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The map label for this gene is rnz

Identifier: 15921184

GI number: 15921184

Start: 922773

End: 923654

Strand: Direct

Name: rnz

Synonym: ST0948

Alternate gene names: 15921184

Gene position: 922773-923654 (Clockwise)

Preceding gene: 15921183

Following gene: 15921187

Centisome position: 34.24

GC content: 30.61

Gene sequence:

>882_bases
ATGATTACAGTATATTTTATAGGTACTGGTGGAGGAGCTCCTAATAAAAGGGGCTTACCAGCAATTATGGTTAGAAGGGA
AGGTTTTGATGCTCTATTTGATTGTGGTGAAGGAACCCAATGGAGGATGATGGAGCATAATCTTAGTTTTATGAAAATAA
AACTCATTGGAATTACTCATATGCATGGTGATCATGTTTTAGGCTTACCTGGAATGATCGAAACCATGGGTATGTATAGT
AGAAAAGAATCATTACTTTTAATGGGACCAAAAGAATTAAAAGAATTTCTAGAGGATATTTTTAAAAAAACTTATTTTTA
CCCAAATTTTGAGATACAGATAATAGATAAATACGAAGACGAAAATATTAAGATTAGTACTTTTGAAACATGCCATACAA
TAGAATCACAAGGATATTTATTTGAGGAAAAGGATAGACTAAAGATTGATATTGATAAATTGAGAAAAGAGGGAATAAAG
GATTGGAGAATTATAAGGATGCTAAAAGAAGGAAAAAGAGTGGAAATAAATGGAAAAGTTCTATTACCGGAAGATTATTT
AATAGTAAAAAAGGGTATAAGAATTGCATATACGGGAGATACGGGACCTTGTGAGAAGGTTATAAATGCTGTAAAAGATG
TGGATCTTCTTATCCATGATTCTACTTTTATTGATGAAAAAGAAGCTTATAAATATGGACATTCAAATAGTTATGATGCA
GCATATGTAGCATTAAAAGCTAATGTGAAAAGGTTAGCTCTTTTTCACATAAGTCCAAGATATGATGATACATACGAAAT
GCTAATAAAGGCTAAAAGAATTTTTGAAAAAACTTTTGTAGCTGAACCATTATCTTATTATATTATTCGTCAGAAGGAAT
AG

Upstream 100 bases:

>100_bases
GGAGAGATAAGTTAAAGGAAGTTGGTTTTAATGATATTTCAATCCATTTTATTTATGAGCATAAAAGTTTAAGCAGAGCA
ATATACGTGGTAAGAAAAAA

Downstream 100 bases:

>100_bases
GATTCTCCCAAAGAGGAACGCCTTTAGCGGTCTTAGGGGTTAACCAATCAATAAGCGCTTGAGGGTCTTTGTACTCTATT
GTTACCTTTATAGGCCCTAG

Product: hypothetical protein

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MITVYFIGTGGGAPNKRGLPAIMVRREGFDALFDCGEGTQWRMMEHNLSFMKIKLIGITHMHGDHVLGLPGMIETMGMYS
RKESLLLMGPKELKEFLEDIFKKTYFYPNFEIQIIDKYEDENIKISTFETCHTIESQGYLFEEKDRLKIDIDKLRKEGIK
DWRIIRMLKEGKRVEINGKVLLPEDYLIVKKGIRIAYTGDTGPCEKVINAVKDVDLLIHDSTFIDEKEAYKYGHSNSYDA
AYVALKANVKRLALFHISPRYDDTYEMLIKAKRIFEKTFVAEPLSYYIIRQKE

Sequences:

>Translated_293_residues
MITVYFIGTGGGAPNKRGLPAIMVRREGFDALFDCGEGTQWRMMEHNLSFMKIKLIGITHMHGDHVLGLPGMIETMGMYS
RKESLLLMGPKELKEFLEDIFKKTYFYPNFEIQIIDKYEDENIKISTFETCHTIESQGYLFEEKDRLKIDIDKLRKEGIK
DWRIIRMLKEGKRVEINGKVLLPEDYLIVKKGIRIAYTGDTGPCEKVINAVKDVDLLIHDSTFIDEKEAYKYGHSNSYDA
AYVALKANVKRLALFHISPRYDDTYEMLIKAKRIFEKTFVAEPLSYYIIRQKE
>Mature_293_residues
MITVYFIGTGGGAPNKRGLPAIMVRREGFDALFDCGEGTQWRMMEHNLSFMKIKLIGITHMHGDHVLGLPGMIETMGMYS
RKESLLLMGPKELKEFLEDIFKKTYFYPNFEIQIIDKYEDENIKISTFETCHTIESQGYLFEEKDRLKIDIDKLRKEGIK
DWRIIRMLKEGKRVEINGKVLLPEDYLIVKKGIRIAYTGDTGPCEKVINAVKDVDLLIHDSTFIDEKEAYKYGHSNSYDA
AYVALKANVKRLALFHISPRYDDTYEMLIKAKRIFEKTFVAEPLSYYIIRQKE

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=319, Percent_Identity=31.3479623824451, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI87082078, Length=300, Percent_Identity=30.6666666666667, Blast_Score=154, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_SULTO (Q973F1)

Other databases:

- EMBL:   BA000023
- RefSeq:   NP_376853.1
- ProteinModelPortal:   Q973F1
- SMR:   Q973F1
- GeneID:   1458913
- GenomeReviews:   BA000023_GR
- KEGG:   sto:ST0948
- NMPDR:   fig|273063.1.peg.1021
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- ProtClustDB:   CLSK883695
- BioCyc:   STOK273063:ST0948-MONOMER
- BRENDA:   3.1.26.11
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 34066; Mature: 34066

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITVYFIGTGGGAPNKRGLPAIMVRREGFDALFDCGEGTQWRMMEHNLSFMKIKLIGITH
CEEEEEEECCCCCCCCCCCCEEEEEECCCHHEEECCCCCEEEEEECCCCEEEEEEEEEEE
MHGDHVLGLPGMIETMGMYSRKESLLLMGPKELKEFLEDIFKKTYFYPNFEIQIIDKYED
ECCCEEECCCHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
ENIKISTFETCHTIESQGYLFEEKDRLKIDIDKLRKEGIKDWRIIRMLKEGKRVEINGKV
CCEEEEEEHHHEEECCCCCEEECCCCEEEEHHHHHHCCCCHHHHHHHHHCCCEEEECCEE
LLPEDYLIVKKGIRIAYTGDTGPCEKVINAVKDVDLLIHDSTFIDEKEAYKYGHSNSYDA
ECCCCEEEEECCEEEEECCCCCHHHHHHHHHHHEEEEEECCCCCCCHHHHHCCCCCCCCE
AYVALKANVKRLALFHISPRYDDTYEMLIKAKRIFEKTFVAEPLSYYIIRQKE
EEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
>Mature Secondary Structure
MITVYFIGTGGGAPNKRGLPAIMVRREGFDALFDCGEGTQWRMMEHNLSFMKIKLIGITH
CEEEEEEECCCCCCCCCCCCEEEEEECCCHHEEECCCCCEEEEEECCCCEEEEEEEEEEE
MHGDHVLGLPGMIETMGMYSRKESLLLMGPKELKEFLEDIFKKTYFYPNFEIQIIDKYED
ECCCEEECCCHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
ENIKISTFETCHTIESQGYLFEEKDRLKIDIDKLRKEGIKDWRIIRMLKEGKRVEINGKV
CCEEEEEEHHHEEECCCCCEEECCCCEEEEHHHHHHCCCCHHHHHHHHHCCCEEEECCEE
LLPEDYLIVKKGIRIAYTGDTGPCEKVINAVKDVDLLIHDSTFIDEKEAYKYGHSNSYDA
ECCCCEEEEECCEEEEECCCCCHHHHHHHHHHHEEEEEECCCCCCCHHHHHCCCCCCCCE
AYVALKANVKRLALFHISPRYDDTYEMLIKAKRIFEKTFVAEPLSYYIIRQKE
EEEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479