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The map label for this gene is fumC [H]

Identifier: 15922343

GI number: 15922343

Start: 2040347

End: 2041666

Strand: Direct

Name: fumC [H]

Synonym: ST2023

Alternate gene names: 15922343

Gene position: 2040347-2041666 (Clockwise)

Preceding gene: 15922340

Following gene: 15922344

Centisome position: 75.72

GC content: 34.92

Gene sequence:

>1320_bases
ATGATGAAATACACTGAGACTGCACCAAAACTTTTTATGAACACAGGAACTAGATTTCCTAGAAAAATAATCTGGGCTAT
GGGACTTATAAAATACGCGGCAGCGAAAGTTAATTCTGATCTTAACCAGTTAGAAAAAGAAATAGCTAAAGGTATTATGC
AAGCAGCAAAAGAAGTTATGGAAGGAAAACATGATGATAAAATAGTTTTAGATGTATTTCAAACAGGCTCTGGTACTGGA
CTAAATATGAATATTAATGAAGTGATAGCAGAAAGGGCAACTGAAATGATTGGAAAAAAAGTTCACCCAAATGATCACGT
AAATTTAGGGCAATCATCTAACGATACTGTTCCTACTGCAATAAGAATAGCAGCAACTTCAGCAGTTGAAGAACAACTTA
TACCAGCACTTAGTAAATTTGTTTCTATTCTTAATAGAAAAAGTGAAGAATTTAAGGATATTGTGAAATCTGGAAGGACT
CATTTAAGGGACGCGTTACCAGTTACCTTAGGTCAAGAGCTTTCAGCATATGCAGACGCTTTCTACCACGATATGACCAA
TTTACAACAAGTACTAGAATATGTTAAGGAGCTTCCTATTGGTGGCACTGCAGTAGGTACTGGATTAAACTCACATCCAG
AATTTCAACTGAGAGTTATTCAAGAGGTTAATAATGAAACTGGATTAGGCTTCAAACCAGCTAATAAGTTTAGAGGATTA
AGGCTTTTAACGGACTTACTTAGTCTAAGCGGTATTATGAGAACAATTGCGGTAGATCTTTACAGACTTGGACAAGATAT
TAGATTAATGTTTTCTGGACCAATGACTGGTTTCAATGAAATAGATCTACCTACTCAAGAAGAAATAGCTGGAAGTAGTA
TTATGCCGGGTAAAACAAACCCAGTTACTGTGGAGGCAACATTATTAGTCTCAGCTCAAGTAGTAGGATTAGATCATGCC
AATCAATTTGCATCAATGTTAGGCGAGTTTGAGTTAGCCATGGGCGTTCCTTTGATTGGATATAATGTGGTTACTCAAAT
AAACTTACTTACAGAGGCATTAAATAAATTTGGAGATTTGGTAATTAATGGTATGGTTCCTAATATAGAAAGAATGAAAA
GATATGCTGAAAGCAGTCCTTCATTAGTTACCGTAATATCACCTATTATTGGTTATGATAAGGCTAGCGAAATAGGGAAG
AGATTAAGCAAAGGAATGTCTATAAGAGAAGCATTAAAAGAGTTAGGCTTTAAGGATGATGAAATAGATAGAATACTAGA
TTTATCAAAATTAGTTAAGCCAGGTTTTCCTGCAAAATGA

Upstream 100 bases:

>100_bases
ACTCGCCTAAGATAAAACGTTTAACTATCATCATAAAAAATCTTTCTGATATCCTAAATAAGTTAACGTAAAAGTAATTA
ATGATTAATACTTTAGTTAT

Downstream 100 bases:

>100_bases
TTACTTGTTTAGTAATTATAAAGGCTAATAATAATTTTTTATTATTTATAAGGAAAAAGAGAGGATTAGGGAAAGGTCTA
ATTACATTCCCTGGAGGTAA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MMKYTETAPKLFMNTGTRFPRKIIWAMGLIKYAAAKVNSDLNQLEKEIAKGIMQAAKEVMEGKHDDKIVLDVFQTGSGTG
LNMNINEVIAERATEMIGKKVHPNDHVNLGQSSNDTVPTAIRIAATSAVEEQLIPALSKFVSILNRKSEEFKDIVKSGRT
HLRDALPVTLGQELSAYADAFYHDMTNLQQVLEYVKELPIGGTAVGTGLNSHPEFQLRVIQEVNNETGLGFKPANKFRGL
RLLTDLLSLSGIMRTIAVDLYRLGQDIRLMFSGPMTGFNEIDLPTQEEIAGSSIMPGKTNPVTVEATLLVSAQVVGLDHA
NQFASMLGEFELAMGVPLIGYNVVTQINLLTEALNKFGDLVINGMVPNIERMKRYAESSPSLVTVISPIIGYDKASEIGK
RLSKGMSIREALKELGFKDDEIDRILDLSKLVKPGFPAK

Sequences:

>Translated_439_residues
MMKYTETAPKLFMNTGTRFPRKIIWAMGLIKYAAAKVNSDLNQLEKEIAKGIMQAAKEVMEGKHDDKIVLDVFQTGSGTG
LNMNINEVIAERATEMIGKKVHPNDHVNLGQSSNDTVPTAIRIAATSAVEEQLIPALSKFVSILNRKSEEFKDIVKSGRT
HLRDALPVTLGQELSAYADAFYHDMTNLQQVLEYVKELPIGGTAVGTGLNSHPEFQLRVIQEVNNETGLGFKPANKFRGL
RLLTDLLSLSGIMRTIAVDLYRLGQDIRLMFSGPMTGFNEIDLPTQEEIAGSSIMPGKTNPVTVEATLLVSAQVVGLDHA
NQFASMLGEFELAMGVPLIGYNVVTQINLLTEALNKFGDLVINGMVPNIERMKRYAESSPSLVTVISPIIGYDKASEIGK
RLSKGMSIREALKELGFKDDEIDRILDLSKLVKPGFPAK
>Mature_439_residues
MMKYTETAPKLFMNTGTRFPRKIIWAMGLIKYAAAKVNSDLNQLEKEIAKGIMQAAKEVMEGKHDDKIVLDVFQTGSGTG
LNMNINEVIAERATEMIGKKVHPNDHVNLGQSSNDTVPTAIRIAATSAVEEQLIPALSKFVSILNRKSEEFKDIVKSGRT
HLRDALPVTLGQELSAYADAFYHDMTNLQQVLEYVKELPIGGTAVGTGLNSHPEFQLRVIQEVNNETGLGFKPANKFRGL
RLLTDLLSLSGIMRTIAVDLYRLGQDIRLMFSGPMTGFNEIDLPTQEEIAGSSIMPGKTNPVTVEATLLVSAQVVGLDHA
NQFASMLGEFELAMGVPLIGYNVVTQINLLTEALNKFGDLVINGMVPNIERMKRYAESSPSLVTVISPIIGYDKASEIGK
RLSKGMSIREALKELGFKDDEIDRILDLSKLVKPGFPAK

Specific function: May function as an auxiliary aerobic enzyme in the citric acid cycle [H]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=425, Percent_Identity=45.4117647058823, Blast_Score=316, Evalue=2e-86,
Organism=Escherichia coli, GI1787896, Length=407, Percent_Identity=44.2260442260442, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI87082375, Length=430, Percent_Identity=36.046511627907, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI1790398, Length=334, Percent_Identity=28.1437125748503, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17553882, Length=426, Percent_Identity=44.131455399061, Blast_Score=321, Evalue=6e-88,
Organism=Caenorhabditis elegans, GI32565146, Length=329, Percent_Identity=41.9452887537994, Blast_Score=233, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6324993, Length=425, Percent_Identity=43.0588235294118, Blast_Score=323, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6321806, Length=235, Percent_Identity=28.5106382978723, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24640179, Length=409, Percent_Identity=43.520782396088, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24640177, Length=409, Percent_Identity=43.520782396088, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24662684, Length=427, Percent_Identity=40.5152224824356, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI78710009, Length=429, Percent_Identity=40.5594405594406, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24583245, Length=427, Percent_Identity=36.2997658079625, Blast_Score=276, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 48178; Mature: 48178

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8276121; 8119400; 11427726; 2124611 [H]