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The map label for this gene is yhcA [H]

Identifier: 15921252

GI number: 15921252

Start: 986850

End: 988271

Strand: Direct

Name: yhcA [H]

Synonym: ST1006

Alternate gene names: 15921252

Gene position: 986850-988271 (Clockwise)

Preceding gene: 15921251

Following gene: 15921253

Centisome position: 36.62

GC content: 35.09

Gene sequence:

>1422_bases
ATGGATTATAAAAGTAAGACACTACTCATCTTATCTGCAATGCTTTTGATTGTTAACTACGTAGAAACAATGGTTATTCC
GGCTTTACCTACTATTGAGTCAGATTTCTCAATTTCTTCAACTTTAGCTGGCTGGATAACTTCAGCATATTTGCTAGTTG
CAGCAGCAACTTCACCATTAATGGGTAAGCTAGCAGACACTTACGGTAAGACCAGAATGTATATAATAGCTATTGTATTC
TATATTATAGCTGTAGCATTAGCTGGTTTTTCACCAAATATTTGGGTTTTAATTGCGGCTAGAGCAATTCAAGGAGTTGG
TTTCTCGATGTTTCCTATAGCAATAGCGATTATTACTGATATTTATCCAAAAGAAAGAGTTGCCTTTGCCCAATCAATAT
TAAGTGCAACAATTGGTATTGGTCCGGCATTAGGTTTACTTATAGGTTCTTACATTGTTGAGGATTTAGGTTGGCCTTAT
GCCTTTCATACTGCGGCAATACTCTCCCTCATAGTTTTCTTTATCTCTTTGAAATATTTACCTCATACTGGGACAAGGTT
AAAGGAGAGAGTTGATTATATAGGAGCTACTTTAATAGGTTTGGCAACTACTTTAGTTTTAGTTTATATAACTGAGGGAC
CAACTTTAGGCTGGGCCGCTTTAGATAATTTATGGATGTTGATTGTAGGTTTAATCTTATATGGGGCTTTTATTGCTTAT
GAGAGGGTTGCAGTAGAACCTTTAATGAAATTGGAGTTATTTAAAATAAGAAACTTTGCTGTTGCTAATATTGTTGGTTT
AATATCCGGTATTGGTATGTTTGCTAATTTCATTTTCCTAGTCTATTATTCTCAACTACCTAAACCGTATGGTTTGGGTC
TTTCAATTATTCAATCTGGTCTATTGATGTCTCCAGTAGCTTTAGGGATGATAATTTTCGGCCCTATTTTAGGGAGATTA
ATGCCAAGAATCGGTCCTAAACCTATAATGATACTAGGTGGTGTTTTAACAGACCTTTCCTATCTACTATTGCTGACTTT
TAGGAGTACACCAGATGAGGTTTTGCTTGATGGTTTTATTTCTTCTGTAGGTTTAGTTGCATTTATTGTACCACTAGTTA
ACATGGTTGCATTATCTTTACCAGATCAATATAGGACTACTGGAATGGGAATGAATACGTTATTAAGGACTATAGGTGGT
TCAATAGGACCAGTAGTTGCTACAGTATTTATGCAGACTTATCAAGATCCTATTGTGATGATGTTTAATAACCAAATTTA
TGTTATGGGATTCTTACCTTCTGCAACAGCATTTAATTATATTGCAATATTCGGAGTGACTATGATGACCTTAGCTCTAA
TAGTTGCCTTATGGACTAAGAATTATAAGTTTAGGACTGCTGCTGTAAGAATAGCAGAATGA

Upstream 100 bases:

>100_bases
TCATAAATGCGTATTATGGTAATATTAATGGGTTTCTTACTATTACGGTGAAATAGATATATCGAAAAATTTAATAGGTA
GCTTGTCTTTCCCTTTATCC

Downstream 100 bases:

>100_bases
TTTATTTTTTATCTCCTTCTACTATTTTATTTTATGCTATCAGACGAACTTTGGGGCTCGATTTCAGATATTTATTCTTC
GATACTATCACATCCATTCA

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MDYKSKTLLILSAMLLIVNYVETMVIPALPTIESDFSISSTLAGWITSAYLLVAAATSPLMGKLADTYGKTRMYIIAIVF
YIIAVALAGFSPNIWVLIAARAIQGVGFSMFPIAIAIITDIYPKERVAFAQSILSATIGIGPALGLLIGSYIVEDLGWPY
AFHTAAILSLIVFFISLKYLPHTGTRLKERVDYIGATLIGLATTLVLVYITEGPTLGWAALDNLWMLIVGLILYGAFIAY
ERVAVEPLMKLELFKIRNFAVANIVGLISGIGMFANFIFLVYYSQLPKPYGLGLSIIQSGLLMSPVALGMIIFGPILGRL
MPRIGPKPIMILGGVLTDLSYLLLLTFRSTPDEVLLDGFISSVGLVAFIVPLVNMVALSLPDQYRTTGMGMNTLLRTIGG
SIGPVVATVFMQTYQDPIVMMFNNQIYVMGFLPSATAFNYIAIFGVTMMTLALIVALWTKNYKFRTAAVRIAE

Sequences:

>Translated_473_residues
MDYKSKTLLILSAMLLIVNYVETMVIPALPTIESDFSISSTLAGWITSAYLLVAAATSPLMGKLADTYGKTRMYIIAIVF
YIIAVALAGFSPNIWVLIAARAIQGVGFSMFPIAIAIITDIYPKERVAFAQSILSATIGIGPALGLLIGSYIVEDLGWPY
AFHTAAILSLIVFFISLKYLPHTGTRLKERVDYIGATLIGLATTLVLVYITEGPTLGWAALDNLWMLIVGLILYGAFIAY
ERVAVEPLMKLELFKIRNFAVANIVGLISGIGMFANFIFLVYYSQLPKPYGLGLSIIQSGLLMSPVALGMIIFGPILGRL
MPRIGPKPIMILGGVLTDLSYLLLLTFRSTPDEVLLDGFISSVGLVAFIVPLVNMVALSLPDQYRTTGMGMNTLLRTIGG
SIGPVVATVFMQTYQDPIVMMFNNQIYVMGFLPSATAFNYIAIFGVTMMTLALIVALWTKNYKFRTAAVRIAE
>Mature_473_residues
MDYKSKTLLILSAMLLIVNYVETMVIPALPTIESDFSISSTLAGWITSAYLLVAAATSPLMGKLADTYGKTRMYIIAIVF
YIIAVALAGFSPNIWVLIAARAIQGVGFSMFPIAIAIITDIYPKERVAFAQSILSATIGIGPALGLLIGSYIVEDLGWPY
AFHTAAILSLIVFFISLKYLPHTGTRLKERVDYIGATLIGLATTLVLVYITEGPTLGWAALDNLWMLIVGLILYGAFIAY
ERVAVEPLMKLELFKIRNFAVANIVGLISGIGMFANFIFLVYYSQLPKPYGLGLSIIQSGLLMSPVALGMIIFGPILGRL
MPRIGPKPIMILGGVLTDLSYLLLLTFRSTPDEVLLDGFISSVGLVAFIVPLVNMVALSLPDQYRTTGMGMNTLLRTIGG
SIGPVVATVFMQTYQDPIVMMFNNQIYVMGFLPSATAFNYIAIFGVTMMTLALIVALWTKNYKFRTAAVRIAE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=382, Percent_Identity=25.130890052356, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789042, Length=422, Percent_Identity=23.2227488151659, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081983, Length=396, Percent_Identity=23.4848484848485, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790195, Length=338, Percent_Identity=25.4437869822485, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788392, Length=447, Percent_Identity=24.6085011185682, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324954, Length=352, Percent_Identity=25.5681818181818, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323735, Length=310, Percent_Identity=26.4516129032258, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323520, Length=297, Percent_Identity=28.6195286195286, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319770, Length=231, Percent_Identity=25.5411255411255, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51451; Mature: 51451

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKSKTLLILSAMLLIVNYVETMVIPALPTIESDFSISSTLAGWITSAYLLVAAATSPL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHH
MGKLADTYGKTRMYIIAIVFYIIAVALAGFSPNIWVLIAARAIQGVGFSMFPIAIAIITD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHH
IYPKERVAFAQSILSATIGIGPALGLLIGSYIVEDLGWPYAFHTAAILSLIVFFISLKYL
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PHTGTRLKERVDYIGATLIGLATTLVLVYITEGPTLGWAALDNLWMLIVGLILYGAFIAY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ERVAVEPLMKLELFKIRNFAVANIVGLISGIGMFANFIFLVYYSQLPKPYGLGLSIIQSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCC
LLMSPVALGMIIFGPILGRLMPRIGPKPIMILGGVLTDLSYLLLLTFRSTPDEVLLDGFI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SSVGLVAFIVPLVNMVALSLPDQYRTTGMGMNTLLRTIGGSIGPVVATVFMQTYQDPIVM
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEE
MFNNQIYVMGFLPSATAFNYIAIFGVTMMTLALIVALWTKNYKFRTAAVRIAE
EECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHEEEECC
>Mature Secondary Structure
MDYKSKTLLILSAMLLIVNYVETMVIPALPTIESDFSISSTLAGWITSAYLLVAAATSPL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHH
MGKLADTYGKTRMYIIAIVFYIIAVALAGFSPNIWVLIAARAIQGVGFSMFPIAIAIITD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHH
IYPKERVAFAQSILSATIGIGPALGLLIGSYIVEDLGWPYAFHTAAILSLIVFFISLKYL
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PHTGTRLKERVDYIGATLIGLATTLVLVYITEGPTLGWAALDNLWMLIVGLILYGAFIAY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ERVAVEPLMKLELFKIRNFAVANIVGLISGIGMFANFIFLVYYSQLPKPYGLGLSIIQSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCC
LLMSPVALGMIIFGPILGRLMPRIGPKPIMILGGVLTDLSYLLLLTFRSTPDEVLLDGFI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SSVGLVAFIVPLVNMVALSLPDQYRTTGMGMNTLLRTIGGSIGPVVATVFMQTYQDPIVM
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCEEE
MFNNQIYVMGFLPSATAFNYIAIFGVTMMTLALIVALWTKNYKFRTAAVRIAE
EECCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]