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The map label for this gene is hisI

Identifier: 15921759

GI number: 15921759

Start: 1469066

End: 1469425

Strand: Direct

Name: hisI

Synonym: ST1467

Alternate gene names: 15921759

Gene position: 1469066-1469425 (Clockwise)

Preceding gene: 15921758

Following gene: 15921760

Centisome position: 54.52

GC content: 31.11

Gene sequence:

>360_bases
ATGATGAAACTAAGTGAGAATGAAGCCTCTAAGTTAATAGAAAAATTATGGTTTAGGCATACAGATTCTACTATAATAGC
TGTTCTTCAAGATTATAAAACTAAAGAAGTTCTAATGGTTGGGCATATGAATAGAGAAGCAGTTTTTAAAACTTTGACAA
CTGGATATGTTCATTTTTGGTCACTAAGTAGGAAGAAGTTATGGTTAAAAGGAGAGACTAGTGGCCATTTTCAATTAGTT
GAAGATTTTAAAATTGATTGTGATGGAGATGCTATGGTTTTCTTAGTCAAATCAGTTGGTCCTGTATGTCATACTGGAAA
TAGGAGTTGCTTCTATAGGAATTTTTCAGATTTAATTTAA

Upstream 100 bases:

>100_bases
TAGTATGTAATGATTTTGCTGTAGGAACTCAGTTTCATCCTGAAAAGAGCAGTGTAACTGGTAAGATATTCCTTAGAAAC
TTTTATTCGTGGGTTAAAAG

Downstream 100 bases:

>100_bases
TGAAGAGTTTAAAATATATGAAGTGGTAATTAAATACGGTTAAAATGTCTACTCAGCAAAATATTAACAAAGAGGAATGG
AAGAAAAAGATTATGGAAGC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 119; Mature: 119

Protein sequence:

>119_residues
MMKLSENEASKLIEKLWFRHTDSTIIAVLQDYKTKEVLMVGHMNREAVFKTLTTGYVHFWSLSRKKLWLKGETSGHFQLV
EDFKIDCDGDAMVFLVKSVGPVCHTGNRSCFYRNFSDLI

Sequences:

>Translated_119_residues
MMKLSENEASKLIEKLWFRHTDSTIIAVLQDYKTKEVLMVGHMNREAVFKTLTTGYVHFWSLSRKKLWLKGETSGHFQLV
EDFKIDCDGDAMVFLVKSVGPVCHTGNRSCFYRNFSDLI
>Mature_119_residues
MMKLSENEASKLIEKLWFRHTDSTIIAVLQDYKTKEVLMVGHMNREAVFKTLTTGYVHFWSLSRKKLWLKGETSGHFQLV
EDFKIDCDGDAMVFLVKSVGPVCHTGNRSCFYRNFSDLI

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=97, Percent_Identity=44.3298969072165, Blast_Score=94, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_SULTO (Q970Y6)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377428.1
- ProteinModelPortal:   Q970Y6
- SMR:   Q970Y6
- GeneID:   1459501
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1467
- NMPDR:   fig|273063.1.peg.1596
- HOGENOM:   HBG294308
- OMA:   SGHYQIV
- ProtClustDB:   PRK00051
- BioCyc:   STOK273063:ST1467-MONOMER
- BRENDA:   3.5.4.19
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 13796; Mature: 13796

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKLSENEASKLIEKLWFRHTDSTIIAVLQDYKTKEVLMVGHMNREAVFKTLTTGYVHFW
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCHHHHHHHHHHCEEEEE
SLSRKKLWLKGETSGHFQLVEDFKIDCDGDAMVFLVKSVGPVCHTGNRSCFYRNFSDLI
ECCCCEEEEECCCCCCEEEEEEEEECCCCCEEEEEECCCCCEEECCCCCEEECCHHHCC
>Mature Secondary Structure
MMKLSENEASKLIEKLWFRHTDSTIIAVLQDYKTKEVLMVGHMNREAVFKTLTTGYVHFW
CCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEECCCHHHHHHHHHHCEEEEE
SLSRKKLWLKGETSGHFQLVEDFKIDCDGDAMVFLVKSVGPVCHTGNRSCFYRNFSDLI
ECCCCEEEEECCCCCCEEEEEEEEECCCCCEEEEEECCCCCEEECCCCCEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479