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The map label for this gene is purL

Identifier: 15921789

GI number: 15921789

Start: 1489406

End: 1491517

Strand: Direct

Name: purL

Synonym: ST1495

Alternate gene names: 15921789

Gene position: 1489406-1491517 (Clockwise)

Preceding gene: 15921788

Following gene: 15921790

Centisome position: 55.27

GC content: 34.28

Gene sequence:

>2112_bases
ATGAAAATAACACTTTCTTCGTACGAAATGGAACTAGTAAGAAAGAAGCTTGCAAGAGAACCTAATGAGGCTGAATGGCT
AACTATAGATGCATTATGGAGTGAACATTGCTCTTATAAGTCGTCTAAAGTTTTCTTAAGAAGTTTTCCTAGTGAGGGAG
AAAAGGTATTAATGGGTATTGAAGATTGGCAAGACGCTGGAGCATTAGATGTTGGAGATGGGTGGGCAATTGTGTTAAAA
CTTGAAAGCCATAATCATCCTTCAGCTATTGATCCCTTTAATGGTGCAGCTACTGGAGTTGGAGGTATAATTAGGGATAT
AATAAGTAAAGGAGCGAAGCCAATTGCCTTATTAGATATGATTAGGGTTGGTAATTTATCTAATCCAAGAAATAAATGGT
TGCTAAAGAATATAATTGCTGGAATTGGATTTTATGGGAATAGTATTGGTGTACCAGTAGTTGGTGGAGAATTAGATTTT
GACGATTCATATAATGATAATCCTTTAGTGGATGTTGCTGGTGTAGGTATAGTAAGAAAAGATAAGATTGTACCAAGTGT
TGTTAAGGAGCCTGGATTAAAGATAGTCATAGTTGGCTTAACTGGTTTAGATGGTTTAGGAGGAGCTTCTTTTGCTTCAA
GAAAATTAAGTGGAGAGGATGAAATAGGTGCTGTACAAATTGCCGACCCATTTGCTGGAAAAATAGTTTTAGACGTTACT
CTTGAAATTGCTGATAAAGTAGAGGCTATTAAGGACCTAGGCGGTGGTGGATTAGTAGTTGGAGTTACTGAAATGGCTAA
TGGTTTAGGGGCAATAGTTAATTTAGATAAGGTTCCCTTAAGGGTTAAAGACCTTAAACCAGAAGAGATTTTGGTATCAG
AAACCCAAGAGAGAATGCTTTTTGCTGTTAAAGAAGAAAATGTTAATGAAGTTTGTAAAGCATTTGAATATTACGATTAT
CCTTGTGCTGTAATAGGTGAATTCGTAAAAGAACCATACATTAAGTTTCTTTATGGAGGTAAAGAGATTGTTTCCTTACC
ATCAGATTTACTTTTATCTCCACCAAGATTTATATGGGAAATTAAAAAGCCTAAACTAATTAAAAGTGATAAAAAACCTG
AAGTTGGGTTAGAAGAAAGTATTAGAGCAATACTCTCTAGAATAATAAGTAAAGAATGGGCTTACTCACAATTTGACTAT
GAAGTAGGTACTTCTACTGTTTTAAAGCCTGGAGAAGCCGATTCTGCTTTAATATCACTTCCGAATGGTAAGCTTTTAGC
ATTAAAGGGTGATGCTAATCCAGACTTATGTGCTGAAGATTCTTATGAATGTGGCAAATCTATTGTTGCTGAAGCATATC
GTAACTTAGCATCTGTCGGTGCAATTGGTATAGGAGTAGTTGATCATCTTCAATTTGGTGATCCTAAAAAACCAGAAGTT
TACTATTCTTTTGTAGAAGCTATTAGAGGTATAGCTGAAGCATCAAAGTTCTTTTCTACCCCAATAGTTGGCGGAAAAGT
ATCATTTTATAATGAAAATAAAGAAGGTAAGGCAATTAAACCCACTCCTTTGATAGTCATGGCAGGCTTAATTAAGGATA
AATTCTTACGTAATAAGGTCGTTGAAGATAGTTATATCACTTTAATAGGTTTTACAAGGGACGAGATGAGGGGGTCTTTA
TTTGGTAAAATATTTGGAAATTATGGCGAGGTTCCAAAAGCGAGGTTAAATGAAGACTATTTAGCGAGTCAGTTAGTTGT
AAATTTAATAAACGACGAGAAAATATTCTTTGCTAAGGACATTAATAAAGGAGGTCTAATTGCCTCGTTATTTTCAATAC
TAGTTAAAGGTATGGGCGTAGAGATTGAAACGTCTTCAATTCCTTCGGATACTGATGATTGGATTCCTAAACTTTATTCT
GAAAATGGTGGTAGGTTTATTGTATTAACTAACGATCCAGAGTACATAATACGTAAGTCCAAAGGAATTCATATATCAGT
AATTGGAAAGATAACTAAGGACCAAGGTATAATAAAAATTGATAATAAAGAGATTAATGTAAATAAAGAGATTGATAATT
ATTATAACTACTTATATGAGGTGATGTCATGA

Upstream 100 bases:

>100_bases
ATGTCATAGGCATGATGCCACATCCAGAGAGGGCATCTTTCAAATTAACCTCTATAACGGGTGAAACTGATGGATTATTA
TTATTTAAGGGGTTAAGAAA

Downstream 100 bases:

>100_bases
AGGTTAAAGAACACTGCGGTATTGTTGGAGTTTATGCTGATAATTCTCCAATGATTTCTTACGAATCCCTAAAATTATTA
CAACATAGGGGACAAGAATC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 703; Mature: 703

Protein sequence:

>703_residues
MKITLSSYEMELVRKKLAREPNEAEWLTIDALWSEHCSYKSSKVFLRSFPSEGEKVLMGIEDWQDAGALDVGDGWAIVLK
LESHNHPSAIDPFNGAATGVGGIIRDIISKGAKPIALLDMIRVGNLSNPRNKWLLKNIIAGIGFYGNSIGVPVVGGELDF
DDSYNDNPLVDVAGVGIVRKDKIVPSVVKEPGLKIVIVGLTGLDGLGGASFASRKLSGEDEIGAVQIADPFAGKIVLDVT
LEIADKVEAIKDLGGGGLVVGVTEMANGLGAIVNLDKVPLRVKDLKPEEILVSETQERMLFAVKEENVNEVCKAFEYYDY
PCAVIGEFVKEPYIKFLYGGKEIVSLPSDLLLSPPRFIWEIKKPKLIKSDKKPEVGLEESIRAILSRIISKEWAYSQFDY
EVGTSTVLKPGEADSALISLPNGKLLALKGDANPDLCAEDSYECGKSIVAEAYRNLASVGAIGIGVVDHLQFGDPKKPEV
YYSFVEAIRGIAEASKFFSTPIVGGKVSFYNENKEGKAIKPTPLIVMAGLIKDKFLRNKVVEDSYITLIGFTRDEMRGSL
FGKIFGNYGEVPKARLNEDYLASQLVVNLINDEKIFFAKDINKGGLIASLFSILVKGMGVEIETSSIPSDTDDWIPKLYS
ENGGRFIVLTNDPEYIIRKSKGIHISVIGKITKDQGIIKIDNKEINVNKEIDNYYNYLYEVMS

Sequences:

>Translated_703_residues
MKITLSSYEMELVRKKLAREPNEAEWLTIDALWSEHCSYKSSKVFLRSFPSEGEKVLMGIEDWQDAGALDVGDGWAIVLK
LESHNHPSAIDPFNGAATGVGGIIRDIISKGAKPIALLDMIRVGNLSNPRNKWLLKNIIAGIGFYGNSIGVPVVGGELDF
DDSYNDNPLVDVAGVGIVRKDKIVPSVVKEPGLKIVIVGLTGLDGLGGASFASRKLSGEDEIGAVQIADPFAGKIVLDVT
LEIADKVEAIKDLGGGGLVVGVTEMANGLGAIVNLDKVPLRVKDLKPEEILVSETQERMLFAVKEENVNEVCKAFEYYDY
PCAVIGEFVKEPYIKFLYGGKEIVSLPSDLLLSPPRFIWEIKKPKLIKSDKKPEVGLEESIRAILSRIISKEWAYSQFDY
EVGTSTVLKPGEADSALISLPNGKLLALKGDANPDLCAEDSYECGKSIVAEAYRNLASVGAIGIGVVDHLQFGDPKKPEV
YYSFVEAIRGIAEASKFFSTPIVGGKVSFYNENKEGKAIKPTPLIVMAGLIKDKFLRNKVVEDSYITLIGFTRDEMRGSL
FGKIFGNYGEVPKARLNEDYLASQLVVNLINDEKIFFAKDINKGGLIASLFSILVKGMGVEIETSSIPSDTDDWIPKLYS
ENGGRFIVLTNDPEYIIRKSKGIHISVIGKITKDQGIIKIDNKEINVNKEIDNYYNYLYEVMS
>Mature_703_residues
MKITLSSYEMELVRKKLAREPNEAEWLTIDALWSEHCSYKSSKVFLRSFPSEGEKVLMGIEDWQDAGALDVGDGWAIVLK
LESHNHPSAIDPFNGAATGVGGIIRDIISKGAKPIALLDMIRVGNLSNPRNKWLLKNIIAGIGFYGNSIGVPVVGGELDF
DDSYNDNPLVDVAGVGIVRKDKIVPSVVKEPGLKIVIVGLTGLDGLGGASFASRKLSGEDEIGAVQIADPFAGKIVLDVT
LEIADKVEAIKDLGGGGLVVGVTEMANGLGAIVNLDKVPLRVKDLKPEEILVSETQERMLFAVKEENVNEVCKAFEYYDY
PCAVIGEFVKEPYIKFLYGGKEIVSLPSDLLLSPPRFIWEIKKPKLIKSDKKPEVGLEESIRAILSRIISKEWAYSQFDY
EVGTSTVLKPGEADSALISLPNGKLLALKGDANPDLCAEDSYECGKSIVAEAYRNLASVGAIGIGVVDHLQFGDPKKPEV
YYSFVEAIRGIAEASKFFSTPIVGGKVSFYNENKEGKAIKPTPLIVMAGLIKDKFLRNKVVEDSYITLIGFTRDEMRGSL
FGKIFGNYGEVPKARLNEDYLASQLVVNLINDEKIFFAKDINKGGLIASLFSILVKGMGVEIETSSIPSDTDDWIPKLYS
ENGGRFIVLTNDPEYIIRKSKGIHISVIGKITKDQGIIKIDNKEINVNKEIDNYYNYLYEVMS

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Escherichia coli, GI48994899, Length=752, Percent_Identity=23.5372340425532, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321498, Length=366, Percent_Identity=26.5027322404372, Blast_Score=95, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_SULTO (Q970V6)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377458.1
- ProteinModelPortal:   Q970V6
- GeneID:   1459531
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1495
- NMPDR:   fig|273063.1.peg.1626
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   STOK273063:ST1495-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 76997; Mature: 76997

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITLSSYEMELVRKKLAREPNEAEWLTIDALWSEHCSYKSSKVFLRSFPSEGEKVLMGI
CEEEECHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHCCCCCCHHHEECCCCCCCEEEEEC
EDWQDAGALDVGDGWAIVLKLESHNHPSAIDPFNGAATGVGGIIRDIISKGAKPIALLDM
CCCCCCCCEECCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
IRVGNLSNPRNKWLLKNIIAGIGFYGNSIGVPVVGGELDFDDSYNDNPLVDVAGVGIVRK
HHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCEECCCCCCCCCCEEEEECCCEEEC
DKIVPSVVKEPGLKIVIVGLTGLDGLGGASFASRKLSGEDEIGAVQIADPFAGKIVLDVT
CCCCHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCCCCCCCEEEECCCCCCEEEEEEE
LEIADKVEAIKDLGGGGLVVGVTEMANGLGAIVNLDKVPLRVKDLKPEEILVSETQERML
HHHHHHHHHHHHCCCCEEEEEHHHHCCCCEEEEECCCCCEEEECCCCHHHHHHCCHHHEE
FAVKEENVNEVCKAFEYYDYPCAVIGEFVKEPYIKFLYGGKEIVSLPSDLLLSPPRFIWE
EEECCCCHHHHHHHHHHCCCCHHHHHHHHHCCHHEEHCCCHHHHHCCHHHHCCCCHHEEE
IKKPKLIKSDKKPEVGLEESIRAILSRIISKEWAYSQFDYEVGTSTVLKPGEADSALISL
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEECCCCCCCEEEEC
PNGKLLALKGDANPDLCAEDSYECGKSIVAEAYRNLASVGAIGIGVVDHLQFGDPKKPEV
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCHH
YYSFVEAIRGIAEASKFFSTPIVGGKVSFYNENKEGKAIKPTPLIVMAGLIKDKFLRNKV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEECCCHHHHHHHHHHHHHHHHHC
VEDSYITLIGFTRDEMRGSLFGKIFGNYGEVPKARLNEDYLASQLVVNLINDEKIFFAKD
CCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCCCEEEEEEC
INKGGLIASLFSILVKGMGVEIETSSIPSDTDDWIPKLYSENGGRFIVLTNDPEYIIRKS
CCCCCHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHCCCCCEEEEEECCCCEEEECC
KGIHISVIGKITKDQGIIKIDNKEINVNKEIDNYYNYLYEVMS
CCEEEEEEEEEECCCCEEEECCCEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKITLSSYEMELVRKKLAREPNEAEWLTIDALWSEHCSYKSSKVFLRSFPSEGEKVLMGI
CEEEECHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHCCCCCCHHHEECCCCCCCEEEEEC
EDWQDAGALDVGDGWAIVLKLESHNHPSAIDPFNGAATGVGGIIRDIISKGAKPIALLDM
CCCCCCCCEECCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
IRVGNLSNPRNKWLLKNIIAGIGFYGNSIGVPVVGGELDFDDSYNDNPLVDVAGVGIVRK
HHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCEECCCCCCCCCCEEEEECCCEEEC
DKIVPSVVKEPGLKIVIVGLTGLDGLGGASFASRKLSGEDEIGAVQIADPFAGKIVLDVT
CCCCHHHHHCCCCEEEEEEECCCCCCCCCHHHHCCCCCCCCCCEEEECCCCCCEEEEEEE
LEIADKVEAIKDLGGGGLVVGVTEMANGLGAIVNLDKVPLRVKDLKPEEILVSETQERML
HHHHHHHHHHHHCCCCEEEEEHHHHCCCCEEEEECCCCCEEEECCCCHHHHHHCCHHHEE
FAVKEENVNEVCKAFEYYDYPCAVIGEFVKEPYIKFLYGGKEIVSLPSDLLLSPPRFIWE
EEECCCCHHHHHHHHHHCCCCHHHHHHHHHCCHHEEHCCCHHHHHCCHHHHCCCCHHEEE
IKKPKLIKSDKKPEVGLEESIRAILSRIISKEWAYSQFDYEVGTSTVLKPGEADSALISL
ECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEECCCCCCCEEEEC
PNGKLLALKGDANPDLCAEDSYECGKSIVAEAYRNLASVGAIGIGVVDHLQFGDPKKPEV
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCHH
YYSFVEAIRGIAEASKFFSTPIVGGKVSFYNENKEGKAIKPTPLIVMAGLIKDKFLRNKV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEECCCHHHHHHHHHHHHHHHHHC
VEDSYITLIGFTRDEMRGSLFGKIFGNYGEVPKARLNEDYLASQLVVNLINDEKIFFAKD
CCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCCCEEEEEEC
INKGGLIASLFSILVKGMGVEIETSSIPSDTDDWIPKLYSENGGRFIVLTNDPEYIIRKS
CCCCCHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHCCCCCEEEEEECCCCEEEECC
KGIHISVIGKITKDQGIIKIDNKEINVNKEIDNYYNYLYEVMS
CCEEEEEEEEEECCCCEEEECCCEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479