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The map label for this gene is eif6

Identifier: 15921658

GI number: 15921658

Start: 1379172

End: 1379843

Strand: Reverse

Name: eif6

Synonym: ST1372

Alternate gene names: 15921658

Gene position: 1379843-1379172 (Counterclockwise)

Preceding gene: 15921660

Following gene: 15921657

Centisome position: 51.2

GC content: 29.17

Gene sequence:

>672_bases
ATGATCATAGATAAGTTAACTATTTTTGGAACCGATAACATAGGGATATATATCTTTACTAATGATAAATATACTATAGT
TCCTAAAAATTTGGATGTTGAAACAATCCAAAAAATCCAAGAAACTTTCAAAACAGAAATAATACAGACAACTATTGCTA
AAAGCTTCCTTATAGGAATTTTTGTAGCTGGCAACAATAATGTTATATTATTACCCAGAAATGTTGATGATGAAGAAGTA
AAGAAGATAAAAGATATAGCTAGAGATGTTAGAGTAGAAATTTTAGATATAAGACCAACTGCTTTAGGAAACATAATTCT
CACTAATTCTTATGGGGCTTTAATTTATCCAGAGTTAAGTAGCATCGAATTTAAAAAAATAAAGGAAAGTCTACAGATTG
ATAATATAGAAAAAGGAAGCATAGCTAATATTATAACTGTAGGTTCTGTAGGAGTTATAACTGATAAAGCTGGTTTAGTT
CACATAGATACAACAGAAGAAGAACTCGATAAATTAAGTAAATTATTTAGAGTAAAAATAGATACTGGTACTGTTAATTT
TGGCAGTGCTTTTATCCATAGTGGTTTAATAGCAAATAGGAATGGAGTTCTAGTAGGTTCAGCAACAACAGGACCAGAGA
TTTTAAGAATCCAAAGAGCTTTTAGTGATTGA

Upstream 100 bases:

>100_bases
TAACATATAACGGAAGAGACAAAATAGTAAGAAAAGTAAGAGTAGCAGTAAAAAAGATAGGAGAAAAAACATATTTAGTC
AGACTTGCATTAAAGAGTGA

Downstream 100 bases:

>100_bases
GATGAGTGAGATAAAAACTTACGTCATAAGAGCAATAGTAACATTTAATGCTTCACATTATCCAATGAAACAAAAAGTAG
TTAAGTATGTAAGAGCATTA

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MIIDKLTIFGTDNIGIYIFTNDKYTIVPKNLDVETIQKIQETFKTEIIQTTIAKSFLIGIFVAGNNNVILLPRNVDDEEV
KKIKDIARDVRVEILDIRPTALGNIILTNSYGALIYPELSSIEFKKIKESLQIDNIEKGSIANIITVGSVGVITDKAGLV
HIDTTEEELDKLSKLFRVKIDTGTVNFGSAFIHSGLIANRNGVLVGSATTGPEILRIQRAFSD

Sequences:

>Translated_223_residues
MIIDKLTIFGTDNIGIYIFTNDKYTIVPKNLDVETIQKIQETFKTEIIQTTIAKSFLIGIFVAGNNNVILLPRNVDDEEV
KKIKDIARDVRVEILDIRPTALGNIILTNSYGALIYPELSSIEFKKIKESLQIDNIEKGSIANIITVGSVGVITDKAGLV
HIDTTEEELDKLSKLFRVKIDTGTVNFGSAFIHSGLIANRNGVLVGSATTGPEILRIQRAFSD
>Mature_223_residues
MIIDKLTIFGTDNIGIYIFTNDKYTIVPKNLDVETIQKIQETFKTEIIQTTIAKSFLIGIFVAGNNNVILLPRNVDDEEV
KKIKDIARDVRVEILDIRPTALGNIILTNSYGALIYPELSSIEFKKIKESLQIDNIEKGSIANIITVGSVGVITDKAGLV
HIDTTEEELDKLSKLFRVKIDTGTVNFGSAFIHSGLIANRNGVLVGSATTGPEILRIQRAFSD

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family

Homologues:

Organism=Homo sapiens, GI4504771, Length=176, Percent_Identity=31.8181818181818, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI31563378, Length=176, Percent_Identity=31.8181818181818, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17506075, Length=219, Percent_Identity=24.2009132420091, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325273, Length=218, Percent_Identity=29.8165137614679, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21492634, Length=217, Percent_Identity=29.4930875576037, Blast_Score=99, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF6_SULTO (Q971I4)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377327.1
- ProteinModelPortal:   Q971I4
- SMR:   Q971I4
- GeneID:   1459398
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1372
- NMPDR:   fig|273063.1.peg.1495
- HOGENOM:   HBG589638
- OMA:   QFENSNE
- ProtClustDB:   PRK04046
- BioCyc:   STOK273063:ST1372-MONOMER
- HAMAP:   MF_00032
- InterPro:   IPR002769
- PANTHER:   PTHR10784
- PIRSF:   PIRSF006413
- SMART:   SM00654
- TIGRFAMs:   TIGR00323

Pfam domain/function: PF01912 eIF-6

EC number: NA

Molecular weight: Translated: 24592; Mature: 24592

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIDKLTIFGTDNIGIYIFTNDKYTIVPKNLDVETIQKIQETFKTEIIQTTIAKSFLIGI
CEEEEEEEEECCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEE
FVAGNNNVILLPRNVDDEEVKKIKDIARDVRVEILDIRPTALGNIILTNSYGALIYPELS
EEECCCCEEEEECCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCEEEECCCCEEEECCCC
SIEFKKIKESLQIDNIEKGSIANIITVGSVGVITDKAGLVHIDTTEEELDKLSKLFRVKI
CCHHHHHHHHHCCCCCCCCCEEEEEEECCEEEEECCCCEEEEECCHHHHHHHHHHEEEEE
DTGTVNFGSAFIHSGLIANRNGVLVGSATTGPEILRIQRAFSD
ECCEEECCHHHHHCCEEECCCEEEEECCCCCHHHHEEEHHHCC
>Mature Secondary Structure
MIIDKLTIFGTDNIGIYIFTNDKYTIVPKNLDVETIQKIQETFKTEIIQTTIAKSFLIGI
CEEEEEEEEECCCEEEEEEECCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEE
FVAGNNNVILLPRNVDDEEVKKIKDIARDVRVEILDIRPTALGNIILTNSYGALIYPELS
EEECCCCEEEEECCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCEEEECCCCEEEECCCC
SIEFKKIKESLQIDNIEKGSIANIITVGSVGVITDKAGLVHIDTTEEELDKLSKLFRVKI
CCHHHHHHHHHCCCCCCCCCEEEEEEECCEEEEECCCCEEEEECCHHHHHHHHHHEEEEE
DTGTVNFGSAFIHSGLIANRNGVLVGSATTGPEILRIQRAFSD
ECCEEECCHHHHHCCEEECCCEEEEECCCCCHHHHEEEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479