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The map label for this gene is trpC

Identifier: 15921490

GI number: 15921490

Start: 1228860

End: 1229600

Strand: Reverse

Name: trpC

Synonym: ST1226

Alternate gene names: 15921490

Gene position: 1229600-1228860 (Counterclockwise)

Preceding gene: 15921491

Following gene: 15921489

Centisome position: 45.63

GC content: 30.23

Gene sequence:

>741_bases
ATGCCCAGGTATTTGGAAGGATGGTTAGCTGATGTTGTTAAAATCTCCTTAAACAGAGAAAGAATAAATAAGGTTAGAGA
AAGACCTATTTATTTACTTTCTAAATTTATAAAATCTACAATTGACAAAAATGCTATTATCGCTGAATTTAAAAGAAAAT
CCCCATCTGGGTTAAATGAAAACAGGGACTTAGAAGAATATGTGAAGTTTATGGAAGAAAATGGGGCTATAGGAATTAGT
GTACTTACTGAAGAAAAATATTTTGGAGGTAGCTATTCTGATTTAGAGAATGCTGCAAAAATAGTAAAAATACCTATACT
TATGAAGGATTTCATTGTTACTGAAAAACAAATAGACACAGCATTTAATTTAGGTGCAGACGCGATTCTTCTGATAGTTA
AGATTCTCACAGAACGAGAATTGATTAACCTATATGAGTATGCTAGAAACTTAGGACTTGAGGCTATTGTTGAAGTTACT
GATGAGAATGATTTAAAAATAGCTTTAATGTATGATTTTAATATAATAGGCGTTAATGCTAGAAATCTAAGTAGCTTAGA
GGTTAACATTAGAAATGCTAGAAAAATTCTAGAAATGATACCTAATGATAGAATTAAAATTGCTGAAAGTGGGATAAAAA
ATAAAGAAGATATCATAGAATTAAAGAAGTATGGGGCCGATGCTTTTCTCATAGGAACGACTTTAATGAAGGACCCAAAC
AAAATTAAGGAACTAATATAA

Upstream 100 bases:

>100_bases
TCAGAATTAAGAATTTATGGCGTTCAATTTCATCCAGAGAGTGTAGGAACACCATTAGGAAAGAGAATTATTTATAACTT
TCTCAATAAAGTATAATTGA

Downstream 100 bases:

>100_bases
TTTTTTCCTATGCCAGTAGATGATTTTTCCCTTTCGGCAAATAGTATATCAGGAGAATCTACCCTAGTATATCAAGATGT
TGCAAGACAAGTACAGAAGA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MPRYLEGWLADVVKISLNRERINKVRERPIYLLSKFIKSTIDKNAIIAEFKRKSPSGLNENRDLEEYVKFMEENGAIGIS
VLTEEKYFGGSYSDLENAAKIVKIPILMKDFIVTEKQIDTAFNLGADAILLIVKILTERELINLYEYARNLGLEAIVEVT
DENDLKIALMYDFNIIGVNARNLSSLEVNIRNARKILEMIPNDRIKIAESGIKNKEDIIELKKYGADAFLIGTTLMKDPN
KIKELI

Sequences:

>Translated_246_residues
MPRYLEGWLADVVKISLNRERINKVRERPIYLLSKFIKSTIDKNAIIAEFKRKSPSGLNENRDLEEYVKFMEENGAIGIS
VLTEEKYFGGSYSDLENAAKIVKIPILMKDFIVTEKQIDTAFNLGADAILLIVKILTERELINLYEYARNLGLEAIVEVT
DENDLKIALMYDFNIIGVNARNLSSLEVNIRNARKILEMIPNDRIKIAESGIKNKEDIIELKKYGADAFLIGTTLMKDPN
KIKELI
>Mature_245_residues
PRYLEGWLADVVKISLNRERINKVRERPIYLLSKFIKSTIDKNAIIAEFKRKSPSGLNENRDLEEYVKFMEENGAIGISV
LTEEKYFGGSYSDLENAAKIVKIPILMKDFIVTEKQIDTAFNLGADAILLIVKILTERELINLYEYARNLGLEAIVEVTD
ENDLKIALMYDFNIIGVNARNLSSLEVNIRNARKILEMIPNDRIKIAESGIKNKEDIIELKKYGADAFLIGTTLMKDPNK
IKELI

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=195, Percent_Identity=33.3333333333333, Blast_Score=101, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322638, Length=221, Percent_Identity=38.0090497737557, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_SULTO (Q972A1)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_377159.1
- ProteinModelPortal:   Q972A1
- SMR:   Q972A1
- GeneID:   1459225
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST1226
- NMPDR:   fig|273063.1.peg.1327
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- ProtClustDB:   PRK00278
- BioCyc:   STOK273063:ST1226-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_A
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28101; Mature: 27970

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRYLEGWLADVVKISLNRERINKVRERPIYLLSKFIKSTIDKNAIIAEFKRKSPSGLNE
CCCHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
NRDLEEYVKFMEENGAIGISVLTEEKYFGGSYSDLENAAKIVKIPILMKDFIVTEKQIDT
CCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFNLGADAILLIVKILTERELINLYEYARNLGLEAIVEVTDENDLKIALMYDFNIIGVNA
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEEEEEEECC
RNLSSLEVNIRNARKILEMIPNDRIKIAESGIKNKEDIIELKKYGADAFLIGTTLMKDPN
CCCCEEEEEHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEHHHHHCCHH
KIKELI
HHHHCC
>Mature Secondary Structure 
PRYLEGWLADVVKISLNRERINKVRERPIYLLSKFIKSTIDKNAIIAEFKRKSPSGLNE
CCHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCC
NRDLEEYVKFMEENGAIGISVLTEEKYFGGSYSDLENAAKIVKIPILMKDFIVTEKQIDT
CCCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFNLGADAILLIVKILTERELINLYEYARNLGLEAIVEVTDENDLKIALMYDFNIIGVNA
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEEEEEEEEECC
RNLSSLEVNIRNARKILEMIPNDRIKIAESGIKNKEDIIELKKYGADAFLIGTTLMKDPN
CCCCEEEEEHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEHHHHHCCHH
KIKELI
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479