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The map label for this gene is tyrS

Identifier: 15922395

GI number: 15922395

Start: 2077436

End: 2078320

Strand: Direct

Name: tyrS

Synonym: ST2074

Alternate gene names: 15922395

Gene position: 2077436-2078320 (Clockwise)

Preceding gene: 15922394

Following gene: 15922396

Centisome position: 77.09

GC content: 33.22

Gene sequence:

>885_bases
ATGTCTATATTAGTAGCTACATGGCATGCTTGGATAAATGATAAACTTGGCGGGAATCTAGATAAGATTAAGCTTGCTGG
GCAATATGCTATTGAAGTTCTTAATGCTTACGGCGTTGATATGTCCAAAGTTAGAATTGTTTATGCTGAAGACTTAGTTA
AAGATAGCAATTACTGGGCTTTAGTAATAAGAATTGCAAAAAATACTAGTTTAGCTAGAATGAAAAGAGCTTTAACCATA
ATGGGAAGAAAAGCTGAAGAAGCCGAACTTGATACTTCAAAACTAATTTATCCAGCAATGCAAGTTGCTGATATATTGTA
TCAAGATCTCGATATAGCATTAGGCGGAACTGATCAAAGAAAGGCTCATATGTTAGCTAGAGATGTTTCTGACAAATTAG
GAAAAAAGAAAGTAATTGCTATACACACTCCTCTACTTATAGGATTACAAGGGGGGCAGAGAATGGAAGGCGTTGAAGAA
GACGATTACTTAGCTAGTGTAAAGATGAGTAAATCCAAACCAGAAACTGCTATATTTGTACATGATCCACCAGAAGTCGT
TGAAGCAAAATTAAGAAGTGCTTATTGCCCAAAAGGAGTTGTAATTGATAATCCAGTTCTACAAATAAACAAGTATATAA
TATTCGCTAAAGATAATGCTACATTAAAAGTAGAAAGGGATATTAAATATGGTGGAGATATAGAATTTAAATCATATGAA
GAACTAGAAAAGATATATTCAGAAGGAAAATTACACCCATTAGACTTAAAGCTTGCTACAGCGAGAAAATTAAATGAAAT
ATTAGATCCAATTAGGAAAAAATTAGAATCAAAAACCGAATTCACACTTCTCGTAGAAGAACTTGAAAAAGGAGTAACAA
GGTGA

Upstream 100 bases:

>100_bases
ATTAAAAGGATATATAGGCTTTGAGCCTAGTGGGTTATTTCATATAGGCTGGTTAATTTGGGCACAGAAGTTAAAGGACT
TAGTTGATGTTGGAGTAGAT

Downstream 100 bases:

>100_bases
AAAAATGAAATATAACATAGTCTTAAAATTTGAAGTAGAAGGAATAGTAGATAAACCGGATGTAATAGGGGCAATATTTG
GACAAACAGAAAACTTATTC

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSILVATWHAWINDKLGGNLDKIKLAGQYAIEVLNAYGVDMSKVRIVYAEDLVKDSNYWALVIRIAKNTSLARMKRALTI
MGRKAEEAELDTSKLIYPAMQVADILYQDLDIALGGTDQRKAHMLARDVSDKLGKKKVIAIHTPLLIGLQGGQRMEGVEE
DDYLASVKMSKSKPETAIFVHDPPEVVEAKLRSAYCPKGVVIDNPVLQINKYIIFAKDNATLKVERDIKYGGDIEFKSYE
ELEKIYSEGKLHPLDLKLATARKLNEILDPIRKKLESKTEFTLLVEELEKGVTR

Sequences:

>Translated_294_residues
MSILVATWHAWINDKLGGNLDKIKLAGQYAIEVLNAYGVDMSKVRIVYAEDLVKDSNYWALVIRIAKNTSLARMKRALTI
MGRKAEEAELDTSKLIYPAMQVADILYQDLDIALGGTDQRKAHMLARDVSDKLGKKKVIAIHTPLLIGLQGGQRMEGVEE
DDYLASVKMSKSKPETAIFVHDPPEVVEAKLRSAYCPKGVVIDNPVLQINKYIIFAKDNATLKVERDIKYGGDIEFKSYE
ELEKIYSEGKLHPLDLKLATARKLNEILDPIRKKLESKTEFTLLVEELEKGVTR
>Mature_293_residues
SILVATWHAWINDKLGGNLDKIKLAGQYAIEVLNAYGVDMSKVRIVYAEDLVKDSNYWALVIRIAKNTSLARMKRALTIM
GRKAEEAELDTSKLIYPAMQVADILYQDLDIALGGTDQRKAHMLARDVSDKLGKKKVIAIHTPLLIGLQGGQRMEGVEED
DYLASVKMSKSKPETAIFVHDPPEVVEAKLRSAYCPKGVVIDNPVLQINKYIIFAKDNATLKVERDIKYGGDIEFKSYEE
LEKIYSEGKLHPLDLKLATARKLNEILDPIRKKLESKTEFTLLVEELEKGVTR

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily

Homologues:

Organism=Homo sapiens, GI4507947, Length=281, Percent_Identity=30.2491103202847, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6321624, Length=303, Percent_Identity=31.023102310231, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21357223, Length=283, Percent_Identity=32.1554770318021, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYY_SULTO (Q96YV3)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_378064.1
- ProteinModelPortal:   Q96YV3
- SMR:   Q96YV3
- GeneID:   1460139
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST2074
- NMPDR:   fig|273063.1.peg.2232
- HOGENOM:   HBG330667
- BioCyc:   STOK273063:ST2074-MONOMER
- BRENDA:   6.1.1.1
- GO:   GO:0005737
- HAMAP:   MF_02009
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002307
- InterPro:   IPR015624
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11946:SF8
- PIRSF:   PIRSF006588
- PRINTS:   PR01040
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 33087; Mature: 32956

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 36-36 BINDING 163-163 BINDING 167-167 BINDING 170-170 BINDING 185-185 BINDING 237-237

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILVATWHAWINDKLGGNLDKIKLAGQYAIEVLNAYGVDMSKVRIVYAEDLVKDSNYWA
CEEEEEEHHHHHCCCCCCCHHEEEECHHHHHHHHHHCCCCHHHEEEEEEHHHHCCCCEEE
LVIRIAKNTSLARMKRALTIMGRKAEEAELDTSKLIYPAMQVADILYQDLDIALGGTDQR
EEEEEECCCHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHEEECCCCHH
KAHMLARDVSDKLGKKKVIAIHTPLLIGLQGGQRMEGVEEDDYLASVKMSKSKPETAIFV
HHHHHHHHHHHHCCCCEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCEEEEE
HDPPEVVEAKLRSAYCPKGVVIDNPVLQINKYIIFAKDNATLKVERDIKYGGDIEFKSYE
ECCHHHHHHHHHHHCCCCCEEECCCEEEEEEEEEEEECCCEEEEEECCCCCCCCCCCCHH
ELEKIYSEGKLHPLDLKLATARKLNEILDPIRKKLESKTEFTLLVEELEKGVTR
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SILVATWHAWINDKLGGNLDKIKLAGQYAIEVLNAYGVDMSKVRIVYAEDLVKDSNYWA
EEEEEEHHHHHCCCCCCCHHEEEECHHHHHHHHHHCCCCHHHEEEEEEHHHHCCCCEEE
LVIRIAKNTSLARMKRALTIMGRKAEEAELDTSKLIYPAMQVADILYQDLDIALGGTDQR
EEEEEECCCHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHEEECCCCHH
KAHMLARDVSDKLGKKKVIAIHTPLLIGLQGGQRMEGVEEDDYLASVKMSKSKPETAIFV
HHHHHHHHHHHHCCCCEEEEEECCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCEEEEE
HDPPEVVEAKLRSAYCPKGVVIDNPVLQINKYIIFAKDNATLKVERDIKYGGDIEFKSYE
ECCHHHHHHHHHHHCCCCCEEECCCEEEEEEEEEEEECCCEEEEEECCCCCCCCCCCCHH
ELEKIYSEGKLHPLDLKLATARKLNEILDPIRKKLESKTEFTLLVEELEKGVTR
HHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479