHHCCEEEEHHHHHHHHCCCCCC
GKTVRRILRDILLNKEIDASILEDPEVVKEIKDEIS
CHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA