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The map label for this gene is argF

Identifier: 15921508

GI number: 15921508

Start: 1247188

End: 1248108

Strand: Reverse

Name: argF

Synonym: ST1245

Alternate gene names: 15921508

Gene position: 1248108-1247188 (Counterclockwise)

Preceding gene: 15921514

Following gene: 15921502

Centisome position: 46.32

GC content: 35.4

Gene sequence:

>921_bases
ATGTTAAAAGGAAAAAGCTTGTTATGCCTACTGGATTTTTCTAAACAGGAAATTGAAAAAATGATGGAAGTTTCTTTCCA
AATGAAGAATTTCCATATGTTGAGATCAGTCCCAAGATCATTAGATGGAAAAACCGTAGCAATGTTATTTGAGAAACCCA
GTACTAGGACAAGAGTAAGTTTTGAGACAGCAATTAGGTTATTAGGTGGCAATCCTATTGTATTAAACAAATCAGACATT
CAGTTAAGTAGAGGAGAACCAGTAGAGGATACAGCAAGAGTTTTAGGGAGGTTTGTAGATGGAATAGCAGCAAGAGTTTT
AAAACACGAAACACTAGAGTTGTTAGCTAAATACTCTAACAAACCTACTATAAATCTTTTAAGTGACCTTTCTCACCCTT
TACAAGCATTAGCAGATTTTATGACAATAAAAGAAAAGTTTGGAGAATATACTTCACTCACTTTTGTAGGAGATGGGGGA
GATAATGTGCTAGTGAGCTTAATGGCTTTTGTAGCTAAAATGGGTTTAGAAATTAAGATAGCTTCTCCCAAAGAATTTAA
GCCCAGAGATGACATTATGAAAAGGATAGAAGAAGAAGCTGAAAAAAGCGGTGCGATAATTGAATTTTATGAGGATCCTT
ATGAAGCTGTGAGAGGTTCAAAGGTTGTATATACTGATGTTTGGGTTAGTATGGGTCAAGAAAGTATAGCTGAAAAAAAG
AAAGAGCTATTGAGAAATTATAGAGTAAGTGTTGATTTAATGAGATATGCGAGTAAAGATGCGATATTTATGCACTGTCT
GCCAGCAGTTAGAGGAGAAGAGGTAGAAAATGAAGTTATAGATGGGCCTAAGAGTGCGGTGTGGGATCAAGCTGAAAACA
GGCTTTATACGGCAATGAGTGTTCTTTCATTACTTCTTTAA

Upstream 100 bases:

>100_bases
CTCATCAAAGTTTGGTTTATTTCCTTTCTTTGGTAAAGTAACTTTAGTTAATGTTAATAGTTCTTCCACATTTTTAAATT
AGTGGTCTAAAATTTAAAAT

Downstream 100 bases:

>100_bases
GAACTCATCAATAGTTCTTTGTGTAATTAGACTTTTTATACTTTTTATTTCAAATAAATTAATTTTAGCTCTTAGTCTCG
TATTAACGTATTTAATTGCA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MLKGKSLLCLLDFSKQEIEKMMEVSFQMKNFHMLRSVPRSLDGKTVAMLFEKPSTRTRVSFETAIRLLGGNPIVLNKSDI
QLSRGEPVEDTARVLGRFVDGIAARVLKHETLELLAKYSNKPTINLLSDLSHPLQALADFMTIKEKFGEYTSLTFVGDGG
DNVLVSLMAFVAKMGLEIKIASPKEFKPRDDIMKRIEEEAEKSGAIIEFYEDPYEAVRGSKVVYTDVWVSMGQESIAEKK
KELLRNYRVSVDLMRYASKDAIFMHCLPAVRGEEVENEVIDGPKSAVWDQAENRLYTAMSVLSLLL

Sequences:

>Translated_306_residues
MLKGKSLLCLLDFSKQEIEKMMEVSFQMKNFHMLRSVPRSLDGKTVAMLFEKPSTRTRVSFETAIRLLGGNPIVLNKSDI
QLSRGEPVEDTARVLGRFVDGIAARVLKHETLELLAKYSNKPTINLLSDLSHPLQALADFMTIKEKFGEYTSLTFVGDGG
DNVLVSLMAFVAKMGLEIKIASPKEFKPRDDIMKRIEEEAEKSGAIIEFYEDPYEAVRGSKVVYTDVWVSMGQESIAEKK
KELLRNYRVSVDLMRYASKDAIFMHCLPAVRGEEVENEVIDGPKSAVWDQAENRLYTAMSVLSLLL
>Mature_306_residues
MLKGKSLLCLLDFSKQEIEKMMEVSFQMKNFHMLRSVPRSLDGKTVAMLFEKPSTRTRVSFETAIRLLGGNPIVLNKSDI
QLSRGEPVEDTARVLGRFVDGIAARVLKHETLELLAKYSNKPTINLLSDLSHPLQALADFMTIKEKFGEYTSLTFVGDGG
DNVLVSLMAFVAKMGLEIKIASPKEFKPRDDIMKRIEEEAEKSGAIIEFYEDPYEAVRGSKVVYTDVWVSMGQESIAEKK
KELLRNYRVSVDLMRYASKDAIFMHCLPAVRGEEVENEVIDGPKSAVWDQAENRLYTAMSVLSLLL

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=310, Percent_Identity=41.9354838709677, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI18105007, Length=312, Percent_Identity=26.2820512820513, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786469, Length=324, Percent_Identity=37.037037037037, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1790703, Length=324, Percent_Identity=35.8024691358025, Blast_Score=188, Evalue=3e-49,
Organism=Escherichia coli, GI48994908, Length=333, Percent_Identity=22.2222222222222, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI2367364, Length=315, Percent_Identity=24.7619047619048, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193204318, Length=330, Percent_Identity=26.969696969697, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322373, Length=319, Percent_Identity=33.5423197492163, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6322331, Length=310, Percent_Identity=26.4516129032258, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24642586, Length=310, Percent_Identity=26.7741935483871, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTC_SULTO (Q971Y3)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377177.1
- ProteinModelPortal:   Q971Y3
- SMR:   Q971Y3
- GeneID:   1459243
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1245
- NMPDR:   fig|273063.1.peg.1345
- HOGENOM:   HBG579429
- OMA:   CVVTDTW
- ProtClustDB:   PRK00779
- BioCyc:   STOK273063:ST1245-MONOMER
- BRENDA:   2.1.3.3
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 34512; Mature: 34512

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 105-105 BINDING 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGKSLLCLLDFSKQEIEKMMEVSFQMKNFHMLRSVPRSLDGKTVAMLFEKPSTRTRVS
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEE
FETAIRLLGGNPIVLNKSDIQLSRGEPVEDTARVLGRFVDGIAARVLKHETLELLAKYSN
HHHHHHHHCCCEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KPTINLLSDLSHPLQALADFMTIKEKFGEYTSLTFVGDGGDNVLVSLMAFVAKMGLEIKI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEEE
ASPKEFKPRDDIMKRIEEEAEKSGAIIEFYEDPYEAVRGSKVVYTDVWVSMGQESIAEKK
CCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCEEEEEHHHHHCCHHHHHHHH
KELLRNYRVSVDLMRYASKDAIFMHCLPAVRGEEVENEVIDGPKSAVWDQAENRLYTAMS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
VLSLLL
HHHHHC
>Mature Secondary Structure
MLKGKSLLCLLDFSKQEIEKMMEVSFQMKNFHMLRSVPRSLDGKTVAMLFEKPSTRTRVS
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEE
FETAIRLLGGNPIVLNKSDIQLSRGEPVEDTARVLGRFVDGIAARVLKHETLELLAKYSN
HHHHHHHHCCCEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KPTINLLSDLSHPLQALADFMTIKEKFGEYTSLTFVGDGGDNVLVSLMAFVAKMGLEIKI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEEE
ASPKEFKPRDDIMKRIEEEAEKSGAIIEFYEDPYEAVRGSKVVYTDVWVSMGQESIAEKK
CCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHCCCEEEEEHHHHHCCHHHHHHHH
KELLRNYRVSVDLMRYASKDAIFMHCLPAVRGEEVENEVIDGPKSAVWDQAENRLYTAMS
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
VLSLLL
HHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479