Click here to switch to the map view.

The map label for this gene is hisB

Identifier: 15921754

GI number: 15921754

Start: 1465691

End: 1466275

Strand: Direct

Name: hisB

Synonym: ST1461

Alternate gene names: 15921754

Gene position: 1465691-1466275 (Clockwise)

Preceding gene: 15921753

Following gene: 15921755

Centisome position: 54.39

GC content: 32.65

Gene sequence:

>585_bases
ATGTCTACTAGGAGTGTAAGAAAAATCAGAGAAACTAAAGAAACTAAAATAGAATTATATCTAGATATAGATAAGAAAGG
AGAGGTAAAAGTATCTACTCCAGTTAATTTTCTTAATCATATGCTTTCAACACTTTTCTATTATATGAATTCCACTGCTA
CTCTCATTGCAGAAGATAAGCAAAATTTCGATGATCATCATGTTGTAGAGGACACTGCAATAGTTATTGGAGAGGCCTTT
AAAGAAGCTTTAGGTGACAAGAAGGGAATAAGAAGGTTTTCTCATCAAATTATTCCCATGGACGATGCTTTAGTTTTGGT
TGCTGTAGATATTTCTGGAAGAGGAGTAAGCAATATTGAACTTAATTTAGAAAGAGATGAGATTGGAGGTTTGGCAACAG
AGAATATTATTCATTTCTTTCAAACTTTCTCTTATAATTCTGGGGTGAATATGCATATTATTCAATTAAGAGGATGGAAT
ACTCATCATGTTATCGAAGCATCGTTTAAGGGTCTTGGTTTTTCGTTGTATGAAGCTTCCAGAATAGTTTATGAAGAAAC
TTACAGTCTAAAGGGATCTTTATGA

Upstream 100 bases:

>100_bases
ATAGGATCTATAGAAGATTTATATAAGTTAAATGAGTATGGTATTAATTATGCGATAATAGGTATGAGCTTTTATTCTGG
CAGTTTAAGAGGGATAAAAT

Downstream 100 bases:

>100_bases
CAGCTAAAAGAATAATTGCTTGTTTAGATGTAAAAAACGGTAGAGTAGTCAAGGGTGTAAATTTCCTTAACTTAAAAGAC
AAGGGAGACCCCGTAGAATT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MSTRSVRKIRETKETKIELYLDIDKKGEVKVSTPVNFLNHMLSTLFYYMNSTATLIAEDKQNFDDHHVVEDTAIVIGEAF
KEALGDKKGIRRFSHQIIPMDDALVLVAVDISGRGVSNIELNLERDEIGGLATENIIHFFQTFSYNSGVNMHIIQLRGWN
THHVIEASFKGLGFSLYEASRIVYEETYSLKGSL

Sequences:

>Translated_194_residues
MSTRSVRKIRETKETKIELYLDIDKKGEVKVSTPVNFLNHMLSTLFYYMNSTATLIAEDKQNFDDHHVVEDTAIVIGEAF
KEALGDKKGIRRFSHQIIPMDDALVLVAVDISGRGVSNIELNLERDEIGGLATENIIHFFQTFSYNSGVNMHIIQLRGWN
THHVIEASFKGLGFSLYEASRIVYEETYSLKGSL
>Mature_193_residues
STRSVRKIRETKETKIELYLDIDKKGEVKVSTPVNFLNHMLSTLFYYMNSTATLIAEDKQNFDDHHVVEDTAIVIGEAFK
EALGDKKGIRRFSHQIIPMDDALVLVAVDISGRGVSNIELNLERDEIGGLATENIIHFFQTFSYNSGVNMHIIQLRGWNT
HHVIEASFKGLGFSLYEASRIVYEETYSLKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=191, Percent_Identity=39.2670157068063, Blast_Score=137, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6324776, Length=152, Percent_Identity=38.1578947368421, Blast_Score=123, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_SULTO (Q970Z1)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377423.1
- ProteinModelPortal:   Q970Z1
- SMR:   Q970Z1
- GeneID:   1459496
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1461
- NMPDR:   fig|273063.1.peg.1591
- HOGENOM:   HBG289010
- OMA:   YYMNSTA
- ProtClustDB:   PRK13598
- BioCyc:   STOK273063:ST1461-MONOMER
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22015; Mature: 21884

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRSVRKIRETKETKIELYLDIDKKGEVKVSTPVNFLNHMLSTLFYYMNSTATLIAEDK
CCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCEEEEECCC
QNFDDHHVVEDTAIVIGEAFKEALGDKKGIRRFSHQIIPMDDALVLVAVDISGRGVSNIE
CCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCEEE
LNLERDEIGGLATENIIHFFQTFSYNSGVNMHIIQLRGWNTHHVIEASFKGLGFSLYEAS
EEEEHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCCCEEHHHHH
RIVYEETYSLKGSL
HHEEEEEEECCCCC
>Mature Secondary Structure 
STRSVRKIRETKETKIELYLDIDKKGEVKVSTPVNFLNHMLSTLFYYMNSTATLIAEDK
CCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHCCCEEEEECCC
QNFDDHHVVEDTAIVIGEAFKEALGDKKGIRRFSHQIIPMDDALVLVAVDISGRGVSNIE
CCCCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCEEE
LNLERDEIGGLATENIIHFFQTFSYNSGVNMHIIQLRGWNTHHVIEASFKGLGFSLYEAS
EEEEHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCCCEEHHHHH
RIVYEETYSLKGSL
HHEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479