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The map label for this gene is mutT [C]

Identifier: 15922344

GI number: 15922344

Start: 2041663

End: 2042118

Strand: Direct

Name: mutT [C]

Synonym: ST2024

Alternate gene names: 15922344

Gene position: 2041663-2042118 (Clockwise)

Preceding gene: 15922343

Following gene: 15922345

Centisome position: 75.76

GC content: 29.61

Gene sequence:

>456_bases
ATGATTACTTGTTTAGTAATTATAAAGGCTAATAATAATTTTTTATTATTTATAAGGAAAAAGAGAGGATTAGGGAAAGG
TCTAATTACATTCCCTGGAGGTAAGGTTAAAGATAACGAGAAGATTGAAGAATGTGCAATAAGAGAAGTTAAAGAAGAAG
TTAACATTACTATTTTTGAACCTAAGCTTGTAGGAAAAATAAAGTTTTACCTAGATGATTATGAAGCGGAAACAACCTAT
GTGTTTGTTACAGATAAATACAAAGGAAAACCAGAAGAAACTGATGAAGCAATACCTATTTGGCTAAATTATATACCTTA
TGAAGAAATGTGGGAAGATGATAAAGTATGGTTACCTCTTGTACTAGAAGGAAAGAAAATTTGCTGTGAATTTAAATTTG
ATAAGAACTGGCAAGAATTTAAGGGAGGATATTGTAATTTATGCGAACTTACATGA

Upstream 100 bases:

>100_bases
TGTCTATAAGAGAAGCATTAAAAGAGTTAGGCTTTAAGGATGATGAAATAGATAGAATACTAGATTTATCAAAATTAGTT
AAGCCAGGTTTTCCTGCAAA

Downstream 100 bases:

>100_bases
TTTTTTTCTAGTAAATAAAATATTGTATATTTTATTAATGCACTCTTTAACATCATCCTTACATTCAAAAAGCTTATACC
CGTTCTCTTTAGCCTTTATG

Product: 7,8-dihydro-8-oxoguanine triphosphatase

Products: 8-Oxo-Dgmp; Pyrophosphate. [C]

Alternate protein names: 7 8-Dihydro-8-Oxoguanine Triphosphatase; Mutator Protein MutT; Mutator Protein; MutT/Nudix Family Protein; NUDIX Domain-Containing Protein; MutT Family Protein

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MITCLVIIKANNNFLLFIRKKRGLGKGLITFPGGKVKDNEKIEECAIREVKEEVNITIFEPKLVGKIKFYLDDYEAETTY
VFVTDKYKGKPEETDEAIPIWLNYIPYEEMWEDDKVWLPLVLEGKKICCEFKFDKNWQEFKGGYCNLCELT

Sequences:

>Translated_151_residues
MITCLVIIKANNNFLLFIRKKRGLGKGLITFPGGKVKDNEKIEECAIREVKEEVNITIFEPKLVGKIKFYLDDYEAETTY
VFVTDKYKGKPEETDEAIPIWLNYIPYEEMWEDDKVWLPLVLEGKKICCEFKFDKNWQEFKGGYCNLCELT
>Mature_151_residues
MITCLVIIKANNNFLLFIRKKRGLGKGLITFPGGKVKDNEKIEECAIREVKEEVNITIFEPKLVGKIKFYLDDYEAETTY
VFVTDKYKGKPEETDEAIPIWLNYIPYEEMWEDDKVWLPLVLEGKKICCEFKFDKNWQEFKGGYCNLCELT

Specific function: Involved In The Go System Responsible For Removing An Oxidatively Damaged Form Of Guanine (7,8-Dihydro-8-Oxoguanine) From DNA And The Nucleotide Pool. 8-Oxo-Dgtp Is Inserted Opposite Da And Dc Residues Of Template DNA With Almost Equal Efficiency Thus Le

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI40288286, Length=133, Percent_Identity=41.3533834586466, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI40288282, Length=133, Percent_Identity=41.3533834586466, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI40288278, Length=133, Percent_Identity=41.3533834586466, Blast_Score=94, Evalue=3e-20,
Organism=Homo sapiens, GI40288284, Length=135, Percent_Identity=40.7407407407407, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI40288280, Length=135, Percent_Identity=40.7407407407407, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI40288276, Length=135, Percent_Identity=40.7407407407407, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI40288274, Length=135, Percent_Identity=40.7407407407407, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.6.1.- [C]

Molecular weight: Translated: 17752; Mature: 17752

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITCLVIIKANNNFLLFIRKKRGLGKGLITFPGGKVKDNEKIEECAIREVKEEVNITIFE
CEEEEEEEEECCCEEEEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEC
PKLVGKIKFYLDDYEAETTYVFVTDKYKGKPEETDEAIPIWLNYIPYEEMWEDDKVWLPL
CCEEEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCEEEEEEEECCHHHHCCCCCEEEEE
VLEGKKICCEFKFDKNWQEFKGGYCNLCELT
EECCCEEEEEEEECCCHHHHCCCCEEEEEEC
>Mature Secondary Structure
MITCLVIIKANNNFLLFIRKKRGLGKGLITFPGGKVKDNEKIEECAIREVKEEVNITIFE
CEEEEEEEEECCCEEEEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCEEEEC
PKLVGKIKFYLDDYEAETTYVFVTDKYKGKPEETDEAIPIWLNYIPYEEMWEDDKVWLPL
CCEEEEEEEEEECCCCCEEEEEEEECCCCCCCCCCCEEEEEEEECCHHHHCCCCCEEEEE
VLEGKKICCEFKFDKNWQEFKGGYCNLCELT
EECCCEEEEEEEECCCHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 8-Oxo-Dgtp; H2O [C]

Specific reaction: 8-Oxo-Dgtp + H2O = 8-Oxo-Dgmp + Pyrophosphate. [C]

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA